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Heritable transposon silencing initiated by a naturally occurring transposon inverted duplication

Slotkin, R Keith, Freeling, Michael, Lisch, Damon·2005·Nature Genetics
DOI 10.1038/ng1576
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Abstract

It has been suggested that gene silencing evolved as a defense against genomic parasites such as transposons. This idea is based on analysis of mutations that reactivate transposons that are stably silenced: they affect maintenance rather than initiation of silencing. Here we describe the cloning and characterization of a naturally occurring locus able to heritably silence the otherwise highly active MuDR transposon in maize. This locus, Mu killer (Muk), results from the inverted duplication of a partially deleted autonomous MuDR element located at the breakpoint of a genomic deletion. Muk produces a hybrid hairpin transcript that is processed into small RNAs, which are amplified when the target MuDR transcript is present. Muk provides the first example of a naturally occurring transposon derivative capable of initiating the heritable silencing of an active transposon family. Further, transposon-generated inverted duplications may be important for the generation of double-stranded RNAs used in gene silencing.

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Research works printed but not linked: 28

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Metadata

Authors
Slotkin, R. K., Freeling, M., & Lisch, D.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2005-05-22
Volume
37
Issue
6
Pages
641-644
ISSN
  • 1061-4036
  • 1546-1718
DOI
10.1038/ng1576
Cited by
164
References
0
Language
en
Licence
www.springer.com/tdm (tdm)

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