The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
Abstract
Although disorders of iron metabolism are prevalent, iron transport remains poorly understood. To address this problem, we undertook a positional cloning strategy to identify the causative mutation in mice with microcytic anaemia (mk). Homozygous mk/mk mice have microcytic, hypochromic anaemia due to severe defects in intestinal iron absorption and erythroid iron utilization. We report the identification of a strong candidate gene for mk, and suggest that the phenotype is a consequence of a missense mutation in Nramp2 (ref. 5), a previously identified gene of unknown function. Nramp2 is homologous to Nramp1, a gene activa in host defense. If Nramp2 is mk, as the cumulative evidence suggests, our findings have broad implications for the understanding of iron transport and resistance to intracellular pathogens.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The freed ferric iron is then reduced to its bio-active ferrous form, Fe2+ by the ferrireductase STEAP3 (six-transmembrane epithelial antigen of prostate 3) and shuttled into the cytosol from the endosome by DMT1 (Fleming et al., 1997; Gunshin et al., 1997; Ohgami et al., 2005; Figure 1).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Fleming et al., 1997
In the citing paper
“However, inorganic iron uptake from the gastrointestinal lumen by enterocytes depends upon the divalent metal transporter protein 1 (DMT1 or NRAMP2), which is not able to import Fe3+. 12 , 13 , 14”
From The battle for iron in enteric infections (2020) · cites this paper as [12]
In the citing paper
“Liberated inorganic iron is then reduced by the ferrireductase STEAP3 to Fe 2ϩ , 10 which is the substrate for transmembrane transport by divalent metal transporter 1 (DMT1 or SLC11A2, formerly called NRAMP2, DCT1).”
From Forging a field: the golden age of iron biology. (2008) · cites this paper as [12]
In the citing paper
“In spite of these obstacles and entirely by chance, the first mammalian transmembrane iron transporter was discovered simultaneously in 2 laboratories, located within a city block of each other in Boston, using singularly modern techniques.12,13”
From Forging a field: the golden age of iron biology. (2008) · cites this paper as [12]
In the citing paper
“Interestingly, the clinical phenotype of patients with DMT1 mutations differs slightly from the corresponding mouse model, mk. 12”
From Forging a field: the golden age of iron biology. (2008) · cites this paper as [12]
In the citing paper
“Unlike TfR1, TfR2 does not contain an IRE in its mRNA and does not appear to be regulated in an iron-dependent manner (90, 315).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [90]
In the citing paper
“Studies of TfR2 expression in a mouse model for hemochromatosis revealed that TfR2 was not downregulated in conditions of iron overload (90), supporting the absence of an iron-mediated posttranscriptional regulatory mechanism.”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [90]
In the citing paper
“Interestingly, iron accumulation in the liver in type 1 HH results in the downregulation of TfR1, but in the case of TfR2, it is continually expressed even during HH-mediated iron loading (90).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [90]
In the citing paper
“In addition, TfR2 does not appear to be regulated by iron concentrations, for it lacks IRE in its mRNA and is not inducible by iron deficiency (90).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [90]
Citations
Cites
Goffeau, A., Barrell, B. G., Bussey, H., Davis, R. W., Dujon, B., Feldmann, H., Galibert, F., Hoheisel, J. D., Jacq, C., Johnston, M., et al. (1996) · Science · doi:10.1126/science.274.5287.546 · Cited by 4,423
Friedreich's Ataxia: Autosomal Recessive Disease Caused by an Intronic GAA Triplet Repeat Expansion
Campuzano, V., Montermini, L., Moltò, M. D., Pianese, L., Cossée, M., Cavalcanti, F., Monros, E., Rodius, F., Duclos, F., Monticelli, A., et al. (1996) · Science · doi:10.1126/science.271.5254.1423 · Cited by 2,786
DNA methylation and the frequency of CpG in animal DNA
Bird, A. P. (1980) · Nucleic Acids Research · doi:10.1093/nar/8.7.1499 · Cited by 1,175
The I.M.A.G.E. Consortium: An Integrated Molecular Analysis of Genomes and Their Expression
Lennon, G., Auffray, C., Polymeropoulos, M. H., & Soares, M. B. (1996) · Genomics · doi:10.1006/geno.1996.0177 · Cited by 1,123
Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg
Vidal, S. M., Malo, D., Vogan, K., Skamene, E., & Gros, P. (1993) · Cell · doi:10.1016/0092-8674(93)90135-d · Cited by 1,104
Harding, A. E. (1981) · Brain · doi:10.1093/brain/104.3.589 · Cited by 929
Homozygosity Mapping: A Way to Map Human Recessive Traits with the DNA of Inbred Children
Lander, E. S., & Botstein, D. (1987) · Science · doi:10.1126/science.2884728 · Cited by 885
The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake.
Askwith, C., Eide, D., Van Ho, A., Bernard, P. S., Li, L., Davis-Kaplan, S., Sipe, D. M., & Kaplan, J. (1994) · Cell · doi:10.1016/0092-8674(94)90346-8 · Cited by 670
Dancis, A., Yuan, D. S., Haile, D., Askwith, C., Eide, D., Moehle, C., Kaplan, J., & Klausner, R. D. (1994) · Cell · doi:10.1016/0092-8674(94)90345-x · Cited by 659
Vidal, S., Tremblay, M. L., Govoni, G., Gauthier, S., Sebastiani, G., Malo, D., Skamene, E., Olivier, M., Jothy, S., & Gros, P. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.3.655 · Cited by 603
Flagged first, then by citations
Research works printed but not linked: 2
- McFarland, E.C. & Russell, E.S. Microcytic anemia (mk) has been located close to Ca on chromosome 15. Mouse News Letter 53, 35 (1975).
- Weinberg, E.D. The iron-withholding defense system. ASM News 59, 559–562 (1993).
Cited by
Sorted by citations
Items 701–800 of 1,000
Iron and erythropoiesis: a dual relationship
Camaschella, C., & Pagani, A. (2010) · International Journal of Hematology · doi:10.1007/s12185-010-0743-1 · Cited by 27
Pourvali, K., Matak, P., Latunde-Dada, G. O., Solomou, S., Mastrogiannaki, M., Peyssonnaux, C., & Sharp, P. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.05.058 · Cited by 29
Belgrade Rats Display Liver Iron Loading
Thompson, K., Molina, R. M., Brain, J. D., & Wessling‐Resnick, M. (2006) · Journal of Nutrition · doi:10.1093/jn/136.12.3010 · Cited by 27
Wang, X., Ong, W.-Y., & Connor, J. R. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7962 · Cited by 27
Malecki, E. A., Devenyi, A. G., Beard, J. L., & Connor, J. R. (1998) · BioMetals · doi:10.1023/a:1009280922387 · Cited by 27
DMT1 expression is increased in the lungs of hypotransferrinemic mice
Ghio, A. J., Wang, X., Silbajoris, R. A., Garrick, M. D., Piantadosi, C. A., & Yang, F. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00225.2002 · Cited by 27
Intestinal metal ion absorption: an update
Rolfs, A., & Hediger, M. A. (2001) · Current Opinion in Gastroenterology · doi:10.1097/00001574-200103000-00014 · Cited by 27
Jiang, S., Yan, K., Sun, B., Gao, S., Yang, X., Ni, Y., Ma, W., & Zhao, R. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b02974 · Cited by 26
Intestinal response to dietary manganese depletion in Drosophila
Vásquez-Procopio, J., Osorio, B., Cortés‐Martínez, L., Hernández‐Hernández, F. D. L. C., Contreras, O. M., Ríos‐Castro, E., Comjean, A., Li, F., Hu, Y., Mohr, S. E., et al. (2019) · Metallomics · doi:10.1039/c9mt00218a · Cited by 27
Abnormal erythroid maturation leads to microcytic anemia in the TSAP6/Steap3 null mouse model
Blanc, L., Papoin, J., Debnath, G., Vidal, M., Amson, R. B., Telerman, A., An, X., & Mohandas, N. (2014) · American Journal of Hematology · doi:10.1002/ajh.23920 · Cited by 26
Dong, X., Gao, W., KONG, W.-N., XIE, H.-L., PENG, Y., Shao, T.-M., Yu, W., & Xi-qing, C. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2234 · Cited by 26
Richardson, D. R., Chua, A. C. G., & Baker, E. (1999) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(99)90007-0 · Cited by 26
Okazaki, Y., Ma, Y., YEH, M. K. Y., Yin, H., Li, Z., Yeh, K., & Glass, J. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00545.2010 · Cited by 26
Richardson, D. R. (1998) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199809057584 · Cited by 26
Iron and calcium in the central nervous system: a close relationship in health and sickness
Pelizzoni, I., Macco, R., Zacchetti, D., Grohovaz, F., & Codazzi, F. (2008) · Biochemical Society Transactions · doi:10.1042/bst0361309 · Cited by 26
Dzikaite, V., Holmström, P., Stål, P., Eckes, K., Hagen, K., Eggertsen, G., Gåfvels, M., Melefors, Ö., & Hultcrantz, R. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2005.07.028 · Cited by 26
Antimicrobial mechanisms of macrophages
Shiloh, M. U., & Nathan, C. (1999) · Advances in cellular and molecular biology of membranes and organelles · doi:10.1016/s1874-5172(99)80042-x · Cited by 26
Iron overload: molecular clues to its cause
Kühn, L. C. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01386-9 · Cited by 26
Regulation of copper absorption by copper availability in the Caco-2 cell intestinal model
Zerounian, N. R., Redekosky, C., Malpe, R., & Linder, M. C. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00415.2002 · Cited by 26
New Developments in Hereditary Hemochromatosis
Felitti, V. J., & Beutler, E. (1999) · The American Journal of the Medical Sciences · doi:10.1016/s0002-9629(15)40629-9 · Cited by 26
Zidova, Z., Kapralova, K., Kořalková, P., Mojzíková, R., Doležal, D., Divoký, V., & Horváthová, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000369665 · Cited by 25
Zhou, X., & Yang, Y. (2004) · Physiological and Molecular Plant Pathology · doi:10.1016/j.pmpp.2005.02.007 · Cited by 26
Functional analysis of the human NRAMP family expressed in fission yeast
Tabuchi, M., Yoshida, T., Takegawa, K., & Kishi, F. (1999) · Biochemical Journal · doi:10.1042/bj3440211 · Cited by 26
Kloss‐Brandstätter, A., Erhart, G., Lamina, C., Meister, B., Haun, M., Coassin, S., Seifert, M., Klein‐Franke, A., Paulweber, B., Kedenko, L., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035015 · Cited by 26
Kinetic analysis of 59 Fe movement across the intestinal wall in duodenal rat segments ex vivo
Schümann, K., Elsenhans, B., & Forth, W. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.2.g431 · Cited by 25
Kelleher, T., Ryan, E., Barrett, S., Sweeney, M., Byrnes, V, O’Keane, C., & Crowe, J. (2004) · Gut · doi:10.1136/gut.2003.033811 · Cited by 24
Natural history of SLC11 genes in vertebrates: tales from the fish world
Neves, J. V., Wilson, J. M., Kuhl, H., Reinhardt, R., Castro, L. F. C., & Rodrigues, P. N. (2011) · BMC Evolutionary Biology · doi:10.1186/1471-2148-11-106 · Cited by 24
Fenton Reaction in vivo and in vitro. Possibilities and Limitations
Muranov, K. O. (2024) · Biochemistry (Moscow) · doi:10.1134/s0006297924140074 · Cited by 26
Navigating Transition Metal‐Dependent Cell Death: Mechanisms, Crosstalk, and Future Directions
Song, Q., Yang, Y., & Yang, L. (2025) · Advanced Science · doi:10.1002/advs.202501974 · Cited by 24
Inborn errors of metabolism: iron
Worwood, M. (1999) · British Medical Bulletin · doi:10.1258/0007142991902628 · Cited by 24
Divalent Metal Transporter 1 Expression and Regulation in Human Placenta
Li, Y., Bai, B., Cao, X., Zhang, Y., YAN, H. H., Zheng, Q.-Q., & Zhuang, G. (2011) · Biological Trace Element Research · doi:10.1007/s12011-011-9214-7 · Cited by 24
Zebrafish as a model system to delineate the role of heme and iron metabolism during erythropoiesis
Zhang, J., & Hamza, I. (2018) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2018.12.007 · Cited by 25
Braliou, G. G., Kontou, P. I., Boleti, H., & Bagos, P. G. (2019) · Parasitology Research · doi:10.1007/s00436-019-06374-y · Cited by 25
A holistic view of mammalian (vertebrate) cellular iron uptake
Kosman, D. J. (2020) · Metallomics · doi:10.1039/d0mt00065e · Cited by 25
Evidence for and consequences of chronic heme deficiency in Belgrade rat reticulocytes
Garrick, M. D., Scott, D., Kulju, D., Romano, M. A., Dolan, K. G., & Garrick, L. M. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(99)00006-3 · Cited by 24
The ferrireductase paraferritin contains divalent metal transporter as well as mobilferrin
Umbreit, J. N., Conrad, M. E., Hainsworth, L. N., & Simovich, M. J. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00199.2001 · Cited by 24
Lafuse, W. P., Alvarez, G. R., & Zwilling, B. S. (2000) · Biochemical Journal · doi:10.1042/bj3510687 · Cited by 25
Yu, J., Yu, Z. K., & Wessling‐Resnick, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.52.34675 · Cited by 24
Advances of Iron and Ferroptosis in Diabetic Kidney Disease
Chu, J., Wang, K., Lu, L., Zhao, H., Hu, J., Xiao, W., & Wu, Q. (2024) · Kidney International Reports · doi:10.1016/j.ekir.2024.04.012 · Cited by 24
Li, L.-B., & Wang, Z. (2016) · PubMed · doi:10.14670/hh-11-737 · Cited by 23
Pathophysiology of the Belgrade rat
Veuthey, T., & Wessling‐Resnick, M. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00082 · Cited by 23
The effect of serum iron concentration on iron secretion into mouse milk
Zhang, P., Sawicki, V., Lewis, A., Hanson, L., Monks, J., & Neville, M. C. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-2-00479.x · Cited by 23
Impaired renal function and development in Belgrade rats
Veuthey, T., Hoffmann, D., Vaidya, V. S., & Wessling‐Resnick, M. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00285.2013 · Cited by 23
The iron islands: Erythroblastic islands and iron metabolism
Yeo, J. H., Colonne, C. K., Tasneem, N., Cosgriff, M. P., & Fraser, S. T. (2018) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2018.10.019 · Cited by 25
Maternal intestinal HIF-2α is necessary for sensing iron demands of lactation in mice
Ramakrishnan, S. K., Anderson, E. R., Martin, A. S., Centofanti, B., & Shah, Y. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1504891112 · Cited by 23
c-Myc Represses and Miz-1 Activates the Murine Natural Resistance-associated Protein 1 Promoter
Bowen, H., Biggs, T. E., Phillips, E. S., Baker, S. T., Perry, V. H., Mann, D. A., & Barton, C. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204232200 · Cited by 23
Gochee, P., & Powell, L. W. (2001) · Current Opinion in Hematology · doi:10.1097/00062752-200103000-00007 · Cited by 23
Thuraisingam, T., Sam, H., Moisan, J., Zhang, Y., Ding, A. H., & Radzioch, D. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700182 · Cited by 23
Vesicular transport of Fe and interaction with other metal ions in polarized Caco2 Cell monolayers
Linder, M. C., Moriya, M., WHON, A., KASSA, A., & Gilley, C. B. (2006) · Biological Research · doi:10.4067/s0716-97602006000100016 · Cited by 23
Tian, J., Zheng, W., Li, X., Cui, Y.-H., & Wang, Z. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00165 · Cited by 22
Chandrapalan, T., & Kwong, R. W. M. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114159 · Cited by 22
Richardson, D. R. (2001) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(01)00034-5 · Cited by 22
A ferrireductase fills the gap in the transferrin cycle
McKie, A. T. (2005) · Nature Genetics · doi:10.1038/ng1105-1159 · Cited by 22
How I Diagnose Non-thalassemic Microcytic Anemias
Bruno, M., Falco, L. D., & Iolascon, A. (2015) · Seminars in Hematology · doi:10.1053/j.seminhematol.2015.05.002 · Cited by 22
Apparent modulation of CD20 by rituximab: an alternative explanation
Cragg, M. S., Bayne, M. C., Illidge, T., Valerius, T., Johnson, P., & Glennie, M. J. (2004) · Blood · doi:10.1182/blood-2003-12-4384 · Cited by 22
Can Iron and Polyunsaturated Fatty Acid Supplementation Induce Ferroptosis?
Delesderrier, E., Monteiro, J. D. C., de Freitas, S. C. V., Pinheiro, I. C., Batista, M. S., & Citelli, M. (2023) · Cellular Physiology and Biochemistry · doi:10.33594/000000620 · Cited by 22
Xue, R., Wang, S., Wang, C., Zhu, T., Li, F., & Sun, H. (2006) · Biopolymers · doi:10.1002/bip.20478 · Cited by 21
Structure and metal ion binding of the first transmembrane domain of DMT1
Wang, D., Song, Y., Li, J., Wang, C., & Li, F. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.11.005 · Cited by 21
Molecular Mechanisms of Intestinal Iron Transport
Collins, J. F., & Anderson, G. J. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382026-6.00071-3 · Cited by 22
Zhang, L. Y., Li, X. F., Liao, X., Zhang, L. Y., Liu, L., & Luo, X. (2017) · Journal of Animal Science · doi:10.2527/jas.2016.1147 · Cited by 21
Dietary iron absorption during early postnatal life
Helman, S. L., Anderson, G. J., & Frazer, D. M. (2019) · BioMetals · doi:10.1007/s10534-019-00181-9 · Cited by 21
He, W., Feng, Y., Li, X., & Yang, X. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0730946 · Cited by 21
Assessment of iron absorption in mice by ICP-MS measurements of 57Fe levels
Fiorito, V., Crich, S. G., Silengo, L., Altruda, F., Aime, S., & Tolosano, E. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0256-6 · Cited by 23
Lam-Yuk-Tseung, S., Picard, V., & Gros, P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601828200 · Cited by 21
Shirase, T., Mori, K., Okazaki, Y., Itoh, K., Yamamoto, M. P., Tabuchi, M., Kishi, F., Jiang, L., Akatsuka, S., Nakao, K., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090823 · Cited by 22
DMT1 genetic variability is not responsible for phenotype variability in hereditary hemochromatosis
Kelleher, T., Ryan, E. M., Barrett, S., O’Keane, C., & Crowe, J. (2004) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2004.04.005 · Cited by 21
Zoller, H., Decristoforo, C., & Weiß, G. (2002) · British Journal of Haematology · doi:10.1046/j.1365-2141.2002.03626.x · Cited by 21
Esparza, A., Gerdtzen, Z. P., Olivera‐Nappa, Á., Salgado, J. C., & Núñez, M. T. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00412.2014 · Cited by 20
PKA modulates iron trafficking in the striatum via small GTPase, Rhes
Choi, B., Bang, S., Chen, Y., Cheah, J. H., & Kim, S. F. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.043 · Cited by 20
Balušíková, K., Neubauerová, J., Dostalikova‐Cimburova, M., Horák, J., & Kovár̆, J. (2008) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-008-9926-y · Cited by 20
Ponka, P., Tenenbein, M., & Eaton, J. W. (2014) · Elsevier eBooks · doi:10.1016/b978-0-444-59453-2.00041-x · Cited by 20
Haemig, H. A. H., Moen, P. J., & Brooker, R. J. (2010) · Biochemistry · doi:10.1021/bi100320y · Cited by 21
Zhang, A., Canonne‐Hergaux, F., Gruenheid, S., Gros, P., & Ponka, P. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.04.014 · Cited by 20
Functional gene expression domains: defining the functional unit of eukaryotic gene regulation
Dillon, N., & Sabbattini, P. M. R. (2000) · BioEssays · doi:10.1002/1521-1878(200007)22:7 · Cited by 100
Genetic Disorders Affecting Proteins of Iron and Copper Metabolism: Clinical Implications.
Miyajima, H. (2002) · Internal Medicine · doi:10.2169/internalmedicine.41.762 · Cited by 20
Nramp1 and NrampB Contribute to Resistance against Francisella in Dictyostelium
Brenz, Y., Ohnezeit, D., Winther-Larsen, H. C., & Hagedorn, M. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00282 · Cited by 19
Jiang, L., Ranganathan, P. N., Lu, Y., Kim, C., & Collins, J. F. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00261.2011 · Cited by 19
Recent developments in the understanding of iron metabolism
Testa, U. (2002) · The Hematology Journal · doi:10.1038/sj.thj.6200163 · Cited by 19
Hypoxia-inducible factor-2α and iron absorptive gene expression in Belgrade rat intestine
Yeh, K., YEH, M. K. Y., Polk, P., & Glass, J. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00538.2010 · Cited by 19
Multivalent Metal-Induced Iron Acquisition from Transferrin and Lactoferrin by Myeloid Cells
Olakanmi, O., Rasmussen, G. T., Lewis, T. S., Stokes, J. B., Kemp, J. D., & Britigan, B. E. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.4.2076 · Cited by 19
Ironing out the details: ferroptosis and its relevance to diabetic cardiomyopathy
Gawargi, F. I., & Mishra, P. K. (2023) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00117.2023 · Cited by 18
Recent Developments in Liver Pathology
Yan, B. C., & Hart, J. A. L. (2009) · Archives of Pathology & Laboratory Medicine · doi:10.5858/133.7.1078 · Cited by 18
Survival of intracellular pathogens within macrophages
Dermine, J. F., & Desjardins, M. (1999) · PROTOPLASMA · doi:10.1007/bf01314950 · Cited by 18
Li, F., Li, H., Hu, L., Kwan, M., Chen, G., He, Q., & Sun, H. (2005) · Journal of the American Chemical Society · doi:10.1021/ja047148t · Cited by 18
Jiang, S., Guo, S., Li, H., Ni, Y., Ma, W., & Zhao, R. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00819 · Cited by 18
Ponka, P., Tenenbein, M., & Eaton, J. W. (2007) · Elsevier eBooks · doi:10.1016/b978-012369413-3/50085-9 · Cited by 19
Sözmen, E. Y., Kavaklı, K., Çetinkaya, B., Akçay, Y., Yılmaz, D., & Aydınok, Y. (2003) · Biological Trace Element Research · doi:10.1385/bter:94:1:79 · Cited by 18
Intestinal iron absorption during suckling in mammals
Frazer, D. M., Darshan, D., & Anderson, G. J. (2011) · BioMetals · doi:10.1007/s10534-011-9429-2 · Cited by 18
Bury, N. R., Boyle, D., & Cooper, C. A. (2011) · Fish physiology · doi:10.1016/s1546-5098(11)31004-7 · Cited by 19
Increased duodenal expression of divalent metal transporter 1 and iron-regulated gene 1 in cirrhosis
Stuart, K. A., Anderson, G. J., Frazer, D. M., Murphy, T. L., Powell, L. W., Fletcher, L. M., & Crawford, D. H. (2004) · Hepatology · doi:10.1002/hep.20038 · Cited by 18
Song, Y., Luo, Z., Chen, Q.-L., Liu, X., Liu, C.-X., & Zheng, J. (2013) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-013-9883-7 · Cited by 18
Données récentes sur le métabolisme du fer : un état de transition
Cadet, E., Gadenne, M., Capron, D., & Rochette, J. (2004) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2004.09.024 · Cited by 20
Bozzi, A. T., McCabe, A. L., Barnett, B. C., & Gaudet, R. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011336 · Cited by 17
Calcium-channel blockers do not affect iron transport mediated by divalent metal-ion transporter-1
Mackenzie, B., Shawki, A., Ghio, A. J., Stonehuerner, J., Zhao, L., Ghadersohi, S., Garrick, L. M., & Garrick, M. D. (2010) · Blood · doi:10.1182/blood-2010-03-274738 · Cited by 17
Ndfip2 is a potential regulator of the iron transporter DMT1 in the liver
Foot, N. J., Gembus, K. M., Mackenzie, K. D., & Kumar, S. (2016) · Scientific Reports · doi:10.1038/srep24045 · Cited by 17
Núñez, M. T., Mazariegos, D. I., Pizarro, F., Olivares, M., & Arredondo, M. (2004) · Journal of Nutrition · doi:10.1093/jn/134.2.395 · Cited by 17
ZHANG, L., Lee, T. T., Yue, W. A. N. G., & Soong, T. W. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3490289 · Cited by 17
Haemochromatosis: an inherited metal and toxicity syndrome
Cox, T. M., & Kelly, A. L. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80081-6 · Cited by 17
Complexes of gallium(III) and other metal ions and their potential in the treatment of neoplasia
Lovejoy, D. B., & Richardson, D. R. (2000) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.9.6.1257 · Cited by 17
Nitric Oxide, Oxygen Radicals, and Iron Metabolism
Pantopoulos, K., & Hentze, M. W. (2000) · Elsevier eBooks · doi:10.1016/b978-012370420-7/50020-4 · Cited by 17
Metadata
- Authors
- Fleming, M. D., Trenor, C. C., Su, M. A., Foernzler, D., Beier, D. R., Dietrich, W. F., & Andrews, N. C.
- Affiliations
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Andrews, Nancy C.
- Venue
- Nature Genetics
- Published
- 1997-08
- Volume
- 16
- Issue
- 4
- Pages
- 383-386
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2082806735
- Cited by
- 1,159
- References
- 35
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 11 · 2023: 16 · 2022: 12 · 2021: 14 · 2020: 13 · 2019: 23 · 2018: 20 · 2017: 23 · 2016: 21 · 2015: 24 · 2014: 28 · 2013: 33 · 2012: 35
- FWCI
- 42.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Funders
- National Institutes of Health (1k08hl003600-01)
- National Heart, Lung, and Blood Institute (K08 HL03600)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- microcytic anemia, DMT1, iron transport, iron metabolism, intestinal iron absorption, missense mutations, positional cloning, NRAMP1, mice
- MeSH terms
- Frataxin, Animals, Friedreich Ataxia, Humans, Mitochondria, Phosphotransferases (Alcohol Group Acceptor), Iron-Binding Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
