The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
Abstract
We report a systematic RNA interference (RNAi) screen of 5,690 Caenorhabditis elegans genes for gene inactivations that increase lifespan. We found that genes important for mitochondrial function stand out as a principal group of genes affecting C. elegans lifespan. A classical genetic screen identified a mutation in the mitochondrial leucyl-tRNA synthetase gene (lrs-2) that impaired mitochondrial function and was associated with longer-lifespan. The long-lived worms with impaired mitochondria had lower ATP content and oxygen consumption, but differential responses to free-radical and other stresses. These data suggest that the longer lifespan of C. elegans with compromised mitochrondria cannot simply be assigned to lower free radical production and suggest a more complex coupling of metabolism and longevity.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Unexpectedly, reduced mitochondrial function can, in some circumstances, increase lifespan.”
From Neural mechanisms of ageing and cognitive decline (2010) · cites this paper as [36]
In the citing paper
“Paradoxically, it is the impairment of mitochondrial function and associated lower ATP levels that prolongs lifespan in worms (Dillin et al., 2002; Lee et al., 2003).”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Lee et al., 2003
In the citing paper
“an unbiased search for genes that extend lifespan has identified a disproportionate number of genes that function in mitochondrial metabolism(273)”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [273]
In the citing paper
“By contrast, knockdown experiments that target other components of the electron transport chain, including essential elements of complexes I, III and IV, lead to lifespan extension in worms 99, 100 .”
From The common biology of cancer and ageing (2007) · cites this paper as [100]
Citations
Cites
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
Kamath, R. S., Fraser, A. G., Yan, D., Poulin, G. B., Durbin, R. M., Gotta, M., Kanapin, A. A., Bot, N. L., Moreno, S., Sohrmann, M., et al. (2003) · Nature · doi:10.1038/nature01278 · Cited by 3,618
Self-citationA C. elegans mutant that lives twice as long as wild type
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387
Mitochondrial diseases in man and mouse
Wallace, D. C. (1999) · Science · doi:10.1126/science.283.5407.1482 · Cited by 3,060
Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250
Self-citationOgg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A., & Ruvkun, G. (1997) · Nature · doi:10.1038/40194 · Cited by 1,935
Self-citationFunctional genomic analysis of C. elegans chromosome I by systematic RNA interference
Fraser, A. G., Kamath, R. S., Zipperlen, P., Martinez-Campos, M., Sohrmann, M., & Ahringer, J. (2000) · Nature · doi:10.1038/35042517 · Cited by 1,720
Self-citationLin, K., Dorman, J. B., Rodan, A. R., & Kenyon, C. J. (1997) · Science · doi:10.1126/science.278.5341.1319 · Cited by 1,501
Longevity, senescence and the genome
(1995) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(95)90026-8 · Cited by 1,403
Genetic pathways that regulate ageing in model organisms
Guarente, L., & Kenyon, C. J. (2000) · Nature · doi:10.1038/35041700 · Cited by 1,337
Flagged first, then by citations
Cited by
Sorted by citations
Items 801–900 of 968
RNAi in Caenorhabditis Elegans
Plasterk, R. H. A., & Simmer, F. (2004) · CRC Press eBooks · doi:10.1201/9780203489253.ch11 · Cited by 2
Miller, D. L., Horsman, J. W., & Heinis, F. I. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-44703-2_9 · Cited by 2
Mitochondrial Longevity Pathways
Schiavi, A., & Ventura, N. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-44703-2_5 · Cited by 3
Control of Gene Expression by RNAi: A Revolution in Functional Genomics
Kumar, S., & Salar, R. K. (2017) · Springer eBooks · doi:10.1007/978-981-10-4732-9_2 · Cited by 2
Recent applications of RNA interference (RNAi) in mammalian systems
Scherer, L. J., & Rossi, J. J. (2003) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-004-4924-8 · Cited by 2
Gems, D., & Doonan, R. (2008) · Cited by 2
Age and Oxidative Stress in the Germ Line
Robaire, B., Paul, C., & Selvaratnam, J. S. (2012) · Humana Press eBooks · doi:10.1007/978-1-61779-776-7_7 · Cited by 2
The Aging Epigenome and The Rejuvenation Strategies
Meiliana, A., Dewi, N. M., & Wijaya, A. (2022) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v14i1.1777 · Cited by 1
Molecular Chaperones and Cellular Aging
Morrow, G., & Tanguay, R. M. (2003) · Springer eBooks · doi:10.1007/978-94-017-0669-8_11 · Cited by 1
Mitochondria as a Key Determinant of Aging
Walter, L., & Lee, S. S. (2009) · Wiley eBooks · doi:10.1002/9780470015902.a0020881 · Cited by 2
Self-citationSignaling Pathways that Regulate C. elegans Life Span
Ruvkun, G., Samuelson, A. V., Carr, C. E., Curran, S. P., & Shore, D. E. (2009) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-642-04302-4_6 · Cited by 2
Self-citationDicer in RNAi: Its roles in vivo and utility in vitro
Myers, J. W., & Ferrell, J. E. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546402.005 · Cited by 2
Studer, L. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-398358-9.00061-6 · Cited by 2
Use of C. elegans to Model Human Movement Disorders
Caldwell, G. A., Cao, S., Izevbaye, I., & Caldwell, K. A. (2005) · Elsevier eBooks · doi:10.1016/b978-012088382-0/50009-8 · Cited by 2
C. elegans as a model for health and disease
Zuryn, S. (2023) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2023.07.006 · Cited by 2
Lifespan regulation by targeting heme signaling in yeast
Patnaik, P. K., Nady, N., Barlit, H., Gülhan, A., & Labunskyy, V. M. (2024) · GeroScience · doi:10.1007/s11357-024-01218-9 · Cited by 1
The role of pyruvate dehydrogenase in the lifespan determination of daphnids
Chen, W., Xu, X., Zeng, Z., Zhou, M., Chen, J., Hu, G., Shen, A., Li, D., & Liu, X. (2025) · Nature Communications · doi:10.1038/s41467-025-58666-w · Cited by 1
Systems genetics of lifespan and senescence in Drosophila melanogaster
Aghdam, M. N., Unselt, D., Adonay, M. E., Morozova, T. V., Carbone, M. A., Arya, G. H., Turlapati, L., Shankar, V., Anholt, R. R. H., & Mackay, T. F. C. (2025) · BMC Biology · doi:10.1186/s12915-025-02485-4 · Cited by 3
Guscelli, E., Chabot, D., Noisette, F., Blier, P. U., Chemel, M., & Calosi, P. (2025) · Conservation Physiology · doi:10.1093/conphys/coaf076 · Cited by 1
Applications of RNAi in C. Elegans Research
Cerón, J., Cabello, J., Monje, J. M., Miranda‐Vizuete, A., Villanueva, A., Schwartz, S., & Lehner, B. (2008) · DIGITAL.CSIC (Spanish National Research Council (CSIC)) · Cited by 1
Genomic analysis of nematode-environment interactions
Adhikari, B. N. (2010) · Cited by 1
Cellular versus Organismal Aging
Dillin, A. G., & Karlseder, J. (2007) · Springer eBooks · doi:10.1007/978-3-540-73709-4_1 · Cited by 1
Telomeres, Senescence and Longevity: The Role of Oxidative Stress and Antioxidants
Saretzki, G. C. (2005) · Current Pharmacogenomics · doi:10.2174/1570160054022926 · Cited by 1
The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated
Durieux, L., Wolff, S., & Dillin, A. G. (2011) · Cited by 2
Systems Biology of Caenorhabditis elegans
Fraser, A. G., & Lehner, B. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-385944-0.00019-8 · Cited by 1
Self-citationOxidative Stress, Gene Expression, and Lifespan
Honda, S., & Honda, Y. (2005) · Oxidative stress and disease · doi:10.1201/9781420028096.ch4 · Cited by 1
Chromatin Signaling in Aging and Cellular Senescence
Couteau, F., & Mallette, F. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802389-1.00016-2 · Cited by 1
Identification of peculiar and common effects of histone modifications on transcription
Liu, Y., Liang, X., & Yang, R. (2015) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2015.04.040 · Cited by 1
The Impact of the Mediterranean Diet on Aging, Frailty, and Longevity
Capurso, A., Crepaldi, G., & Capurso, C. A. (2018) · Practical issues in geriatrics · doi:10.1007/978-3-319-78084-9_16 · Cited by 1
Lifespan regulation by evolutionarily conserved genes essential for viability
Curran, S. P., & Ruvkun, G. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0030056.eor · Cited by 1
Self-citationSearching for the elusive mitochondrial longevity signal in C. elegans
Bennett, C. F., Choi, H., & Kaeberlein, M. R. (2014) · Worm · doi:10.4161/worm.29868 · Cited by 1
Cornwell, A. B., Llop, J. R., Salzman, P., Rasmussen, N., Thakar, J., & Samuelson, A. V. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.861701 · Cited by 1
Invertebrate model organisms for aging research
Shukla, A. K., Scott, A., & Giniger, E. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90235-9.00004-5 · Cited by 1
Molecular and Biological Factors in Aging
Litke, R. R., & Mobbs, C. V. (2023) · Springer eBooks · doi:10.1007/978-3-030-01782-8_102-1 · Cited by 1
High-Throughput Behavioral Aging and Lifespan Assays Using the Lifespan Machine
Carmen-Fabregat, A. D., Sedlackova, L., Oswal, N., & Stroustrup, N. (2024) · Journal of Visualized Experiments · doi:10.3791/65462 · Cited by 1
Molecular and Biological Factors in Aging
Litke, R. R., & Mobbs, C. V. (2024) · Springer eBooks · doi:10.1007/978-3-030-74720-6_102 · Cited by 1
Patange, V., Ahirwar, K., Tripathi, T., Tripathi, P., & Shukla, R. (2024) · Mitochondrion (Amsterdam. Print) · doi:10.1016/j.mito.2024.101979
Gene Silencing through RNA Interference
Azorsa, D. O., Mousses, S., & Caplen, N. J. (2007) · Springer eBooks · doi:10.1007/0-387-32956-0_17 · Cited by 1
2 Common Aging Mechanisms: Energy Metabolism and Longevity in Caenorhabditis elegans
Artal‐Sanz, M., & Tavernarakis, N. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-507-1_2 · Cited by 1
Golden, T. R., Morten, K., Johnson, F., Samper, E., & Melov, S. (2005) · Elsevier eBooks · doi:10.1016/b978-012088387-5/50008-x · Cited by 1
Methods and models for functional studies on mtDNA mutations
Iommarini, L., Ghelli, A. M., & Díaz, F. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819656-4.00013-9 · Cited by 1
Response to Hypoxia in Cognitive Decline
Larrick, J. W., Larrick, J. W., & Mendelsohn, A. R. (2021) · Rejuvenation Research · doi:10.1089/rej.2021.0051 · Cited by 1
RNAi machinery in insects and its challenges in pest management: A review
Gopalakrishnan, R., Subramanian, S., & Kalia, V. K. (2020) · Journal of Entomology and Zoology Studies · doi:10.22271/j.ento.2020.v8.i6g.7901 · Cited by 1
Mitochondrial Inheritance and Natural Phenotypic Variation among Caenorhabditis briggsae Populations
Coleman-Hulbert, A. L. (2000) · doi:10.15760/etd.340 · Cited by 1
Skipper, M. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1007 · Cited by 1
Practical applications of RNAi in C. elegans
Stephens, K. E., Zugasti, O., O’Neil, N. J., & Kuwabara, P. E. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546402.020 · Cited by 1
Strange, K. B., & Estevez, A. Y. (2005) · CRC Press eBooks · doi:10.1201/9781420038231.ch8 · Cited by 1
Samaddar, M., Goudeau, J. F., Sanchez, M., Hall, D. H., Bohnert, K. A., Ingaramo, M., & Kenyon, C. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.31.276006 · Cited by 1
Knapp-Wilson, A., Pereira, G. C., Buzzard, E., Richardson, A. P., Corey, R. A., Neal, C., Verkade, P., Halestrap, A. P., Gold, V. A. M., Kuwabara, P. E., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.06.425530 · Cited by 1
Blackiston, D. J., Shomrat, T., Nicolas, C. L., Granata, C., & Levin, M. (2011) · PLoS ONE · doi:10.1371/annotation/f5985f4c-c70a-498d-887f-9c9635c0ef77 · Cited by 1
Gene silencing through RNA interference: Potential for therapeutics and functional genomics
Azorsa, D. O., Mousses, S., & Caplen, N. J. (2003) · International Journal of Peptide Research and Therapeutics · doi:10.1007/bf02484571 · Cited by 1
Litke, R. R., Vicari, J. M., Huang, B. T., Shapiro, L. R., Roh, K.-H., Silver, A. E., Talreja, P., Palacios, N., Yoon, Y., Kellner, C. P., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.12.544352 · Cited by 1
Rathor, L., Curry, S., Park, Y., McElroy, T., Robles, B., Sheng, Y., Chen, W., Min, K., Xiao, R., Lee, M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.20.585932 · Cited by 2
Rathor, L., Curry, S., Park, Y., McElroy, T., Robles, B., Sheng, Y., Chen, W., Min, K., Xiao, R., Lee, M., et al. (2024) · eLife · doi:10.7554/elife.97767.1 · Cited by 2
Transcriptomic analysis of mitohormesis associated with lifespan extension in Caenorhabditis elegansPreprint
Kim, J., Dutta, N., Garcia, G., & Higuchi‐Sanabria, R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.15.648933 · Cited by 1
Aging: Evolutionary Theory Meets Genomic Approaches
Sutphin, G. L., & Kennedy, B. K. (2009) · Springer eBooks · doi:10.1007/978-3-642-00952-5_20 · Cited by 2
Lazarillo and Related Lipocalins: Ligands and Funcions
García, M. R. (2013) · UVaDOC UVaDOC University of Valladolid Documentary Repository (University of Valladolid) · doi:10.35376/10324/3603 · Cited by 1
Proteostasis and the aging pathways
Nicastro, I. A., & Dillin, A. G. (2012) · Research and perspectives in Alzheimer's disease · doi:10.1007/978-3-642-27928-7_3
3 Conserved Mechanisms of Life-Span Regulation and Extension in Caenorhabditis elegans
Curran, S. P. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-507-1_3
Synthetic Lethal Genetic Interaction Networks and Their Utility for Anticancer Therapy
Khan, S., Sonkar, A. K., & Ahmed, S. (2013) · Springer eBooks · doi:10.1007/978-94-007-5931-2_16
Honnen, S. (2012) · Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver
Six methods of inducing RNAi in mammalian cells
Latham, K., Pallotta, V., Ford, L. P., Byrom, M., Banan, M., Ku, P.-T., & Brown, D. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546402.013
Alriyami, M. (2010) · Summit (Simon Fraser University)
Worming to Complete the Insulin/IGF-1 Signaling Cascade: A Dissertation
Padmanabhan, S. (2009) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/40am-yf26
Bai, H. (2012) · InTech eBooks · doi:10.5772/49945 · Cited by 1
Lundbæk, M. B., & Sætrom, P. (2013) · Wiley-VCH eBooks · doi:10.1002/3527600906.mcb.201200034
The regulation of hypoxia-inducible factor (HIF-1) and the role of HIF-1 in C. elegans longevity
Zhai, Z. (2010) · Iowa State University Digital Repository (Iowa State University) · doi:10.31274/etd-180810-2485
Exploiting Model Organisms for Disease Intervention
Creasy, C. L., Livi, G. P., & Debouck, C. M. (2006) · Wiley-VCH eBooks · doi:10.1002/3527600906.mcb.200300164
Kim, Y. (2013) · University of Minnesota Digital Conservancy (University of Minnesota)
Wang, C., & Fu, Z. (2008) · The Chinese-German Journal of Clinical Oncology · doi:10.1007/s10330-008-0061-8
Early Life Predictors of Old-Age Life Expectancy
Rikke, B. A. (2004) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2004.20.pe21
New genetic strategies for protein discovery based on whole-genome sequences
DeVit, M. J., & Powers, T. (2004) · Drug Discovery Today TARGETS · doi:10.1016/s1741-8372(04)02403-x
Caenorhabditis elegans functional genomics: Omic resonance
Astin, J. W. (2004) · Briefings in Functional Genomics and Proteomics · doi:10.1093/bfgp/3.1.26
Phylogenetic ubiquity of the effects of altered ubiquinone biosynthesis on survival
Hekimi, S., & Hughes, B. G. (2011) · Aging · doi:10.18632/aging.100310
Use of RNA interference to investigate gene function in the
Aboobaker, A. A., & Blaxter, M. (2003)
Quantitative evidence for conserved longevity pathways between divergent eukaryotic speciesPreprint
Smith, E. D., Tsuchiya, M., Fox, L. A., Dang, N., Hu, D., Kerr, E. O., Johnston, E. D., Tchao, B. N., Pak, D. N., Welton, K. L., et al. (2008) · Genome Research · doi:10.1101/gr.074724.107 · Cited by 200
IDENTIFICATION AND CHARACTERIZATION OF REGULATORS OF THE
Daf, L. F., & Elegans, C. (2009)
Oxidative Stress and C. elegans Models
Ishii, N., Ishii, T., & Hartman, P. S. (2015) · Springer eBooks · doi:10.1007/978-4-431-55763-0_7
Calorie Restriction, Mitochondria and Longevity in Saccharomyces cerevisiae
Skinner, C., & Lin, S.-J. (2012) · Oxidative stress and disease · doi:10.1201/b12308-18
Caenorhabditis elegans Models to Study the Molecular Biology of Ataxias
González‐Cabo, P., & Vázquez‐Manrique, R. P. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405195-9.00068-8
High-throughput RNA interference
Chang, H. Y., Wang, N. N., & Chi, J. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546402.036
Quantitative Genetics and Genomics of Drosophila Life Span
Wilson, R. H. (2006) · NCSU Libraries Repository (North Carolina State University Libraries)
Mitochondrial dynamics and quality control in ageing
Tam, Z. Y. (2013) · Repository for Publications and Research Data (ETH Zurich) · doi:10.3929/ethz-a-009756828
Aging and oxidants in the nematode Caenorhabditis elegans
Gems, D. (2009) · UCL Discovery (University College London)
Integration of Metabolic Signals
Lynn, D. A., & Curran, S. P. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-44703-2_17
Hwang, C. (2010) · TSpace (University of Toronto)
Chen, B.-R. (2011) · OhioLink ETD Center (Ohio Library and Information Network)
Almohammed, Z. N., Bitsue, Z. K., Kashani, P. I., & Pasbakhsh, P. (2017) · International Journal of Scientific and Engineering Research · doi:10.14299/ijser.2017.05.001
Studer, L. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-385942-6.00059-7
Köester, V. (2018) · ChemViews · doi:10.1002/chemv.201800061
Mazucanti, C. H. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2018.tde-01082018-094137
Genetics of Life Span: Lessons from Model Organisms
Marı́n-Garcı́a, J., Goldenthal, M. J., & Moe, G. W. P. L. (2007) · Springer eBooks · doi:10.1007/978-0-387-74072-0_12
Effects of AMP-activated kinase modulators on intracellular Ca2+ signalling and C. elegans lifespan
Arias-del-Val, J. (2018) · UVaDOC UVaDOC University of Valladolid Documentary Repository (University of Valladolid) · doi:10.35376/10324/33455
Molecular Basis for Reduced Lifespan Induced by Environmental Toxicants or Stresses
Wang, D. (2019) · Springer eBooks · doi:10.1007/978-981-13-3633-1_2
Metadata
- Authors
- Lee, S. S., Lee, R. Y. N., Fraser, A. G., Kamath, R. S., Ahringer, J., & Ruvkun, G.
- Affiliations
- Harvard University (US)
- University of Cambridge (GB)
- Corresponding author
- Ruvkun, Gary
- Venue
- Nature Genetics
- Published
- 2002-11-25
- Volume
- 33
- Issue
- 1
- Pages
- 40-48
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2155265427
- Cited by
- 969
- References
- 47
- Citations by year
- 2026: 18 · 2025: 20 · 2024: 18 · 2023: 26 · 2022: 34 · 2021: 39 · 2020: 34 · 2019: 30 · 2018: 42 · 2017: 32 · 2016: 40 · 2015: 32 · 2014: 43 · 2013: 26 · 2012: 46
- FWCI
- 16.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (054523)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- Caenorhabditis elegans, lifespan, longevity, mitochondria, mitochondrial function, leucyl-tRNA synthetase, RNAi screen, ATP levels, oxygen consumption, free radicals, stress response
- MeSH terms
- Adenosine Triphosphate, Animals, Gene Expression Regulation, Genetic Testing, Leucine-tRNA Ligase, Longevity, Mitochondria, Oxygen Consumption, Stress, Physiological, Caenorhabditis elegans, Genes, Helminth, RNA Interference
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review