A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

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  1. 14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans
    Caroline Araiz, Marie‐Thérèse Château, Simon Galas · 2008 · Experimental Gerontology
  2. Parasite genomes
    Ross L. Coppel, Casilda G. Black · 2005 · International Journal for Parasitology
  3. The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
    Kai Mao, Peter C. Breen, Gary Ruvkun · 2022 · Proceedings of the National Academy of Sciences
  4. Mutations of the Electron Transport Chain Affect Lifespan and ROS Levels in C. elegans
    Fanni Ősz, Aamir Nazir, Krisztina Takács‐Vellai, Zsolt Farkas · 2025 · Antioxidants
  5. GLTSCR2/PICT1 links mitochondrial stress and Myc signaling
    John C. Yoon, Alvin J. Y. Ling, Meltem Isik, Dong-Young Donna Lee, Michael J. Steinbaugh, Laura Magill Sack, Abigail N. Boduch, T. Keith Blackwell, David A. Sinclair, Stephen Joseph Elledge · 2014 · Proceedings of the National Academy of Sciences
  6. Functional genomics applications and therapeutic implications in sarcopenia
    Aicha Melouane, Abdelaziz Ghanemi, Mayumi Yoshioka, Jonny St‐Amand · 2019 · Mutation Research/Reviews in Mutation Research
  7. Mitochondrial Respiration Changes in R6/2 Huntington’s Disease Model Mice during Aging in a Brain Region Specific Manner
    Johannes Burtscher, Alba Di Pardo, Vittorio Maglione, Christoph Schwarzer, Ferdinando Squitieri · 2020 · International Journal of Molecular Sciences
  8. Mitochondrial DNA‐Deficient Models and Aging
    Abdullah Olgun, Şerif Akman · 2007 · Annals of the New York Academy of Sciences
  9. Is life span extension in single gene long-lived Caenorhabditis elegans mutants due to hypometabolism?
    Wayne A. Van Voorhies · 2003 · Experimental Gerontology
  10. Genome-Scale Studies of Aging: Challenges and Opportunities
    Mark A. McCormick, Brian Keith Kennedy · 2012 · Current Genomics
  11. Basic principle of the lifespan in the nematode C. elegans
    Tetsuji Shoyama, Takami Ozaki, Naoaki Ishii, Shigefumi Yokota, Hitoshi Suda · 2007 · Mechanisms of Ageing and Development
  12. 5′-Hydroxy-6, 7, 8, 3′, 4′-pentamethoxyflavone extends longevity mediated by DR-induced autophagy and oxidative stress resistance in C. elegans
    Shalini Trivedi, Rakesh Pandey · 2020 · GeroScience
  13. Collaboration between mitochondria and the nucleus is key to long life in Caenorhabditis elegans
    Chang, Hsin-Wen, Shtessel, Ludmila, Lee, Siu Sylvia · 2015 · Free Radical Biology and Medicine
  14. Multiple genetic pathways regulating lifespan extension are neuroprotective in a G2019S LRRK2 nematode model of Parkinson's disease
    Megan M. Senchuk, Jeremy M. Van Raamsdonk, Darren J. Moore · 2021 · Neurobiology of Disease
  15. The million-molecule challenge: a moonshot project to rapidly advance longevity intervention discovery
    Mitchell B. Lee, Benjamin W. Blue, Michael Muir, Matt R. Kaeberlein · 2023 · GeroScience
  16. Molecular characterization of the transition to mid-life in Caenorhabditis elegans
    David Mark Eckley, Salim Rahimi, Sandra Mantilla, Nikita V. Orlov, Christopher E. Coletta, Mark A. Wilson, Wendy B. Iser, John D. Delaney, Yongqing Zhang, William H. Wood et al. · 2012 · AGE
  17. A Simple Method for High Throughput Chemical Screening in Caenorhabditis Elegans
    Mark Lucanic, Theo Garrett, Matthew S. Gill, Gordon J. Lithgow · 2018 · Journal of Visualized Experiments
  18. SIGNAL: A web-based iterative analysis platform integrating pathway and network approaches optimizes hit selection from high-throughput assays
    Samuel Katz, Jian Song, Kyle P. Webb, Nicolas W. Lounsbury, C. Bryant, Iain D. C. Fraser · 2021 · Cell Systems
  19. Loss of SET1/COMPASS methyltransferase activity reduces lifespan and fertility in Caenorhabditis elegans
    Matthieu J. Caron, Loïc Gely, Steve Garvis, Annie Adrait, Yohann Couté, Francesca Palladino, Paola Fabrizio · 2021 · Life Science Alliance
  20. Oxidative Stress and Aging in the Nematode Caenorhabditis elegans
    David Gems, Ryan Doonan · 2008 · Humana Press eBooks
  21. Evidence that a mitochondrial death spiral underlies antagonistic pleiotropy
    Michael Stern · 2017 · Aging Cell
  22. Overexpression of malic enzyme in the larval stage extends Drosophila lifespan
    Gye-Hyeong Kim, Young‐Eun Lee, Gun-Ho Lee, Youn-Ho Cho, Young-Nam Lee, Yeogil Jang, Donggi Paik, Joong‐Jean Park · 2014 · Biochemical and Biophysical Research Communications
  23. How should we assess the impact of genetic changes on ageing in model species?
    Nadège Minois · 2005 · Ageing Research Reviews
  24. Bioinformatics and Proteomics Approaches for Aging Research
    Raghothama Chaerkady, Harsha Gowda, C. Krishna Prasad, Akhilesh Pandey · 2005 · Biogerontology
  25. Dietary Restriction, Hormesis, and Small Molecule Mimetics
    David A. Sinclair, Konrad T. Howitz · 2005 · Elsevier eBooks
  26. Xenotopic synthetic biology: Prospective tools for delaying aging and age-related diseases
    Andrey A. Parkhitko, Valentin Cracan · 2025 · Science Advances
  27. Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
    Toni Castro Torres, Darius Moaddeli, Maxim Averbukh, Aeowynn J. Coakley, Naibedya Dutta, Gilberto Garcia, Ryo Higuchi‐Sanabria · 2022 · Journal of Visualized Experiments
  28. Caenorhabditis elegans as a Model for the Effects of Phytochemicals on Mitochondria and Aging
    Fabian Schmitt, Gunter Peter Eckert · 2022 · Biomolecules
  29. The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans
    Felicity J. Emerson, Caitlin Chiu, Laura Y. Lin, Christian G. Riedel, Ming Liang Zhu, Siu Sylvia Lee · 2024 · Nature Communications
  30. DIC‐1 over‐expression enhances respiratory activity in Caenorhabditis elegans by promoting mitochondrial cristae formation
    Tae Hoon Lee, Ji Young Mun, Sung Min Han, Gyesoon Yoon, Sung‐Sik Han, Hyeon‐Sook Koo · 2009 · Genes to Cells
  31. Invertebrate and vertebrate models in aging research
    Manoj Kumar Chaudhary, Syed Ibrahim Rizvi · 2019 · Biomedical Papers
  32. Do You Remember Mitochondria?
    Flavia Messina, Francesco Cecconi, Carlo Rodolfo · 2020 · Frontiers in Physiology
  33. Temperature regulates synaptic subcellular specificity mediated by inhibitory glutamate signaling
    Mengqing Wang, Daniel K. Witvliet, Mengting Wu, Lijun Kang, Zhiyong Shao · 2021 · PLoS Genetics
  34. Invertebrates Mitochondrial Function and Energetic Challenges
    Oliviert Martínez‐Cruz, Arturo Sánchez‐Paz, Fernando Luis García-Carreño, Laura Rebeca Jiménez-Gutiérrez, M. Ángeles Navarrete del Toro, Adriana Muhlia‐Almazán · 2012 · InTech eBooks
  35. Decrease in cytochrome c oxidase reserve capacity diminishes robustness of Drosophila melanogaster and shortens lifespan
    Vladimir I. Klichko, Barbara H. Sohal, Svetlana N. Radyuk, William C. Orr, Rajindar S. Sohal · 2014 · Biochemical Journal
  36. Regulation of Age-related Decline by Transcription Factors and Their Crosstalk with the Epigenome
    Xin Zhou, Ilke Sen, Xin-Xuan Lin, Christian G. Riedel · 2018 · Current Genomics
  37. C. elegans as a Resource for Studies on Plant Parasitic Nematodes
    Laura Jones, Carla De Giorgi, Peter E. Urwin · 2011 · Springer eBooks
  38. RNAi as a bioinformatics consumer
    Ravi Sachidanandam · 2005 · Briefings in Bioinformatics
  39. Deconvolution of the epigenetic age discloses distinct inter-personal variability in epigenetic aging patterns
    Tamar Shahal, Elad Segev, Thomas Konstantinovsky, Yonit Marcus, Gabi Shefer, Metsada Pasmanik‐Chor, Assaf Buch, Yuval Ebenstein, Paul Zimmet, Naftali Stern · 2022 · Epigenetics & Chromatin
  40. Mitochondrial translational defect extends lifespan in C. elegans by activating UPRmt
    Miaomiao Guo, Xinhua Qiao, Yuan‐Yuan Wang, Zi-Han Li, Shi Chang, Yun Chen, Lu Kang, Chang Chen, Xiao-Long Zhou · 2023 · Redox Biology
  41. Consolidating multiple evolutionary theories of ageing suggests a need for new approaches to study genetic contributions to ageing decline
    Luke Slade, Timothy Etheridge, Nathaniel J. Szewczyk · 2024 · Ageing Research Reviews
  42. Loss of seryl-tRNA synthetase (SARS1) causes complex spastic paraplegia and cellular senescence
    Edgard Verdura, Bruno Senger, Miquel Raspall‐Chaure, Agatha Schlüter, Nathalie Launay, Montserrat Ruíz, Carlos Casasnovas, Agustí Rodríguez‐Palmero, Alfons Macaya, Hubert Dominique Becker et al. · 2022 · Journal of Medical Genetics
  43. Changes in neuronal CycD/Cdk4 activity affect aging, neurodegeneration, and oxidative stress
    Amalia Icreverzi, Aida Flor A. de la Cruz, David W. Walker, Bruce A. Edgar · 2015 · Aging Cell
  44. Identification of respiratory chain gene mutations that shorten replicative life span in yeast
    Elise Hacioglu, Ayşe Banu Demir, Ahmet Koç · 2011 · Experimental Gerontology
  45. Longevity Genomics Across Species
    Matt R. Kaeberlein · 2007 · Current Genomics
  46. Mitochondria, metabolism, and aging in yeast
    S. Michal Jazwinski · 2003 · Topics in current genetics
  47. Aging and mitochondrial dysfunction in the filamentous fungus Podospora anserina
    Heinz Dieter Osiewacz · 2003 · Topics in current genetics
  48. Mechanisms of defense against products of cysteine catabolism in the nematode Caenorhabditis elegans
    Leonid Livshits, Arijit Kumar Chatterjee, Netanel Karbian, Rachel Abergel, Zohar Abergel, Einav Gross · 2017 · Free Radical Biology and Medicine
  49. Metallome evolution in ageingC. elegansand a copper stable isotope perspective
    Lucie Sauzéat, Anne Laurençon, Vincent Balter · 2018 · Metallomics
  50. Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes
    Maria Armakola, Gary Ruvkun · 2019 · Proceedings of the National Academy of Sciences
  51. Caenorhabditis elegans ubiquinone biosynthesis genes
    Juan Carlos Rodríguez‐Aguilera, Claudio Asencio, Macarena Ruiz‐Ferrer, Jordana Vela, Plácido Navas · 2003 · BioFactors
  52. The efficiency of mitochondrial electron transport chain is increased in the long‐lived mrg19 Saccharomyces cerevisiae
    Nitish Mittal, M. Madan Babu, Nilanjan Roy · 2009 · Aging Cell
  53. RNAi Applications in Target Validation
    Antonis Kourtidis, Cheryl Eifert, Douglas S. Conklin · 2007 · Springer eBooks
  54. Nutritional approaches targeting mitochondria for the prevention of sarcopenia
    Jeong‐Hoon Hahm, Farida Sukma Nirmala, Tae Youl Ha, Jiyun Ahn · 2023 · Nutrition Reviews
  55. Hypoxia, Acidification and Inflammation: Partners in Crime in Parkinson’s Disease Pathogenesis?
    Johannes Burtscher, Grégoire Paul Millet · 2021 · Immuno
  56. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells
    Joshua Jackson, Lena Wischhof, Enzo Scifo, Anna Pellizzer, Yiru Wang, Antonia Piazzesi, Debora Gentile, Sana Siddig, Miriam Stork, Christopher E. Hopkins et al. · 2022 · Molecular Metabolism
  57. Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function in Caenorhabditis elegans
    Haikel Dridi, Frances M. Forrester, Alisa Umanskaya, Wenjun Xie, Steven R. Reiken, Alain Lacampagne, Andrew R. Marks · 2022 · eLife
  58. Proteomics analysis in Caenorhabditis elegans to elucidate the response induced by tyrosol, an olive phenol that stimulates longevity and stress resistance
    Ana Cañuelo, Juan Peragón · 2013 · PROTEOMICS
  59. CEST‐2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants
    Antonia Piazzesi, Yiru A. Wang, Joshua Jackson, Lena Wischhof, Viktoria Valeska Zeisler-Diehl, Enzo Scifo, Ina Oganezova, Thorben Hoffmann, Pablo Gómez Martín, Fabio Bertan et al. · 2022 · EMBO Reports
  60. Advances in systems biology: measurement, modeling and representation.
    Susie M Stephens, Johan Rung · 2006 · PubMed
  61. Countering neurodegeneration by reducing the activity of the insulin/IGF signaling pathway: Current knowledge and future prospects
    Ehud Cohen · 2010 · Experimental Gerontology
  62. Aging-Related Research in the "-omics" Age
    Matt R. Kaeberlein · 2004 · Science of Aging Knowledge Environment
  63. Dissecting the Processes of Aging Using the Nematode Caenorhabditis elegans
    Samuel T. Henderson, Shane L. Rea, Thomas E. Johnson · 2005 · Elsevier eBooks
  64. Shaping longevity early in life: developmental ROS and H3K4me3 set the clock
    Bryndon J. Oleson, Daphne Bazopoulou, Ursula Jakob · 2021 · Cell Cycle
  65. Microarray analysis of Drosophila dicer‐2 mutants reveals potential regulation of mitochondrial metabolism by endogenous siRNAs
    Do‐Hwan Lim, Langho Lee, Chun-Taek Oh, Nam‐Hoon Kim, Seungwoo Hwang, Sung‐Jun Han, Young Sik Lee · 2012 · Journal of Cellular Biochemistry
  66. Ageing research in the post-genome era: new technologies for an old problem.
    João Pedro de Magalhães · 2009 · PubMed
  67. A Genome-Wide Association Study in Human Lymphoblastoid Cells Supports Safety of Mitochondrial Complex I Inhibitor
    Huan-Yao Gao, Utkarsh Tripathi, S. Trushin, L. Okromelidze, Nicholas P Pichurin, Lixuan Wei, Yong-Xian Zhuang, Lie-Wei Wang, E. Trushina · 2021 · Mitochondrion (Amsterdam. Print)
  68. The emerging roles of tRNAs and tRNA-derived fragments during aging: Lessons from studies on model organisms
    Agata Tyczewska, Alicja Rzepczak, Daria Sobańska, Kamilla Grzywacz · 2023 · Ageing Research Reviews
  69. Two sides of lifespan regulating genes: pro-longevity or anti-longevity?
    Sakiko Honjoh, Eisuke Nishida · 2011 · The Journal of Biochemistry
  70. THE HUNT FOR THE RECORD LIFE SPAN IN CAENORHABDITIS ELEGANS
    Koen Houthoofd, Bart P. Braeckman, Jacques R. Vanfleteren · 2004 · The Journals of Gerontology Series A
  71. Conserved components of the macroautophagy machinery in Caenorhabditis elegans
    Hong Zhang, Alicia Meléndez · 2025 · Genetics
  72. Identification of longevity genes with systems biology approaches
    Fusheng Tang · 2009 · Advances and Applications in Bioinformatics and Chemistry
  73. Molecular Machines in the Synapse: Overlapping Protein Sets Control Distinct Steps in Neurosecretion
    Lennart Niels Cornelisse, Evgeni Tsivtsivadze, Marieke Meijer, Tjeerd M. H. Dijkstra, Tom Heskes, Matthijs Verhage · 2012 · PLoS Computational Biology
  74. Evidence that conserved essential genes are enriched for pro-longevity factors
    Naci Oz, Elena M. Vayndorf, Mitsuhiro Tsuchiya, Samantha McLean, Lesly Turcios-Hernandez, Jason N. Pitt, Benjamin W. Blue, Michael Muir, Michael G. Kiflezghi, Alexander Tyshkovskiy et al. · 2022 · GeroScience
  75. Knockdown of neuronal DAF-15/Raptor promotes healthy aging in C. elegans
    Xiao Zang, Qi Wang, Hanxin Zhang, Yiyan Zhang, Zi Wang, Zixing Wu, Di Chen · 2023 · Journal of genetics and genomics/Journal of Genetics and Genomics
  76. Considering Caenorhabditis elegans Aging on a Temporal and Tissue Scale: The Case of Insulin/IGF-1 Signaling
    Paola Fabrizio, Allan Alcolei, Florence Solari · 2024 · Cells
  77. Caenorhabditis elegans expressing the Saccharomyces cerevisiae NADH alternative dehydrogenase Ndi1p, as a tool to identify new genes involved in complex I related diseases
    Raynald Cossard, Michela Esposito, Carole H. Sellem, Laras Pitayu-Nugroho, Christelle Vasnier, Agnés Delahodde, Emmanuel Philippe Dassa · 2015 · Frontiers in Genetics
  78. New cellular and molecular approaches to ageing brain
    Anurag Tripathi · 2012 · Annals of Neurosciences
  79. Empowering Melatonin Therapeutics with Drosophila Models
    Cassandra Millet-Boureima, Caroline C. Ennis, Jurnee Jamison, Shana McSweeney, Anna Park, Chiara Gamberi · 2021 · Diseases
  80. A Functional Genomics Approach to Identify New Regulators of Wnt Signaling
    Eileen E. M. Furlong · 2005 · Developmental Cell
  81. Mitochondria and Aging: Dilution Is the Solution
    Jenni Durieux, Andrew G. Dillin · 2007 · Cell Metabolism
  82. Is it possible to prove the existence of an aging program by quantitative analysis of mortality dynamics?
    Gregory A. Shilovsky, T. S. Putyatina, Sergei N. Lysenkov, Vasily V. Ashapkin, O. S. Luchkina, Alexander V Markov, Vladimir P. Skulachev · 2016 · Biochemistry (Moscow)
  83. Application of High-Throughput Technologies to Aging-Related Research
    Matt R. Kaeberlein · 2006 · Elsevier eBooks
  84. Towards full employment: using RNAi to find roles for the redundant
    Andrew G. Fraser · 2004 · Oncogene
  85. Emerging Technologies: Trendy RNA Tools for Aging Research
    Custer C. Deocaris, Sunil C. Kaul, Kazunari Taira, Renu Wadhwa · 2004 · The Journals of Gerontology Series A
  86. Physiological Differences Underlying Divergent Hypoxia Responses and Altitude Adaptations in Humans, Rats and Mice
    Johannes Burtscher, Robert T. Mallet, Anupam Sah, Max Gassmann, Martin Burtscher, Rodrigo Iturriaga · 2025 · Comprehensive physiology
  87. Loss of hif-1 promotes resistance to the exogenous mitochondrial stressor ethidium bromide in Caenorhabditis elegans
    Muntasir Kamal, Dayana R D'Amora, Terrance J. Kubiseski · 2016 · BMC Cell Biology
  88. Maintenance of protein homeostasis in glia extends lifespan in C. elegans
    Lei Wang, Laura K. Bianchi · 2021 · Experimental Neurology
  89. Amyloid β accelerates age-related proteome-wide protein insolubility
    Edward Anderton, Manish Chamoli, Dipa Bhaumik, Christina D. King, Xueshu Xie, Anna Foulger, Julie Kay Andersen, Birgit Schilling, Gordon J. Lithgow · 2024 · GeroScience
  90. Cytosolic and mitochondrial tRNA synthetase inhibitors increase lifespan in a GCN4/atf-4-dependent manner
    Christine Reiser Robbins, Bhumil Patel, Danielle L. Sawyer, Barrie Wilkinson, Brian Keith Kennedy, Mark A. McCormick · 2022 · iScience
  91. Mutation in a mitochondrial ribosomal protein causes increased sensitivity to oxygen with decreased longevity in the nematode Caenorhabditis elegans
    Michihiko Fujii, Kazuki Shikatani, Ken‐ichi Ogura, Yoshio Goshima, Dai Ayusawa · 2010 · Genes to Cells
  92. Caenorhabditis elegans ATR checkpoint kinase ATL-1 influences life span through mitochondrial maintenance
    Kazuhiro Suetomi, Stefan Mereiter, Chihiro Mori, Takako Takanami, Atsushi Higashitani · 2013 · Mitochondrion
  93. Functional genomics and transcriptomics of prostate cancer: promises and limitations
    Olli Kallioniemi · 2005 · British Journal of Urology
  94. Term-tissue specific models for prediction of gene ontology biological processes using transcriptional profiles of aging in drosophila melanogaster
    Wensheng Zhang, Sige Zou, Jiuzhou Song · 2008 · BMC Bioinformatics
  95. Evolution, Chance, and Aging
    Stewart A. Frankel, Blanka Rogina · 2021 · Frontiers in Genetics
  96. Genome-wide approaches to understanding human ageing
    Matt R. Kaeberlein · 2006 · Human Genomics
  97. My adventures with genes from the fountain of youth.
    Cynthia J. Kenyon · 2004 · PubMed
  98. Detection of Mitochondrial Toxicity of Environmental Pollutants UsingCaenorhabditis elegans
    Laura L. Maurer, Anthony L. Luz, Joel N. Meyer · 2018 · Wiley eBooks
  99. Mitochondrial metabolism and the continuing search for ultimate regulators of developmental rate
    Margarete Díaz-Cuadros · 2024 · Current Opinion in Genetics & Development
  100. Dietary cobalt oxide nanoparticles alleviate aging through activation of mitochondrial UPR in Caenorhabditis elegans
    Wenshu Cong, Yajie Wang, Chunhui Yuan, Xu Mei, Han Wang, You Hu, Xuyan Dai, Yuhua Weng, Peter S. Timashev, Xing‐Jie Liang et al. · 2023 · Theranostics