A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
Ohm, Joyce E, McGarvey, Kelly M, Yu, Xiaobing, Cheng, Linzhao, Schuebel, Kornel E, Cope, Leslie, Mohammad, Helai P, Chen, Wei, Daniel, Vincent C, Yu, Wayne, Berman, David M, Jenuwein, Thomas, Pruitt, Kevin, Sharkis, Saul J, Watkins, D Neil, Herman, James G, Baylin, Stephen B·2007·Nature Genetics
DOI 10.1038/ng1972
Cited by (999)
Items 201–300 of 999
- Identification of Driver and Passenger DNA Methylation in Cancer by Epigenomic AnalysisSatish K. Kalari, Gerd P. Pfeifer · 2010 · Advances in genetics
- Abnormal DNA Methylation of CD133 in Colorectal and Glioblastoma TumorsJoo Mi Yi, Hsing-Chen Tsai, Sabine C. Glöckner, Steven Hsesheng Lin, Joyce Ellen Ohm, Hariharan Easwaran, Charles David James, J Costello, Gregory Joseph Riggins, Charles G. Eberhart et al. · 2008 · Cancer Research
- Minireview: Epigenetic Alterations in Human Prostate CancersWilliam G. Nelson, Angelo Michael De Marzo, Srinivasan Yegnasubramanian · 2009 · Endocrinology
- Analysis of Promoter CpG Island Hypermethylation in Cancer: Location, Location, Location!Iris J.H. van Vlodrop, Hanneke E.C. Niessen, Sarah Derks, Marcella M.L.L. Baldewijns, Wim Van Criekinge, James Gordon Herman, Manon van Engeland · 2011 · Clinical Cancer Research
- Editing the Epigenome: Reshaping the Genomic LandscapeLiad Holtzman, Charles A. Gersbach · 2018 · Annual Review of Genomics and Human Genetics
- Methylation across the central dogma in health and diseases: new therapeutic strategiesRuochen Liu, Erhu Zhao, Huijuan Yu, Chaoyu Yuan, Muhammad Nadeem Abbas, Hongjuan Cui · 2023 · Signal Transduction and Targeted Therapy
- Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell ‘stemness’ via the bone morphogenetic protein pathwayLiudmila L. Kodach, Rutger J. Jacobs, Philip W. Voorneveld, Manon E. Wildenberg, Henricus W Verspaget, Tom van Wezel, Hans M. Morreau, Daniël W. Hommes, Maikel Petrus Peppelenbosch, Gijs R. VAN DEN BRINK et al. · 2011 · Gut
- Epigenetic Repression of p16INK4A by Latent Epstein-Barr Virus Requires the Interaction of EBNA3A and EBNA3C with CtBPLenka Skalska, Robert E. White, Melanie Franz, Michaela Ruhmann, Martin J. Allday · 2010 · PLoS Pathogens
- Epigenetic changes in healthy human skeletal muscle following exercise– a systematic reviewMacsue Jacques, Danielle Hiam, Jeffrey Mark Craig, Romain Barrès, Nir Eynon, Sarah Amandine Caroline Voisin · 2019 · Epigenetics
- Epithelial Progeny of Estrogen-Exposed Breast Progenitor Cells Display a Cancer-like MethylomeAlfred S.L. Cheng, Aedín C. Culhane, Michael W.Y. Chan, Chinnambally R. Venkataramu, Mathias Ehrich, Aejaz Nasir, Benjamin A.T. Rodriguez, Joseph Liu, Pearlly S. Yan, John F Quackenbush et al. · 2008 · Cancer Research
- Epigenetic regulation of signaling pathways in cancer: Role of the histone methyltransferase EZH2Daisy P. Tsang, Alfred S.L. Cheng · 2010 · Journal of Gastroenterology and Hepatology
- DNA methylation aberrancies as a guide for surveillance and treatment of human cancersGangning Liang, Daniel J. Weisenberger · 2017 · Epigenetics
- Decoding the function of bivalent chromatin in development and cancerDhirendra Kumar, Senthilkumar Cinghu, Andrew Oldfield, Pengyi Yang, Raja Jothi · 2021 · Genome Research
- Terminal differentiation and loss of tumorigenicity of human cancers via pluripotency-based reprogrammingXiao Zhang, F D Cruz, Mary Beth Terry, Fabrizio Remotti, Igor Matushansky · 2012 · Oncogene
- Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domainsTrowbridge, Jennifer J., Sinha, Amit U., Zhu, Nan, Li, Mingjie, Armstrong, Scott A., Orkin, Stuart H. · 2012 · Genes & Development
- CpG Island Hypermethylation in Human AstrocytomasXiwei Wu, Tibor A. Rauch, Xueyan Zhong, William P. Bennett, Farida Latif, Dietmar Krex, Gerd P. Pfeifer · 2010 · Cancer Research
- Detection of Long Non-Coding RNA in Archival Tissue: Correlation with Polycomb Protein Expression in Primary and Metastatic Breast CarcinomaKaren M. Chisholm, Yue Wan, Rui Li, Kelli D. Montgomery, Howard Y. Chang, Robert B. West · 2012 · PLoS ONE
- LSH Cooperates with DNA Methyltransferases To Repress TranscriptionKevin Myant, Irina Stancheva · 2007 · Molecular and Cellular Biology
- CpG island methylator phenotype (CIMP) in cancer: Causes and implicationsJens M. Teodoridis, Catriona Hardie, Robert Eldon Brown · 2008 · Cancer Letters
- The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islandsHideyuki Takeshima, Satoshi Yamashita, Taichi Shimazu, Tohru Niwa, Toshikazu Ushijima · 2009 · Genome Research
- A Comprehensive Microarray-Based DNA Methylation Study of 367 Hematological NeoplasmsMartin-Subero, Jose I., Ammerpohl, Ole, Bibikova, Marina, Wickham-Garcia, Eliza, Agirre, Xabier, Alvarez, Sara, Brüggemann, Monika, Bug, Stefanie, Calasanz, Maria J., Deckert, Martina et al. · 2009 · PLoS ONE
- Mutator pathways unleashed by epigenetic silencing in human cancerFilipe V. Jacinto, Manel Esteller · 2007 · Mutagenesis
- Genomic insights into cancer-associated aberrant CpG island hypermethylationDuncan Sproul, Richard R. Meehan · 2013 · Briefings in Functional Genomics
- Defining a Chromatin Pattern that Characterizes DNA-Hypermethylated Genes in Colon Cancer CellsKelly M. McGarvey, Leander Van Neste, Leslie Cope, Joyce Ellen Ohm, James Gordon Herman, Wim Van Criekinge, Kornel E. Schuebel, Stephen B. Baylin · 2008 · Cancer Research
- Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinomaMatthias Lechner, Tim R. Fenton, James West, Gareth A. Wilson, Andrew Feber, Stephen R Henderson, Christina Thirlwell, Harpreet K. Dibra, Amrita Jay, Lee M Butcher et al. · 2013 · Genome Medicine
- Genome-wide age-related DNA methylation changes in blood and other tissues relate to histone modification, expression and cancerZongli Xu, Jack A. Taylor · 2013 · Carcinogenesis
- Combination therapy with epigenetic-targeted and chemotherapeutic drugs delivered by nanoparticles to enhance the chemotherapy response and overcome resistance by breast cancer stem cellsShi-Yong Li, Rong Sun, Hongxia Wang, Song Shen, Yang Liu, Xiao‐Jiao Du, Yanhua Zhu, Wang Jun · 2014 · Journal of Controlled Release
- Homeobox oncogene activation by pan-cancer DNA hypermethylationJianzhong Su, Yung‐Hsin Huang, Xiaodong Cui, Xinyu Wang, Xiaotian Zhang, Yong Lei, Jianfeng Xu, Xueqiu Lin, Kaifu Chen, Jie Lv et al. · 2018 · Genome biology
- Changes of bivalent chromatin coincide with increased expression of developmental genes in cancerStephan H. Bernhart, Helene Kretzmer, Lesca Miriam Holdt, Frank Jühling, Ole Ammerpohl, Anke Katharina Bergmann, Bernd H. Northoff, Gero Doose, Reiner Siebert, Peter Florian Stadler et al. · 2016 · Scientific Reports
- miRNA Gene Promoters Are Frequent Targets of Aberrant DNA Methylation in Human Breast CancerLukáš Vrba, José L. Muñoz-Rodríguez, Martha R. Stampfer, Bernard W. Futscher · 2013 · PLoS ONE
- Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signalingAnne‐Marie Martinez, Bernd Schuettengruber, Samy Sakr, Ana Janic, Cayetano González, Giacomo Cavalli · 2009 · Nature Genetics
- The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosaeTakeshi Nakajima, Satoshi Yamashita, Takao Maekita, Tohru Niwa, Kazuyuki Nakazawa, Toshikazu Ushijima · 2008 · International Journal of Cancer
- A novel 6C assay uncovers Polycomb-mediated higher order chromatin conformationsVijay Kumar Tiwari, Leslie Cope, Kelly M. McGarvey, Joyce Ellen Ohm, Stephen B. Baylin · 2008 · Genome Research
- Targeting EZH2 and PRC2 dependence as novel anticancer therapyBowen Xu, Kyle D. Konze, Jian Jun Jin, Gang Greg Wang · 2015 · Experimental Hematology
- Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomasWentao Gao, Yutaka Kondo, Lanlan Shen, Yasuhiro Shimizu, Tsuyoshi Sano, Kenji Yamao, Atsushi Natsume, Yasuhiro Gotô, Motokazu Ito, Hideki Murakami et al. · 2008 · Carcinogenesis
- Coordinate Regulation of DNA Methylation and H3K27me3 in Mouse Embryonic Stem CellsJames A. Hagarman, Michael P. Motley, Katla Kristjánsdóttir, Paul D. Soloway · 2013 · PLoS ONE
- Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lungJulien D. F. Licchesi, William H. Westra, Craig M. Hooker, Emi Ota Machida, Stephen B. Baylin, James Gordon Herman · 2008 · Carcinogenesis
- DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer RiskXie, Wenbing, Kagiampakis, Ioannis, Pan, Lixia, Zhang, Yang W., Murphy, Lauren, Tao, Yong, Kong, Xiangqian, Kang, Byunghak, Xia, Limin, Carvalho, Filipe L.F. et al. · 2018 · Cancer Cell
- Bivalent domains enforce transcriptional memory of DNA methylated genes in cancer cellsJairo Rodríguez, Mar Muñoz, Laura Vives, Costakis G. Frangou, Mark T. Groudine, Miguel Angel Peinado · 2008 · Proceedings of the National Academy of Sciences
- CD133: to be or not to be, is this the real question?Elena Irollo, Giuseppe Pirozzi · 2013 · Europe PMC (PubMed Central)
- DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymesEriko G. Clements, Helai P. Mohammad, Benjamin R. Leadem, Hariharan Easwaran, Yi Cai, Leander Van Neste, Stephen B. Baylin · 2012 · Nucleic Acids Research
- DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancersChing-Yu Yen, Hurng‐Wern Huang, Chih‐Wen Shu, Ming‐Feng Hou, Shyng‐Shiou F. Yuan, Hui-Ru Wang, Yung-Ting Chang, Ammad Ahmad Farooqı, Jen‐Yang Tang, Hsueh‐Wei Chang · 2016 · Cancer Letters
- Genome‐wide DNA methylation profiles in precancerous conditions and cancersYae Kanai · 2009 · Cancer Science
- DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation PatternsKsenia Skvortsova, Etienne Masle‐Farquhar, Phuc‐Loi Luu, Jenny Z. Song, Wenjia Qu, Elena Zotenko, Cathryn M. Gould, Qian Du, Timothy J. Peters, Yolanda Colino‐Sanguino et al. · 2019 · Cancer Cell
- DNA methylation dynamics and dysregulation delineated by high-throughput profiling in the mouseWanding Zhou, Toshinori Hinoue, Bret Barnes, Owen D. Mitchell, Waleed Iqbal, Sol Moe Lee, Kelly K. Foy, Kwang‐Ho Lee, Ethan Jacob Moyer, Alexandra VanderArk et al. · 2022 · Cell Genomics
- Promoter DNA Hypermethylation and Gene Repression in Undifferentiated Arabidopsis CellsMaría Berdasco, Rubén Alcázar, Maria Victoria García‐Ortiz, Esteban Ballestar, Agustín F. Fernández, Teresa Roldán‐Arjona, Antonio F. Tiburcio, Teresa Altabella, Nicolas Buisine, Hadi Quesneville et al. · 2008 · PLoS ONE
- Differential variability improves the identification of cancer risk markers in DNA methylation studies profiling precursor cancer lesionsAndrew Erich Teschendorff, Martin Widschwendter · 2012 · Bioinformatics
- Induction of cells with cancer stem cell properties from nontumorigenic human mammary epithelial cells by defined reprogramming factorsMayuko Nishi, Yasuyuki Sakai, Hideo Akutsu, Yoji Nagashima, Gary Quinn, Shinji Masui, Hirokazu Kimura, Kilian Perrem, Akihiro Umezawa, Naoki Yamamoto et al. · 2013 · Oncogene
- A histone demethylase is necessary for regeneration in zebrafishScott Stewart, Zhi-Yang Tsun, Juan Carlos Izpisúa Belmonte · 2009 · Proceedings of the National Academy of Sciences
- Epigenetic Drift, Epigenetic Clocks and Cancer RiskShijie Zheng, Martin Widschwendter, Andrew Erich Teschendorff · 2016 · Epigenomics
- DNA methylation patterns in lung carcinomasGerd P. Pfeifer, Tibor A. Rauch · 2009 · Seminars in Cancer Biology
- Epigenetics and cancerRajnee Kanwal, Sanjay Gupta · 2010 · Journal of Applied Physiology
- Aberrant DNA methylation in contrast with mutationsToshikazu Ushijima, Kiyoshi Asada · 2009 · Cancer Science
- Action at a distance: epigenetic silencing of large chromosomal regions in carcinogenesisSusan J. Clark · 2007 · Human Molecular Genetics
- The role of 5-hydroxymethylcytosine in human cancerGerd P. Pfeifer, Wenying Xiong, Maria A. Hahn, Seung‐Gi Jin · 2014 · Cell and Tissue Research
- Polycomb-mediated silencing in neuroendocrine prostate cancerPier‐Luc Clermont, Dong Lin, Francesco Crea, Rebecca Chung‐Fern Wu, Hui Xue, Yuwei Wang, Kelsie L. Thu, Wan L. Lam, Colin C. Collins, Yuzhuo Z. Wang et al. · 2015 · Clinical Epigenetics
- The Dynamics and Prognostic Potential of DNA Methylation Changes at Stem Cell Gene Loci in Women's CancerJoanna J. Zhuang, Allison Jones, Shih‐Han Lee, Esther Ng, Heidi Fiegl, Michal Zikán, David Cibula, Alexandra Sargent, Helga Birgitte Salvesen, Ian J. Jacobs et al. · 2012 · PLoS Genetics
- Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitmentOlivia Alder, Fabrice Lavial, Anne Helness, Emily Brookes, Sandra Pinho, Anil Chandrashekran, Philippe Arnaúd, Ana Pombo, Laura P. O’Neill, Véronique Azuara · 2010 · Development
- DNMT1 and DNMT3B Modulate Distinct Polycomb-Mediated Histone Modifications in Colon CancerBilian Jin, Bing Yao, Jian‐Liang Li, C. Robert Fields, Amber L. Delmas, Chen Liu, Keith D. Robertson · 2009 · Cancer Research
- A Comparative Analysis of 5-Azacytidine- and Zebularine-Induced DNA DemethylationPatrick T. Griffin, Chad E. Niederhuth, Robert J. Schmitz · 2016 · G3 Genes Genomes Genetics
- DNA Methylation and Complete Transcriptional Silencing of Cancer Genes Persist after Depletion of EZH2Kelly M. McGarvey, Eriko Greene, Jill A. Fahrner, Thomas Jenuwein, Stephen B. Baylin · 2007 · Cancer Research
- BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin AJulian Puppe, Rinske Drost, Xiaoling Liu, Simon Andreas Joosse, Bastiaan Evers, Paulien Cornelissen‐Steijger, Petra M. Nederlof, Qiang Yu, Jos Jonkers, Maarten van Lohuizen et al. · 2009 · Breast Cancer Research
- BIM promoter directly targeted by EBNA3C in polycomb-mediated repression by EBVKostas Paschos, Gillian A. Parker, Ekularn Watanatanasup, Robert E. White, Martin J. Allday · 2012 · Nucleic Acids Research
- DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancerVarun Sasidharan Nair, Salman M. Toor, Rowaida Ziad Taha, Hibah Shaath, Eyad Elkord · 2018 · Clinical Epigenetics
- EPISCORE: cell type deconvolution of bulk tissue DNA methylomes from single-cell RNA-Seq dataAndrew Erich Teschendorff, Tianyu Zhu, Charles E. Breeze, Stephan Beck · 2020 · Genome biology
- Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative diseaseAntonio Herrera-Merchan, Lorena Arranz, Jose Manuel Ligos, Antonio de Molina-Iracheta, Orlando Domı́nguez, Susana González · 2012 · Nature Communications · Retracted
- Epigenetic Priming in Cancer InitiationCarolina Vicente‐Dueñas, Julia Hauer, César Cobaleda, Arndt Borkhardt, Isidro Sánchez-Garcı́a · 2018 · Trends in cancer
- The role of DNA methylation in directing the functional organization of the cancer epigenomeFides D. Lay, Yaping Liu, Theresa Kathleen Kelly, Heather N. Witt, Peggy Farnham, Peter A. Jones, Benjamin P. Berman · 2015 · Genome Research
- Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastomaKimberly J. Briggs, Ian M. Corcoran-Schwartz, Wei Zhang, Thomas Harcke, Wendy L. Devereux, Stephen B. Baylin, Charles G. Eberhart, D. Neil Watkins · 2008 · Genes & Development
- Concepts of epigenetics in prostate cancer developmentChristopher S. Cooper, Christopher S. Foster · 2008 · British Journal of Cancer
- The dynamic epigenetic program in male germ cells: Its role in spermatogenesis, testis cancer, and its response to the environmentMaren Godmann, Romain Lambrot, Sarah Kimmins · 2009 · Microscopy Research and Technique
- Genome-Wide DNA Methylation as an Epigenetic Consequence of Epstein-Barr Virus Infection of Immortalized KeratinocytesChristine E. Birdwell, Krista J. Queen, Phillip C. S. R. Kilgore, Phoebe A. Rollyson, Marjan Trutschl, Urška Cvek, Rona S. Scott · 2014 · Journal of Virology
- Altered Histone Modifications in GliomasYoung Zoon Kim · 2014 · Brain Tumor Research and Treatment
- Retraction Note: Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative diseaseAntonio Herrera-Merchan, Lorena Arranz, Jose Manuel Ligos, Antonio de Molina-Iracheta, Orlando Domı́nguez, Susana González · 2017 · Nature Communications · Retracted
- Epigenetic regulation of hepatocellular carcinoma in non-alcoholic fatty liver diseaseYuan Tian, Vincent Wai‐Sun Wong, Henry Lik‐Yuen Chan, Alfred S.L. Cheng · 2013 · Seminars in Cancer Biology
- Genome-wide Analysis of CpG Island Methylation in Bladder Cancer Identified TBX2, TBX3, GATA2, and ZIC4 as pTa-Specific Prognostic MarkersRaju Kandimalla, Angela A.G. van Tilborg, Lucie C. Kompier, Dominique J. P. M. Stumpel, Ronald W. Stam, Chris H. Bangma, Ellen C. Zwarthoff · 2012 · European Urology
- EZH2: Not EZHY (Easy) to DealGauri Deb, Anup Kumar Singh, Sanjay Gupta · 2014 · Molecular Cancer Research
- Implications of DNA Methylation in Parkinson’s DiseaseErnesto G. Miranda-Morales, Karin Meier, Ada Agustina Sandoval-Carrillo, Jose Manuel Salas-Pacheco, Paola Vázquez-Cárdenas, Óscar Arias-Carrión · 2017 · Frontiers in Molecular Neuroscience
- The context and potential of epigenetics in oncologyJuanita Suzanne Lopez, Michelle Percharde, Helen M. Coley, A Webb, Tim Crook · 2009 · British Journal of Cancer
- Global Promoter Methylation Analysis Reveals Novel Candidate Tumor Suppressor Genes in Natural Killer Cell LymphomaCan Küçük, Xiaozhou Hu, Bei Jiang, David L. Klinkebiel, Huimin Geng, Qiang Gong, Alyssa C. Bouska, Javeed Iqbal, Philippe Gaulard, Timothy W. McKeithan et al. · 2015 · Clinical Cancer Research
- HOXA11 DNA methylation—A novel prognostic biomarker in ovarian cancerHeidi Fiegl, Gudrun H. Windbichler, Elisabeth Mueller‐Holzner, Georg Goebel, Matthias Lechner, Ian J. Jacobs, Martin Widschwendter · 2008 · International Journal of Cancer
- The role of aberrant DNA methylation in cancer initiation and clinical impactsFranziska Geissler, Ksenija Nesic, Olga Kondrashova, Alexander Dobrovic, Elizabeth M. Swisher, Clare L. Scott, Matthew J. Wakefield · 2024 · Therapeutic Advances in Medical Oncology
- Chronic Inflammation Induces a Novel Epigenetic Program That Is Conserved in Intestinal Adenomas and in Colorectal CancerMonther Abu-Remaileh, Sebastian Bender, Günter Raddatz, Ihab Ansari, Daphne Cohen, Julian Gutekunst, Tanja Musch, Heinz Linhart, Achim Breiling, Eli Pikarsky et al. · 2015 · Cancer Research
- TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal TransitionAurélie Morin, Judith Goncalves, Sophie Moog, Luis Jaime Castro‐Vega, Sylvie Job, Alexandre Buffet, Marie‐Joséphine Fontenille, Justine Woszczyk, Anne‐Paule Gimenez‐Roqueplo, Éric Letouzé et al. · 2020 · Cell Reports
- Histone Modifications in Cancer Biology and PrognosisSiavash K. Kurdistani · 2010 · Springer eBooks
- Stem Cell Chromatin Patterns: An Instructive Mechanism for DNA Hypermethylation?Joyce Ellen Ohm, Stephen B. Baylin · 2007 · Cell Cycle
- Linking DNA Methyltransferases to Epigenetic Marks and Nucleosome Structure Genome-wide in Human Tumor CellsBilian Jin, Jason Ernst, Rochelle L. Tiedemann, Hongyan Xu, Suhas Sureshchandra, M Kellis, Stephen Dalton, Chen Liu, Jeong-Hyeon Choi, Keith D. Robertson · 2012 · Cell Reports
- Sirt1 Regulates DNA Methylation and Differentiation Potential of Embryonic Stem Cells by Antagonizing Dnmt3lJinbeom Heo, Jisun Lim, Seungun Lee, Jaeho Jeong, Hyun-Sook Kang, Yong Hwan Kim, Jeong Wook Kang, Hwan Yeul Yu, Eui Man Jeong, Kyunggon Kim et al. · 2017 · Cell Reports
- Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islandsDaniel N. Weinberg, Phillip Rosenbaum, Xiao Chen, Douglas Barrows, Cynthia Horth, Matthew R. Marunde, Irina K Popova, Zachary B Gillespie, Michael‐Christopher Keogh, Chao Lü et al. · 2021 · Nature Genetics
- Breast cancer epigenetics: normal human mammary epithelial cells as a model systemRebecca A. Hinshelwood, Susan J. Clark · 2008 · Journal of Molecular Medicine
- An integrated genomics analysis of epigenetic subtypes in human breast tumors links DNA methylation patterns to chromatin states in normal mammary cellsKarolina Holm, Johan Staaf, Martin Lauss, Mattias Aine, David Lindgren, Pär‐Ola Bendahl, Johan Vallon‐Christersson, Rosa Bjork Barkardottir, Mattias Höglund, Åke Borg et al. · 2016 · Breast Cancer Research
- The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcomeMartí Duran‐Ferrer, Guillem Clot, Ferran Nadeu, Renée Beekman, Tycho Baumann, Jessica Nordlund, Yanara Marincevic-Zuniga, Gudmar Lönnerholm, Alfredo Rivas‐Delgado, Silvia Martín et al. · 2020 · Nature Cancer
- Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomasXin Hu, Marcos R. Estecio, Runzhe Chen, Alexandre Reuben, Linghua Wang, Junya Fujimoto, Jian Carrot‐Zhang, Nicholas McGranahan, Lisha Ying, Junya Fukuoka et al. · 2021 · Nature Communications
- Distinct DNA methylation patterns in cirrhotic liver and hepatocellular carcinomaOle Ammerpohl, Johann Pratschke, Clemens Schafmayer, Andrea Haake, Wladimir Faber, Oliver von Kampen, Mario Brosch, Bence Sipos, Witigo V Schönfels, Katharina Balschun et al. · 2011 · International Journal of Cancer
- Poised chromatin in the mammalian germ lineBluma J. Lesch, David C. Page · 2014 · Development
- Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancerLi Zhang, Lisheng Deng, Fengju Chen, Yuan Yao, Bulan Wu, Liping Wei, Qianxing Mo, Yongcheng Song · 2014 · Oncotarget
- Targeted Methylation of Two Tumor Suppressor Genes Is Sufficient to Transform Mesenchymal Stem Cells into Cancer Stem/Initiating CellsI-Wen Teng, Pei‐Chi Hou, Kuan‐Der Lee, Pei‐Yi Chu, Kun‐Tu Yeh, Victor X. Jin, Min‐Jen Tseng, Shaw‐Jenq Tsai, Yu‐Sun Chang, Chi‐Sheng Wu et al. · 2011 · Cancer Research
- DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiationJunji Koya, Keisuke Kataoka, Tomohiko Sato, Masashige Bando, Yuki Kato, Takako Tsuruta-Kishino, Hiroshi Kobayashi, Kensuke Narukawa, Hiroyuki Miyoshi, Katsuhiko Shirahige et al. · 2016 · Nature Communications
- Distinct chromatin signatures of DNA hypomethylation in aging and cancerRaúl F. Pérez, Juan Ramón Tejedor, Gustavo F. Bayón, Agustín F. Fernández, Mario F. Fraga · 2018 · Aging Cell
- Genomic Deregulation of the E2F/Rb Pathway Leads to Activation of the Oncogene EZH2 in Small Cell Lung CancerBradley P. Coe, Kelsie L. Thu, Sarit Aviel‐Ronen, Emily A. Vucic, Adi F. Gazdar, Stephen C. Lam, Ming‐Sound Tsao, Wan L. Lam · 2013 · PLoS ONE