The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations
Open accessAbstract
Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including individuals of European American, African American or African Caribbean, and Latino ancestry, with replication in an additional 12,649 individuals from the same ethnic groups. We identified five susceptibility loci. Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. In addition, we identified a new asthma susceptibility locus at PYHIN1, with the association being specific to individuals of African descent (P = 3.9 × 10−9). These results suggest that some asthma susceptibility loci are robust to differences in ancestry when sufficiently large samples sizes are investigated, and that ancestry-specific associations also contribute to the complex genetic architecture of asthma.
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Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
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Discovering susceptibility genes for asthma and allergy
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Self-citationGenetics of Asthma and Hay Fever in Australian Twins
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Effect of 17q21 Variants and Smoking Exposure in Early-Onset Asthma
Bouzigon, E., Corda, E., Aschard, H., Dizier, M.-H., Boland, A., Bousquet, J., Chateigner, N., Gormand, F., Just, J., Le Moual, N., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0806604 · Cited by 400
Cited by
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Chung, K. F., Wenzel, S. E., Brozek, J. L., Bush, A., Castro, M., Sterk, P. J., Adcock, I. M., Bateman, E. D., Bel, E. H., Bleecker, E. R., et al. (2014) · European Respiratory Journal · doi:10.1183/09031936.00202013 · Cited by 3,926
10 Years of GWAS Discovery: Biology, Function, and Translation
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Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations
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After asthma: redefining airways diseases
Pavord, I. D., Beasley, R., Agusti, A., Anderson, G. P., Bel, E., Brusselle, G., Cullinan, P., Custovic, A., Ducharme, F. M., Fahy, J. V., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)30879-6 · Cited by 1,073
IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy
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Metadata
- Authors
- (MCAAS), M. C. C. A. S., Ober, C., study, C. H. S. (. A. H., Genetics of Asthma in Latino Americans (GALA) Study, T. S. O. G.-E. A. A. I. L. A. (. A. T. S. O. A. A., Childhood Asthma Research and Education (CARE) Network, (CAMP), C. A. M. P., (SAPPHIRE), S. O. A. P. A. P. I. B. R.-E., Study, G. R. O. A. I. T. A. D. (., & Nicolae, D. L.
- Venue
- Nature Genetics
- Published
- 2011-07-31
- Volume
- 43
- Issue
- 9
- Pages
- 887-892
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W1747499909
- Cited by
- 833
- References
- 26
- FWCI
- 8.61
- Type
- journal article
- Language
- en
- Open access
- green
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- (MCAAS), M. C. C. A. S., Ober, C., study, C. H. S. (. A. H., Genetics of Asthma in Latino Americans (GALA) Study, T. S. O. G.-E. A. A. I. L. A. (. A. T. S. O. A. A., Childhood Asthma Research and Education (CARE) Network, (CAMP), C. A. M. P., (SAPPHIRE), S. O. A. P. A. P. I. B. R.-E., Study, G. R. O. A. I. T. A. D. (., & Nicolae, D. L. (2011). Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nature Genetics. https://doi.org/10.1038/ng.888
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
