The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
TRPV2 has a pivotal role in macrophage particle binding and phagocytosis
Open accessAbstract
Macrophage phagocytosis is critical for defense against pathogens. Whereas many steps of phagocytosis involve ionic flux, the underlying ion channels remain ill defined. Here we show that zymosan-, immunoglobulin G (IgG)- and complement-mediated particle binding and phagocytosis were impaired in macrophages lacking the cation channel TRPV2. TRPV2 was recruited to the nascent phagosome and depolarized the plasma membrane. Depolarization increased the synthesis of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2), which triggered the partial actin depolymerization necessary for occupancy-elicited phagocytic receptor clustering. TRPV2-deficient macrophages were also defective in chemoattractant-elicited motility. Consequently, TRPV2-deficient mice showed accelerated mortality and greater organ bacterial load when challenged with Listeria monocytogenes. Our data demonstrate the participation of TRPV2 in early phagocytosis and its fundamental importance in innate immunity.
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Cites
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Yeung, T., Terebiznik, M., Yu, L., Silvius, J., Abidi, W. M., Philips, M., Levine, T., Kapus, A., & Grinstein, S. (2006) · Science · doi:10.1126/science.1129551 · Cited by 329
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Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing
Atcha, H., Jairaman, A., Holt, J. R., Meli, V. S., Nagalla, R. R., Veerasubramanian, P. K., Brumm, K. T., Lim, H. E., Othy, S., Cahalan, M. D., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23482-5 · Cited by 644
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A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis via Focal Exocytosis
Samie, M., Wang, X., Zhang, X., Goschka, A., Li, X., Cheng, X., Gregg, E., Azar, M., Zhuo, Y., Garrity, A. G., et al. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.08.003 · Cited by 317
Metadata
- Authors
- Link, T. M., Park, U., Vonakis, B. M., Raben, D. M., Soloski, M. J., & Caterina, M. J.
- Venue
- Nature Immunology
- Published
- 2010-01-31
- Volume
- 11
- Issue
- 3
- Pages
- 232-239
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1964159573
- Cited by
- 323
- References
- 1
- FWCI
- 10.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Link, T. M., Park, U., Vonakis, B. M., Raben, D. M., Soloski, M. J., & Caterina, M. J. (2010). TRPV2 has a pivotal role in macrophage particle binding and phagocytosis. Nature Immunology. https://doi.org/10.1038/ni.1842
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