Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
Babitt, Jodie L, Huang, Franklin W, Wrighting, Diedra M, Xia, Yin, Sidis, Yisrael, Samad, Tarek A, Campagna, Jason A, Chung, Raymond T +4 more·2006·Nature Genetics
DOI 10.1038/ng1777
Cited by (1,000)
Items 101–200 of 1,000
- Erythropoiesis: Model systems, molecular regulators, and developmental programsAsterios S. Tsiftsoglou, Ioannis S. Vizirianakis, John Strouboulis · 2009 · IUBMB Life
- TGF-β family co-receptor function and signalingNickel, Joachim, Ten Dijke, Peter, Mueller, Thomas D · 2018 · Acta Biochimica et Biophysica Sinica
- Hepcidin Regulation of Iron TransportJames F. Collins, Marianne Wessling‐Resnick, Mitchell D. Knutson · 2008 · Journal of Nutrition
- Out of Balance—Systemic Iron Homeostasis in Iron-Related DisordersAndrea Ulrike Steinbicker, Martina Ulrike Muckenthaler · 2013 · Nutrients
- Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in miceCorradini, Elena, Meynard, Delphine, Wu, Qifang, Chen, Shan, Ventura, Paolo, Pietrangelo, Antonello, Babitt, Jodie L. · 2011 · Hepatology
- Bone Morphogenetic Proteins Signal through the Transforming Growth Factor-β Type III ReceptorKellye C. Kirkbride, Todd A. Townsend, Monique W. Bruinsma, Joey V. Barnett, Gerard C. Blobe · 2008 · Journal of Biological Chemistry
- Pathways underlying iron accumulation in human nonalcoholic fatty liver diseaseAigner, Elmar, Theurl, Igor, Theurl, Milan, Lederer, Dieter, Haufe, Heike, Dietze, Otto, Strasser, Michael, Datz, Christian, Weiss, Guenter · 2008 · The American Journal of Clinical Nutrition
- Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in ratsTheurl, Igor, Schroll, Andrea, Sonnweber, Thomas, Nairz, Manfred, Theurl, Milan, Willenbacher, Wolfgang, Eller, Kathrin, Wolf, Dominik, Seifert, Markus, Sun, Chia Chi et al. · 2011 · Blood
- Iron homeostasis: An anthropocentric perspectiveRichard Coffey, Tomas Ganz · 2017 · Journal of Biological Chemistry
- Role of hepcidin in the pathophysiology and diagnosis of anemiaGuido D’Angelo · 2013 · Blood Research
- “Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levelsNairz, Manfred, Theurl, Igor, Swirski, Filip K., Weiss, Guenter · 2017 · Pflügers Archiv - European Journal of Physiology
- Targeting the hepcidin–ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammationChia Chi Sun, Valentina Vaja, Jodie L. Babitt, Herbert Yih-Fuu Lin · 2011 · American Journal of Hematology
- Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in miceAndrea Ulrike Steinbicker, Thomas Benedict Bartnikas, Lisa Kristina Isbell, Patricio Leyton, Claire Mayeur, Sonya M. Kao, Alexandra E. Pappas, Randall Theodore Peterson, Donald B. Bloch, Paul B. Yu et al. · 2011 · Blood
- Iron regulation and erythropoiesisElizabeta Nemeth · 2008 · Current Opinion in Hematology
- Liver iron transportRoss M. Graham · 2007 · World Journal of Gastroenterology
- The liver: conductor of systemic iron balanceDelphine Meynard, Jodie L. Babitt, Herbert Yih-Fuu Lin · 2013 · Blood
- Regulation of Iron Metabolism by Hepcidin under Conditions of InflammationPaul Joseph Schmidt · 2015 · Journal of Biological Chemistry
- Iron Accumulation and Lipid Peroxidation in the Aging Retina: Implication of Ferroptosis in Age-Related Macular DegenerationTantai Zhao, Xiaojian Guo, Yun Sun · 2021 · Aging and Disease
- Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammationSteinbicker, Andrea U., Sachidanandan, Chetana, Vonner, Ashley J., Yusuf, Rushdia Z., Deng, Donna Y., Lai, Carol S., Rauwerdink, Kristen M., Winn, Julia C., Saez, Borja, Cook, Colleen M. et al. · 2011 · Blood
- Regulation of Hepcidin and Iron-Overload DiseasePauline L. Lee, Ernest Beutler · 2009 · Annual Review of Pathology Mechanisms of Disease
- The Hepcidin-Ferroportin System as a Therapeutic Target in Anemias and Iron Overload DisordersGanz, Tomas, Nemeth, Elizabeta · 2011 · Hematology
- Hepcidin regulation: ironing out the detailsIvana De Domenico, Diane McVey Ward, Jerry Kaplan · 2007 · Journal of Clinical Investigation
- Iron refractory iron deficiency anemiaLuigia De Falco, Mayka Sánchez, Laura Silvestri, Caroline Kannengiesser, Martina Ulrike Muckenthaler, Achille Iolascon, Laurent Gouya, Clara Camaschella, Carole Beaumont · 2013 · Haematologica
- Iron and Immunity: Immunological Consequences of Iron Deficiency and OverloadCherayil, Bobby J. · 2010 · Archivum Immunologiae et Therapiae Experimentalis
- A Systems Biology Approach to Iron MetabolismJulia Chifman, Reinhard Laubenbacher, Suzy V. Torti · 2014 · Advances in experimental medicine and biology
- The Regulation of Cellular Iron MetabolismAnita C. G. Chua, Ross M. Graham, Debbie Trinder, John Kevin Olynyk · 2007 · Critical Reviews in Clinical Laboratory Sciences
- Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuliHua Huang, Marco Constante, Antonio Layoun, Manuela M. Santos · 2009 · Blood
- Review article: the iron overload syndromesSiddique, A., Kowdley, K. V. · 2012 · Alimentary Pharmacology & Therapeutics
- Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasisKarin E. Finberg, Rebecca L. Whittlesey, Mark D. Fleming, Nancy C. Andrews · 2010 · Blood
- Erythropoiesis: insights into pathophysiology and treatments in 2017Andrea Zivot, Jeffrey Michael M Lipton, Anupama Narla, Lionel Blanc · 2018 · Molecular Medicine
- Crossing the Iron Gate: Why and How Transferrin Receptors Mediate Viral EntryMarianne Wessling‐Resnick · 2018 · Annual Review of Nutrition
- Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in miceWang, Lijian, Harrington, Lynne, Trebicka, Estela, Shi, Hai Ning, Kagan, Jonathan C., Hong, Charles C., Lin, Herbert Y., Babitt, Jodie L., Cherayil, Bobby J. · 2009 · Journal of Clinical Investigation
- Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMADCasanovas, Guillem, Mleczko-Sanecka, Katarzyna, Altamura, Sandro, Hentze, Matthias W., Muckenthaler, Martina U. · 2009 · Journal of Molecular Medicine
- HaemochromatosisPaul C. Adams, James C. Barton · 2007 · The Lancet
- Iron, ferroptosis, and ischemic strokeJun Guo, Qing‐zhang Tuo, Peng Lei · 2023 · Journal of Neurochemistry
- Iron deficiency or anemia of inflammation?: Differential diagnosis and mechanisms of anemia of inflammationNairz, Manfred, Theurl, Igor, Wolf, Dominik, Weiss, Günter · 2016 · Wiener Medizinische Wochenschrift
- Multifactorial Scores and Biomarkers of Prognosis of Acute Pancreatitis: Applications to Research and PracticePedro Silva-Vaz, Ana Margarida Abrantes, Miguel Castelo-Branco, António Gouveia, Maria Filomena Botelho, José Guilherme Tralhão · 2020 · International Journal of Molecular Sciences
- Hepcidin-ferroportin axis in health and diseaseYelena Z. Ginzburg · 2019 · Vitamins and hormones
- Molecular basis of inherited microcytic anemia due to defects in iron acquisition or heme synthesisAchille Iolascon, Luigia De Falco, Carole Beaumont · 2009 · Haematologica
- Iron Homeostasis: Recently Identified Proteins Provide Insight into Novel Control MechanismsAn-Sheng Zhang, Caroline A. Enns · 2008 · Journal of Biological Chemistry
- Heparin: a potent inhibitor of hepcidin expression in vitro and in vivoPoli, Maura, Girelli, Domenico, Campostrini, Natascia, Maccarinelli, Federica, Finazzi, Dario, Luscieti, Sara, Nai, Antonella, Arosio, Paolo · 2011 · Blood
- Hfe Acts in Hepatocytes to Prevent HemochromatosisMaja Vujić Spasić, Judit Kiss, Thomas R. W. Herrmann, Bruno Galy, Stefanie Martinache, Jens Stolte, Hermann‐Josef Gröne, Wolfgang Stremmel, Matthias W. Hentze, Martina Ulrike Muckenthaler · 2008 · Cell Metabolism
- Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BBSonnweber, Thomas, Nachbaur, David, Schroll, Andrea, Nairz, Manfred, Seifert, Markus, Demetz, Egon, Haschka, David, Mitterstiller, Anna-Maria, Kleinsasser, Axel, Burtscher, Martin et al. · 2014 · Gut
- Cardiac Involvement in HemochromatosisVinay Gulati, Prakash Harikrishnan, Chandrasekar Palaniswamy, Wilbert S. Aronow, Diwakar Jain, William H. Frishman · 2013 · Cardiology in Review
- A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cellsVerga Falzacappa, Maria Vittoria, Casanovas, Guillem, Hentze, Matthias W., Muckenthaler, Martina U. · 2008 · Journal of Molecular Medicine
- A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptorDionys A. Weber, Alexander Kotzsch, Joachim Nickel, Stefan Harth, Axel Seher, U. Müeller, Walter Sebald, Thomas D. Mueller · 2007 · BMC Structural Biology
- Iron levels in polarized macrophages: regulation of immunity and autoimmunityRecalcati, Stefania, Locati, Massimo, Gammella, Elena, Invernizzi, Pietro, Cairo, Gaetano · 2012 · Autoimmunity Reviews
- Molecular mechanisms of normal iron homeostasisAn-Sheng Zhang, Caroline A. Enns · 2009 · Hematology
- BMP signaling in vascular development and diseaseJonathan Wayne Lowery, Mark P. de Caestecker · 2010 · Cytokine & Growth Factor Reviews
- Pharmacological Targeting of the Hepcidin/Ferroportin AxisSebastiani, Giada, Wilkinson, Nicole, Pantopoulos, Kostas · 2016 · Frontiers in Pharmacology
- Bone Morphogenetic Protein Signaling Is Impaired in an Hfe Knockout Mouse Model of HemochromatosisElena Corradini, Cinzia Garuti, Giuliana Montosi, Paolo Ventura, Billy Andriopoulos, Herbert Yih-Fuu Lin, Antonello Pietrangelo, Jodie L. Babitt · 2009 · Gastroenterology
- Mechanisms of iron loading and toxicityGregory Jon Anderson · 2007 · American Journal of Hematology
- Ironing out mechanisms of iron homeostasis and disorders of iron deficiencyNavid Koleini, Jason Solomon Shapiro, Justin Geier, Hossein Ardehali · 2021 · Journal of Clinical Investigation
- A potential pathogenetic role of iron in Alzheimer's diseaseLaura Silvestri, Clara Camaschella · 2008 · Journal of Cellular and Molecular Medicine
- Intestinal Ferritin H Is Required for an Accurate Control of Iron AbsorptionVanoaica, Liviu, Darshan, Deepak, Richman, Larry, Schümann, Klaus, Kühn, Lukas C. · 2010 · Cell Metabolism
- Role of alcohol in the regulation of iron metabolismHarrison-Findik, Duygu Dee · 2007 · World Journal of Gastroenterology
- Low hepcidin accounts for the proinflammatory status associated with iron deficiencyPagani, Alessia, Nai, Antonella, Corna, Gianfranca, Bosurgi, Lidia, Rovere-Querini, Patrizia, Camaschella, Clara, Silvestri, Laura · 2011 · Blood
- Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasisDaehoon Lee, Li-Juan Zhou, Zheng Zhou, Jianxin Xie, Ji-Ung Jung, Yu Liu, Cai-Xia Xi, Lin Mei, Wen‐Cheng Xiong · 2010 · Blood
- In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2Maes, Ken, Nemeth, Elizabeta, Roodman, G. David, Huston, Alissa, Esteve, Flavia, Freytes, Cesar, Callander, Natalie, Katodritou, Eirini, Tussing-Humphreys, Lisa, Rivera, Seth et al. · 2010 · Blood
- Common Variants in the BMP2, BMP4, and HJV Genes of the Hepcidin Regulation Pathway Modulate HFE Hemochromatosis PenetranceJacqueline Milet, Valérie Déhais, Catherine Bourgain, Anne Marie Jouanolle, Annick Mosser, Michèle Perrin, Jeff Morçet, Pierre Brissot, Véronique David, Yves Deugnier et al. · 2007 · The American Journal of Human Genetics
- The genetics of essential metal homeostasis during developmentTaiho Kambe, Benjamin P. Weaver, Glen K. Andrews · 2008 · genesis
- Hepcidin, the iron watcherLydie Viatte, Sophie Vaulont · 2009 · Biochimie
- The Regulation of Hepcidin and Its Effects on Systemic and Cellular Iron MetabolismMark D. Fleming · 2008 · Hematology
- Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasisAndrew J. Ramsay, John David Hooper, Alicia R. Folgueras, Gloria Velasco, Carlos López-Otı́n · 2009 · Haematologica
- HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expressionXing-gang Wu, Yang Wang, Qian Wu, Wai Hang Cheng, Wenjing Liu, Yueshui Zhao, Claire Mayeur, Paul Joseph Schmidt, Paul B. Yu, Fudi Wang et al. · 2014 · Blood
- Current approach to hemochromatosisPierre Brissot, Marie‐Bérengère Troadec, Edouard Bardou‐Jacquet, Caroline Le Lan, Anne‐Marie Jouanolle, Yves Deugnier, Olivier Loréal · 2008 · Blood Reviews
- HepcidinJing L. Liu, Bingbing Sun, Hui-jun Yin, Sijin Liu · 2016 · Medicine
- Hepcidin and the BMP-SMAD pathway: An unexpected liaisonLaura Silvestri, Antonella Nai, Alessandro Dulja, Alessia Pagani · 2019 · Vitamins and hormones
- Hepcidin antagonists for potential treatments of disorders with hepcidin excessPoli, Maura, Asperti, Michela, Ruzzenenti, Paola, Regoni, Maria, Arosio, Paolo · 2014 · Frontiers in Pharmacology
- Neogenin Regulation of BMP-Induced Canonical Smad Signaling and Endochondral Bone FormationZheng Zhou, Jianxin Xie, Daehoon Lee, Yu Liu, Ji-Ung Jung, Lijuan Zhou, Shan Xiong, Lin Mei, Wen‐Cheng Xiong · 2010 · Developmental Cell
- Iron and innate antimicrobial immunity-depriving the pathogen, defending the hostNairz, Manfred, Dichtl, Stefanie, Schroll, Andrea, Haschka, David, Tymoszuk, Piotr, Theurl, Igor, Weiss, Günter · 2018 · Journal of Trace Elements in Medicine and Biology
- The Liver in Regulation of Iron HomeostasisRishi, Gautam, Subramaniam, V. Nathan · 2017 · American Journal of Physiology-Gastrointestinal and Liver Physiology
- Negative regulators of TGF-β1 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunitiesCody C. Gifford, Jiaqi Tang, Angelica Costello, Nidah Shabbir Khakoo, Tri Q. Nguyen, Roel Goldschmeding, Paul J. Higgins, Rohan Samarakoon · 2021 · Clinical Science
- Anemia of Chronic DiseaseNaseema Gangat, Alexandra P. Wolanskyj · 2013 · Seminars in Hematology
- Regulation of TMPRSS6 by BMP6 and iron in human cells and miceDelphine Meynard, Valentina Vaja, Chia Chi Sun, Elena Corradini, Shanzhuo Chen, Carlos López-Otı́n, Lovorka Grgurević, Charles C. Hong, Marit Stirnberg, Michael Gütschow et al. · 2011 · Blood
- Manipulation of the hepcidin pathway for therapeutic purposesEileen Fung, Elizabeta Nemeth · 2013 · Haematologica
- Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytesG. Ramey, Jean‐Christophe Deschemin, Sophie Vaulont · 2009 · Haematologica
- Membrane-Anchored Serine Proteases in Vertebrate Cell and Developmental BiologyRoman Szabo, Thomas Henrik Bugge · 2011 · Annual Review of Cell and Developmental Biology
- Systemic iron homeostasis and erythropoiesisGeorge V. Papanikolaou, Kostas Pantopoulos · 2017 · IUBMB Life
- Hepcidin – central regulator of iron metabolismValeriu Atanasiu, Bogdan Nicolae Manolescu, Irina Anna-Maria Stoian · 2006 · European Journal Of Haematology
- Applications of small molecule BMP inhibitors in physiology and diseaseCharles C. Hong, Paul B. Yu · 2009 · Cytokine & Growth Factor Reviews
- The RGM/DRAGON family of BMP co-receptorsElena Corradini, Jodie L. Babitt, Herbert Yih-Fuu Lin · 2009 · Cytokine & Growth Factor Reviews
- The Anemia of Inflammation/Malignancy: Mechanisms and ManagementJohn W. Adamson · 2008 · Hematology
- SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expressionKatarzyna Mleczko‐Sanecka, Guillem Casanovas, Anan Ragab, K Breitkopf, Alexandra Müller, Michael Boutros, Steven Dooley, Matthias W. Hentze, Martina Ulrike Muckenthaler · 2009 · Blood
- Molecular evolution and characterization of hepcidin gene products in vertebratesKalley B. Hilton, Lisa A. Lambert · 2008 · Gene
- Iron Homeostasis: Fitting the Puzzle Pieces TogetherTomas Ganz · 2008 · Cell Metabolism
- Bone morphogenetic protein 2 controls iron homeostasis in mice independent of Bmp6Canali, Susanna, Wang, Chia‐Yu, Zumbrennen‐Bullough, Kimberly B., Bayer, Abraham, Babitt, Jodie L. · 2017 · American Journal of Hematology
- Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitorsGonzalo Sánchez‐Duffhues, Eleanor Williams, Marie‐José Goumans, Carl‐Henrik Heldin, Peter ten Dijke · 2020 · Bone
- Iron-Refractory Iron Deficiency AnemiaKarin E. Finberg · 2009 · Seminars in Hematology
- Regulation of hepcidin: Insights from biochemical analyses on human serum samplesErwin Kemna, Apriliana E. R. Kartikasari, Lambertus J.H. van Tits, Peter Pickkers, Harold Tjalsma, Dorine W. Swinkels · 2007 · Blood Cells Molecules and Diseases
- A Genome-Wide Association Study of Red Blood Cell Traits Using the Electronic Medical RecordIftikhar J. Kullo, Keyue Ding, Hayan Jouni, Carin Y. Smith, Christopher G. Chute · 2010 · PLoS ONE
- RGMs: Structural Insights, Molecular Regulation, and Downstream SignalingSiebold, Christian, Yamashita, Toshihide, Monnier, Philippe P., Mueller, Bernhard K., Pasterkamp, R. Jeroen · 2017 · Trends in Cell Biology
- Molecular mechanisms of the defective hepcidin inhibition in TMPRSS6 mutations associated with iron-refractory iron deficiency anemiaLaura Silvestri, Flavia Guillem, Alessia Pagani, Antonella Nai, Claire Oudin, Muriel Silva, Fabienne Toutain, Caroline Kannengiesser, Carole Beaumont, Clara Camaschella et al. · 2009 · Blood
- Evidence That Inhibition of Hemojuvelin Shedding in Response to Iron Is Mediated through NeogeninAn‐Sheng Zhang, Sheila A. Anderson, Kathrin R. Meyers, Catalina Hernandez, Richard S. Eisenstein, Caroline A. Enns · 2007 · Journal of Biological Chemistry
- Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male MiceCanali, Susanna, Core, Amanda B., Zumbrennen-Bullough, Kimberly B., Merkulova, Maria, Wang, Chia-Yu, Schneyer, Alan L., Pietrangelo, Antonello, Babitt, Jodie L. · 2016 · Endocrinology
- Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 proteinAn‐Sheng Zhang, Sheila A. Anderson, Jiaohong Wang, Fan Yang, Kristina DeMaster, Riffat Ahmed, Christopher P. Nizzi, Richard S. Eisenstein, Hidekazu Tsukamoto, Caroline A. Enns · 2010 · Blood
- Anemia of chronic disorders: new diagnostic tools and new treatment strategiesWeiss, Guenter · 2015 · Seminars in Hematology
- Hepcidin in human iron disorders: Therapeutic implicationsAntonello Pietrangelo · 2010 · Journal of Hepatology
- Hepcidin modulation in human diseases: From research to clinicAlberto Piperno, Raffaella Mariani, Paola Trombini, Domenico Girelli · 2009 · World Journal of Gastroenterology
- Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible FactorsSamira Lakhal‐Littleton, Johannes Schödel, Alain Townsend, Christopher William Pugh, Peter John Ratcliffe, David Robert Mole · 2010 · Journal of Biological Chemistry