The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling
Open accessAbstract
The deaminase ADAR1 edits adenosines in nuclear transcripts of nervous tissue and is required in the fetal liver of the developing mouse embryo. Here we show by inducible gene disruption in mice that ADAR1 is essential for maintenance of both fetal and adult hematopoietic stem cells. Loss of ADAR1 in hematopoietic stem cells led to global upregulation of type I and II interferon–inducible transcripts and rapid apoptosis. Our findings identify ADAR1 as an essential regulator of hematopoietic stem cell maintenance and suppressor of interferon signaling that may protect organisms from the deleterious effects of interferon activation associated with many pathological processes, including chronic inflammation, autoimmune disorders and cancer.
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Self-citationInducible Gene Targeting in Mice
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RNA Editing by Adenosine Deaminases That Act on RNA
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An early haematopoietic defect in mice lacking the transcription factor GATA-2
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Self-citationModulation of microRNA processing and expression through RNA editing by ADAR deaminases
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Cited by
Functions and Regulation of RNA Editing by ADAR Deaminases
Nishikura, K. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060208-105251 · Cited by 1,242
A-to-I editing of coding and non-coding RNAs by ADARs
Nishikura, K. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2015.4 · Cited by 1,041
Aicardi–Goutières syndrome and the type I interferonopathies
Crow, Y. J., & Manel, N. (2015) · Nature Reviews Immunology · doi:10.1038/nri3850 · Cited by 925
Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature
Rice, G. I., Kasher, P. R., Forte, G. M. A., Mannion, N. M., Greenwood, S. M., Szynkiewicz, M., Dickerson, J. E., Bhaskar, S. S., Zampini, M., Briggs, T. A., et al. (2012) · Nature Genetics · doi:10.1038/ng.2414 · Cited by 923
Decoding type I and III interferon signalling during viral infection
Mesev, E. V., LeDesma, R. A., & Ploss, A. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0421-x · Cited by 538
Metadata
- Authors
- Hartner, J. C., Walkley, C. R., Lu, J., & Orkin, S. H.
- Venue
- Nature Immunology
- Published
- 2008-12-07
- Volume
- 10
- Issue
- 1
- Pages
- 109-115
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2059439438
- Cited by
- 490
- References
- 44
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Hartner, J. C., Walkley, C. R., Lu, J., & Orkin, S. H. (2009). ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. Nature Immunology. https://doi.org/10.1038/ni.1680
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
