After asthma: redefining airways diseases
Open accessAbstract
Asthma is responsible for considerable global morbidity and health-care costs. Substantial progress was made against key outcomes such as hospital admissions with asthma and mortality in the 1990s and early 2000s, but little improvement has been observed in the past 10 years, despite escalating treatment costs. New assessment techniques are not being adopted and new drug discovery has progressed more slowly than in other specialties.
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Asthma may not be a single disease but a group of heterogeneous phenotypes with different etiologies and prognoses.
“It is also now recognized that asthma may not be a single disease but a group of heterogeneous phenotypes with different etiologies and prognoses (5).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [5]
A consolidated definition of asthma may not be desirable given the emerging consensus that asthma is an umbrella term for several diseases with similar clinical manifestations but different underlying pathophysiological mechanisms.
“A consolidated definition of asthma may not be desirable given the emerging consensus in the research community that “asthma” is an umbrella term for several diseases with similar clinical manifestations but different underlying pathophysiological mechanisms (5)”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [5]
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A Comparison of the Validity of Different Diagnostic Tests in Adults With Asthma
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The microbial environment and its influence on asthma prevention in early life
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Cesarean Section and Risk of Severe Childhood Asthma: A Population-Based Cohort Study
Tollånes, M. C., Moster, D., Daltveit, A. K., & Irgens, L. M. (2008) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2008.01.029 · Cited by 193 · see citing works
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Sputum inflammatory phenotypes are not stable in children with asthma
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Self-citationTrajectories of lung function during childhood
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The immunostimulant OM-85 BV prevents wheezing attacks in preschool children
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Pavord, I. D., & Chung, K. F. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60596-6 · Cited by 177 · see citing works
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Self-citationThe asthma–COPD overlap syndrome: towards a revised taxonomy of chronic airways diseases?
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Effect of pneumonia and whooping cough in childhood on adult lung function
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The novel TLR-9 agonist QbG10 shows clinical efficacy in persistent allergic asthma
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The Early Development of Wheeze. Environmental Determinants and Genetic Susceptibility at 17q21
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Exacerbations of asthma without sputum eosinophilia.
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Flagged first, then by citations
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Cited by
Sorted by citations
Epidemiology of Asthma in Children and Adults
Dharmage, S. C., Perret, J. L., & Custovic, A. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00246 · Cited by 1,200 · see citing works
Self-citationPractitioner’s guide to latent class analysis: Methodological considerations and common pitfalls
Sinha, P., Calfee, C. S., & Delucchi, K. L. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000004710 · Cited by 1,204 · see citing works
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Optimal Asthma Control: Time for a New Target
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Self-citationRusconi (2018) · doi:10.1183/13993003.01665-2018 · Cited by 28 · see citing works
- Authors
- Pavord, I. D., Beasley, R., Agusti, A., Anderson, G. P., Bel, E., Brusselle, G., Cullinan, P., Custovic, A., Ducharme, F. M., Fahy, J. V., Frey, U., Gibson, P., Heaney, L. G., Holt, P. G., Humbert, M., Lloyd, C. M., Marks, G., Martinez, F. D., Sly, P. D., von Mutius, E., Wenzel, S., Zar, H. J., & Bush, A.
- Affiliations
- University of Oxford (GB)
- Medical Research Institute of New Zealand (NZ)
- The University of Melbourne (AU)
- Amsterdam UMC Location University of Amsterdam (NL)
- Ghent University Hospital (BE)
- Imperial College London (GB)
- Université de Montréal (CA)
- University of California, San Francisco (US)
- University of Basel (CH)
- John Hunter Hospital (AU)
- Queen's University Belfast (GB)
- The Kids Research Institute Australia (AU)
- Université Paris-Sud (FR)
- UNSW Sydney (AU)
- Children's Health Queensland Hospital and Health Service (AU)
- University of Pittsburgh (US)
- University of Cape Town (ZA)
- Corresponding author
- Pavord, Ian D
- ORCID
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 391
- Issue
- 10118
- Pages
- 350-400
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2754586014
- Cited by
- 1,073
- References
- 336
- Citations by year
- 2026: 88 · 2025: 95 · 2024: 98 · 2023: 126 · 2022: 115 · 2021: 138 · 2020: 166 · 2019: 118 · 2018: 116 · 2017: 13
- FWCI
- 13.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- The Lancet (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- edoc (University of Basel) (acceptedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- HAL (submittedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Deakin Research Online (Deakin University) (submittedVersion)
- Figshare (submittedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
- NOVA (University of Newcastle Australia) (submittedVersion)
- edoc (University of Basel)
- Funders
- National Institute of Allergy and Infectious Diseases
- Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory and Cough-Related Research
- Keywords
- asthma, airway disease, asthma outcomes, asthma mortality, hospitalization, treatment costs, drug discovery, health care costs
- MeSH terms
- Asthma, United Kingdom, Humans, Public Health, Respiration Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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