A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

Prospective identification of tumorigenic breast cancer cells

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The fundamental role of epigenetic events in cancer

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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

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Polycomb complexes repress developmental regulators in murine embryonic stem cells

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The history of cancer epigenetics

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Cancer-epigenetics comes of age

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Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells

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The Polycomb group protein EZH2 directly controls DNA methylation

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Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

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Global DNA hypomethylation suppresses squamous carcinogenesis in the tongue and esophagus

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Cancer stem/progenitor cell active compound 8-quinolinol in combination with paclitaxel achieves an improved cure of breast cancer in the mouse model

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Treatment of breast cancer cells with DNA demethylating agents leads to a release of Pol II stalling at genes with DNA-hypermethylated regions upstream of TSS

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Progressive Chromatin Repression and Promoter Methylation of CTNNA1 Associated with Advanced Myeloid Malignancies

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Molecular marks for epigenetic identification of developmental and cancer stem cells

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Aging and cancer epigenetics: Where do the paths fork?

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DNA Methylation Changes and Inflammaging in Aging-Associated Diseases

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DNA–Methylome Analysis of Mouse Intestinal Adenoma Identifies a Tumour-Specific Signature That Is Partly Conserved in Human Colon Cancer

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H3K9me-Enhanced DNA Hypermethylation of the p16 INK4a Gene: An Epigenetic Signature for Spontaneous Transformation of Rat Mesenchymal Stem Cells

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Remodeling of the Methylation Landscape in Breast Cancer Metastasis

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Progressive age-dependent DNA methylation changes start before adulthood in mouse tissues

Takasugi, M. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.12.003 · Cited by 43

Epigenetic stability of embryonic stem cells and developmental potential

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Regulation of Stem Cell Differentiation by Histone Methyltransferases and DemethylasesPreprint

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PRC2, Chromatin Regulation, and Human Disease: Insights From Molecular Structure and Function

Liu, X., & Liu, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.894585 · Cited by 48

Prospective Epigenetic Actions of Organo-Sulfur Compounds against Cancer: Perspectives and Molecular Mechanisms

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Select EZH2 inhibitors enhance viral mimicry effects of DNMT inhibition through a mechanism involving NFAT:AP-1 signaling

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Epigenetic silencing of neurofilament genes promotes an aggressive phenotype in breast cancer

Calmon, M. F., Jeschke, J., Zhang, W., Dhir, M., Siebenkäs, C., Herrera, A., Tsai, H.-C., O’Hagan, H. M., Pappou, E. P., Hooker, C. M., et al. (2015) · Epigenetics · doi:10.1080/15592294.2015.1050173 · Cited by 42

TGF-β: friend or foe? The role of TGF-β/SMAD signaling in epigenetic silencing of ovarian cancer and its implication in epigenetic therapy

Chou, J.-L., Chen, L.-Y., Lai, H., & Chan, M. W. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2010.525353 · Cited by 42

Investigating micronutrients and epigenetic mechanisms in relation to inflammatory bowel disease

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Methylation profile of DNA repetitive elements in human testicular germ cell tumor

Ushida, H., Kawakami, T., Minami, K., Chano, T., Okabe, H., Okada, Y., & Okamoto, K. (2011) · Molecular Carcinogenesis · doi:10.1002/mc.20831 · Cited by 42

Loss of imprinting of IGF2 and the epigenetic progenitor model of cancer.

Leick, M. B., Shoff, C. J., Wang, E., Congress, J. L., & Gallicano, G. I. (2012) · Europe PMC (PubMed Central) · Cited by 42

Polycomb genes, miRNA, and their deregulation in B-cell malignancies

Wang, G. G., Konze, K. D., & Tao, J. (2015) · Blood · doi:10.1182/blood-2014-10-606822 · Cited by 42

Heterogeneous epigenetic regulation ofTIMP3in prostate cancer

Shinojima, T., Yu, Q., Huang, S. K., Li, M., Mizuno, R., Liu, E. T., Hoon, D. S. �., & Lessard, L. (2012) · Epigenetics · doi:10.4161/epi.22333 · Cited by 41

Therapeutic approach of Cancer stem cells (CSCs) in gastric adenocarcinoma; DNA methyltransferases enzymes in cancer targeted therapy

Norollahi, S. E., Mansour‐Ghanaei, F., Joukar, F., Ghadarjani, S., Mojtahedi, K., Nejad, K. G., Hemmati, H., Gharibpoor, F., Khaksar, R., & Samadani, A. A. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108958 · Cited by 41

Epigenetic “bivalently marked” process of cancer stem cell‐driven tumorigenesis

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Transcriptional alterations in glioma result primarily from DNA methylation–independent mechanismsPreprint

Court, F., Boiteux, E. L., Fogli, A., Müller-Barthélémy, M., Vaurs‐Barrière, C., Chautard, E., Pereira, B., Biau, J., Kémény, J., Khalil, T., et al. (2019) · Genome Research · doi:10.1101/gr.249219.119 · Cited by 49

DNA Repair and the Control of DNA Methylation

Schär, P., & Fritsch, O. (2010) · Springer eBooks · doi:10.1007/978-3-7643-8989-5_3 · Cited by 40

EFS shows biallelic methylation in uveal melanoma with poor prognosis as well as tissue-specific methylation

Neumann, L. C., Weinhäusel, A., Thomas, S., Horsthemke, B., Lohmann, D. R., & Zeschnigk, M. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-380 · Cited by 41

A Tox21 Approach to Altered Epigenetic Landscapes: Assessing Epigenetic Toxicity Pathways Leading to Altered Gene Expression and Oncogenic Transformation In Vitro

Parfett, C. L. J., & Desaulniers, D. M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061179 · Cited by 41

Epigenetic Signaling of Cancer Stem Cells During Inflammation

Liu, Z., Ren, Y., Meng, L., Li, L., Beatson, R., Deng, J., Zhang, T., Liu, J., & Han, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.772211 · Cited by 42

H3K27me3-H3K4me1 transition at bivalent promoters instructs lineage specification in development

Yu, Y., Li, X., Jiao, R., Lu, Y., Jiang, X., & Li, X. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01017-3 · Cited by 39

DNA methylation‐mediated nucleosome dynamics and oncogenic Ras signaling

Patra, S. K., & Szyf, M. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06658.x · Cited by 39

A Network of Cancer Genes with Co-Occurring and Anti-Co-Occurring Mutations

Cui, Q. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013180 · Cited by 39

DNA methylation profiling in cancer

Kondo, Y., & Issa, J. J. (2010) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399410001559 · Cited by 38

Deciphering the cancer imprintome

Monk, D. (2010) · Briefings in Functional Genomics · doi:10.1093/bfgp/elq013 · Cited by 39

Regulation and function of mammalian DNA methylation patterns: a genomic perspective

Wu, H., Tao, J., & Sun, Y. E. (2012) · Briefings in Functional Genomics · doi:10.1093/bfgp/els011 · Cited by 40

Chemical Protein Degradation Approach and its Application to Epigenetic Targets

Itoh, Y. (2018) · The Chemical Record · doi:10.1002/tcr.201800032 · Cited by 41

Ezh2 loss propagates hypermethylation at T cell differentiation–regulating genes to promote leukemic transformation

Wang, C., Oshima, M., Sato, D., Matsui, H., Kubota, S., Aoyama, K., Nakajima‐Takagi, Y., Koide, S., Matsubayashi, J., Mochizuki‐Kashio, M., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci94645 · Cited by 40

Epigenetic regulation of the intestinal epithelium

Elliott, E. N., & Kaestner, K. H. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1997-9 · Cited by 38

Polycomb group complexes are recruited to reactivated FMR1 alleles in Fragile X syndrome in response to FMR1 transcription

Kumari, D., & Usdin, K. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu378 · Cited by 38

Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma

Tshuikina, M., Jernberg‐Wiklund, H., Nilsson, K., & Oberg, F. G. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.08.001 · Cited by 39

DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states

Liu, Y., Hrit, J. A., Chomiak, A. A., Stransky, S., Hoffman, J. R., Tiedemann, R. L., Wiseman, A. K., Kariapper, L. S., Dickson, B. M., Worden, E. J., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.11.009 · Cited by 38

The role of epigenetics in colorectal cancer

Coppedè, F. (2014) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2014.924397 · Cited by 38

Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer

Taniguchi, H., Hoshino, D., Moriya, C., Zembutsu, H., Nishiyama, N., Yamamoto, H., Kataoka, K., & Imai, K. (2017) · Oncotarget · doi:10.18632/oncotarget.16776 · Cited by 38

Epigenetic Regulation of Intestinal Stem Cells and Disease: A Balancing Act of DNA and Histone Methylation

Lorzadeh, A., Romero-Wolf, M., Goel, A., & Jadhav, U. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.03.036 · Cited by 40

Targeting Enhancer of Zeste Homolog 2 as a promising strategy for cancer treatment

Marchesi, I., & Bagella, L. (2016) · World Journal of Clinical Oncology · doi:10.5306/wjco.v7.i2.135 · Cited by 38

Epigenetic alterations in cancer and personalized cancer treatment

Miozzo, M. R., Vaira, V., & Sirchia, S. M. (2015) · Future Oncology · doi:10.2217/fon.14.237 · Cited by 37

Polycomb group genes are targets of aberrant DNA methylation in renal cell carcinoma

Avissar-Whiting, M., Koestler, D. C., Houseman, E. A., Christensen, B. C., Kelsey, K. T., & Marsit, C. J. (2011) · Epigenetics · doi:10.4161/epi.6.6.16158 · Cited by 37

Synergistic chromatin repression of the tumor suppressor geneRARBin human prostate cancers

Moison, C., Assemat, F., Daunay, A., Tost, J., Guieysse‐Peugeot, A., & Arimondo, P. B. (2014) · Epigenetics · doi:10.4161/epi.27869 · Cited by 40

A DNA methylation signature associated with the epigenetic repression of glycine N-methyltransferase in human hepatocellular carcinoma

Huidobro, C., Toraño, E. G., Fernández, A. F., Urdinguio, R. G., Rodríguez, R. M., Ferrero, C., Martínez‐Camblor, P., Boix, L., Bruix, J., García‐Rodríguez, J. L., et al. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1010-8 · Cited by 37

Epigenome remodelling in breast cancer: insights from an early in vitro model of carcinogenesis

Locke, W. J., & Clark, S. J. (2012) · Breast Cancer Research · doi:10.1186/bcr3237 · Cited by 36

Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors

Martín-Trujillo, Á., Vidal, E., Monteagudo, A., Sánchez-Delgado, M., Morán, S., Mora, J. R. H., Heyn, H., Guitart, M., Esteller, M., & Monk, D. (2017) · Nature Communications · doi:10.1038/s41467-017-00639-9 · Cited by 37

Epigenetic alterations associated with cellular senescence: A barrier against tumorigenesis or a red carpet for cancer?

Decottignies, A., & di Fagagna, F. D. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.09.003 · Cited by 37

Ovarian cancer plasticity and epigenomics in the acquisition of a stem-like phenotype

Berry, N. B., & Bapat, S. A. (2008) · Journal of Ovarian Research · doi:10.1186/1757-2215-1-8 · Cited by 35

DNA methylation associated with polycomb repression in retinoic acid receptor β silencing

Moison, C., Sénamaud‐Beaufort, C., Fourrière, L., Champion, C., Ceccaldi, A., Lacomme, S., Daunay, A., Tost, J., Arimondo, P. B., & Guieysse‐Peugeot, A. (2013) · The FASEB Journal · doi:10.1096/fj.12-210971 · Cited by 38

As time flies by: Investigating cardiac aging in the short-lived Drosophila model

Blice‐Baum, A. C., Guida, M. C., Hartley, P. S., Adams, P. D., Bodmer, R., & Cammarato, A. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.11.010 · Cited by 41

Neural cell state shifts and fate loss in ageing and age-related diseases

Traxler, L., Lucciola, R., Herdy, J. R., Jones, J. R., Mertens, J., & Gage, F. H. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00815-0 · Cited by 37

A Summary of the Biological Processes, Disease-Associated Changes, and Clinical Applications of DNA Methylation

Andersen, G. B., & Tost, J. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7481-8_1 · Cited by 36

Targets and genomic constraints of ectopic Dnmt3b expression

Zhang, Y., Charlton, J., Karnik, R., Beerman, I., Smith, Z. D., Gu, H., Boyle, P., Mi, X., Clement, K., Pop, R., et al. (2018) · eLife · doi:10.7554/elife.40757 · Cited by 37

ACK1–AR and AR–HOXB13 signaling axes: epigenetic regulation of lethal prostate cancers

Kim, E. H., Cao, D., Mahajan, N. P., Andriole, G. L., & Mahajan, K. N. (2020) · NAR Cancer · doi:10.1093/narcan/zcaa018 · Cited by 37

Improved detection of tumor suppressor events in single-cell RNA-Seq data

Teschendorff, A. E., & Wang, N. (2020) · npj Genomic Medicine · doi:10.1038/s41525-020-00151-y · Cited by 33

Charting the dynamic epigenome during B-cell development

Martín-Subero, J. I., & Oakes, C. C. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.08.008 · Cited by 41

Writing and Rewriting the Epigenetic Code of Cancer Cells: From Engineered Proteins to Small Molecules

Blancafort, P., Jin, J. J., & Frye, S. V. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.080697 · Cited by 34

Distinct DNA methylation targets by aging and chronic inflammation: a pilot study using gastric mucosa infected with Helicobacter pylori

Yamashita, S., Nanjo, S., Rehnberg, E., Iida, N., Takeshima, H., Ando, T., Maekita, T., Sugiyama, T., & Ushijima, T. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0789-8 · Cited by 34

Loss of EZH2-like or SU(VAR)3–9-like proteins causes simultaneous perturbations in H3K27 and H3K9 tri-methylation and associated developmental defects in the fungus Podospora anserina

Carlier, F., Li, M., Maroc, L., Debuchy, R., Souaid, C., Noordermeer, D., Grognet, P., & Malagnac, F. (2021) · Epigenetics & Chromatin · doi:10.1186/s13072-021-00395-7 · Cited by 32

CD133 immunohistochemical expression predicts progression and cancer-related death in renal cell carcinoma

da Costa, W. H., Rocha, R. M., da Cunha, I. W., Fonseca, F. P., Guimarães, G. C., & Zéqui, S. D. C. (2011) · World Journal of Urology · doi:10.1007/s00345-011-0769-x · Cited by 34

Epigenetic Marking Prepares the Human HOXA Cluster for Activation During Differentiation of Pluripotent Cells

Atkinson, S. P., Koch, C. M., Clelland, G. K., Willcox, S., Fowler, J. C., Stewart, R., Lako, M., Dunham, I., & Armstrong, L. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0497 · Cited by 34

Chromatin‐modifying proteins in cancer

Fog, C. K., Jensen, K. T., & Lund, A. H. (2007) · Apmis · doi:10.1111/j.1600-0463.2007.apm_776.xml.x · Cited by 35

Profiling of aberrant DNA methylation in acute myeloid leukemia reveals subclasses of CG-rich regions with epigenetic or genetic association

Gebhard, C., Glatz, D., Schwarzfischer, L., Wimmer, J., Stasik, S., Nuetzel, M., Heudobler, D., Andreesen, R., Ehninger, G., Thiede, C., et al. (2018) · Leukemia · doi:10.1038/s41375-018-0165-2 · Cited by 34

Structural biology-based insights into combinatorial readout and crosstalk among epigenetic marks

Du, J., & Patel, D. J. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.04.011 · Cited by 32

Signification of Hypermethylated in Cancer 1 (HIC1) as Tumor Suppressor Gene in Tumor Progression

Zheng, J., Xiong, D., Sun, X., Wang, J., Hao, M., Ding, T., Xiao, G., Wang, X., Mao, Y., Fu, Y., et al. (2012) · Cancer Microenvironment · doi:10.1007/s12307-012-0103-1 · Cited by 32

DNA Methylation Profiles in Precancerous Tissue and Cancers: Carcinogenetic Risk Estimation and Prognostication Based on DNA Methylation Status

Arai, E., & Kanai, Y. (2010) · Epigenomics · doi:10.2217/epi.10.16 · Cited by 33

Polycomb Repressive Complex 2 Enacts Wnt Signaling in Intestinal Homeostasis and Contributes to the Instigation of Stemness in Diseases Entailing Epithelial Hyperplasia or Neoplasia

Oittinen, M., Popp, A., Kurppa, K., Lindfors, K., Mäki, M., Kaikkonen, M. U., & Viiri, K. M. (2016) · Stem Cells · doi:10.1002/stem.2479 · Cited by 33

Principles of Epigenetic Homeostasis Shared Between Flowering Plants and Mammals

Williams, B. P., & Gehring, M. A. (2020) · Trends in Genetics · doi:10.1016/j.tig.2020.06.019 · Cited by 35

Stochastic Epigenetic Mutations Are Associated with Risk of Breast Cancer, Lung Cancer, and Mature B-cell Neoplasms

Gagliardi, A., Dugué, P., Nøst, T. H., Southey, M. C., Buchanan, D. D., Schmidt, D. F., Makalic, E., Hodge, A. M., English, D. R., Doo, N. W., et al. (2020) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-20-0451 · Cited by 31

Histone modification alteration coordinated with acquisition of promoter DNA methylation during Epstein-Barr virus infection

Funata, S., Matsusaka, K., Yamanaka, R., Yamamoto, S., Okabe, A., Fukuyo, M., Aburatani, H., Fukayama, M., & Kaneda, A. (2017) · Oncotarget · doi:10.18632/oncotarget.19423 · Cited by 33

Epigenetic and Epigenomic Mechanisms Shape Sarcoma and Other Mesenchymal Tumor Pathogenesis

Bennani-Baïti, I. M. (2011) · Epigenomics · doi:10.2217/epi.11.93 · Cited by 32

ConteXt of change—X inactivation and disease

Agrelo, R., & Wutz, A. (2009) · EMBO Molecular Medicine · doi:10.1002/emmm.200900053 · Cited by 33

Agglomerates of aberrant DNA methylation are associated with toxicant-induced malignant transformation

Severson, P. L., Tokar, E. J., Vrba, L., Waalkes, M. P., & Futscher, B. (2012) · Epigenetics · doi:10.4161/epi.22163 · Cited by 33

Induction of aberrant trimethylation of histone H3 lysine 27 by inflammation in mouse colonic epithelial cells

Takeshima, H., Ikegami, D., Wakabayashi, M., Niwa, T., Kim, Y.-J., & Ushijima, T. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs294 · Cited by 32

The multi-omic landscape of transcription factor inactivation in cancer

Teschendorff, A. E., Zheng, S., Feber, A., Yang, Z., Beck, S., & Widschwendter, M. (2016) · Genome Medicine · doi:10.1186/s13073-016-0342-8 · Cited by 30

Insight into origins, mechanisms, and utility of DNA methylation in B-cell malignancies

Oakes, C. C., & Martín-Subero, J. I. (2018) · Blood · doi:10.1182/blood-2018-02-692970 · Cited by 33

DNA methylation correlates of chronological age in diverse human tissue types

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Epigenetic silencing ofNTSR1is associated with lateral and noninvasive growth of colorectal tumors

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