The Liver in Regulation of Iron Homeostasis

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

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Regulating the fate of mRNA: the control of cellular iron metabolism

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Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

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Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis

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The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

Feder, J. N., Penny, D. M., Irrinki, A., Lee, V. K., Lebrón, J. A., Watson, N., Tsuchihashi, Z., Sigal, E., Bjorkman, P. J., & Schatzman, R. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1472 · Cited by 827 · see citing works

The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22

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Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

Finberg, K. E., Heeney, M. M., Campagna, D. R., Aydınok, Y., Pearson, H. A., Hartman, K. R., Mayo, M. M., Samuel, S. M., Strouse, J. J., Markianos, K., et al. (2008) · Nature Genetics · doi:10.1038/ng.130 · Cited by 675 · see citing works

Molecular Cloning of Transferrin Receptor 2

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Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor.

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A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

Wang, R.-H., Li, C., Xu, X., Zheng, Y., Xiao, C., Zerfas, P., Cooperman, S., Eckhaus, M., Rouault, T., Mishra, L., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.10.010 · Cited by 614 · see citing works

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

Meynard, D., Kautz, L., Darnaud, V., Canonne-Hergaux, F., Coppin, H., & Roth, M.-P. (2009) · Nature Genetics · doi:10.1038/ng.320 · Cited by 587 · see citing works

The serine protease TMPRSS6 is required to sense iron deficiency

Du, X., She, E., Gelbart, T., Truksa, J., Lee, P., Xia, Y., Khovananth, K., Mudd, S., Mann, N., Moresco, E. M. Y., et al. (2008) · Science · doi:10.1126/science.1157121 · Cited by 578 · see citing works

Transferrin receptor is necessary for development of erythrocytes and the nervous system

Levy, J. E., Jin, O., Fujiwara, Y., Kuo, F., & Andrews, N. (1999) · Nature Genetics · doi:10.1038/7727 · Cited by 574 · see citing works

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

Silvestri, L., Pagani, A., Nai, A., De Domenico, I., Kaplan, J., & Camaschella, C. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.09.012 · Cited by 555 · see citing works

HFE gene knockout produces mouse model of hereditary hemochromatosis

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Increased Adipose Tissue Expression of Hepcidin in Severe Obesity Is Independent From Diabetes and NASH

Bekri, S., Gual, P., Anty, R., Luciani, N., Dahman, M., Ramesh, B., Iannelli, A., Staccini–Myx, A., Casanova, D., Ben Amor, I., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.07.007 · Cited by 496 · see citing works

The Hemochromatosis Founder Mutation in HLA-H Disrupts β2-Microglobulin Interaction and Cell Surface Expression

Feder, J. N., Tsuchihashi, Z., Irrinki, A., Lee, V. K., Mapa, F. A., Morikang, E., Prass, C. E., Starnes, S. M., Wolff, R. K., Parkkila, S., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.22.14025 · Cited by 471 · see citing works

Hereditary hemochromatosis: Effects of C282Y and H63D mutations on association with β ₂ -microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells

Waheed, A., Parkkila, S., Zhou, X. Y., Tomatsu, S., Tsuchihashi, Z., Feder, J. N., Schatzman, R. C., Britton, R. S., Bacon, B. R., & Sly, W. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12384 · Cited by 380 · see citing works

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload

Niederkofler, V. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25683 · Cited by 368 · see citing works

A mouse model of juvenile hemochromatosis

Huang, F. W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25049 · Cited by 363 · see citing works

Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing.

Goswami, T., & Andrews, N. C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c600197200 · Cited by 352 · cited 2× · see citing works

The Transferrin Receptor Modulates Hfe-Dependent Regulation of Hepcidin Expression

Schmidt, P. J., Toran, P. T., Giannetti, A. M., Bjorkman, P. J., & Andrews, N. C. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.016 · Cited by 345 · see citing works

Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis

Parkkila, S., Waheed, A., Britton, R. S., Bacon, B. R., Zhou, X. Y., Tomatsu, S., Fleming, R. E., & Sly, W. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13198 · Cited by 336 · see citing works

Hepcidin-Induced Endocytosis of Ferroportin Is Dependent on Ferroportin Ubiquitination

Qiao, B., Sugianto, P., Fung, E., del-Castillo-Rueda, A., Moran-Jimenez, M.-J., Ganz, T., & Nemeth, E. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.018 · Cited by 334 · see citing works

Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

Gao, J., Chen, J., Kramer, M., Tsukamoto, H., Zhang, A.-S., & Enns, C. A. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.01.010 · Cited by 326 · see citing works

Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis

Folgueras, A. R., de Lara, F. M., Pendás, A. M., Garabaya, C., Rodríguez, F. J., Astudillo, A., Bernal, T., Cabanillas, R., López-Otı́n, C., & Velasco, G. (2008) · Blood · doi:10.1182/blood-2008-04-149773 · Cited by 300 · see citing works

Transferrin receptor 2: Continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis

Fleming, R. E., Migas, M. C., Holden, C. C., Waheed, A., Britton, R. S., Tomatsu, S., Bacon, B. R., & Sly, W. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040548097 · Cited by 273 · see citing works

Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4

Lin, L., Valore, E. V., Nemeth, E., Goodnough, J. B., Gabayan, V., & Ganz, T. (2007) · Blood · doi:10.1182/blood-2007-04-087593 · Cited by 267 · see citing works

Comparison of the Interactions of Transferrin Receptor and Transferrin Receptor 2 with Transferrin and the Hereditary Hemochromatosis Protein HFE

West, A. P., Bennett, M. J., Sellers, V. M., Andrews, N. C., Enns, C. A., & Bjorkman, P. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000664200 · Cited by 257 · see citing works

Hepcidin regulation in the anemia of inflammation

Wang, C., & Babitt, J. L. (2016) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000236 · Cited by 256 · see citing works

Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract

Parkkila, S., Waheed, A., Britton, R. S., Feder, J. N., Tsuchihashi, Z., Schatzman, R. C., Bacon, B. R., & Sly, W. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2534 · Cited by 253 · see citing works

Transferrin Receptor 2-α Supports Cell Growth Both in Iron-chelated Cultured Cells and in Vivo

Kawabata, H., Germain, R. S., Vuong, P. T., Nakamaki, T., SAID, J. W., & Koeffler, H. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m908846199 · Cited by 245 · see citing works

Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis

Fleming, R. E., Ahmann, J. R., Migas, M. C., Waheed, A., Koeffler, H. P., Kawabata, H., Britton, R. S., Bacon, B. R., & Sly, W. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162360699 · Cited by 244 · see citing works

Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin

Lin, L., Goldberg, Y. P., & Ganz, T. (2005) · Blood · doi:10.1182/blood-2005-05-1845 · Cited by 241 · see citing works

Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

Ramos, E., Kautz, L., Rodriguez, R., Hansen, M., Gabayan, V. R., Ginzburg, Y. Z., Roth, M., Nemeth, E., & Ganz, T. (2011) · Hepatology · doi:10.1002/hep.24178 · Cited by 235 · see citing works

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

Preza, G. C., Ruchala, P., Pinon, R., Ramos, E., Qiao, B., Peralta, M. A., Sharma, S., Waring, A., Ganz, T., & Nemeth, E. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57693 · Cited by 234 · see citing works

Diferric transferrin regulates transferrin receptor 2 protein stability

Johnson, M. B., & Enns, C. A. (2004) · Blood · doi:10.1182/blood-2004-06-2477 · Cited by 230 · see citing works

Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice

Guo, S., Casu, C., Gardenghi, S., Booten, S. L., Aghajan, M., Peralta, R. Q., Watt, A., Freier, S., Monia, B. P., & Rivella, S. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66969 · Cited by 224 · see citing works

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

Xia, Y. Y., Babitt, J. L., Sidis, Y., Chung, R. T., & Lin, H. Y.-F. (2008) · Blood · doi:10.1182/blood-2007-09-111567 · Cited by 223 · see citing works

Hepcidin: regulation of the master iron regulator

Rishi, G., Wallace, D. F., & Subramaniam, V. N. (2015) · Bioscience Reports · doi:10.1042/bsr20150014 · Cited by 223 · see citing works

Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice

Canali, S., Zumbrennen‐Bullough, K. B., Core, A. B., Wang, C., Nairz, M., Bouley, R., Świrski, F. K., & Babitt, J. L. (2016) · Blood · doi:10.1182/blood-2016-06-721571 · Cited by 214 · see citing works

Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis

Ramos, E., Ruchala, P., Goodnough, J. B., Kautz, L., Preza, G. C., Nemeth, E., & Ganz, T. (2012) · Blood · doi:10.1182/blood-2012-07-440743 · Cited by 213 · see citing works

Idiopathic Hemochromatosis, an Interim Report

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An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe−/− mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia

Schmidt, P. J., Toudjarska, I., Sendamarai, A. K., Racie, T., Milstein, S., Bettencourt, B. R., Hettinger, J., Bumcrot, D., & Fleming, M. D. (2013) · Blood · doi:10.1182/blood-2012-09-453977 · Cited by 204 · see citing works

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

D’Alessio, F., Hentze, M. W., & Muckenthaler, M. U. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.06.015 · Cited by 200 · see citing works

The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer’s disease

Raha, A. A., Vaishnav, R., Friedland, R. P., Bomford, A. B., & Raha‐Chowdhury, R. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-55 · Cited by 179 · see citing works

Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages

Liu, X.-B., Nguyen, N.-B., Marquess, K. D., Yang, F., & Haile, D. J. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.04.006 · Cited by 177 · see citing works

Localization of iron metabolism–related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes

Zhang, A., Xiong, S., Tsukamoto, H., & Enns, C. A. (2003) · Blood · doi:10.1182/blood-2003-07-2378 · Cited by 174 · see citing works

The Iron Regulatory Peptide Hepcidin Is Expressed in the Heart and Regulated by Hypoxia and Inflammation

Merle, U., Fein, E., Gehrke, S. G., Stremmel, W., & Kulaksiz, H. (2007) · Endocrinology · doi:10.1210/en.2006-1331 · Cited by 173 · see citing works

First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin

Wallace, D. F., Summerville, L., Lusby, P. E., & Subramaniam, V. N. (2005) · Gut · doi:10.1136/gut.2004.062018 · Cited by 160 · see citing works

The second transferrin receptor regulates red blood cell production in mice

Nai, A., Lidonnici, M. R., Rausa, M., Mandelli, G., Pagani, A., Silvestri, L., Ferrari, G., & Camaschella, C. (2015) · Blood · doi:10.1182/blood-2014-08-596254 · Cited by 156 · see citing works

Hfe Acts in Hepatocytes to Prevent Hemochromatosis

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Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera

Casu, C., Oikonomidou, P. R., Chen, H., Nandi, V., Ginzburg, Y., Prasad, P., Fleming, R. E., Shah, Y. M., Valore, E. V., Nemeth, E., et al. (2016) · Blood · doi:10.1182/blood-2015-10-676742 · Cited by 148 · see citing works

Molecular Mechanism of Hepcidin-Mediated Ferroportin Internalization Requires Ferroportin Lysines, Not Tyrosines or JAK-STAT

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Hepcidin expression and iron transport in alveolar macrophages

Nguyen, N.-B., Callaghan, K. D., Ghio, A. J., Haile, D. J., & Yang, F. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00484.2005 · Cited by 143 · see citing works

Regulation of expression of murine transferrin receptor 2

Kawabata, H., Germain, R. S., Ikezoe, T., Tong, X., Green, E. M., Gombart, A. F., & Koeffler, H. P. (2001) · Blood · doi:10.1182/blood.v98.6.1949 · Cited by 139 · see citing works

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

Wu, X.-G., Wang, Y., Wu, Q., Cheng, W. H., Liu, W., Zhao, Y., Mayeur, C., Schmidt, P. J., Yu, P. B., Wang, F., et al. (2014) · Blood · doi:10.1182/blood-2014-01-552281 · Cited by 129 · see citing works

Targeted Disruption of the Hepatic Transferrin Receptor 2 Gene in Mice Leads to Iron Overload

Wallace, D. F., Summerville, L., & Subramaniam, V. N. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.11.028 · Cited by 124 · see citing works

Regulation of TMPRSS6 by BMP6 and iron in human cells and mice

Meynard, D., Vaja, V., Sun, C. C., Corradini, E., Chen, S., López-Otı́n, C., Grgurević, L., Hong, C. C., Stirnberg, M., Gütschow, M., et al. (2011) · Blood · doi:10.1182/blood-2011-04-348698 · Cited by 123 · see citing works

Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells

Kawabata, H., Nakamaki, T., Ikonomi, P., Smith, R. D., Germain, R. S., & Koeffler, H. P. (2001) · Blood · doi:10.1182/blood.v98.9.2714 · Cited by 120 · see citing works

Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein

Zhang, A., Anderson, S. A., Wang, J., Yang, F., DeMaster, K., Ahmed, R., Nizzi, C. P., Eisenstein, R. S., Tsukamoto, H., & Enns, C. A. (2010) · Blood · doi:10.1182/blood-2010-06-287292 · Cited by 117 · see citing works

BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice

Corradini, E., Schmidt, P. J., Meynard, D., Garuti, C., Montosi, G., Chen, S., Vukicevic, S., Pietrangelo, A., Lin, H. Y., & Babitt, J. L. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.07.044 · Cited by 109 · see citing works

Iron Regulation of Hepcidin Despite Attenuated Smad1,5,8 Signaling in Mice Without Transferrin Receptor 2 or Hfe

Corradini, E., Rozier, M., Meynard, D., Odhiambo, A., Lin, H. Y.-F., Feng, Q., Migas, M. C., Britton, R. S., Babitt, J. L., & Fleming, R. E. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.077 · Cited by 102 · see citing works

Transferrin Receptor 2: Evidence for Ligand-induced Stabilization and Redirection to a Recycling Pathway

Johnson, M. B., Chen, J., Murchison, N., Green, F. A., & Enns, C. A. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-09-0798 · Cited by 101 · see citing works

Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site

Lin, L., Nemeth, E., Goodnough, J. B., Thapa, D. R., Gabayan, V. R., & Ganz, T. (2007) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2007.06.023 · Cited by 95 · see citing works

The Molecular Pathogenesis of Hereditary Hemochromatosis

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Kupffer cell staining by an HFE‐specific monoclonal antibody: implications for hereditary haemochromatosis

Bastin, J. M., Jones, M., O’Callaghan, C. A., Schimanski, L. M., Mason, D. Y., & Townsend, A. (1998) · British Journal of Haematology · doi:10.1046/j.1365-2141.1998.01102.x · Cited by 89 · see citing works

Mouse matriptase-2: identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues

Hooper, J. D., Campagnolo, L., Goodarzi, G., Truong, T., Stuhlmann, H., & Quigley, J. P. (2003) · Biochemical Journal · doi:10.1042/bj20030390 · Cited by 82 · see citing works

HFE Modulates Transferrin Receptor 2 Levels in Hepatoma Cells via Interactions That Differ from Transferrin Receptor 1-HFE Interactions

Chen, J., Chloupková, M., Gao, J., Arvedson, T., & Enns, C. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706720200 · Cited by 81 · see citing works

Therapeutic potential of hepcidin − the master regulator of iron metabolism

Vyoral, D., & Petrák, J. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.11.010 · Cited by 79 · see citing works

Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading

Makui, H., Soares, R., 蒋文雷, Constante, M., & Santos, M. M. (2005) · Blood · doi:10.1182/blood-2005-02-0629 · Cited by 69 · see citing works

Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway

Enns, C. A., Ahmed, R., Wang, J., Ueno, A., Worthen, C., Tsukamoto, H., & Zhang, A.-S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060534 · Cited by 69 · see citing works

Differing impact of the deletion of hemochromatosis‐associated molecules HFE and transferrin receptor‐2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin

Latour, C., Besson‐Fournier, C., Meynard, D., Silvestri, L., Gourbeyre, O., Aguilar‐Martinez, P., Schmidt, P. J., Fleming, M. D., Roth, M., & Coppin, H. (2015) · Hepatology · doi:10.1002/hep.28254 · Cited by 66 · see citing works

Neogenin Interacts with Matriptase-2 to Facilitate Hemojuvelin Cleavage

Enns, C. A., Ahmed, R., & Zhang, A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.363937 · Cited by 64 · see citing works

Suppression of the hepcidin‐encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase‐2/TMPRSS6

Truksa, J., Gelbart, T., Peng, H., Beutler, E., Beutler, B., & Lee, P. L. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.07873.x · Cited by 63 · see citing works

Large-Scale Sequencing of Two Regions in Human Chromosome 7q22: Analysis of 650 kb of Genomic Sequence around the EPO and CUTL1 Loci Reveals 17 GenesPreprint

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Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis

Chen, W., Huang, F. W., Renshaw, T. B. D., & Andrews, N. C. (2011) · Blood · doi:10.1182/blood-2010-12-327957 · Cited by 58 · see citing works

Iron absorption and hepatic iron uptake are increased in a transferrin receptor 2 (Y245X) mutant mouse model of hemochromatosis type 3

Drake, S. F., Morgan, E. H., Herbison, C. E., Delima, R. D., Graham, R. M., Chua, A. C. G., Leedman, P. J., Fleming, R. E., Bacon, B. R., Olynyk, J. K., et al. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00278.2006 · Cited by 57 · see citing works

Control of cell cycle gene expression in bone development and during c-Fos-induced osteosarcoma formation

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Transgenic HFE‐dependent induction of hepcidin in mice does not require transferrin receptor‐2

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Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis

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