Cited by 1,073Asthma and respiratory diseasesChronic Obstructive Pulmonary Disease (COPD) ResearchRespiratory and Cough-Related Research

After asthma: redefining airways diseases

Open access
Pavord, Ian D, Beasley, Richard, Agusti, Alvar, Anderson, Gary P, Bel, Elisabeth, Brusselle, Guy, Cullinan, Paul, Custovic, Adnan +15 more·2018·The Lancet

Abstract

Asthma is responsible for considerable global morbidity and health-care costs. Substantial progress was made against key outcomes such as hospital admissions with asthma and mortality in the 1990s and early 2000s, but little improvement has been observed in the past 10 years, despite escalating treatment costs. New assessment techniques are not being adopted and new drug discovery has progressed more slowly than in other specialties.

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Crossref · 10.1016/s0140-6736(17)30879-6

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  • Asthma may not be a single disease but a group of heterogeneous phenotypes with different etiologies and prognoses.

    “It is also now recognized that asthma may not be a single disease but a group of heterogeneous phenotypes with different etiologies and prognoses (5).”

    From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [5]

  • A consolidated definition of asthma may not be desirable given the emerging consensus that asthma is an umbrella term for several diseases with similar clinical manifestations but different underlying pathophysiological mechanisms.

    “A consolidated definition of asthma may not be desirable given the emerging consensus in the research community that “asthma” is an umbrella term for several diseases with similar clinical manifestations but different underlying pathophysiological mechanisms (5)”

    From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [5]

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Research works printed but not linked: 7

  1. Martinez FD, Vercelli D. Asthma. Lancet 2013; 382: 1360-72.
  2. Ciba Guest Symposium. Terminology, definitions and classifications of chronic pulmonary emphysema and related conditions. Thorax 1959; 14: 13.
  3. Rackemann FM. A clinical survey of 1074 patients with asthma followed for two years. J Lab Clin Med 1927; 12: 1185-97.
  4. Tiffeneau R, Drutel P. Etude des facteurs alvéolaires et bronchiques de la ventilation pulmonaire. J Fr Med Chir Thorac 1949; 3: 401-31.
  5. Holt S, Suder A, Weatherall M, Cheng S, Shirtcliffe P, Beasley R. Dose-response relation of inhaled fluticasone propionate in adolescents and adults with asthma: meta-analysis. BMJ 2001; 323: 253-56. 201
  6. Donaldson GC, Wedzicha JA. COPD exacerbations. 1: Epidemiology. Thorax 2006; 61: 164-68. 271
  7. Pavord ID, Brightling CE, Woltmann G, Wardlaw AJ. Non-eosinophilic corticosteroid unresponsive asthma. Lancet 1999; 353: 2213-14. 297

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Authors
Pavord, I. D., Beasley, R., Agusti, A., Anderson, G. P., Bel, E., Brusselle, G., Cullinan, P., Custovic, A., Ducharme, F. M., Fahy, J. V., Frey, U., Gibson, P., Heaney, L. G., Holt, P. G., Humbert, M., Lloyd, C. M., Marks, G., Martinez, F. D., Sly, P. D., von Mutius, E., Wenzel, S., Zar, H. J., & Bush, A.
Affiliations
  • University of Oxford (GB)
  • Medical Research Institute of New Zealand (NZ)
  • The University of Melbourne (AU)
  • Amsterdam UMC Location University of Amsterdam (NL)
  • Ghent University Hospital (BE)
  • Imperial College London (GB)
  • Université de Montréal (CA)
  • University of California, San Francisco (US)
  • University of Basel (CH)
  • John Hunter Hospital (AU)
  • Queen's University Belfast (GB)
  • The Kids Research Institute Australia (AU)
  • Université Paris-Sud (FR)
  • UNSW Sydney (AU)
  • Children's Health Queensland Hospital and Health Service (AU)
  • University of Pittsburgh (US)
  • University of Cape Town (ZA)
Corresponding author
Pavord, Ian D
Venue
The Lancet
Publisher
Elsevier BV
Published
2018-01
Volume
391
Issue
10118
Pages
350-400
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
OpenAlex
W2754586014
Cited by
1,073
References
336
Citations by year
2026: 88 · 2025: 95 · 2024: 98 · 2023: 126 · 2022: 115 · 2021: 138 · 2020: 166 · 2019: 118 · 2018: 116 · 2017: 13
FWCI
13.86
Type
journal article
Language
en
Open access
Locations
  • The Lancet (publishedVersion, public-domain)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
  • edoc (University of Basel) (acceptedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • HAL (submittedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
  • Deakin Research Online (Deakin University) (submittedVersion)
  • Figshare (submittedVersion)
  • Research Portal (Queen's University Belfast) (submittedVersion)
  • Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
  • NOVA (University of Newcastle Australia) (submittedVersion)
  • edoc (University of Basel)
Funders
  • National Institute of Allergy and Infectious Diseases
  • Medical Research Council
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory and Cough-Related Research
Keywords
asthma, airway disease, asthma outcomes, asthma mortality, hospitalization, treatment costs, drug discovery, health care costs
MeSH terms
Asthma, United Kingdom, Humans, Public Health, Respiration Disorders

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