Iron and Immunity: Immunological Consequences of Iron Deficiency and Overload

Cherayil, Bobby J.

doi:10.1007/s00005-010-0095-9

Cited by 170Iron Metabolism and DisordersTrace Elements in HealthFerroptosis and cancer prognosis

Iron and Immunity: Immunological Consequences of Iron Deficiency and Overload

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Cherayil, Bobby J.·2010·Archivum Immunologiae et Therapiae Experimentalis

DOI 10.1007/s00005-010-0095-9PMC PMC3173740

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Abstract

The influence of iron on immune function has been long appreciated. However, the molecular basis for this interaction is less well understood. Recently, there have been several important advances that have shed light on the mechanisms that regulate mammalian iron metabolism. The new insights provide a conceptual framework for understanding and manipulating the cross-talk between iron homeostasis and the immune system. This article will review what is currently known about how disturbances of iron metabolism can affect immunity and how activation of the immune system can lead to alterations in iron balance.

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Iron regulates the activity of transcription factors NF-κB and HIF-1α, which promote expression of genes involved in survival and metastasis of cancer cells.
“In addition, iron regulates the activity of the transcription factors NF-κB and HIF-1α [58], which promote the expression of genes involved in the survival and metastasis of cancer cells [59, 60].”
From The utility of iron chelators in the management of inflammatory disorders (2015) · cites this paper as [58]

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Iron Causes Interactions of TAK1, p21ras, and Phosphatidylinositol 3-Kinase in Caveolae to Activate IκB Kinase in Hepatic Macrophages
Chen, L., Xiong, S., She, H., Lin, S. W., Wang, J., & Tsukamoto, H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609273200 · Cited by 64 · see citing works
Ironing Out the Wrinkles in Host Defense: Interactions between Iron Homeostasis and Innate Immunity
Wang, L., & Cherayil, B. J. (2009) · Journal of Innate Immunity · doi:10.1159/000210016 · Cited by 63 · see citing works
Self-citation
Nramp1 equips macrophages for efficient iron recycling
Soe-Lin, S., Sheftel, A. D., Wasyluk, B., & Ponka, P. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.02.013 · Cited by 56 · see citing works
Hereditary Hemochromatosis
Pietrangelo, A. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111226 · Cited by 56 · see citing works
Tuberculosis and iron overload in Africa: a review.
Moyo, V. M., Gangaidzo, I. T., Gordeuk, V. R., Kiire, C. F., & MacPhail, A. P. (1997) · PubMed · Cited by 44 · see citing works
Effect of Dietary Iron Overload on Lipid Peroxidation, Prostaglandin Synthesis and Lymphocyte Proliferation in Young and Old Rats
Wu, W.-H., Meydani, M., Meydani, S. N., Burklund, P. M., Blumberg, J. B., & Munro, H. N. (1990) · Journal of Nutrition · doi:10.1093/jn/120.3.280 · Cited by 37 · see citing works
Toll-like receptors mediate induction of hepcidin in mice infected with Borrelia burgdorferi
Koening, C. L., Miller, J. C., Nelson, J. M., Ward, D. M., Kushner, J. P., Bockenstedt, L. K., Weis, J. J., Kaplan, J., & Domenico, I. D. (2009) · Blood · doi:10.1182/blood-2009-03-209577 · Cited by 32 · see citing works
Total blood lymphocyte counts in hemochromatosis probands with HFEC282Y homozygosity: relationship to severity of iron overload and HLA-A and -B alleles and haplotypes
Barton, J. C., Wiener, H. W., Acton, R. T., & Go, R. C. P. (2005) · BMC Hematology · doi:10.1186/1471-2326-5-5 · Cited by 31 · see citing works
Effects of iron deficiency anemia on delayed cutaneous hypersensitivity in mice
Kuvibidila, S. R., Baliga, B. S., & Suskind, R. M. (1981) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/34.12.2635 · Cited by 30 · see citing works
Protein Tyrosine Phosphatases Are Regulated by Mononuclear Iron Dicitrate
Gómez, M. A., Alisaraie, L., Shio, M. T., Berghuis, A. M., Lebrun, C., Gautier‐Luneau, I., & Olivier, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.107037 · Cited by 30 · see citing works
Low numbers of CD8+ T lymphocytes in hereditary haemochromatosis are explained by a decrease of the most mature CD8+ effector memory T cells
Macedo, M. F., Porto, G., Costa, M., Vieira, C. P., Rocha, B., & Cruz, E. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.04066.x · Cited by 28 · see citing works
Inhibition of lymphocyte activation with anti-transferrin receptor Mabs: A comparison of three reagents and further studies of their range of effects and mechanism of action
Kemp, J. D., Thorson, J., Gómez, F. J., Smith, K. M., Cowdery, J. S., & Ballas, Z. K. (1989) · Cellular Immunology · doi:10.1016/0008-8749(89)90162-7 · Cited by 24 · see citing works
The glucocorticoid inhibition of LFA-1 and CD2 expression by human mononuclear cells is reversed by IL-2, IL-7 and IL-15
Pipitone, N., Sinha, M., Theodoridis, E., Goulding, N. J., Hall, M. D., Lanchbury, J. S. S., Corrigall, V., Panayi, G. S., & Pitzalis, C. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200107)31:7 · Cited by 19 · see citing works
Genetic Analysis of Resistance to Infections in Mice: A/J meets C57BL/6J
Marquis, J. F., & Gros, P. (2008) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-75203-5_2 · Cited by 19 · see citing works
Lymphocyte Subsets in Experimental Hemochromatosis
Melo, R. A. M., Garcı́a, A., Viana, S. R., & Falcão, R. P. (2009) · Acta Haematologica · doi:10.1159/000203595 · Cited by 8 · see citing works
W1376 Tumor Necrosis Factor Alpha and Interferon Gamma Induce Apoptosis in Enteric Glia: Protective Role of Brain-Derived Neurotrophic Factor
Hartmann, C., Degenkolb, N., Steinkamp, M., Adler, G., & von Boyen, G. B. (2008) · Gastroenterology · doi:10.1016/s0016-5085(08)63226-6 · Cited by 5 · see citing works

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Nutrition, immunity and COVID-19
Calder, P. C. (2020) · BMJ Nutrition Prevention & Health · doi:10.1136/bmjnph-2020-000085 · Cited by 587 · see citing works
Impact of Childhood Malnutrition on Host Defense and Infection
Ibrahim, M. K., Zambruni, M., Melby, C. L., & Melby, P. C. (2017) · Clinical Microbiology Reviews · doi:10.1128/cmr.00119-16 · Cited by 359 · see citing works
Gut Microbiota and Iron: The Crucial Actors in Health and Disease
Yilmaz, B., & Li, H. (2018) · Pharmaceuticals · doi:10.3390/ph11040098 · Cited by 317 · see citing works
Feeding the immune system
Calder, P. C. (2013) · Proceedings of The Nutrition Society · doi:10.1017/s0029665113001286 · Cited by 283 · see citing works
Inflammation and nutritional science for programs/policies and interpretation of research evidence (INSPIRE)
Raiten, D. J., Ashour, F. A. S., Ross, A. C., Meydani, S. N., Dawson, H. D., Stephensen, C. B., Brabin, B. J., Suchdev, P. S., & van Ommen, B. (2015) · The Journal of Nutrition · doi:10.3945/jn.114.194571 · Cited by 234 · see citing works
Iron Deficiency in Heart Failure: Mechanisms and Pathophysiology
Alnuwaysir, R. I. S., Hoes, M. F., van Veldhuisen, D. J., van der Meer, P., & Beverborg, N. G. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm11010125 · Cited by 170 · see citing works
Anemia as a risk factor for tuberculosis: a systematic review and meta-analysis
Gelaw, Y., Getaneh, Z., & Melku, M. (2021) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-020-00931-z · Cited by 149 · see citing works
The Role of Diet and Gut Microbiota in Regulating Gastrointestinal and Inflammatory Disease
Gill, P. A., Inniss, S., Kumagai, T., Rahman, F. Z., & Smith, A. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.866059 · Cited by 140 · see citing works
Impact of Metabolism in on T-Cell Differentiation and Function and Cross Talk with Tumor Microenvironment
Kouidhi, S., Elgaaïed, A. B., & Chouaı̈b, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00270 · Cited by 138 · see citing works
Consensus Statement Immunonutrition and Exercise.
Bermon, S., Castell, L. M., Calder, P. C., BISHOP, N. C., Blomstrand, E., Mooren, F. C., Krüger, K., Kavazis, A. N., Quindry, J. C., Senchina, D. S., et al. (2017) · PubMed · Cited by 138 · see citing works
Iron Regulation of Pancreatic Beta-Cell Functions and Oxidative Stress
Backe, M. B., Moen, I. W., Ellervik, C., Hansen, J. B., & Mandrup-Poulsen, T. R. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050939 · Cited by 116 · see citing works
The role of hepcidin and iron homeostasis in atherosclerosis
Wunderer, F., Traeger, L., Sigurslid, H. H., Meybohm, P., Bloch, D. B., & Malhotra, R. K. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104664 · Cited by 107 · see citing works
HIV-Associated Neurocognitive Impairment in the Modern ART Era: Are We Close to Discovering Reliable Biomarkers in the Setting of Virological Suppression?
Bandera, A., Taramasso, L., Bozzi, G., Muscatello, A., Robinson, J., Burdo, T., & Gori, A. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00187 · Cited by 75 · see citing works
Iron and zinc exploitation during bacterial pathogenesis
Ma, L. M., Terwilliger, A. L., & Maresso, A. W. (2015) · Metallomics · doi:10.1039/c5mt00170f · Cited by 83 · see citing works
The role of iron homeostasis and iron-mediated ROS in cancer.
Ying, J., Lu, Z.-B., Fu, L., Tong, Y., Wang, Z., Li, W., & Mou, X. (2021) · PubMed Central · Cited by 74 · see citing works
Association of iron overload with allogeneic hematopoietic cell transplantation outcomes: a prospective cohort study using R2-MRI–measured liver iron content
Trottier, B. J., Burns, L. J., DeFor, T. E., Cooley, S., & Majhail, N. S. (2013) · Blood · doi:10.1182/blood-2013-04-499772 · Cited by 72 · see citing works
Environmentally sustainable synthesis of whey-based carbon dots for ferric ion detection in human serum and water samples: evaluating the greenness of the method
Kayani, K. F., Shatery, O. B. A., Mustafa, M. S., Alshatteri, A. H., Mohammed, S. J., & Aziz, S. B. (2024) · RSC Advances · doi:10.1039/d3ra08680a · Cited by 71 · see citing works
Iron chelators in cancer therapy
Ibrahim, O., & O’Sullivan, J. (2020) · BioMetals · doi:10.1007/s10534-020-00243-3 · Cited by 70 · see citing works
Low dietary iron intake restrains the intestinal inflammatory response and pathology of enteric infection by food‐borne bacterial pathogens
Kortman, G. A. M., Mulder, M. L. M., Richters, T. J. W., Shanmugam, N. K. N., Trebicka, E., Boekhorst, J., Timmerman, H. M., Roelofs, R., Wiegerinck, E. T., Laarakkers, C. M., et al. (2015) · European Journal of Immunology · doi:10.1002/eji.201545642 · Cited by 65 · see citing works
Self-citation
Lipocalin 2 Bolsters Innate and Adaptive Immune Responses to Blood-Stage Malaria Infection by Reinforcing Host Iron Metabolism
Zhao, H., Konishi, A., Fujita, Y., Yagi, M., Ohata, K., Aoshi, T., Itagaki, S., Sato, S., Narita, H., Abdelgelil, N. H., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.10.010 · Cited by 65 · see citing works
Pathomechanisms of Immunological Disturbances in β-Thalassemia
Gluba-Brzózka, A., Franczyk, B., Rysz-Górzyńska, M., Rokicki, R., Koziarska-Rościszewska, M., & Rysz, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189677 · Cited by 64 · see citing works
Plasma proteomic signature predicts who will get persistent symptoms following SARS-CoV-2 infection
Captur, G., Moon, J., Topriceanu, C., Joy, G., Swadling, L., Hällqvist, J., Doykov, I., Patel, N., Śpiewak, J., Baldwin, T., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104293 · Cited by 64 · see citing works
Ingestion, Immunity, and Infection: Nutrition and Viral Respiratory Tract Infections
Govers, C., Calder, P. C., Savelkoul, H. F. J., Albers, R., & van Neerven, R. J. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.841532 · Cited by 66 · see citing works
COVID-19 Vaccination in Patients with Heart Failure: A Position Paper of the Heart Failure Association of the European Society of Cardiology
Rosano, G. M. C., Jankowska, E. A., Ray, R., Metra, M., Abdelhamid, M., Adamopoulos, S. N., Anker, S. D., Bayés‐Genís, A., Belenkov, Y. N., Gal, T. B., et al. (2021) · European Journal of Heart Failure · doi:10.1002/ejhf.2356 · Cited by 58 · see citing works
The utility of iron chelators in the management of inflammatory disorders
Lehmann, C., Islam, S., Jarosch, S., Zhou, J., Hoskin, D., Greenshields, A., Al-Banna, N., Sharawy, N., Sczcesniak, A., Kelly, M., et al. (2015) · Mediators of Inflammation · doi:10.1155/2015/516740 · Cited by 54 · see citing works
“In addition, iron regulates the activity of the transcription factors NF-𝜅B and HIF-1𝛼 [58], which promote the expression of genes involved in the survival andmetastasis of cancer cells [59, 60].”
Background
Chronic Iron Overload Results in Impaired Bacterial Killing of THP-1 Derived Macrophage through the Inhibition of Lysosomal Acidification
Kao, J., Wang, S., Ho, L.-W., Huang, S.-W., Chang, S.-H., Yang, R.-C., Ke, Y., Wu, C., Wang, J., & Shieh, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156713 · Cited by 54 · see citing works
Dietary diversity and poverty as risk factors for leprosy in Indonesia: A case-control study
Oktaria, S., Hurif, N. S., Naim, W., Thio, H. B., Nijsten, T. E. C., & Richardus, J. H. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006317 · Cited by 48 · see citing works
Biofortification revisited: Addressing the role of beneficial soil microbes for enhancing trace elements concentration in staple crops
Mishra, P., Mishra, J., & Arora, N. K. (2023) · Microbiological Research · doi:10.1016/j.micres.2023.127442 · Cited by 45 · see citing works
Iron and intestinal immunity
Cherayil, B. J., Ellenbogen, S., & Shanmugam, N. K. N. (2011) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32834a4cd1 · Cited by 45 · see citing works
Self-citation
Early Environmental Upheaval and the Risk for Schizophrenia
Paquin, V., Lapierre, M., Veru, F., & King, S. (2021) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-081219-103805 · Cited by 45 · see citing works
Exogenous Iron Induces NADPH Oxidases-Dependent Ferroptosis in the Conidia of Aspergillus flavus
Yao, L., Ban, F., Peng, S., Xu, D., Li, H., Mo, H., Hu, L., & Zhou, X. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c04411 · Cited by 43 · see citing works
Effects of Dietary Iron Level on Growth Performance, Immune Organ Indices and Meat Quality in Chinese Yellow Broilers
Lin, X., Gou, Z., Wang, Y., Li, L., Fan, Q., Ding, F., Zheng, C., & Jiang, S. (2020) · Animals · doi:10.3390/ani10040670 · Cited by 44 · see citing works
Mechanisms of Kwashiorkor-Associated Immune Suppression: Insights From Human, Mouse, and Pig Studies
Michael, H., Amimo, J. O., Rajashekara, G., Saif, L. J., & Vlasova, A. N. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.826268 · Cited by 43 · see citing works
Oral iron supplementation and anaemia in children according to schedule, duration, dose and cosupplementation: a systematic review and meta-analysis of 129 randomised trials
Andersen, C. T., Marsden, D., Duggan, C., Liu, E., Mozaffarian, D., & Fawzi, W. W. (2023) · BMJ Global Health · doi:10.1136/bmjgh-2022-010745 · Cited by 44 · see citing works
Molecular pathogenesis and clinical consequences of iron overload in liver cirrhosis
Sikorska, K., Bernat, A., & Wróblewska, A. (2016) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(16)60135-2 · Cited by 40 · see citing works
Decreased Iron in Cancer Cells and Their Microenvironment Improves Cytolysis of Breast Cancer Cells by Natural Killer Cells
Jiang, X., & Elliott, R. L. (2017) · Anticancer Research · doi:10.21873/anticanres.11567 · Cited by 37 · see citing works
Cerebrospinal Fluid Ceruloplasmin, Haptoglobin, and Vascular Endothelial Growth Factor Are Associated with Neurocognitive Impairment in Adults with HIV Infection
the CHARTER Study Group, Kallianpur, A. R., Gittleman, H. R., Letendre, S. L., Ellis, R. J., Barnholtz‐Sloan, J. S., Bush, W. S., Heaton, R. K., Samuels, D. C., Franklin, D. R., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1329-9 · Cited by 35 · see citing works
Iron deficiency is associated with increased risk for cardiovascular disease and all-cause mortality in the elderly living in long-term care facilities
Hsu, H.-S., Li, C.-I., Liu, C.-S., Lin, C., Huang, K., Li, T., Huang, H.-Y., & Lin, W. (2013) · Nutrition · doi:10.1016/j.nut.2012.10.015 · Cited by 35 · see citing works
n–3 Long-chain PUFAs reduce respiratory morbidity caused by iron supplementation in iron-deficient South African schoolchildren: a randomized, double-blind, placebo-controlled intervention
Malan, L., Baumgartner, J., Calder, P. C., Zimmermann, M. B., & Smuts, C. M. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.081208 · Cited by 34 · see citing works
Reactive oxygen species mediated T lymphocyte abnormalities in an iron-overloaded mouse model and iron-overloaded patients with myelodysplastic syndromes
Chen, J., Lu, W., Zhao, M., Cao, X., Jiang, Y., Jin, X. K., Xu, P., Yuan, T., Zhang, Y., Chai, X., et al. (2017) · Annals of Hematology · doi:10.1007/s00277-017-2985-y · Cited by 33 · see citing works
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis
Benyamin, B., Esko, T., Ried, J. S., Radhakrishnan, A., Vermeulen, S. H., Traglia, M., Gögele, M., Anderson, D., Broer, L., Podmore, C., et al. (2014) · Nature Communications · doi:10.1038/ncomms5926 · Cited by 30 · see citing works
“Iron deficiency is the leading cause of anaemia 1 , and it also compromises immune function 2 and cognitive development 3.”
Nutrition and Immunity
(2020) · American Academy of PediatricsItasca, IL eBooks · doi:10.1542/9781610023610-35 · Cited by 27 · see citing works
Effects of iron deficiency and iron supplementation at the host-microbiota interface: Could a piglet model unravel complexities of the underlying mechanisms?
Abbas, M., Hayirli, Z., Drakesmith, H., Andrews, S. C., & Lewis, M. C. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.927754 · Cited by 28 · see citing works
Identification, characterization and modulation of ferritin-H in the sub-Antarctic Notothenioid Eleginops maclovinus challenged with Piscirickettsia salmonis
Martínez, D. P., Oyarzún, R., Vargas-Lagos, C., Pontigo, J. P., Soto‐Dávila, M., Saravia, J., Romero, A., Núñez, J. J., Yáñez, A. J., & Vargas‐Chacoff, L. (2017) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2017.03.015 · Cited by 27 · see citing works
Coffee Infusions: Can They Be a Source of Microelements with Antioxidant Properties?
Olechno, E., Puścion‐Jakubik, A., Socha, K., & Zujko, M. E. (2021) · Antioxidants · doi:10.3390/antiox10111709 · Cited by 25 · see citing works
Newly diagnosed iron deficiency anemia and subsequent autoimmune disease: a matched cohort study in Taiwan
Chang, R., Chu, K., Lin, M., Chu, Y.-H., Hung, Y., & Wei, J. C. (2020) · Current Medical Research and Opinion · doi:10.1080/03007995.2020.1748585 · Cited by 24 · see citing works
Omega-3 Fatty Acid and Iron Supplementation Alone, but Not in Combination, Lower Inflammation and Anemia of Infection in Mycobacterium tuberculosis-Infected Mice
Nienaber, A., Baumgartner, J., Dolman, R., Ozturk, M., Zandberg, L., Hayford, F. E. A., Brombacher, F., Blaauw, R., Parihar, S. P., Smuts, C. M., et al. (2020) · Nutrients · doi:10.3390/nu12092897 · Cited by 24 · see citing works
A Bioinformatics-Assisted Review on Iron Metabolism and Immune System to Identify Potential Biomarkers of Exercise Stress-Induced Immunosuppression
Bonilla, D. A., Moreno, Y., Petro, J. L., Forero, D. A., Vargas-Molina, S., Odriozola-Martínez, A., Orozco, C. A., Stout, J. R., Rawson, E. S., & Kreider, R. B. (2022) · Biomedicines · doi:10.3390/biomedicines10030724 · Cited by 26 · see citing works
Iron Status and Supplementation during Tuberculosis
Nienaber, A., Uyoga, M. A., Dolman, R., & Malan, L. (2023) · Microorganisms · doi:10.3390/microorganisms11030785 · Cited by 24 · see citing works
The Impact of Iron on Cancer-Related Immune Functions in Oncology: Molecular Mechanisms and Clinical Evidence
Badran, O., Cohen, I., & Bar‐Sela, G. (2024) · Cancers · doi:10.3390/cancers16244156 · Cited by 25 · see citing works
Iron overload may promote alteration of NK cells and hematopoietic stem/progenitor cells by JNK and P38 pathway in myelodysplastic syndromes
Hua, Y., Wang, C., Jiang, H., Wang, Y., Liu, C., Li, L., Liu, H., Shao, Z., & Fu, R. (2017) · International Journal of Hematology · doi:10.1007/s12185-017-2237-x · Cited by 21 · see citing works
Effect of microencapsulated ferrous sulfate particle size on Cheddar cheese composition and quality
Arce, A., & Ustunol, Z. (2018) · Journal of Dairy Science · doi:10.3168/jds.2017-13952 · Cited by 21 · see citing works
Bone morphogenetic protein 6 (BMP-6) modulates lung function, pulmonary iron levels and cigarette smoke-induced inflammation
Verhamme, F. M., Smet, E. G. D., Hooste, W. V., Delanghe, J., Verleden, S. E., Joos, G., Brusselle, G., & Bracke, K. R. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0116-2 · Cited by 21 · see citing works
Peripheral blood immune cells from individuals with Parkinson's disease or inflammatory bowel disease share deficits in iron storage and transport that are modulated by non-steroidal anti-inflammatory drugs
Bolen, M. L., Gomes, B. N., Gill, B., Menees, K. B., Staley, H. A., Jernigan, J. E., McFarland, N. R., Zimmermann, E. M., Forsmark, C. E., & Tansey, M. G. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106794 · Cited by 20 · see citing works
The Effect of Iron Dextran Injection on Daily Weight Gain and Haemoglobin Values in Whole Milk Fed Calves
Allan, J., Plate, P., & Winden, S. C. L. V. (2020) · Animals · doi:10.3390/ani10050853 · Cited by 20 · see citing works
Machine learning-based models for the qualitative classification of potassium ferrocyanide using electrochemical methods
Kayalı, D., Shama, N. A., Aşır, S., & Dimililer, K. (2023) · The Journal of Supercomputing · doi:10.1007/s11227-023-05137-y · Cited by 19 · see citing works
Association of iron deficiency anemia with tuberculosis in Taiwan: A nationwide population-based study
Chu, K., Hsu, C.-H., Lin, M., Chu, Y.-H., Hung, Y., & Wei, J. C. (2019) · PLoS ONE · doi:10.1371/journal.pone.0221908 · Cited by 19 · see citing works
MANAGEMENT STRATEGIES OF IRON ACCUMULATION IN A CAPTIVE POPULATION OF BLACK RHINOCEROSES ( DICEROS BICORNIS MINOR )
Mylniczenko, N. D., Sullivan, K. E., Corcoran, M. E., Fleming, G. J., & Valdes, E. V. (2012) · Journal of Zoo and Wildlife Medicine · doi:10.1638/2011-0168.1 · Cited by 18 · see citing works
How Do Minerals, Vitamins, and Intestinal Microbiota Affect the Development and Progression of Heart Disease in Adult and Pediatric Patients?
Brecht, P., Dring, J. C., Yanez, F., Styczeń, A., Mertowska, P., Mertowski, S., & Grywalska, E. (2023) · Nutrients · doi:10.3390/nu15143264 · Cited by 17 · see citing works
Impact of Different Dietary Patterns and Micronutrients on the Immune System and COVID-19 Infection
Aljadani, H. (2021) · Current Research in Nutrition and Food Science Journal · doi:10.12944/crnfsj.9.1.13 · Cited by 17 · see citing works
Asbestos and Zeolites: from A to Z via a Common Ion
Reid, G., Klebe, S., van Zandwijk, N., & George, A. M. (2021) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.0c00286 · Cited by 17 · see citing works
Vitamins, microelements and the immune system: current standpoint in the fight against coronavirus disease 2019
Djordjevic, B., Milenković, J., Stojanovic, D., Velickov, A., Djindjic, B., & Stoimenov, T. J. (2022) · British Journal Of Nutrition · doi:10.1017/s0007114522000083 · Cited by 17 · see citing works
Vitamin, antioxidant and micronutrient supplementation and the risk of developing incident autoimmune diseases: a systematic review and meta-analysis
Low, C. E., Loke, S., Chew, N. S. M., Lee, A. R. Y. B., & Tay, S. H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1453703 · Cited by 16 · see citing works
TLR4 and C5aR crosstalk in dendritic cells induces a core regulatory network of RSK2, PI3Kβ, SGK1, and FOXO transcription factors
Zaal, A., Nota, B., Moore, K., Dieker, M. C., van Ham, S. M., & ten Brinke, A. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.2ma0217-058r · Cited by 16 · see citing works
Determination of Blood Glucose, Total Protein, Certain Minerals, and Triiodothyronine during Late Pregnancy and Postpartum Periods in Crossbred Dairy Cows
Mohammed, S. E., Ahmad, F. O., Frah, E. A. M., & Elfaki, I. (2021) · Veterinary Medicine International · doi:10.1155/2021/6610362 · Cited by 16 · see citing works
Previous Vaccination and Age are More Important Predictors of Immune Response to Influenza Vaccine than Inflammation and Iron Status in Dialysis Patients
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Iron-related Biomarkers in the Diagnosis and Management of Iron Disorders
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Authors: Cherayil, B. J.
Affiliations: Harvard University (US)
Corresponding author: Cherayil, Bobby J.
ORCID: Cherayil, Bobby J.
Venue: Archivum Immunologiae et Therapiae Experimentalis
Publisher: Walter de Gruyter GmbH
Published: 2010-09-28
Volume: 58
Issue: 6
Pages: 407-415
ISSN: 0004-069X (ISSN-L)
1661-4917
DOI: 10.1007/s00005-010-0095-9
PMC: PMC3173740
OpenAlex: W2000542026
Cited by: 170
References: 95
Citations by year: 2026: 3 · 2025: 7 · 2024: 14 · 2023: 17 · 2022: 21 · 2021: 25 · 2020: 22 · 2019: 13 · 2018: 7 · 2017: 10 · 2016: 9 · 2015: 6 · 2014: 4 · 2013: 6 · 2012: 4
FWCI: 0.61
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Archivum Immunologiae et Therapiae Experimentalis (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (R56AI089700)
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK040561)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
Keywords: iron metabolism, iron homeostasis, iron deficiency, iron overload, immunity, immune activation, iron deficiency anemia
MeSH terms: Iron Deficiencies, Animals, Homeostasis, Humans, Immunity, Innate, Inflammation, Iron, Signal Transduction, Inflammation Mediators, Iron Overload, Adaptive Immunity

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Iron and Immunity: Immunological Consequences of Iron Deficiency and Overload

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