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Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy

Savkur, Rajesh S., Philips, Anne V., Cooper, Thomas A.·2001·Nature Genetics

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  1. Fu, Y.H. et al. An unstable triplet repeat in a gene related to myotonic muscular dystrophy. Science 255, 1256–1258 (1992). · DOI · Paper page
  2. Mahadevan, M. et al. Myotonic dystrophy mutation—an unstable CTG repeat in the 3′ untranslated region of the gene. Science 255, 1253–1255 (1992). · DOI · Paper page
  3. Brook, J.D. et al. Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family member. Cell 68, 799–808 (1992). · DOI · Paper page
  4. Wang, J. et al. Myotonic dystrophy: evidence for a possible dominant-negative RNA mutation. Hum. Mol. Genet. 4, 599–606 (1995). · DOI · Paper page
  5. Tapscott, S.J. Deconstructing myotonic dystrophy. Science 289, 1701–1702 (2000). · DOI
  6. Mankodi, A. et al. Myotonic dystrophy in transgenic mice expressing an expanded CUG repeat. Science 289, 1769–1773 (2000). · DOI · Paper page
  7. Timchenko, L.T. Myotonic dystrophy: the role of RNA CUG triplet repeats. Am. J. Hum. Genet. 64, 360–364 (1999). · DOI
  8. Miller, J.W. et al. Recruitment of human muscleblind proteins to (CUG)n expansions associated with myotonic dystrophy. EMBO J. 19, 4439–4448 (2000). · DOI · Paper page
  9. Ladd, A.N., Charlet-B., N. & Cooper, T.A. The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing. Mol. Cell. Biol. 21, 1285–1296 (2001). · DOI · Paper page
  10. Roberts, R. et al. Altered phosphorylation and intracellular distribution of a (CUG)n triplet repeat RNA-binding protein in patients with myotonic dystrophy and in myotonin protein kinase knockout mice. Proc. Natl Acad. Sci. USA 94, 13221–13226 (1997). · DOI
  11. Philips, A.V., Timchenko, L.T. & Cooper, T.A. Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy. Science 280, 737–741 (1998). · DOI · Paper page
  12. Moxley, R.T., Corbett, A.J., Minaker, K.L. & Rowe, J.W. Whole body insulin resistance in myotonic dystrophy. Ann. Neurol. 15, 157–162 (1984). · DOI
  13. Moxley, R.T. III et al. Decreased insulin sensitivity of forearm muscle in myotonic dystrophy. J. Clin. Invest. 62, 857–867 (1978). · DOI
  14. Vialettes, B. et al. Mechanism and significance of insulin resistance in myotonic dystrophy. Horm. Metab. Res. 18, 395–399 (1986). · doi:10.1055/s-2007-1012325
  15. Moller, D.E., Yokota, A., Caro, J.F. & Flier, J.S. Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man. Mol. Endocrinol. 3, 1263–1269 (1989). · DOI · Paper page
  16. Seino, S. & Bell, G.I. Alternative splicing of human insulin receptor messenger RNA. Biochem. Biophys. Res. Commun. 159, 312–316 (1989). · DOI · Paper page
  17. Mosthaf, L. et al. Functionally distinct insulin receptors generated by tissue-specific alternative splicing. EMBO J. 9, 2409–2413 (1990). · DOI · Paper page
  18. McClain, D.A. Different ligand affinities of the two human insulin receptor splice variants are reflected in parallel changes in sensitivity for insulin action. Mol. Endocrinol. 5, 734–739 (1991). · DOI
  19. Vogt, B., Carrascosa, J.M., Ermel, B., Ullrich, A. & Häring, H.-U. The two isotypes of the human insulin receptor (HIR-A and HIR-B) follow different internalization kinetics. Biochem. Biophys. Res. Commun. 177, 1013–1018 (1991). · DOI
  20. Kellerer, M. et al. Distinct α-subunit structures of human insulin receptor A and B variants determine differences in tyrosine kinase activities. Biochemistry 31, 4588–4596 (1992). · DOI
  21. Kosaki, A. & Webster, N.J.G. Effect of dexamethasone on the alternative splicing of the insulin receptor mRNA and insulin action in HepG2 hepatoma cells. J. Biol. Chem. 268, 21990–21996 (1993). · DOI
  22. Kosaki, A., Pillay, T.S., Xu, L. & Webster, N.J.G. The B isoform of the insulin receptor signals more efficiently than the A isoform in HepG2 cells. J. Biol. Chem. 270, 20816–20823 (1995). · DOI
  23. Morrone, A. et al. RNA metabolism in myotonic dystrophy—patient muscle shows decreased insulin receptor RNA and protein consistent with abnormal insulin resistance. J. Clin. Invest. 99, 1691–1698 (1997). · DOI
  24. Furling, D., Marette, A. & Puymirat, J. Insulin-like growth factor I circumvents defective insulin action in human myotonic dystrophy skeletal muscle cells. Endocrinology 140, 4244–4250 (1999). · DOI
  25. Kellerer, M. et al. Altered pattern of insulin receptor isotypes in skeletal muscle membranes of type 2 (non-insulin-dependent) diabetic subjects. Diabetologia 36, 628–632 (1993). · doi:10.1007/bf00404072
  26. Benecke, H., Flier, J.S. & Moller, D.E. Alternatively spliced variants of the insulin receptor protein. Expression in normal and diabetic human tissues. J. Clin. Invest. 89, 2066–2070 (1992). · DOI
  27. DePirro, R. et al. Decreased insulin receptors but normal glucose metabolism in Duchenne muscular dystrophy. Science 216, 311–313 (1982). · doi:10.1126/science.7063889
  28. Davis, B.M., McCurrach, M.E., Taneja, K.L., Singer, R.H. & Housman, D.E. Expansion of a CUG trinucleotide repeat in the 3′ untranslated region of myotonic dystrophy protein kinase transcripts results in nuclear retention of transcripts. Proc. Natl Acad. Sci. USA 94, 7388–7393 (1997). · DOI · Paper page
  29. Otten, A.D. & Tapscott, S.J. Triplet repeat expansion in myotonic dystrophy alters the adjacent chromatin structure. Proc. Nat. Acad. Sci.USA 92, 5465–5469 (1995). · DOI · Paper page
  30. Klip, A. & Leiter, L.A. Cellular mechanism of action of metformin. Diabetes Care 13, 696–704 (1990). · DOI · Paper page
  31. Kosaki, A., Nelson, J. & Webster, N.J.G. Identification of intron and exon sequences involved in alternative splicing of insulin receptor pre-mRNA. J. Biol. Chem. 273, 10331–10337 (1998). · DOI
  32. DeFronzo, R.A. et al. The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 30, 1000–1007 (1981). · DOI · Paper page
  33. Frasca, F. et al. Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Mol. Cell. Biol. 19, 3278–3288 (1999). · DOI · Paper page
  34. Timchenko, N.A., Welm, A.L., Lu, X. & Timchenko, L.T. CUG repeat binding protein (CUGBP1) interacts with the 5′ region of C/EBPβ mRNA and regulates translation of C/EBPβ isoforms. Nucleic Acids Res. 27, 4517–4525 (1999). · DOI · Paper page
  35. Timchenko, N.A. et al. RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1. J. Biol. Chem. 276, 7820–7826 (2001). · DOI · Paper page
  36. Korade-Mirnics, Z. et al. Myotonic dystrophy: tissue-specific effect of somatic CTG expansions on allele-specific DMAHP/SIX5 expression. Hum. Mol. Genet. 8, 1017–1023 (1999). · doi:10.1093/hmg/8.6.1017
  37. Weintraub, H. et al. Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. Proc. Natl Acad. Sci. USA 86, 5434–5438 (1989). · DOI · Paper page
  38. Sarabia, V., Lam, L., Burdett, E., Leiter, L.A. & Klip, A. Glucose transport in human skeletal muscle cells in culture. Stimulation by insulin and metformin. J. Clin. Invest. 90, 1386–1395 (1992). · DOI · Paper page

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Metadata

Authors
Savkur, R. S., Philips, A. V., & Cooper, T. A.
Venue
Nature Genetics
Published
2001-08-27
Volume
29
Issue
1
Pages
40-47
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
OpenAlex
W1555409852
Cited by
795
References
1
FWCI
11.60
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)

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CoChat. (2026). Citation check: Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy. https://app.cochat.ai/papers/10.1038/ng704
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Savkur, R. S., Philips, A. V., & Cooper, T. A. (2001). Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy. Nature Genetics. https://doi.org/10.1038/ng704

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