MdmX regulates transformation and chromosomal stability in p53-deficient cells
Open accessAbstract
The cellular homologues Mdm2 and MdmX play critical roles in regulating the activity of the p53 tumor suppressor in damaged and non-damaged cells and during development in mice. Recently, we have utilized genetically defined primary cells and mice to reveal that endogenous levels of MdmX can also suppress multipolar mitosis and transformation in hyperploid p53-deficient cells and tumorigenesis in p53-deficient mice. These MdmX functions are not shared by Mdm2, and are distinct from the well-established ability of MdmX to complex with and inhibit p53 activity. Here we discuss some of the ramifications of MdmX loss in p53-deficient cells and mice, and we explore further the fate of MdmX/p53-double null embryonic fibroblasts undergoing multi-polar cell division using time-lapse video microscopy. We also discuss the relationship between chromosomal loss, cell proliferation, and the tumorigenic potential of p53-deficient cells lacking MdmX.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Recent studies determined that Mdmx influences genome stability independently of p53.
“Recent studies determined that Mdmx influences genome stability independent of p53.32,33”
From Mdmx promotes genomic instability independent of p53 and Mdm2 (2015) · cites this paper as [33]
Mdmx has p53-independent functions.
“the identification of Mdmx overexpression in tumors with mutated or deleted p53 and effects of Mdmx on genome instability in cells lacking p53 indicate p53-independent functions of Mdmx.3,19,30–33”
From Mdmx promotes genomic instability independent of p53 and Mdm2 (2015) · cites this paper as [33]
Mdmx−/−p53−/− MEFs have multipolar spindle formation and altered chromosome number.
“Specifically, Mdmx−/−p53−/− MEFs had multipolar spindle formation and altered chromosome number.32,33”
From Mdmx promotes genomic instability independent of p53 and Mdm2 (2015) · cites this paper as [33]
Loss of Mdmx leads to genome instability in MEFs lacking p53.
“Loss of Mdmx also led to genome instability in MEFs lacking p53.”
From Mdmx promotes genomic instability independent of p53 and Mdm2 (2015) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Mdm2 promotes the rapid degradation of p53
Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997) · Nature · doi:10.1038/387296a0 · Cited by 4,506 · see citing works
Momand, J., Zambetti, G. P., Olson, D. C., George, D., & Levine, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90644-r · Cited by 3,113 · see citing works
DNA methylation and epigenetic inheritance
Holliday, R. (1990) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1990.0015 · Cited by 2,290 · see citing works
Vousden, K. H., & Lane, D. P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2147 · Cited by 2,275 · see citing works
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
Honda, R., Tanaka, H., & Yasuda, H. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01480-4 · Cited by 1,951 · see citing works
The p53-mdm-2 autoregulatory feedback loop.
Wu, X., Bayle, J. H., Olson, D., & Levine, A. J. (1993) · Genes & Development · doi:10.1101/gad.7.7a.1126 · Cited by 1,801 · see citing works
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
de Oca Luna, R. M., Wagner, D. S., & Lozano, G. (1995) · Nature · doi:10.1038/378203a0 · Cited by 1,420 · see citing works
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
Toledo, F., & Wahl, G. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc2012 · Cited by 1,286 · see citing works
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
Jones, S. N., Roe, A. E., Donehower, L. A., & Bradley, A. (1995) · Nature · doi:10.1038/378206a0 · Cited by 1,280 · see citing works
Self-citationRegulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
Shenoy, S. K., McDonald, P. H., Kohout, T. A., & Lefkowitz, R. J. (2001) · Science · doi:10.1126/science.1063866 · Cited by 824 · see citing works
From polyploidy to aneuploidy, genome instability and cancer
Štorchová, Z., & Pellman, D. S. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1276 · Cited by 810 · see citing works
Mono- Versus Polyubiquitination: Differential Control of p53 Fate by Mdm2
Li, M., Brooks, C. L., Wu-Baer, F., Chen, D., Baer, R., & Gu, W. (2003) · Science · doi:10.1126/science.1091362 · Cited by 804 · see citing works
Abnormal Centrosome Amplification in the Absence of p53
Fukasawa, K., Choi, T., Kuriyama, R., Rulong, S., & Woude, G. F. V. (1996) · Science · doi:10.1126/science.271.5256.1744 · Cited by 798 · see citing works
Rajagopalan, H., & Christoph Lengauer, C. (2004) · Nature · doi:10.1038/nature03099 · Cited by 730 · see citing works
Aneuploidy Acts Both Oncogenically and as a Tumor Suppressor
Weaver, B. A. A., Silk, A. D., Montagna, C., Verdier-Pinard, P., & Cleveland, D. W. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.12.003 · Cited by 729 · see citing works
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
Yang, J.-Y., Zong, C. S., Xia, W., Yamaguchi, H., Ding, Q., Xie, X., Lang, J.-Y., Lai, C., Chang, C. J., Huang, W., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1676 · Cited by 698 · see citing works
A p53-Dependent Mouse Spindle Checkpoint
Cross, S. M., Sanchez, C. A., Morgan, C. A., Schimke, M. K., Ramel, S., Idzerda, R. L., Raskind, W. H., & Reid, B. J. (1995) · Science · doi:10.1126/science.7871434 · Cited by 660 · see citing works
Assessing TP53 status in human tumours to evaluate clinical outcome
Soussi, T., & Béroud, C. (2001) · Nature reviews. Cancer · doi:10.1038/35106009 · Cited by 659 · see citing works
MDMX: a novel p53‐binding protein with some functional properties of MDM2.
Shvarts, A., Steegenga, W. T., Riteco, N., van Laar, T., Dekker, P., Bazuine, M., van Ham, R. C., van der Houven van Oordt, W., Hateboer, G., van der Eb, A. J., et al. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00919.x · Cited by 648 · see citing works
Inactivation of the p53 pathway in retinoblastoma
Laurie, N. A., Donovan, S. L., Shih, C.-S., Zhang, J., Mills, N., Fuller, C., Teunisse, A., Lam, S., Ramos, Y., Mohan, A., et al. (2006) · Nature · doi:10.1038/nature05194 · Cited by 595 · see citing works
Interaction between the retinoblastoma protein and the oncoprotein MDM2
Xiao, Z.-X., Chen, J., Levine, A. J., Modjtahedi, N., Xing, J. W., Sellers, W. R., & Livingston, D. M. (1995) · Nature · doi:10.1038/375694a0 · Cited by 586 · see citing works
Mdm2-Mediated NEDD8 Conjugation of p53 Inhibits Its Transcriptional Activity
Xirodimas, D. P., Saville, M. K., Bourdon, J.-C., Hay, R. T., & Lane, D. P. (2004) · Cell · doi:10.1016/j.cell.2004.06.016 · Cited by 570 · see citing works
p53 Mutation and MDM2 amplification in human soft tissue sarcomas.
Leach, F. S., Tokino, T., Meltzer, P. S., Burrell, M., Oliner, J., Smith, S., HILL, D. E., Sidransky, D., Kinzler, K. W., & Vogelstein, B. (1993) · PubMed · Cited by 533 · see citing works
Parant, J., Chavez-Reyes, A., Little, N. A., Yan, W., Reinke, V., Jochemsen, A. G., & Lozano, G. (2001) · Nature Genetics · doi:10.1038/ng714 · Cited by 517 · see citing works
Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6
Freedman, D. A., & Levine, A. J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.12.7288 · Cited by 513 · see citing works
(1994) · PubMed · Cited by 509 · see citing works
Requirement of Cdk2-Cyclin E Activity for Repeated Centrosome Reproduction in Xenopus Egg Extracts
Hinchcliffe, E. H., Li, C., Thompson, E. A., Maller, J. L., & Sluder, G. (1999) · Science · doi:10.1126/science.283.5403.851 · Cited by 506 · see citing works
Self-citation(1993) · PubMed · Cited by 469 · see citing works
Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein
Martin, K., Trouche, D., Hagemeier, C., Sørensen, T. S., Thangue, N. B. L., & Kouzarides, T. (1995) · Nature · doi:10.1038/375691a0 · Cited by 454 · see citing works
Managing the centrosome numbers game: from chaos to stability in cancer cell division
Brinkley, B. R. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01872-9 · Cited by 402 · see citing works
Iwakuma, T., & Lozano, G. (2003) · PubMed · Cited by 390 · see citing works
Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis
Jones, S. N., Hancock, A. R., Vogel, H., Donehower, L. A., & Bradley, A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15608 · Cited by 386 · see citing works
Self-citationThe MDM2 RING-finger domain is required to promote p53 nuclear export
Geyer, R. K., Yu, Z. K., & Maki, C. G. (2000) · Nature Cell Biology · doi:10.1038/35023507 · Cited by 361 · see citing works
Juven‐Gershon, T., Barak, Y., Zauberman, A., George, D. L., & Oren, M. (1993) · PubMed · Cited by 332 · see citing works
Migliorini, D., Denchi, E. L., Danovi, D., Jochemsen, A., Capillo, M., Gobbi, A., Helin, K., Pelicci, P. G., & Marine, J.-C. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5527-5538.2002 · Cited by 313 · see citing works
Proteolytic Cleavage of Human p53 by Calpain: a Potential Regulator of Protein Stability
Kubbutat, M. H. G., & Vousden, K. H. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.1.460 · Cited by 307 · see citing works
MDM2 Promotes Proteasome-Dependent Ubiquitin-Independent Degradation of Retinoblastoma Protein
Sdek, P., Ying, H., Chang, D. L. F., Qiu, W., Zheng, H., Touitou, R., Allday, M. J., & Jim Xiao, Z.-X. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.10.017 · Cited by 288 · see citing works
Sigalas, I., Calvert, A. H., Anderson, J. J., Neal, D. E., & Lunec, J. (1996) · Nature Medicine · doi:10.1038/nm0896-912 · Cited by 268 · see citing works
Osteoblast differentiation and skeletal development are regulated by Mdm2–p53 signaling
Lengner, C. J., Steinman, H. A., Gagnon, J. A., Smith, T. W., Henderson, J. E., Kream, B. E., Stein, G. S., Lian, J. B., & Jones, S. N. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200508130 · Cited by 266 · see citing works
Self-citationMdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells <i>in vivo</i>
Francoz, S., Froment, P., Bogaerts, S., De Clercq, S., Maetens, M., Doumont, G., Bellefroid, E., & Marine, J.-C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508476103 · Cited by 260 · see citing works
Lundgren, K., Montes de Oca Luna, R., McNeill, Y. B., Emerick, E. P., Spencer, B., Barfield, C. R., Lozano, G., Rosenberg, M. P., & Finlay, C. A. (1997) · Genes & Development · doi:10.1101/gad.11.6.714 · Cited by 235 · see citing works
Regulation of Transcription Functions of the p53 Tumor Suppressor by the mdm-2 Oncogene
Chen, J., Lin, J., & Levine, A. J. (1995) · Molecular Medicine · doi:10.1007/bf03401562 · Cited by 214 · see citing works
MDM2 Promotes Cell Motility and Invasiveness by Regulating E-Cadherin Degradation
Yang, J.-Y., Zong, C. S., Xia, W., Wei, Y., Ali-Seyed, M., Li, Z., Broglio, K., Berry, D. A., & Hung, M.-C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00172-06 · Cited by 211 · see citing works
Toledo, F., Krummel, K. A., Lee, C. J., Liu, C.-W., Rodewald, L.-W., Tang, M., & Wahl, G. M. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.03.014 · Cited by 199 · see citing works
mdmx is a negative regulator of p53 activity in vivo.
Finch, R. A., Donoviel, D. B., Potter, D., Shi, M., Fan, A., Freed, D. D., Wang, C.-Y., Zambrowicz, B., Ramírez‐Solis, R., Sands, A., et al. (2002) · PubMed · Cited by 192 · see citing works
Enhanced Mdm2 activity inhibits pRB function via ubiquitin‐dependent degradation
Uchida, C., Miwa, S., Kitagawa, K., Hattori, T., Isobe, T., Otani, S., Oda, T., Sugimura, H., Kamijo, T., Ookawa, K., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600486 · Cited by 184 · see citing works
Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development
Xiong, S., Van Pelt, C. S., Elizondo-Fraire, A. C., Liu, G., & Lozano, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508500103 · Cited by 155 · see citing works
Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4
Grier, J. D., Xiong, S., Elizondo-Fraire, A. C., Parant, J. M., & Lozano, G. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.1.192-198.2006 · Cited by 149 · see citing works
Tip60 is targeted to proteasome‐mediated degradation by Mdm2 and accumulates after UV irradiation
Legube, G., Linares, L. K., Lemercier, C., Scheffner, M., Khochbin, S., & Trouche, D. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1704 · Cited by 145 · see citing works
Genetic convergence and divergence in tumor progression.
Heim, S., Mandahl, N., & Mitelman, F. (1988) · PubMed · Cited by 144 · see citing works
(2002) · PubMed · Cited by 143 · see citing works
The good, the bad and the ugly: the practical consequences of centrosome amplification
Sluder, G., & Nordberg, J. J. (2003) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2003.11.006 · Cited by 136 · see citing works
Self-citationThe Mdm2 Oncoprotein Interacts with the Cell Fate Regulator Numb
Juven‐Gershon, T., Shifman, O., Unger, T., Elkeles, A., Haupt, Y., & Oren, M. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.3974 · Cited by 136 · see citing works
p53 and p21 Form an Inducible Barrier that Protects Cells against Cyclin E-cdk2 Deregulation
Minella, A. C., Swanger, J., Bryant, E. M., Welcker, M., Hwang, H. C., & Clurman, B. E. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01225-3 · Cited by 117 · see citing works
Tritarelli, A., Oricchio, E., Ciciarello, M., Mangiacasale, R., Palena, A., Lavia, P., Soddu, S., & Cundari, E. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-12-0900 · Cited by 98 · see citing works
An Alternative Splice Form of Mdm2 Induces p53-independent Cell Growth and Tumorigenesis
Steinman, H. A., Burstein, E., Lengner, C., Gosselin, J., Pihan, G., Duckett, C. S., & Jones, S. N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m305966200 · Cited by 96 · see citing works
Self-citationCentrosomal amplification and spindle multipolarity in cancer cells
Saunders, W. S. (2004) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2004.09.003 · Cited by 94 · see citing works
A Novel Cellular Protein (MTBP) Binds to MDM2 and Induces a G1 Arrest That Is Suppressed by MDM2
Boyd, M. T., Vlatković, N., & Haines, D. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004252200 · Cited by 93 · see citing works
Two for two: Cdk2 and its role in centrosome doubling
Hinchcliffe, E. H., & Sluder, G. (2002) · Oncogene · doi:10.1038/sj.onc.1205826 · Cited by 88 · see citing works
Self-citationShinmura, K., Bennett, R. A. O., Tarapore, P., & Fukasawa, K. (2006) · Oncogene · doi:10.1038/sj.onc.1210085 · Cited by 87 · see citing works
Wang, P., Lushnikova, T., Odvody, J., Greiner, T. C., Jones, S. N., & Eischen, C. M. (2008) · Oncogene · doi:10.1038/sj.onc.1210788 · Cited by 86 · see citing works
Self-citationTumor promotion by Mdm2 splice variants unable to bind p53.
Fridman, J. S., Hernando, E., Hemann, M. T., de Stanchina, E., Cordon‐Cardo, C., & Lowe, S. W. (2003) · PubMed · Cited by 82 · see citing works
Overexpression of the<i>MDM2</i>Oncogene in Leukemia and Lymphoma
Watanabe, T., Ichikawa, A., Saito, H., & Hotta, T. (1996) · Leukemia & Lymphoma · doi:10.3109/10428199609093436 · Cited by 80 · see citing works
Sdek, P., Ying, H., Zheng, H., Margulis, A. R., Tang, X., Tian, K., & Xiao, Z. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406062200 · Cited by 74 · see citing works
Loss of <i>Mdm4</i> Results in <i>p53</i> -Dependent Dilated Cardiomyopathy
Xiong, S., Van Pelt, C. S., Elizondo-Fraire, A. C., Fernandez-Garcia, B., & Lozano, G. (2007) · Circulation · doi:10.1161/circulationaha.107.689901 · Cited by 71 · see citing works
Boesten, L. S. M., Zadelaar, S. M., De Clercq, S., Francoz, S., van Nieuwkoop, A., Biessen, E. A. L., Hofmann, F., Feil, S., Feil, R., Jochemsen, A. G., et al. (2006) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401973 · Cited by 70 · see citing works
Transcriptional Control of BubR1 by p53 and Suppression of Centrosome Amplification by BubR1
Oikawa, T., Okuda, M., Ma, Z., Goorha, R. M., Tsujimoto, H., INOKUMA, H., & Fukasawa, K. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.10.4046-4061.2005 · Cited by 68 · see citing works
Chiba, S., Okuda, M., Mussman, J. G., & Fukasawa, K. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4916 · Cited by 65 · see citing works
Distinct roles of Mdm2 and Mdm4 in red cell production
Maetens, M., Doumont, G., Clercq, S. D., Francoz, S., Froment, P., Bellefroid, E., Klingmuller, U., Lozano, G., & Marine, J.-C. (2007) · Blood · doi:10.1182/blood-2006-03-013656 · Cited by 64 · see citing works
Matijasevic, Z., Steinman, H. A., Hoover, K., & Jones, S. N. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01108-07 · Cited by 58 · see citing works
Self-citationRescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development
Steinman, H. A., Hoover, K. L., Keeler, M. L., Sands, A., & Jones, S. N. (2005) · Oncogene · doi:10.1038/sj.onc.1208930 · Cited by 52 · see citing works
Self-citationMDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins.
Yam, C. H., Siu, W. Y., Arooz, T., Chiu, C. H. S., Lau, A. W. S., Wang, X. Q., & Poon, R. Y. C. (1999) · PubMed · Cited by 46 · see citing works
MdmX inhibits Smad transactivation
Kadakia, M., Brown, T. L., McGorry, M. M., & Berberich, S. J. (2002) · Oncogene · doi:10.1038/sj.onc.1205993 · Cited by 39 · see citing works
Steinman, H. A., Sluss, H. K., Sands, A., Pihan, G. A., & Jones, S. N. (2004) · Oncogene · doi:10.1038/sj.onc.1206925 · Cited by 35 · see citing works
Self-citationThe E2F‐1 transcription factor is negatively regulated by its interaction with the MDMX protein
Strachan, G. D., Jordan‐Sciutto, K. L., Rallapalli, R., Tuan, R. S., & Hall, D. J. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10318 · Cited by 24 · see citing works
MdmX Represses E2F1 Transactivation
Wunderlich, M., Ghosh, M., Weghorst, K., & Berberich, S. J. (2004) · Cell Cycle · doi:10.4161/cc.3.4.746 · Cited by 23 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
MDM2, MDMX and p53 in oncogenesis and cancer therapy
Wade, M., Li, Y.-C., & Wahl, G. M. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3430 · Cited by 1,279 · see citing works
Eischen, C. M. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026096 · Cited by 161 · see citing works
The Mdm network and its regulation of p53 activities: a rheostat of cancer risk
Eischen, C. M., & Lozano, G. (2014) · Human Mutation · doi:10.1002/humu.22524 · Cited by 79 · see citing works
Mdmx promotes genomic instability independent of p53 and Mdm2
Carrillo, A. M., Bouska, A., Arrate, M. P., & Eischen, C. M. (2015) · Oncogene · doi:10.1038/onc.2014.27 · Cited by 69 · see citing works
Protecting the genome from mdm2 and mdmx
Melo, A. N., & Eischen, C. M. (2012) · Genes & Cancer · doi:10.1177/1947601912454139 · Cited by 20 · see citing works
- Authors
- Matijasevic, Z., Krzywicka-Racka, A., Sluder, G., & Jones, S. N.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Jones, Stephen N.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2008-10
- Volume
- 7
- Issue
- 19
- Pages
- 2967-2973
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- PMC
- PMC2716213
- OpenAlex
- W2025966252
- Cited by
- 34
- References
- 76
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 6 · 2015: 2 · 2014: 5 · 2013: 3 · 2012: 4
- FWCI
- 0.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell Cycle (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (R01CA077735, R01CA77735)
- National Institute of General Medical Sciences (R01GM30758, R01GM030758)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- MDMX, MDM2, p53, p53-deficient cells, chromosome stability, chromosome loss, multipolar mitosis, cell transformation, carcinogenesis, hyperploidy, embryonic fibroblasts, cell proliferation, tumor suppressor regulation
- MeSH terms
- Animals, Cell Division, Cell Transformation, Neoplastic, Humans, Mitosis, Tumor Suppressor Protein p53, Centrosome, Chromosomal Instability, Mice, Proto-Oncogene Proteins c-mdm2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
