The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
Abstract
Although disorders of iron metabolism are prevalent, iron transport remains poorly understood. To address this problem, we undertook a positional cloning strategy to identify the causative mutation in mice with microcytic anaemia (mk). Homozygous mk/mk mice have microcytic, hypochromic anaemia due to severe defects in intestinal iron absorption and erythroid iron utilization. We report the identification of a strong candidate gene for mk, and suggest that the phenotype is a consequence of a missense mutation in Nramp2 (ref. 5), a previously identified gene of unknown function. Nramp2 is homologous to Nramp1, a gene activa in host defense. If Nramp2 is mk, as the cumulative evidence suggests, our findings have broad implications for the understanding of iron transport and resistance to intracellular pathogens.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The freed ferric iron is then reduced to its bio-active ferrous form, Fe2+ by the ferrireductase STEAP3 (six-transmembrane epithelial antigen of prostate 3) and shuttled into the cytosol from the endosome by DMT1 (Fleming et al., 1997; Gunshin et al., 1997; Ohgami et al., 2005; Figure 1).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Fleming et al., 1997
In the citing paper
“However, inorganic iron uptake from the gastrointestinal lumen by enterocytes depends upon the divalent metal transporter protein 1 (DMT1 or NRAMP2), which is not able to import Fe3+. 12 , 13 , 14”
From The battle for iron in enteric infections (2020) · cites this paper as [12]
In the citing paper
“Liberated inorganic iron is then reduced by the ferrireductase STEAP3 to Fe 2ϩ , 10 which is the substrate for transmembrane transport by divalent metal transporter 1 (DMT1 or SLC11A2, formerly called NRAMP2, DCT1).”
From Forging a field: the golden age of iron biology. (2008) · cites this paper as [12]
In the citing paper
“In spite of these obstacles and entirely by chance, the first mammalian transmembrane iron transporter was discovered simultaneously in 2 laboratories, located within a city block of each other in Boston, using singularly modern techniques.12,13”
From Forging a field: the golden age of iron biology. (2008) · cites this paper as [12]
In the citing paper
“Interestingly, the clinical phenotype of patients with DMT1 mutations differs slightly from the corresponding mouse model, mk. 12”
From Forging a field: the golden age of iron biology. (2008) · cites this paper as [12]
In the citing paper
“Unlike TfR1, TfR2 does not contain an IRE in its mRNA and does not appear to be regulated in an iron-dependent manner (90, 315).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [90]
In the citing paper
“Studies of TfR2 expression in a mouse model for hemochromatosis revealed that TfR2 was not downregulated in conditions of iron overload (90), supporting the absence of an iron-mediated posttranscriptional regulatory mechanism.”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [90]
In the citing paper
“Interestingly, iron accumulation in the liver in type 1 HH results in the downregulation of TfR1, but in the case of TfR2, it is continually expressed even during HH-mediated iron loading (90).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [90]
In the citing paper
“In addition, TfR2 does not appear to be regulated by iron concentrations, for it lacks IRE in its mRNA and is not inducible by iron deficiency (90).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [90]
Citations
Cites
Goffeau, A., Barrell, B. G., Bussey, H., Davis, R. W., Dujon, B., Feldmann, H., Galibert, F., Hoheisel, J. D., Jacq, C., Johnston, M., et al. (1996) · Science · doi:10.1126/science.274.5287.546 · Cited by 4,423
Friedreich's Ataxia: Autosomal Recessive Disease Caused by an Intronic GAA Triplet Repeat Expansion
Campuzano, V., Montermini, L., Moltò, M. D., Pianese, L., Cossée, M., Cavalcanti, F., Monros, E., Rodius, F., Duclos, F., Monticelli, A., et al. (1996) · Science · doi:10.1126/science.271.5254.1423 · Cited by 2,786
DNA methylation and the frequency of CpG in animal DNA
Bird, A. P. (1980) · Nucleic Acids Research · doi:10.1093/nar/8.7.1499 · Cited by 1,175
The I.M.A.G.E. Consortium: An Integrated Molecular Analysis of Genomes and Their Expression
Lennon, G., Auffray, C., Polymeropoulos, M. H., & Soares, M. B. (1996) · Genomics · doi:10.1006/geno.1996.0177 · Cited by 1,123
Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg
Vidal, S. M., Malo, D., Vogan, K., Skamene, E., & Gros, P. (1993) · Cell · doi:10.1016/0092-8674(93)90135-d · Cited by 1,104
Harding, A. E. (1981) · Brain · doi:10.1093/brain/104.3.589 · Cited by 929
Homozygosity Mapping: A Way to Map Human Recessive Traits with the DNA of Inbred Children
Lander, E. S., & Botstein, D. (1987) · Science · doi:10.1126/science.2884728 · Cited by 885
The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake.
Askwith, C., Eide, D., Van Ho, A., Bernard, P. S., Li, L., Davis-Kaplan, S., Sipe, D. M., & Kaplan, J. (1994) · Cell · doi:10.1016/0092-8674(94)90346-8 · Cited by 670
Dancis, A., Yuan, D. S., Haile, D., Askwith, C., Eide, D., Moehle, C., Kaplan, J., & Klausner, R. D. (1994) · Cell · doi:10.1016/0092-8674(94)90345-x · Cited by 659
Vidal, S., Tremblay, M. L., Govoni, G., Gauthier, S., Sebastiani, G., Malo, D., Skamene, E., Olivier, M., Jothy, S., & Gros, P. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.3.655 · Cited by 603
Flagged first, then by citations
Research works printed but not linked: 2
- McFarland, E.C. & Russell, E.S. Microcytic anemia (mk) has been located close to Ca on chromosome 15. Mouse News Letter 53, 35 (1975).
- Weinberg, E.D. The iron-withholding defense system. ASM News 59, 559–562 (1993).
Cited by
Sorted by citations
Items 401–500 of 1,000
Systemic iron metabolism: a review and implications for brain iron metabolism
Rouault, T. A. (2001) · Pediatric Neurology · doi:10.1016/s0887-8994(01)00260-0 · Cited by 81
Wessling‐Resnick, M. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.129 · Cited by 83
Garrick, M. D., Kuo, H.-C., Vargas, F. P., Singleton, S. T., Zhao, L., Smith, J. J., Paradkar, P. N., Roth, J. A., & Garrick, L. M. (2006) · Biochemical Journal · doi:10.1042/bj20051987 · Cited by 80
Iron Homeostasis and Its Interaction with Prolyl Hydroxylases
Mole, D. R. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2790 · Cited by 80
New insights into the regulation of iron homeostasis
Deicher, R., & Hörl, W. H. (2006) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2006.01633.x · Cited by 80
Intestinal iron uptake in the European flounder (Platichthys flesus)
Bury, N. R., Grosell, M., Wood, C. M., Högstrand, C., Wilson, R. W., Rankin, J. C., Busk, M., Lecklin, T., & Jensen, F. B. (2001) · Journal of Experimental Biology · doi:10.1242/jeb.204.21.3779 · Cited by 80
Zumbrennen‐Bullough, K. B., & Babitt, J. L. (2013) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gft443 · Cited by 82
Kuhn, D. E., Lafuse, W. P., & Zwilling, B. S. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.69.1.43 · Cited by 79
Xie, L., Zheng, W. H., Xin, N., Xie, J., Wang, T., & Wang, Z. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.05.016 · Cited by 79
AhNRAMP1 iron transporter is involved in iron acquisition in peanut
Xiong, H., Kobayashi, T., Kakei, Y., Senoura, T., Nakazono, M., Takahashi, H., Nakanishi, H., Shen, H., Duan, P., Guo, X., et al. (2012) · Journal of Experimental Botany · doi:10.1093/jxb/ers117 · Cited by 80
In vivo characterization of renal iron transport in the anaesthetized rat
Wareing, M., Ferguson, C. J., Green, R., Riccardi, D., & Smith, C. P. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00581.x · Cited by 79
Distribution of divalent metal transporter-1 in the monkey basal ganglia
Huang, E., Ong, W., & Connor, J. R. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.06.055 · Cited by 79
Chen, H., Davidson, T. L., Singleton, S. T., Garrick, M. D., & Costa, M. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.11.011 · Cited by 79
Wardrop, S. L., & Richardson, D. R. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00447.x · Cited by 79
Chen, L., Zhang, Z., Wang, T., Chen, C., & Kang, Y. J. (2015) · Metallomics · doi:10.1039/c5mt00097a · Cited by 78
Leong, W.-I., Bowlus, C. L., Tallkvist, J., & Lönnerdal, B. L. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.6.1203 · Cited by 78
Iron increases expression of iron-export protein MTP1 in lung cells
Yang, F., Wang, X., Haile, D. J., Piantadosi, C. A., & Ghio, A. J. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00114.2002 · Cited by 78
Iron regulatory protein as an endogenous sensor of iron in rat intestinal mucosa
Schümann, K., Moret, R., Künzle, H., & Kühn, L. C. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00155.x · Cited by 79
Non-transferrin-bound iron uptake in Belgrade and normal rat erythroid cells
Garrick, L. M., Dolan, K. G., Romano, M. A., & Garrick, M. D. (1999) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199903)178:3 · Cited by 78
Hoal, E. G., Lewis, L., Jamieson, S., Tanzer, F., Rossouw, M., Victor, T., Hillerman, R., Beyers, N., Blackwell, J. M., & van Helden, P. D. (2004) · PubMed · Cited by 77
Reciprocal Regulation of HFE and Nramp2 Gene Expression by Iron in Human Intestinal Cells
Han, O., Fleet, J. C., & Wood, R. J. (1999) · Journal of Nutrition · doi:10.1093/jn/129.1.98 · Cited by 77
Richardson, D. R., & Lok, H. C. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2007.12.009 · Cited by 76
Iron, hepcidin, and the metal connection
Loréal, O., Cavey, T., Bardou‐Jacquet, E., Guggenbuhl, P., Ropert, M., & Brissot, P. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00128 · Cited by 78
Hayashi, N., Ito, M., Horiike, S., & Taguchi, H. (2001) · Applied Microbiology and Biotechnology · doi:10.1007/s002530100600 · Cited by 76
Rethinking the role of ceruloplasmin in brain iron metabolism
Qian, Z. M., & Ke, Y. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00056-x · Cited by 76
Oates, P. S. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i27.4281 · Cited by 76
DMT1 and FPN1 expression during infancy: developmental regulation of iron absorption
Leong, W.-I., Bowlus, C. L., Tallkvist, J., & Lönnerdal, B. L. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00107.2003 · Cited by 76
Inulin–iron complexes: A potential treatment of iron deficiency anaemia
Pitarresi, G. L., Tripodo, G., Cavallaro, G., Palumbo, F. S., & Giammona, G. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2007.05.006 · Cited by 75
REVIEW: Small Bowel Review: Normal Physiology Part 1
Thomson, A. B. R., Keelan, M., Thiesen, A., Clandinin, M. T., Ropeleski, M. J., & Wild, G. (2001) · Digestive Diseases and Sciences · doi:10.1023/a:1012794505897 · Cited by 75
Iron uptake and Nramp2/DMT1/DCT1 in human bronchial epithelial cells
Wang, X., Ghio, A. J., Yang, F., Dolan, K. G., Garrick, M. D., & Piantadosi, C. A. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00253.2001 · Cited by 74
Roth, J. A., Singleton, S. T., Feng, J., Garrick, M. D., & Paradkar, P. N. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06607.x · Cited by 74
Mechanisms of iron metabolism in Caenorhabditis elegans
Anderson, C. P., & Leibold, E. A. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00113 · Cited by 77
Hepcidin: A novel peptide hormone regulating iron metabolism
Singh, B. M., Arora, S., Agrawal, P., & Gupta, S. (2011) · Clinica Chimica Acta · doi:10.1016/j.cca.2011.02.014 · Cited by 77
Mechanisms of divalent metal toxicity in affective disorders
Menon, A. V., Chang, J., & Kim, J. (2015) · Toxicology · doi:10.1016/j.tox.2015.11.001 · Cited by 77
Siah, C. W., Trinder, D., & Olynyk, J. K. (2005) · Clinica Chimica Acta · doi:10.1016/j.cccn.2005.02.022 · Cited by 75
nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse
Ohgami, R. S., Campagna, D. R., Antiochos, B., Wood, E., Sharp, J. J., Barker, J. E., & Fleming, M. D. (2005) · Blood · doi:10.1182/blood-2005-01-0379 · Cited by 74
Self-citationJabado, N., Canonne‐Hergaux, F., Gruenheid, S., Picard, V., & Gros, P. (2002) · Blood · doi:10.1182/blood-2002-04-1182 · Cited by 75
ATKINSON, & Barton (1999) · Immunology · doi:10.1046/j.1365-2567.1999.00672.x · Cited by 74
Becker, E., Greer, J. M., Ponka, P., & Richardson, D. R. (2002) · Blood · doi:10.1182/blood.v99.10.3813 · Cited by 74
JianZhong, W., & Theil, E. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910334199 · Cited by 74
Genetic Disorders Affecting Proteins of Iron Metabolism: Clinical Implications
Sheth, S., & Brittenham, G. M. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.443 · Cited by 74
Discrepancies between genotype and phenotype in hematology: an important frontier
Beutler, E. (2001) · Blood · doi:10.1182/blood.v98.9.2597 · Cited by 73
Min, K.-S., Ueda, H., & Tanaka, K. (2007) · Toxicology Letters · doi:10.1016/j.toxlet.2007.10.011 · Cited by 73
Song, N., Jiang, H. F., Wang, J., & Xie, J. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21430 · Cited by 73
A Spontaneous, Recurrent Mutation in Divalent Metal Transporter-1 Exposes a Calcium Entry Pathway
Xu, H., Jin, J., DeFelice, L. J., Andrews, N. C., & Clapham, D. E. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020050 · Cited by 72
Self-citationWessling‐Resnick, M. (1999) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409239991209318 · Cited by 73
Metal ion transport in eukaryotic microorganisms: insights from Saccharomyces cerevisiae
Eide, D. J. (2000) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/s0065-2911(00)43001-8 · Cited by 72
Frataxin: its role in iron metabolism and the pathogenesis of Friedreich's ataxia
Becker, E., & Richardson, D. R. (2001) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(00)00067-4 · Cited by 71
Structure and mechanism of a eukaryotic transmembrane ascorbate-dependent oxidoreductase
Lu, P., Ma, D., Yan, C., Gong, X., Du, M., & Shi, Y. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1323931111 · Cited by 71
Single gene effects in mouse models of host: pathogen interactions
Fortier, A. H., Min‐Oo, G., Forbes, J., Lam-Yuk-Tseung, S., & Gros, P. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1004616 · Cited by 72
SHINDO, M., Torimoto, Y., SAITO, H., Motomura, W., Ikuta, K., SATO, K., FUJIMOTO, Y., & KOHGO, Y. (2006) · Hepatology Research · doi:10.1016/j.hepres.2006.03.011 · Cited by 73
Novel Roles for Iron Regulatory Proteins in the Adaptive Response to Iron Deficiency
Eisenstein, R. S., & Ross, K. L. (2003) · Journal of Nutrition · doi:10.1093/jn/133.5.1510s · Cited by 71
Evidence for Cadmium Uptake through Nramp2: Metal Speciation Studies with Caco-2 Cells
Elisma, F., & Jumarie, C. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5245 · Cited by 70
Iron transport: emerging roles in health and disease
Goswami, T., Rolfs, A., & Hediger, M. A. (2002) · Biochemistry and Cell Biology · doi:10.1139/o02-159 · Cited by 70
Both Nramp1 and DMT1 are necessary for efficient macrophage iron recycling
Soe-Lin, S., Apte, S. S., Mikhael, M. R., Kayembe, L. K., Nie, G., & Ponka, P. (2010) · Experimental Hematology · doi:10.1016/j.exphem.2010.04.003 · Cited by 69
Iron transport across cell membranes: molecular understanding of duodenal and placental iron uptake
Srai, S. K., Bomford, A. B., & McArdle, H. J. (2002) · Best Practice & Research Clinical Haematology · doi:10.1053/beha.2002.0003 · Cited by 70
Ban, X.-X., Wan, H., Wan, X.-X., Tan, Y.-T., Hu, X., Ban, H.-X., Chen, X., Huang, K. L., Zhāng, Q., & Xiong, K. (2024) · Current Medical Science · doi:10.1007/s11596-024-2832-z · Cited by 68
Polymorphisms and mutations of human TMPRSS6 in iron deficiency anemia
Beutler, E., Geet, C. V., Loo, D. M. W. M. T., Gelbart, T., Crain, K., Truksa, J., & Lee, P. L. (2009) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2009.09.001 · Cited by 67
Sharp, P., Tandy, S., Yamaji, S., Tennant, J. P., Williams, M. R., & Srai, S. K. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03225-2 · Cited by 67
Ectopic expression of Nramp1 in COS‐1 cells modulates iron accumulation
Atkinson, P. G. P., & Barton, C. H. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00236-1 · Cited by 67
Interaction of calcium with the human divalent metal-ion transporter-1
Shawki, A., & Mackenzie, B. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.025 · Cited by 66
Non‐transferrin‐bound iron and cellular toxicity
Anderson, G. J. (1999) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.1999.01828.x · Cited by 66
Bozzi, A. T., Bane, L. B., Weihofen, W. A., Singharoy, A., Guillén, E., Ploegh, H. L., Schulten, K. J., & Gaudet, R. (2016) · Structure · doi:10.1016/j.str.2016.09.017 · Cited by 65
Pathophysiology of Hereditary Hemochromatosis
Fleming, R. E., Britton, R. S., Waheed, A., Sly, W. S., & Bacon, B. R. (2005) · Seminars in Liver Disease · doi:10.1055/s-2005-923313 · Cited by 68
Wardrop, S. L., & Richardson, D. R. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01752.x · Cited by 65
Divalent metal transporter 1 is a hypoxia‐inducible gene
Qian, Z., Wu, X. M., Fan, M., Yang, L., Du, F., Yung, W., & Ke, Y. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22485 · Cited by 64
Molecular mechanism of intestinal iron absorption
Han, O. (2011) · Metallomics · doi:10.1039/c0mt00043d · Cited by 70
Ma, Q., Kim, E., & Han, O. (2010) · Journal of Nutrition · doi:10.3945/jn.109.117499 · Cited by 64
Hereditary hemochromatosis: update for 2003
Harrison, S. A., & Bacon, B. R. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00428-2 · Cited by 64
FCOLLINS, J. (2006) · Biological Research · doi:10.4067/s0716-97602006000100004 · Cited by 64
Liu, X. F., & Culotta, V. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.2815 · Cited by 64
Recalcati, S., Pometta, R., Levi, S., Conte, D., & Cairo, G. (1998) · Blood · doi:10.1182/blood.v91.7.2565 · Cited by 64
Recently Identified Molecular Aspects of Intestinal Iron Absorption
Wood, R. J., & Han, O. (1998) · Journal of Nutrition · doi:10.1093/jn/128.11.1841 · Cited by 65
Wu, F., Zhang, W., Zhang, L., Wu, J., Li, C.-Z., Meng, X., Wang, X., He, P., & Zhang, J. (2013) · BioMed Research International · doi:10.1155/2013/484535 · Cited by 65
Wang, X., Li, G. J., & Zheng, W. (2006) · Brain Research · doi:10.1016/j.brainres.2006.04.046 · Cited by 62
Harrison, S. A., & Bacon, B. R. (2005) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.08.005 · Cited by 62
Intracellular iron and heme trafficking and metabolism in developing erythroblasts
Kafina, M. D., & Paw, B. H. (2017) · Metallomics · doi:10.1039/c7mt00103g · Cited by 65
Duodenal expression of iron transport molecules in untreated haemochromatosis subjects
Stuart, K. A., Anderson, G. J., Frazer, D. M., Powell, L. W., McCullen, M., Fletcher, L. M., & Crawford, D. H. G. (2003) · Gut · doi:10.1136/gut.52.7.953 · Cited by 61
An analysis of the Petri net based model of the human body iron homeostasis process
Sackmann, A., Formanowicz, D., Formanowicz, P., Koch, I., & Błażewicz, J. (2006) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2006.09.005 · Cited by 61
L-DOPA Neurotoxicity Is Mediated by Up-Regulation of DMT1−IRE Expression
Du, F., Qian, Z., Zhu, L., Wu, X. M., Yung, W., Tsim, T. Y., & Ke, Y. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004593 · Cited by 61
Nanocompounds of iron and zinc: their potential in nutrition
Zimmermann, M. B., & Hilty, F. M. (2011) · Nanoscale · doi:10.1039/c0nr00858c · Cited by 64
Functional and molecular responses of human intestinal Caco-2 cells to iron treatment
Tallkvist, J., Bowlus, C. L., & Lönnerdal, B. L. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.3.770 · Cited by 62
Griffiths, W. J., Cox, T. M., & Sly, W. S. (2001) · Gastroenterology · doi:10.1053/gast.2001.24050 · Cited by 61
Role of ceruloplasmin and ascorbate in cellular iron release
Richardson, D. R. (1999) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(99)90166-x · Cited by 61
Choi, J., Masaratana, P., Latunde-Dada, G. O., Arno, M. J., Simpson, R. J., & McKie, A. T. (2012) · Journal of Nutrition · doi:10.3945/jn.112.160358 · Cited by 60
DMT1 Expression and Iron Levels at the Crossroads Between Aging and Neurodegeneration
Ingrassia, R., Garavaglia, B., & Memo, M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00575 · Cited by 63
Johnson, D., Bayele, H. K., Johnston, K. L., Tennant, J. P., Srai, S. K., & Sharp, P. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.081 · Cited by 60
Roy, C. N., Weinstein, D. A., & Andrews, N. C. (2003) · Pediatric Research · doi:10.1203/01.pdr.0000049513.67410.2d · Cited by 60
Self-citationHemochromatosis gene modifies course of hepatitis C viral infection
Pietrangelo, A. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00275-0 · Cited by 60
Arredondo, M., Uauy, R. D., & González, M. (2000) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(00)00015-5 · Cited by 60
Bettedi, L., Aslam, M. F., Szular, J., Mandilaras, K., & Missirlis, F. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.051664 · Cited by 60
Dong, X., Gao, W., Shao, T.-M., Hong-lin, X., Jiang-tao, B., Jing-yi, Z., & Xi-qing, C. (2014) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2014.11.009 · Cited by 59
Beyond soluble transferrin receptor: Old challenges and new horizons
Harms, K., & Kaiser, T. (2015) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2015.09.003 · Cited by 59
Copper repletion enhances apical iron uptake and transepithelial iron transport by Caco-2 cells
Han, O., & Wessling‐Resnick, M. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00414.2001 · Cited by 60
The battle for iron in enteric infections
Sousa Gerós, A., Simmons, A., Drakesmith, H., Aulicino, A., & Frost, J. N. (2020) · Immunology · doi:10.1111/imm.13236 · Cited by 58
Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia
Chiang, S., Kovačević, Ž., Sahni, S., Lane, D. J. R., Merlot, A. M., Kalinowski, D. S., Huang, M. L. H., & Richardson, D. R. (2016) · Clinical Science · doi:10.1042/cs20160072 · Cited by 58
Iron, the retina and the lens: A focused review
García-Castiñeiras, S. (2010) · Experimental Eye Research · doi:10.1016/j.exer.2010.03.003 · Cited by 60
Chapter 6 Iron Homeostasis and Erythropoiesis
Wrighting, D. M., & Andrews, N. C. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(07)00006-3 · Cited by 59
Self-citationIron Treatment Downregulates DMT1 and IREG1 mRNA Expression in Caco-2 Cells
Martini, L. A., Tchack, L., & Wood, R. J. (2002) · Journal of Nutrition · doi:10.1093/jn/132.4.693 · Cited by 58
Intestinal Hypoxia-inducible Factor-2α (HIF-2α) Is Critical for Efficient Erythropoiesis
Anderson, E. R., Xue, X., & Shah, Y. M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.238667 · Cited by 58
Metadata
- Authors
- Fleming, M. D., Trenor, C. C., Su, M. A., Foernzler, D., Beier, D. R., Dietrich, W. F., & Andrews, N. C.
- Affiliations
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Andrews, Nancy C.
- Venue
- Nature Genetics
- Published
- 1997-08
- Volume
- 16
- Issue
- 4
- Pages
- 383-386
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2082806735
- Cited by
- 1,159
- References
- 35
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 11 · 2023: 16 · 2022: 12 · 2021: 14 · 2020: 13 · 2019: 23 · 2018: 20 · 2017: 23 · 2016: 21 · 2015: 24 · 2014: 28 · 2013: 33 · 2012: 35
- FWCI
- 42.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Funders
- National Institutes of Health (1k08hl003600-01)
- National Heart, Lung, and Blood Institute (K08 HL03600)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- microcytic anemia, DMT1, iron transport, iron metabolism, intestinal iron absorption, missense mutations, positional cloning, NRAMP1, mice
- MeSH terms
- Frataxin, Animals, Friedreich Ataxia, Humans, Mitochondria, Phosphotransferases (Alcohol Group Acceptor), Iron-Binding Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
