The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-γ
Open accessAbstract
The differentiation of activated CD4(+) T cells into the T helper type 1 (T(H)1) or T(H)2 fate is regulated by cytokines and the transcription factors T-bet and GATA-3. Whereas interleukin 12 (IL-12) produced by antigen-presenting cells initiates the T(H)1 fate, signals that initiate the T(H)2 fate are not completely characterized. Here we show that early GATA-3 expression, required for T(H)2 differentiation, was induced by T cell factor 1 (TCF-1) and its cofactor beta-catenin, mainly from the proximal Gata3 promoter upstream of exon 1b. This activity was induced after T cell antigen receptor (TCR) stimulation and was independent of IL-4 receptor signaling through the transcription factor STAT6. Furthermore, TCF-1 blocked T(H)1 fate by negatively regulating interferon-gamma (IFN-gamma) expression independently of beta-catenin. Thus, TCF-1 initiates T(H)2 differentiation of activated CD4(+) T cells by promoting GATA-3 expression and suppressing IFN-gamma expression.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In fact, GATA3 expression can also be induced by T cell receptor (TCR) signaling [41] and other pathways, such as Notch [42] and WNT signaling [43].”
From Picroside II Attenuates Airway Inflammation by Downregulating the Transcription Factor GATA3 and Th2-Related Cytokines in a Mouse Model of HDM-Induced Allergic Asthma (2016) · cites this paper as [43]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Zheng, W.-P., & Flavell, R. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80240-8 · Cited by 2,384
XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos
Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O., & Clevers, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80112-9 · Cited by 1,824
Zhu, Z., Homer, R., Wang, Z., Chen, Q., Geba, G. P., Wang, J., Zhang, Y., & Elias, J. A. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5909 · Cited by 1,732
Self-citationThe lineage decisions of helper T cells
MURPHY, K. M. M., & Reiner, S. L. (2002) · Nature reviews. Immunology · doi:10.1038/nri954 · Cited by 1,690
Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells
Kaplan, M. H., Schindler, U., Smiley, S. T., & Grusby, M. J. (1996) · Immunity · doi:10.1016/s1074-7613(00)80439-2 · Cited by 1,629
T-cell priming by type-1and type-2 polarized dendritic cells: the concept of a third signal
Kaliński, P., Hilkens, C. M. U., Wierenga, E. A., & Kapsenberg, M. L. (1999) · Immunology Today · doi:10.1016/s0167-5699(99)01547-9 · Cited by 933
Amsen, D., Blander, J. M., Lee, G. R., Tanigaki, K., Honjo, T., & Flavell, R. A. (2004) · Cell · doi:10.1016/s0092-8674(04)00451-9 · Cited by 910
Prostaglandin E 2 Promotes Colon Cancer Cell Growth Through a G s -Axin-ß-Catenin Signaling Axis
Castellone, M. D., Teramoto, H., Williams, B. O., Druey, K. M., & Gutkind, J. S. (2005) · Science · doi:10.1126/science.1116221 · Cited by 893
Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors
Maretto, S., Cordenonsi, M., Dupont, S., Braghetta, P., Broccoli, V., Hassan, A. B., Volpin, D., Bressan, G. M., & Piccolo, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0434590100 · Cited by 759
The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
Roose, J. P., Molenaar, M., Peterson, J., Hurenkamp, J., Brantjes, H., Moerer, P., van de Wetering, M., Destrée, O., & Clevers, H. C. (1998) · Nature · doi:10.1038/26989 · Cited by 674
Flagged first, then by citations
Cited by
Sorted by citations
Sun, L., Su, Y., Jiao, A., Wang, X., & Zhang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01471-y · Cited by 1,153
How are TH2-type immune responses initiated and amplified?
Paul, W. E., & Zhu, J. (2010) · Nature reviews. Immunology · doi:10.1038/nri2735 · Cited by 997
Differentiation and persistence of memory CD8+ T cells depend on T cell factor 1
Zhou, X.-Y., Yu, S.-Y., Zhao, D.-M., Harty, J., Badovinac, V., & Xue, H.-H. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.002 · Cited by 689
GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice
Wohlfert, E. A., Grainger, J. R., Bouladoux, N., Konkel, J. E., Oldenhove, G., Ribeiro, C. H., Hall, J. A., Yagi, R., Naik, S., Bhairavabhotla, R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57456 · Cited by 556
Iqbal, J., Wright, G. W., Wang, C., Rosenwald, A., Gascoyne, R. D., Weisenburger, D. D., Greiner, T. C., Smith, L. M., Guo, S., Wilcox, R. A., et al. (2014) · Blood · doi:10.1182/blood-2013-11-536359 · Cited by 552
Th17 cells are long lived and retain a stem cell-like molecular signature
Muranski, P., Borman, Z. A., Kerkar, S. P., Klebanoff, C. A., Ji, Y., Sanchez-Perez, L., Sukumar, M., Reger, R. N., Yu, Z., Kern, S. J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.019 · Cited by 443
A critical role for TCF-1 in T-lineage specification and differentiation
Weber, B., Chi, A. W. S., Chavez, A., Yashiro–Ohtani, Y., Yang, Q., Shestova, O. E., & Bhandoola, A. (2011) · Nature · doi:10.1038/nature10279 · Cited by 433
Essentials of Th17 cell commitment and plasticity
Muranski, P. J., & Restifo, N. P. (2013) · Blood · doi:10.1182/blood-2012-09-378653 · Cited by 421
Choi, Y. S., Gullicksrud, J. A., Xing, S., Zeng, Z., Shan, Q., Li, F., Love, P. E., Peng, W., Xue, H., & Crotty, S. (2015) · Nature Immunology · doi:10.1038/ni.3226 · Cited by 337
WNT/β-Catenin Signaling Pathway Regulating T Cell-Inflammation in the Tumor Microenvironment
Li, X., Xiang, Y., Li, F., Yin, C., Li, B., & Ke, X. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02293 · Cited by 291
A cellular and molecular view of T helper 17 cell plasticity in autoimmunity
Stadhouders, R., Lubberts, E., & Hendriks, R. W. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.12.007 · Cited by 298
TCF1 in T cell immunity: a broadened frontier
Zhao, X., Shan, Q., & Xue, H. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00563-6 · Cited by 252
GATA3: a master of many trades in immune regulation
Wan, Y. Y. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.04.002 · Cited by 248
T Cell Factor 1 Is Required for Group 2 Innate Lymphoid Cell Generation
Yang, Q., Monticelli, L. A., Saenz, S. A., Chi, A. W.-S., Sonnenberg, G. F., Tang, J.-B., Obaldia, M. E. D., Bailis, W., Bryson, J. L., Toscano, K., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.003 · Cited by 254
WNT Signaling in Cancer Immunosurveillance
Galluzzi, L., Spranger, S., Fuchs, E. V., & López‐Soto, A. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.08.005 · Cited by 245
Xu, L., Cao, Y., Xie, Z., Huang, Q., Baï, Q., Yang, X., He, R., Hao, Y., Wang, H., Zhao, T., et al. (2015) · Nature Immunology · doi:10.1038/ni.3229 · Cited by 230
Canonical and Non-Canonical Wnt Signaling in Immune Cells
Chae, W.-J., & Bothwell, A. L. M. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.08.006 · Cited by 221
T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling
Germar, K., Dose, M., Konstantinou, T., Zhang, J., Wang, H., Lobry, C., Arnett, K. L., Blacklow, S. C., Aifantis, I., Aster, J. C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110230108 · Cited by 225
NK Cell Terminal Differentiation: Correlated Stepwise Decrease of NKG2A and Acquisition of KIRs
Béziat, V., Descours, B., Parizot, C., Debré, P., & Vieillard, V. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011966 · Cited by 228
T cell factor 1: A master regulator of the T cell response in disease
Escobar, G., Mangani, D., & Anderson, A. C. (2020) · Science Immunology · doi:10.1126/sciimmunol.abb9726 · Cited by 211
“However, enforced expression of ICAT, which specifically inhibits the interaction between -catenin and TCF1, did not affect IFN production by CD4+ T cells (25).”
BackgroundThe Effects of TLR Activation on T-Cell Development and Differentiation
Jin, B., Sun, T., Yu, X., Yang, Y., & Yeo, A. E. T. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/836485 · Cited by 209
Global Regulator SATB1 Recruits β-Catenin and Regulates TH2 Differentiation in Wnt-Dependent Manner
Notani, D., Gottimukkala, K. P., Jayani, R. S., Limaye, A. S., Damle, M., Mehta, S. S., Purbey, P. K., Joseph, J., & Galande, S. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000296 · Cited by 198
The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex
Heikamp, E., Patel, C. H., Collins, S., Waickman, A. T., Oh, M. H., Sun, I., Illei, P. B., Sharma, A., Náray‐Fejes‐Tóth, A., Fejes‐Tóth, G., et al. (2014) · Nature Immunology · doi:10.1038/ni.2867 · Cited by 198
Self-citationTargeting Wnt/β-Catenin Signaling for Cancer Immunotherapy
Wang, B., Tian, T., Kalland, K., Ke, X., & Qu, Y. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.03.008 · Cited by 194
STAT6‐dependent and ‐independent mechanisms in T h2 polarization
Maier, E., Duschl, A., & Horejs‐Hoeck, J. (2012) · European Journal of Immunology · doi:10.1002/eji.201242433 · Cited by 191
Wnt/β-Catenin Signaling in T-Cell Immunity and Cancer Immunotherapy
Gattinoni, L., Ji, Y., & Restifo, N. P. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0356 · Cited by 176
TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection
Wu, T., Shin, H. M., Moseman, E. A., Ji, Y., Huang, B., Harly, C., Sen, J. M., Berg, L. J., Gattinoni, L., McGavern, D. B., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.049 · Cited by 172
Self-citationWnt your brain be inflamed? Yes, it Wnt!
Marchetti, B., & Pluchino, S. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.12.001 · Cited by 167
Transcriptional Regulation of Innate and Adaptive Lymphocyte Lineages
Obaldia, M. E. D., & Bhandoola, A. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112032 · Cited by 167
From the cradle to the grave: activities of GATA‐3 throughout T‐cell development and differentiation
Hosoya, T., Maillard, I. P., & Engel, J. D. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00954.x · Cited by 157
The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns
Oestreich, K. J., Huang, A. C., & Weinmann, A. S. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20102144 · Cited by 160
The IFITM protein family in adaptive immunity
Yánez, D. C., Ross, S. E., & Crompton, T. (2019) · Immunology · doi:10.1111/imm.13163 · Cited by 154
Pace, M. J., Graf, E. H., Agosto, L. M., Mexas, A. M., Male, F., Brady, T., Bushman, F. D., & O'Doherty, U. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002818 · Cited by 144
Wnt Signaling in Normal and Malignant HematopoiesisPreprint
Lento, W. E., Congdon, K. L., Voermans, C., Kritzik, M. R., & Reya, T. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008011 · Cited by 139
Notch Simultaneously Orchestrates Multiple Helper T Cell Programs Independently of Cytokine Signals
Bailis, W., Yashiro–Ohtani, Y., Fang, T., Hatton, R. D., Weaver, C. T., Artis, D., & Pear, W. S. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.006 · Cited by 132
STAT4 and T-bet control follicular helper T cell development in viral infections
Weinstein, J. S., Laidlaw, B. J., Lu, Y., Wang, J. K., Schulz, V., Li, N., Herman, E. I., Kaech, S. M., Gallagher, P. G., & Craft, J. E. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170457 · Cited by 128
Wnt Signaling in the Regulation of Immune Cell and Cancer Therapeutics
Haseeb, M., Pirzada, R. H., Ain, Q. U., & Choi, S. (2019) · Cells · doi:10.3390/cells8111380 · Cited by 136
Cytokines of the γc family control CD4+ T cell differentiation and function
Yamane, H., & Paul, W. E. (2012) · Nature Immunology · doi:10.1038/ni.2431 · Cited by 133
Tubular Dickkopf-3 promotes the development of renal atrophy and fibrosis
Federico, G., Meister, M. T., Mathow, D., Heine, G. H., Moldenhauer, G., Popović, Z. V., Nordström, V., Kopp‐Schneider, A., Hielscher, T., Nelson, P. J., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.84916 · Cited by 129
Pathogenic memory type Th2 cells in allergic inflammation
Endo, Y., Hirahara, K., Yagi, R., Tumes, D. J., & Nakayama, T. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.11.003 · Cited by 123
Transcriptional regulatory network for the establishment of CD8+ T cell exhaustion
Seo, W., Jerin, C., & Nishikawa, H. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00568-0 · Cited by 125
IFITM proteins: Understanding their diverse roles in viral infection, cancer, and immunity
Gómez-Herranz, M., Taylor, J., & Sloan, R. D. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102741 · Cited by 125
Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells
Xing, S.-J., Gai, K., Li, X., Shao, P., Zeng, Z., Zhao, X.-D., Zhao, X., Chen, X., Paradee, W., Meyerholz, D., et al. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20182010 · Cited by 101
Transcriptional and epigenetic regulation of T‐helper lineage specification
Tripathi, S. K., & Lahesmaa, R. (2014) · Immunological Reviews · doi:10.1111/imr.12204 · Cited by 118
Pathogenic CD4+ T cells in patients with asthma
Muehling, L. M., Lawrence, M. G., & Woodfolk, J. A. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.02.025 · Cited by 113
Wang, Y., Misumi, I., Gu, A.-D., Curtis, T. A., Su, L., Whitmire, J. K., & Wan, Y. Y. (2013) · Nature Immunology · doi:10.1038/ni.2623 · Cited by 109
Control of Lymphocyte Fate, Infection, and Tumor Immunity by TCF-1
Raghu, D., Xue, H., & Mielke, L. A. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.10.006 · Cited by 98
Onodera, A., Yamashita, M., Endo, Y., Kuwahara, M., Tofukuji, S., Hosokawa, H., Kanai, A., Suzuki, Y., & Nakayama, T. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100760 · Cited by 100
What determines Th2 differentiation, in vitro and in vivo?
Paul, W. E. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.2 · Cited by 99
TCF-1: a maverick in T cell development and function
Gounari, F., & Khazaie, K. (2022) · Nature Immunology · doi:10.1038/s41590-022-01194-2 · Cited by 95
Role of TCF‐1 in differentiation, exhaustion, and memory of CD8 + T cells: A review
Zhang, J., Lyu, T., Cao, Y., & Feng, H. (2021) · The FASEB Journal · doi:10.1096/fj.202002566r · Cited by 109
Regulation of IL-4 Expression in Immunity and Diseases
Ho, I., & Miaw, S. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-0921-5_3 · Cited by 97
Rosen, M. J., Chaturvedi, R., Washington, M. K., Kuhnhein, L. A., Moore, P. D., Coggeshall, S. S., McDonough, E. M., Weitkamp, J.-H., Singh, A. B., Coburn, L. A., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201373 · Cited by 87
Regulation of mature T cell responses by the Wnt signaling pathway
Xue, H., & Zhao, D. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06302.x · Cited by 89
β-Catenin/TCF-1 Pathway in T Cell Development and Differentiation
Ma, J., Wang, R., Fang, X., & Sun, Z. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9367-y · Cited by 83
TCR-Dependent Translational Control of GATA-3 Enhances Th2 Differentiation
Cook, K. D., & Miller, J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902544 · Cited by 79
Zhu, M., Han, Y., Gu, T., Wang, R. Y., Si, X., Kong, D., Zhao, P., Wang, X., Li, J., Zhai, X., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114065 · Cited by 90
Identification of a unique subset of tissue-resident memory CD4 + T cells in Crohn’s disease
Yokoi, T., Murakami, M., Kihara, T., Seno, S., Arase, M., Wing, J. B., Søndergaard, J. N., Kuwahara, R., Minagawa, T., Oguro-Igashira, E., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204269120 · Cited by 82
TCF1 and β-catenin regulate T cell development and function
Yu, Q., Sharma, A., & Sen, J. M. (2010) · Immunologic Research · doi:10.1007/s12026-009-8137-2 · Cited by 80
Self-citationWnts and the hallmarks of cancer
Zhong, Z., Yu, J., Virshup, D. M., & Madan, B. (2020) · Cancer and Metastasis Reviews · doi:10.1007/s10555-020-09887-6 · Cited by 81
Transcriptional regulation of Th2 cell differentiation
Zhu, J. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2009.114 · Cited by 82
Transcription tipping points for T follicular helper cell and T-helper 1 cell fate commitment
Sheikh, A. A., & Groom, J. R. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00554-y · Cited by 72
Godefroy, E., Manches, O., Dréno, B., Hochman, T., Rolnitzky, L. M., Labarrière, N., Guilloux, Y., Goldberg, J. D., Jotereau, F., & Bhardwaj, N. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.01.037 · Cited by 70
Carr, T. M., Krishnamoorthy, V., Yu, S., Xue, H., Kee, B. L., & Verykokakis, M. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20141849 · Cited by 69
From inception to output, Tcf1 and Lef1 safeguard development of T cells and innate immune cells
Steinke, F. C., & Xue, H. (2014) · Immunologic Research · doi:10.1007/s12026-014-8545-9 · Cited by 69
Gullicksrud, J. A., Li, F., Xing, S., Zeng, Z., Peng, W., Badovinac, V. P., Harty, J. T., & Xue, H. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700595 · Cited by 70
TCF-1 limits the formation of Tc17 cells via repression of the MAF–RORγt axis
Mielke, L. A., Liao, Y., Clemens, E. B., Firth, M. A., Duckworth, B. C., Huang, Q., Almeida, F. F., Chopin, M., Koay, H., Bell, C. A., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181778 · Cited by 67
Transcriptional Regulatory Networks for CD4 T Cell Differentiation
Christie, D. A., & Zhu, J. (2014) · Current topics in microbiology and immunology · doi:10.1007/82_2014_372 · Cited by 69
Amodio, V., Mauri, G., Reilly, N. M., Bianchi, A. S., Siena, S., Bardelli, A., & Germano, G. (2021) · Cancers · doi:10.3390/cancers13112638 · Cited by 67
Yu, Q., Sharma, A., Ghosh, A., & Sen, J. M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003497 · Cited by 65
Self-citationRothenberg, E. V., Ungerbäck, J., & Champhekar, A. (2016) · Advances in Immunology · doi:10.1016/bs.ai.2015.09.002 · Cited by 61
Pharmacologic Induction of CD8 + T Cell Memory: Better Living Through Chemistry
Gattinoni, L., Klebanoff, C. A., & Restifo, N. P. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000302 · Cited by 61
Chromatin remodeling resets the immune system to protect against autoimmune diabetes in mice
Patel, T., Patel, V., Singh, R., & Jayaraman, S. (2011) · Immunology and Cell Biology · doi:10.1038/icb.2010.144 · Cited by 57
Wnt Signaling in Remyelination in Multiple Sclerosis: Friend or Foe?
Xie, C., Li, Z., Zhang, G., & Guan, Y. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8584-6 · Cited by 57
Driessens, G., Zheng, Y., Locke, F. L., Cannon, J. L., Gounari, F., & Gajewski, T. F. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001562 · Cited by 54
Critical Role of TCF-1 in Repression of the IL-17 Gene
Ma, J., Wang, R., Fang, X., Ding, Y. P., & Sun, Z. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024768 · Cited by 55
Roles of transcriptional factor 7 in production of inflammatory factors for lung diseases
Zhu, Y., Wang, W. Y., & Wang, X. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0617-7 · Cited by 52
Dai, W., Liu, F., Li, C., Lu, Y., Lu, X., Du, S., Chen, Y., Weng, D., & Chen, J. (2016) · Mediators of Inflammation · doi:10.1155/2016/6235614 · Cited by 54
CD96 expression determines the inflammatory potential of IL-9–producing Th9 cells
Stanko, K., Iwert, C., Appelt, C., Vogt, K., Schumann, J., Strunk, F. J., Ahrlich, S., Schlickeiser, S., Romagnani, C., Jürchott, K., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1708329115 · Cited by 51
Dickkopf-3, a Tissue-Derived Modulator of Local T-Cell Responses
Meister, M. T., Papatriantafyllou, M., Nordström, V., Kumar, V., Ludwig, J., Lui, K. O., Boyd, A. S., Popović, Z. V., Fleming, T. H., Moldenhauer, G., et al. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00078 · Cited by 52
The Role of WNT Signaling in Mature T Cells: T Cell Factor Is Coming Home
van Loosdregt, J., & Coffer, P. J. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800633 · Cited by 50
Transcriptional regulation of adaptive and innate lymphoid lineage specification
Spinner, C. A., & Lazarevic, V. (2020) · Immunological Reviews · doi:10.1111/imr.12935 · Cited by 54
The Wnt inhibitor secreted Frizzled‐Related Protein 1 (sFRP1) promotes human Th17 differentiation
Lee, Y. S., Lee, K., Yoon, H., Yoo, S., Park, Y. W., Chung, Y., Kim, W., & Kang, C. (2012) · European Journal of Immunology · doi:10.1002/eji.201242445 · Cited by 45
Stabilisation of β-Catenin Downstream of T Cell Receptor Signalling
Lovatt, M., & Bijlmakers, M.-J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012794 · Cited by 49
Preite, S., Huang, B., Cannons, J. L., McGavern, D. B., & Schwartzberg, P. L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03079 · Cited by 45
Zhang, H., Fei, C., Wu, H., Yang, M., Liu, Q., Wang, Q., & Zhang, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073871 · Cited by 46
An NK and T Cell Enhancer Lies 280 Kilobase Pairs 3′ to the Gata3 Structural Gene
Hosoya-Ohmura, S., Lin, Y.-H., Herrmann, M., Kuroha, T., Rao, A. U. K., Moriguchi, T., Lim, K.-C., Hosoya, T., & Engel, J. D. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05065-11 · Cited by 45
Memory CD4+ T Cells: fate determination, positive feedback and plasticity
Yamane, H., & Paul, W. E. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0966-9 · Cited by 45
Kang, J., & Malhotra, N. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112025 · Cited by 44
Valencia, J., Martínez, V. G., Hidalgo, L., Hernández‐López, C., Canseco, N. M., Vicente, Á., Varas, A., & Sacedón, R. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.08.015 · Cited by 42
Regulatory gene network circuits underlying T cell development from multipotent progenitors
Kueh, H. Y., & Rothenberg, E. V. (2011) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.162 · Cited by 42
PU.1 Suppresses Th2 Cytokine Expression via Silencing of GATA3 Transcription in Dendritic Cells
Yashiro, T., Kubo, M., Ogawa, H., Okumura, K., & Nishiyama, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137699 · Cited by 43
Mazzola, M. A., Raheja, R., Murugaiyan, G., Rajabi, H. N., Kumar, D. V., Pertel, T., Regev, K., Griffin, R. L., Aly, L., Kivisäkk, P., et al. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0460-z · Cited by 41
Colorectal cancer cells suppress CD4+ T cells immunity through canonical Wnt signaling
Sun, X., Liu, S., Wang, D., Zhang, Y., Li, W., Guo, Y., Zhang, H., & Suo, J. (2017) · Oncotarget · doi:10.18632/oncotarget.14834 · Cited by 40
Transcriptional regulation of CD4+ TH cells that mediate tissue inflammation
Loo, T. T., Gao, Y., & Lazarevic, V. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.1ri0418-152rr · Cited by 43
A Critical Role for the Regulated Wnt–Myc Pathway in Naive T Cell Survival
Wong, C.-S., Chen, C., Wu, Q., Liu, Y., & Zheng, P. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401238 · Cited by 41
Functional definition of a transcription factor hierarchy regulating T cell lineage commitment
García-Pérez, L., Famili, F., Cordes, M., Brugman, M. H., van Eggermond, M. C. J. A., Wu, H., Chouaref, J., León, D. S., Tiemessen, M. M., Pike‐Overzet, K., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaw7313 · Cited by 40
TCF-1 maintains CD8+ T cell stemness in tumor microenvironment
Wen, S., Lu, H., Wang, D., Guo, J., Dai, W., & Wang, Z. (2021) · Journal of Leukocyte Biology · doi:10.1002/jlb.5mr1120-778r · Cited by 43
T Cell Factor-1 and β-Catenin Control the Development of Memory-like CD8 Thymocytes
Sharma, A., Chen, Q., Nguyen, T. T. T., Yu, Q., & Sen, J. M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103729 · Cited by 38
Self-citationThe effect of Wnt/β-catenin signaling on PD-1/PDL-1 axis in HPV-related cervical cancer
Aghbash, P. S., Hemmat, N., Baradaran, B., Mokhtarzadeh, A., Poortahmasebi, V., Oskouee, M. A., & Baghi, H. B. (2022) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2022.026776 · Cited by 39
Metadata
- Authors
- Yu, Q., Sharma, A., Oh, S. Y., Moon, H.-G., Hossain, M. Z., Salay, T. M., Leeds, K. E., Du, H., Wu, B., Waterman, M. L., Zhu, Z., & Sen, J. M.
- Affiliations
- National Institutes of Health (US)
- Johns Hopkins University (US)
- University of California, Irvine (US)
- Corresponding author
- Sen, Jyoti Misra
- ORCID
- Venue
- Nature Immunology
- Published
- 2009-08-02
- Volume
- 10
- Issue
- 9
- Pages
- 992-999
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC2824257
- OpenAlex
- W2007359758
- Cited by
- 208
- References
- 50
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 11 · 2023: 4 · 2022: 10 · 2021: 16 · 2020: 12 · 2019: 11 · 2018: 10 · 2017: 12 · 2016: 16 · 2015: 20 · 2014: 13 · 2013: 14 · 2012: 15
- FWCI
- 7.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Canadian Institute for Theoretical Astrophysics
- National Institutes of Health
- National Institute on Aging (Z01AG000772)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Keywords
- TCF1, GATA3, T cell receptor signaling, β-catenin, CD4+ T cell polarization, STAT6, T-bet
- MeSH terms
- Animals, Cell Differentiation, Interferon-gamma, Mice, Inbred C57BL, Promoter Regions, Genetic, Receptors, Antigen, T-Cell, Interleukin-4, Th2 Cells, Interleukin-12, GATA3 Transcription Factor, beta Catenin, Mice, T Cell Transcription Factor 1, Receptors, Notch
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review