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Evolution of microRNA genes by inverted duplication of target gene sequences in Arabidopsis thaliana

Allen, Edwards, Xie, Zhixin, Gustafson, Adam M, Sung, Gi-Ho, Spatafora, Joseph W, Carrington, James C·2004·Nature Genetics
DOI 10.1038/ng1478
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Abstract

MicroRNAs (miRNAs) in plants and animals function as post-transcriptional regulators of target genes, many of which are involved in multicellular development. miRNAs guide effector complexes to target mRNAs through base-pair complementarity, facilitating site-specific cleavage or translational repression. Biogenesis of miRNAs involves nucleolytic processing of a precursor transcript with extensive foldback structure. Here, we provide evidence that genes encoding miRNAs in plants originated by inverted duplication of target gene sequences. Several recently evolved genes encoding miRNAs in Arabidopsis thaliana and other small RNA-generating loci possess the hallmarks of inverted duplication events that formed the arms on each side of their respective foldback precursors. We propose a model for miRNA evolution that suggests a mechanism for de novo generation of new miRNA genes with unique target specificities.

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Metadata

Authors
Allen, E., Xie, Z., Gustafson, A. M., Sung, G.-H., Spatafora, J. W., & Carrington, J. C.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2004-11-21
Volume
36
Issue
12
Pages
1282-1290
ISSN
  • 1061-4036
  • 1546-1718
DOI
10.1038/ng1478
Cited by
520
References
2
Language
en
Licence
www.springer.com/tdm (tdm)

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