The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells
Open accessAbstract
Weak T cell antigen receptor (TCR) signals from contact with self ligands act in synergy with antiapoptotic signals induced by interleukin 7 (IL-7) to promote the survival of naive T cells in a resting state. The amount of background TCR signaling in naive T cells is set by post-thymic TCR tuning and operates at an intensity just below that required to induce entry into the cell cycle. Costimulation from higher concentrations of IL-7 and other common γ-chain cytokines can induce T cells to undergo homeostatic proliferation and conversion into cells with a memory phenotype; many of these memory phenotype cells may be the progeny of cells responding to self antigens. The molecular mechanisms that control the conversion of naive resting T cells into memory-phenotype cells TCR-dependent in normal animals are beginning to be understood.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Homeostasis of Naive and Memory T Cells
Surh, C. D., & Sprent, J. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.002 · Cited by 1,193
Self-citationTurnover of naive- and memory-phenotype T cells.
Tough, D. F., & Sprent, J. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.4.1127 · Cited by 869
Self-citationEndogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection
Obar, J. J., Khanna, K. M., & Lefrançois, L. (2008) · Immunity · doi:10.1016/j.immuni.2008.04.010 · Cited by 449
Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes
Stefanová, I., Dorfman, J. R., & Germain, R. N. (2002) · Nature · doi:10.1038/nature01146 · Cited by 389 · cited 1×
“Depriving CD4 + T cells of contact with MHC class II induces a rapid decrease in phosphorylation of TCRζ and lower responses to foreign antigen”
BackgroundKieper, W. C., Troy, A., Burghardt, J. T., Ramsey, C., Lee, J. Y., Jiang, H.-Q., Dummer, W., Shen, H., Cebra, J. J., & Surh, C. D. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3158 · Cited by 250
Lo, W.-L., Felix, N. J., Walters, J. J., Rohrs, H., Gross, M. L., & Allen, P. M. (2009) · Nature Immunology · doi:10.1038/ni.1796 · Cited by 105
Cited by
The twilight of immunity: emerging concepts in aging of the immune system
Nikolich-Žugich, J. (2018) · Nature Immunology · doi:10.1038/s41590-017-0006-x · Cited by 1,240
Regulation and function of mTOR signalling in T cell fate decisions
Chi, H. (2012) · Nature Reviews Immunology · doi:10.1038/nri3198 · Cited by 1,035
Immunosenescence and human vaccine immune responses
Crooke, S. N., Ovsyannikova, I. G., Poland, G. A., & Kennedy, R. B. (2019) · Immunity & Ageing · doi:10.1186/s12979-019-0164-9 · Cited by 530
Mechanisms underlying T cell ageing
Goronzy, J. J., & Weyand, C. M. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0180-1 · Cited by 506
Understanding subset diversity in T cell memory
Jameson, S. C., & Masopust, D. (2018) · Immunity · doi:10.1016/j.immuni.2018.02.010 · Cited by 523
Metadata
- Authors
- Sprent, J., & Surh, C. D.
- Venue
- Nature Immunology
- Published
- 2011-05-18
- Volume
- 12
- Issue
- 6
- Pages
- 478-484
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2058158581
- Cited by
- 479
- References
- 6
- FWCI
- 15.71
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells. https://app.cochat.ai/papers/10.1038/ni.2018
- The paper
- Sprent, J., & Surh, C. D. (2011). Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells. Nature Immunology. https://doi.org/10.1038/ni.2018
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
