Cited by 1,037Bacterial Infections and VaccinesMicrobial infections and disease researchGenomics and Phylogenetic Studies

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Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica

Parkhill, Julian, Sebaihia, Mohammed, Preston, Andrew, Murphy, Lee D, Thomson, Nicholas, Harris, David E, Holden, Matthew T G, Churcher, Carol M, Bentley, Stephen D, Mungall, Karen L, Cerdeño-Tárraga, Ana M, Temple, Louise, James, Keith, Harris, Barbara, Quail, Michael A, Achtman, Mark, Atkin, Rebecca, Baker, Steven, Basham, David, Bason, Nathalie, Cherevach, Inna, Chillingworth, Tracey, Collins, Matthew, Cronin, Anne, Davis, Paul, Doggett, Jonathan, Feltwell, Theresa, Goble, Arlette, Hamlin, Nancy, Hauser, Heidi, Holroyd, Simon, Jagels, Kay, Leather, Sampsa, Moule, Sharon, Norberczak, Halina, O'Neil, Susan, Ormond, Doug, Price, Claire, Rabbinowitsch, Ester, Rutter, Simon, Sanders, Mandy, Saunders, David, Seeger, Katherine, Sharp, Sarah, Simmonds, Mark, Skelton, Jason, Squares, Robert, Squares, Steven, Stevens, Kim, Unwin, Louise, Whitehead, Sally, Barrell, Bart G, Maskell, Duncan J·2003·Nature Genetics

DOI 10.1038/ng1227

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Abstract

Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica are closely related Gram-negative beta-proteobacteria that colonize the respiratory tracts of mammals. B. pertussis is a strict human pathogen of recent evolutionary origin and is the primary etiologic agent of whooping cough. B. parapertussis can also cause whooping cough, and B. bronchiseptica causes chronic respiratory infections in a wide range of animals. We sequenced the genomes of B. bronchiseptica RB50 (5,338,400 bp; 5,007 predicted genes), B. parapertussis 12822 (4,773,551 bp; 4,404 genes) and B. pertussis Tohama I (4,086,186 bp; 3,816 genes). Our analysis indicates that B. parapertussis and B. pertussis are independent derivatives of B. bronchiseptica-like ancestors. During the evolution of these two host-restricted species there was large-scale gene loss and inactivation; host adaptation seems to be a consequence of loss, not gain, of function, and differences in virulence may be related to loss of regulatory or control functions.

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Authors: Parkhill, J., Sebaihia, M., Preston, A., Murphy, L. D., Thomson, N., Harris, D. E., Holden, M. T. G., Churcher, C. M., Bentley, S. D., Mungall, K. L., Cerdeño-Tárraga, A. M., Temple, L., James, K., Harris, B., Quail, M. A., Achtman, M., Atkin, R., Baker, S., Basham, D., Bason, N., Cherevach, I., Chillingworth, T., Collins, M., Cronin, A., Davis, P., Doggett, J., Feltwell, T., Goble, A., Hamlin, N., Hauser, H., Holroyd, S., Jagels, K., Leather, S., Moule, S., Norberczak, H., O'Neil, S., Ormond, D., Price, C., Rabbinowitsch, E., Rutter, S., Sanders, M., Saunders, D., Seeger, K., Sharp, S., Simmonds, M., Skelton, J., Squares, R., Squares, S., Stevens, K., Unwin, L., Whitehead, S., Barrell, B. G., & Maskell, D. J.
Affiliations: Wellcome Sanger Institute (GB)
University of Cambridge (GB)
Drew University (US)
Max Planck Institute for Infection Biology (DE)
Corresponding author: Parkhill, Julian
Maskell, Duncan J
ORCID: Parkhill, Julian
Sebaihia, Mohammed
Preston, Andrew
Murphy, Lee D
Thomson, Nicholas
Harris, David E
Holden, Matthew T G
Bentley, Stephen D
Temple, Louise
Quail, Michael A
Achtman, Mark
Collins, Matthew
Davis, Paul
Feltwell, Theresa
Price, Claire
Saunders, David
Sharp, Sarah
Maskell, Duncan J
Venue: Nature Genetics
Publisher: Springer Science and Business Media LLC
Published: 2003-08-10
Volume: 35
Issue: 1
Pages: 32-40
ISSN: 1061-4036 (ISSN-L)
1546-1718
DOI: 10.1038/ng1227
OpenAlex: W2155534524
Cited by: 1,037
References: 53
Citations by year: 2026: 24 · 2025: 36 · 2024: 26 · 2023: 28 · 2022: 31 · 2021: 40 · 2020: 29 · 2019: 45 · 2018: 30 · 2017: 40 · 2016: 32 · 2015: 61 · 2014: 61 · 2013: 37 · 2012: 42
FWCI: 47.55
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Genetics (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
Bristol Research (University of Bristol) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords: Bordetella pertussis, Bordetella parapertussis, Bordetella bronchiseptica, genome sequencing, comparative genomics, bacterial evolution, gene loss, host adaptation, virulence, Betaproteobacteria, respiratory pathogens
MeSH terms: Base Sequence, Bordetella, Bordetella pertussis, DNA, Bacterial, Molecular Sequence Data, Species Specificity, Genome, Bacterial, Bordetella bronchiseptica, Sequence Analysis, DNA

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Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica

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