The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques
Open accessAbstract
Atherosclerotic plaque formation is fueled by the persistence of lipid-laden macrophages in the artery wall. The mechanisms by which these cells become trapped, thereby establishing chronic inflammation, remain unknown. Here we found that netrin-1, a neuroimmune guidance cue, was secreted by macrophages in human and mouse atheroma, where it inactivated the migration of macrophages toward chemokines linked to their egress from plaques. Acting via its receptor, UNC5b, netrin-1 inhibited the migration of macrophages directed by the chemokines CCL2 and CCL19, activation of the actin-remodeling GTPase Rac1 and actin polymerization. Targeted deletion of netrin-1 in macrophages resulted in much less atherosclerosis in mice deficient in the receptor for low-density lipoprotein and promoted the emigration of macrophages from plaques. Thus, netrin-1 promoted atherosclerosis by retaining macrophages in the artery wall. Our results establish a causative role for negative regulators of leukocyte migration in chronic inflammation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Three mechanisms are available for cholesterol removal from the atherosclerotic plaque (FIG. 3).”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [138]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Macrophages in the Pathogenesis of Atherosclerosis
Moore, K. J., & Tabas, I. (2011) · Cell · doi:10.1016/j.cell.2011.04.005 · Cited by 2,669
Self-citationStewart, C. R., Stuart, L. M., Wilkinson, K., van Gils, J. M., Deng, J., Halle, A., Rayner, K. J., Boyer, L., Zhong, R., Frazier, W. A., et al. (2010) · Nature Immunology · doi:10.1038/ni.1836 · Cited by 1,513
Self-citationTacke, F., Alvarez, D., Kaplan, T. J., Jakubzick, C., Spanbroek, R., Llodra, J., Garin, A., Liu, J., Mack, M., van Rooijen, N., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28549 · Cited by 1,323
Kunjathoor, V., Febbraio, M., Podrez, E., Moore, K., Andersson, L., Koehn, S. L., Rhee, J. S., Silverstein, R., Hoff, H., & Freeman, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209649200 · Cited by 1,064
Self-citationStabilization of atherosclerotic plaques: New mechanisms and clinical targets
Libby, P., & Aikawa, M. (2002) · Nature Medicine · doi:10.1038/nm1102-1257 · Cited by 581
Llodrá, J., Angeli, V., Liu, J. J., Trogan, E., Fisher, E. A. A., & Randolph, G. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403259101 · Cited by 520
Self-citationThe role of the monocyte in atherogenesis: II. Migration of foam cells from atherosclerotic lesions.
Gerrity, R. G. (1981) · PubMed · Cited by 459
Park, Y. M., Febbraio, M., & Silverstein, R. L. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35535 · Cited by 407
Hypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia
Rosenberger, P., Schwab, J. M., Mirakaj, V., Masekowsky, E., Mager, A., Morote–Garcia, J. C., Unertl, K. E., & Eltzschig, H. K. (2009) · Nature Immunology · doi:10.1038/ni.1683 · Cited by 406
The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors
Wu, J. Y., Feng, L., Park, H.-T., Havlioglu, N., Wen, L., Tang, H., Bacon, K. B., Jiang, Z., Zhang, X.-C., & Rao, Y. (2001) · Nature · doi:10.1038/35073616 · Cited by 397
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 364
Netrin-1 Alters Adipose Tissue Macrophage Fate and Function in Obesity
Sharma, M., Schlegel, M., Brown, E. J., Sansbury, B. E., Weinstock, A., Afonso, M. S., Corr, E. M., Solingen, C. V., Shanley, L. C., Peled, D., et al. (2019) · Immunometabolism · doi:10.20900/immunometab20190010 · Cited by 55
Self-citationChronic inflammation and vascular cell plasticity in atherosclerosis
Lin, A., Miano, J. M., Fisher, E. A. A., & Misra, A. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00569-y · Cited by 56
Self-citationStöhr, R., & Federici, M. (2013) · Biochemical Journal · doi:10.1042/bj20130121 · Cited by 51
The Entry and Egress of Monocytes in Atherosclerosis: A Biochemical and Biomechanical Driven Process
Kang, H., Li, X., Xiong, K., Song, Z., Tian, J., Wen, Y., Sun, A., & Deng, X. (2021) · Cardiovascular Therapeutics · doi:10.1155/2021/6642927 · Cited by 57
Silencing Myeloid Netrin-1 Induces Inflammation Resolution and Plaque Regression
Schlegel, M., Sharma, M., Brown, E. J., Newman, A. A. C., Cyr, Y., Afonso, M. S., Corr, E. M., Koelwyn, G. J., Solingen, C. V., Guzman, J., et al. (2021) · Circulation Research · doi:10.1161/circresaha.121.319313 · Cited by 51
Self-citationRoufaiel, M., Gracey, E., Siu, A., Zhu, S.-N., Lau, A. C., Ibrahim, H. M., Althagafi, M. G., Tai, K., Hyduk, S. J., Cybulsky, K. O., et al. (2016) · Nature Immunology · doi:10.1038/ni.3564 · Cited by 50
Boytard, L., Hadi, T., Silvestro, M., Qu, H., Kumpfbeck, A. R., Tellaoui, R. S., Fils, K. H., Alebrahim, D., Boccalatte, F. E., Kugler, M. C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18088-2 · Cited by 49
Self-citationDucarouge, B., Redavid, A. R., Victoor, C., Chira, R., Fonseca, A., Hervieu, M., Bergé, R., Lengrand, J., Vieugué, P., Neves, D., et al. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01209-x · Cited by 46
Self-citationHalvorsen, B. L., Dahl, T. B., Smedbakken, L. M., Singh, A., Michelsen, A. E., Skjelland, M., Krohg‐Sørensen, K., Russell, D., Höpken, U. E., Lipp, M., et al. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu036 · Cited by 50
PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling
Li, J., Conrad, C., Mills, T., Berg, N. K., Kim, B., Ruan, W., Lee, J. W., Zhang, X., Yuan, X., & Eltzschig, H. K. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210008 · Cited by 47
Passacquale, G., Phinikaridou, A., Warboys, C. M., Cooper, M. S., Lavín, B., Alfieri, A., Andía, M. E., Botnar, R. M., & Ferro, A. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13144 · Cited by 51
PCSK9 regulates the chemokine receptor CCR2 on monocytes
Grune, J., Meýborg, H., Bezhaeva, T., Kappert, K., Hillmeister, P., Kintscher, U., Pieske, B. M., & Stawowy, P. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.02.085 · Cited by 51
Passacquale, G., Giosia, P. D., & Ferro, A. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv227 · Cited by 46
Bin, J. M., Rajasekharan, S., Kuhlmann, T., Hanes, I., Marçal, N., Han, D. C., Rodrigues, S., Leong, S. Y., Newcombe, J., Antel, J. P., et al. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.06.004 · Cited by 45
Efferocytosis as a regulator of macrophage chemokine receptor expression and polarization
Angsana, J., Chen, J., Liu, L., Haller, C. A., & Chaikof, E. L. (2016) · European Journal of Immunology · doi:10.1002/eji.201546262 · Cited by 45
The Monocyte in Atherosclerosis — Should I Stay or Should I Go Now?
Gerszten, R. E., & Tager, A. M. (2012) · New England Journal of Medicine · doi:10.1056/nejmcibr1200164 · Cited by 44
Sheng, Q., Lv, Z., Cai, W., Song, H.-L., Qian, L., Mu, H., Shi, J., & Wang, X. (2014) · Pediatric Research · doi:10.1038/pr.2014.93 · Cited by 43
Oksala, N., Pärssinen, J., Seppälä, I., Raitoharju, E., Kholová, I., Hernesniemi, J. A., Lyytikäinen, L., Levula, M., Mäkelä, K.-M., Sioris, T., et al. (2013) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.113.000141 · Cited by 43
Boneschansker, L., Nakayama, H., Eisenga, M. F., Wedel, J., Klagsbrun, M., Irimia, D., & Briscoe, D. M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502432 · Cited by 43
Ferns, G. A., & Heikal, L. (2016) · Angiology · doi:10.1177/0003319716662423 · Cited by 44
Mechanisms of Myeloid Cell Modulation of Atherosclerosis
Świrski, F. K., Nahrendorf, M., & Libby, P. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0026-2015 · Cited by 44
The neuroimmune guidance cue netrin-1: A new therapeutic target in cardiovascular disease
Bongo, J. B., & Peng, D. Q. (2013) · Journal of Cardiology · doi:10.1016/j.jjcc.2013.10.006 · Cited by 42
Netrin-1: A Modulator of Macrophage Driven Acute and Chronic Inflammation
Ziegon, L., & Schlegel, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010275 · Cited by 48
Shu, F., Huang, H., Xiao, S., Xia, Z., & Zheng, Y. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.04.019 · Cited by 41
Ramsey, S. A., Vengrenyuk, Y., Menon, P., Podolsky, I., Feig, J. E., Aderem, A. A., Fisher, E. A. A., & Gold, E. S. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004828 · Cited by 40
Self-citationNetrin Family: Role for Protein Isoforms in Cancer
Bruikman, C. S., Zhang, H., Kemper, A. M., & van Gils, J. M. (2019) · Journal of Nucleic Acids · doi:10.1155/2019/3947123 · Cited by 43
Inosine monophosphate and inosine differentially regulate endotoxemia and bacterial sepsis
Lovászi, M., Németh, Z. H., Gause, W. C., Beesley, J., Pacher, P., & Haskó, G. (2021) · The FASEB Journal · doi:10.1096/fj.202100862r · Cited by 41
Mediero, A., Ramkhelawon, B., Wilder, T., Purdue, P. E., Goldring, S. R., Dewan, M. Z., Loomis, C. A., Moore, K. J., & Cronstein, B. N. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2015-207593 · Cited by 40
Self-citationDuan, H., Jing, L., Xiang, J., Ju, C., Wu, Z., Liu, J., Ma, X., Chen, X., Liu, Z., Feng, J., et al. (2022) · Advanced Science · doi:10.1002/advs.202103719 · Cited by 38
Gonzalez, A. L., Dungan, M. M., Smart, C. D., Madhur, M. S., & Doran, A. C. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0284 · Cited by 42
The phenomenon of atherosclerosis reversal and regression: Lessons from animal models
Chistiakov, D. A., Myasoedova, V. A., Ревин, В. В., Orekhov, A. N., & Bobryshev, Y. V. (2017) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2017.01.013 · Cited by 40
Hypoxia in murine atherosclerotic plaques and its adverse effects on macrophages
Parathath, S., Yang, Y., Mick, S., & Fisher, E. A. A. (2013) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2012.09.004 · Cited by 39
Self-citationInhibition of neogenin fosters resolution of inflammation and tissue regeneration
Schlegel, M., Körner, A., Kaussen, T., Knausberg, U., Gerber, C., Hansmann, G., Jónasdóttir, H. S., Giera, M. A., & Mirakaj, V. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96259 · Cited by 37
Ephrin-Eph signaling usage by a variety of viruses
de Boer, E. C. W., van Gils, J. M., & van Gils, M. J. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105038 · Cited by 37
ATVB Distinguished Scientist Award
Ley, K. F., Gerdes, N., & Winkels, H. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.308611 · Cited by 37
Allergic ocular disorders: a spectrum of diseases.
Ehlers, W. H., & Donshik, P. C. (1992) · PubMed · Cited by 37
Macrophage-derived netrin-1 contributes to endometriosis- associated pain
Ding, S., Guo, X., Zhu, L., Wang, J., Li, T., Yu, Q., & Zhang, X. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-2161 · Cited by 35
Liu, C., Zhao, J., Liu, Y., Huang, Y., Shen, Y., Wang, J., Sun, W., & Sun, Y. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.08.024 · Cited by 38
Netrin‐1 and its receptor Unc5b are novel targets for the treatment of inflammatory arthritis
Mediero, A., Wilder, T., Ramkhelawon, B., Moore, K. J., & Cronstein, B. N. (2016) · The FASEB Journal · doi:10.1096/fj.201600615r · Cited by 36
Self-citationTargeting netrin‐3 in small cell lung cancer and neuroblastoma
Jiang, S., Richaud, M., Vieugué, P., Rama, N., Delcros, J., Siouda, M., Sanada, M., Redavid, A. R., Ducarouge, B., Hervieu, M., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202012878 · Cited by 37
Iqbal, A. J., Regan-Komito, D., Christou, I., White, G. E., McNeill, E., Kenyon, A., Taylor, L., Kapellos, T. S., Fisher, E. A. A., Channon, K. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058744 · Cited by 38
Self-citationMyeloid Cell−Specific ABCA1 Deletion Protects Mice From Bacterial Infection
Zhu, X., Westcott, M. M., Bi, X., Liu, M., Gowdy, K. M., Seo, J., Cao, Q., Gebre, A. K., Fessler, M. B., Hiltbold, E. M., et al. (2012) · Circulation Research · doi:10.1161/circresaha.112.269043 · Cited by 34
Bone-protective Functions of Netrin 1 Protein
Maruyama, K., Kawasaki, T., Hamaguchi, M., Hashimoto, M., Furu, M., Ito, H., Fujii, T., Takemura, N., Karuppuchamy, T., Kondo, T., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.738518 · Cited by 36
Understanding netrins and semaphorins in mature endothelial cell biology
Zhang, H., Vreeken, D., Bruikman, C. S., van Zonneveld, A. J., & van Gils, J. M. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.09.015 · Cited by 35
Neuroimmune interactions in cardiovascular diseases
Carnevale, D., & Lembo, G. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa151 · Cited by 34
Mutual Interplay of Host Immune System and Gut Microbiota in the Immunopathology of Atherosclerosis
Yeh, C., Chen, Y.-H., Liu, S.-F., Kao, H., Wu, M., Yang, K., & Wu, W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228729 · Cited by 37
Mallat, Z. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304794 · Cited by 34
Regulation of Macrophage Activation and Differentiation in Atherosclerosis
Park, S. H. (2021) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2021.10.3.251 · Cited by 33
Low, V. F., Fiorini, Z., Fisher, L. C., & Jasoni, C. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046999 · Cited by 31
Tu, Y., Zhang, L., Tong, L., Wang, Y., Zhang, S., Wang, R., Li, L., & Wang, Z. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.12.030 · Cited by 33
Jackson, W. D., Weinrich, T. W., & Woollard, K. J. (2016) · Scientific Reports · doi:10.1038/srep20038 · Cited by 32
Role of myeloid-derived chemokine CCL5/RANTES at an early stage of atherosclerosis
Jongstra‐Bilen, J., Tai, K., Althagafi, M. G., Siu, A., Scipione, C. A., Karim, S., Polenz, C. K., Ikeda, J., Hyduk, S. J., & Cybulsky, M. I. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.03.010 · Cited by 32
Protective role for netrin-1 during diabetic nephropathy
Tak, E., Ridyard, D. G., Badulak, A., Giebler, A., Shabeka, U., Werner, T., Clambey, E. T., Moldovan, R., Zimmerman, M. A., Eltzschig, H. K., et al. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1041-1 · Cited by 33
Targeting a Monocyte Subset to Reduce Inflammation
Gordon, S. (2012) · Circulation Research · doi:10.1161/res.0b013e31825ec26d · Cited by 31
Aherne, C. M., Collins, C. B., & Eltzschig, H. K. (2013) · Tissue Barriers · doi:10.4161/tisb.24957 · Cited by 31
Developments in the Role of Endothelin-1 in Atherosclerosis: A Potential Therapeutic Target?
Sutton, G., Pugh, D., & Dhaun, N. (2019) · American Journal of Hypertension · doi:10.1093/ajh/hpz091 · Cited by 31
Single-cell RNA sequencing in atherosclerosis: Mechanism and precision medicine
Li, Q., Wang, M., Zhang, S., Jin, M., Chen, R., Luo, Y., & Sun, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.977490 · Cited by 29
The Role of Endoplasmic Reticulum Stress-Glycogen Synthase Kinase-3 Signaling in Atherogenesis
Huang, A., Patel, S., McAlpine, C. S., & Werstuck, G. H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061607 · Cited by 31
Netrin-1: Focus on its role in cardiovascular physiology and atherosclerosis
Claro, V., & Ferro, A. (2020) · JRSM Cardiovascular Disease · doi:10.1177/2048004020959574 · Cited by 34
The Ins and Outs of Inflammatory Cells in Atheromata
Świrski, F. K., Nahrendorf, M., & Libby, P. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.012 · Cited by 30
Netrin Ligands and Receptors: Lessons From Neurons to the Endothelium
Larrieu-Lahargue, F., Thomas, K. R., & Li, D. Y. (2012) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2012.06.010 · Cited by 30
Netrin-1 and the Grade of Atherosclerosis Are Inversely Correlated in Humans
Bruikman, C. S., Vreeken, D., Hoogeveen, R. M., Bom, M. J., Danad, I., Pinto‐Sietsma, S., van Zonneveld, A. J., Knaapen, P., Hovingh, G. K., Stroes, E. S. G., et al. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313624 · Cited by 30
The diverse roles of macrophages in metabolic inflammation and its resolution
Ray, A. G., Odum, O., Wiseman, D., & Weinstock, A. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1147434 · Cited by 31
Deciphering Macrophage Phenotypes upon Lipid Uptake and Atherosclerosis
Lee, J., & Choi, J. (2020) · Immune Network · doi:10.4110/in.2020.20.e22 · Cited by 30
Brown, R. A., Shantsila, E., Varma, C., & Lip, G. Y. H. (2016) · Annals of Medicine · doi:10.1080/07853890.2016.1190861 · Cited by 29
Dual actions of Netrin-1 on islet insulin secretion and immune modulation
Gao, S., Zhang, X., Qin, Y., Xu, S., Zhang, J., Wang, Z., Wang, W., Kong, D., & Li, C. (2016) · Clinical Science · doi:10.1042/cs20160133 · Cited by 29
Liu, R., & Jin, J. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.08.019 · Cited by 29
Wu, X., Ying, H., Yang, Q., Yang, Q., Liu, H., Ding, Y., Zhao, H., Chen, Z., Zheng, R., Lin, H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53621-7 · Cited by 31
Gürses, K. M., Özmen, F., Koçyiğit, D., Yersal, N., Bilgiç, E., Kaya, E., Köprü, Ç. Z., Soyal, T., Doğancı, S., Tokgözoğlu, L. S., et al. (2016) · Journal of Cardiology · doi:10.1016/j.jjcc.2016.08.016 · Cited by 28
Current Understanding of the Mechanisms for Clearance of Apoptotic Cells—A Fine Balance
Hawkins, L., & Devitt, A. (2013) · Journal of Cell Death · doi:10.4137/jcd.s11037 · Cited by 28
Macrophage Polarization in Cerebral Aneurysm: Perspectives and Potential Targets
Shao, L., Qin, X., Liu, J., Jian, Z., Xiong, X., & Liu, R. (2017) · Journal of Immunology Research · doi:10.1155/2017/8160589 · Cited by 28
Dube, P. R., Chikkamenahalli, L. L., Birnbaumer, L., & Vázquez, G. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.12.025 · Cited by 28
Gomez, D. A., & Owens, G. K. (2016) · Circulation Research · doi:10.1161/circresaha.116.310104 · Cited by 28
Plaque-penetrating peptide inhibits development of hypoxic atherosclerotic plaque
She, Z., Hamzah, J., Kotamraju, V. R., Pang, H., Jansen, S. J., & Ruoslahti, E. I. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.07.020 · Cited by 28
Park, G. T., Kwon, Y. W., Lee, T. W., Kwon, S. G., Ko, H., Kim, M. B., & Kim, J. H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02095 · Cited by 27
Recent Advances in the Role of Immunity in Atherosclerosis
Fredman, G., & Spite, M. R. (2013) · Circulation Research · doi:10.1161/circresaha.113.302986 · Cited by 26
Evaluation of Netrin‐1 Levels and Albuminuria in Patients With Diabetes
Ay, E., Marakoğlu, K., Kızmaz, M., & Ünlü, A. (2016) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.21965 · Cited by 26
Netrins & Semaphorins: Novel regulators of the immune response
Feinstein, J., & Ramkhelawon, B. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.09.010 · Cited by 26
Self-citationYin, S., Wang, N., Riabov, V., Mossel, D. M., Larionova, I., Schledzewski, K., Trofimova, O., Sevastyanova, T. N., Zajakina, A., Schmuttermaier, C., et al. (2019) · International Journal of Cancer · doi:10.1002/ijc.32685 · Cited by 26
Hewing, B., & Fisher, E. (2012) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2012.660143 · Cited by 19
Self-citationUNC5 dependence receptor family in human cancer: A controllable double-edged sword
Zhu, Y., Li, Y., & Nakagawara, A. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.05.034 · Cited by 25
Berg, N. K., Li, J., Kim, B., Mills, T., Pei, G., Zhao, Z., Li, X., Zhang, X., Ruan, W., Eltzschig, H. K., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202002407r · Cited by 28
Mukovozov, I., Huang, Y., Zhang, Q., Liu, G. Y., Siu, A., Sokolskyy, Y., Patel, S., Hyduk, S. J., Kutryk, M. J. B., Cybulsky, M. I., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500640 · Cited by 26
Long-term effects on lipid metabolism of weight reduction on lactovegetarian and mixed diet.
Marniemi, J., Seppänen, A., & Hakala, P. (1990) · PubMed · Cited by 25
Bruton's TK regulates myeloid cell recruitment during acute inflammation
Purvis, G. S. D., Aranda-Tavío, H., Channon, K. M., & Greaves, D. R. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15778 · Cited by 23
From netrin‐1‐targeted SPECT/CT to internal radiotherapy for management of advanced solid tumors
Kryza, D., Wischhusen, J. C., Richaud, M., Hervieu, M., Sidi‐Boumedine, J., Delcros, J., Besse, S., Baudier, T., Laval, P., Breusa, S., et al. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202216732 · Cited by 26
Cavin1; a Regulator of Lung Function and Macrophage Phenotype
Govender, P., Romero, F., Shah, D., Paez-Cortez, J. R., Ding, S.-Y., Liu, L., Gower, A. C., Baez, E., Aly, S., Pilch, P. F., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062045 · Cited by 24
MRTF-A regulates proliferation and survival properties of pro-atherogenic macrophages
An, J., Naruse, T. K., Hinohara, K., Soejima, Y., Sawabe, M., Nakagawa, Y., Kuwahara, K., & Kimura, A. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.05.015 · Cited by 23
Kaul, S., Xu, H., Zabalawi, M., Maruko, E. C., Fulp, B. E., Bluemn, T., Brzoza‐Lewis, K. L., Gerelus, M., Weerasekera, R., Kallinger, R., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.004401 · Cited by 24
Guidance Molecules in Vascular Smooth Muscle
Finney, A. C., & Orr, A. W. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01311 · Cited by 23
The role of UNC5b in ox-LDL inhibiting migration of RAW264.7 macrophages and the involvement of CCR7
Yang, X., Zhang, J., Chen, L., Yuan, Z., Qin, X., Wu, Q., Shen, D., He, H., & Yu, C. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.09.178 · Cited by 23
Wu, G., Wang, Z., Shan, P., Huang, S., Lin, S., Huang, W., & Huang, Z. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110495 · Cited by 23
Semaphorin 3F and Netrin-1: The Novel Function as a Regulator of Tumor Microenvironment
Nakayama, H., Kusumoto, C., Nakahara, M., Fujiwara, A., & Higashiyama, S. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01662 · Cited by 31
Haka, A. S., Potteaux, S., Fraser, H., Randolph, G. J., & Maxfield, F. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044823 · Cited by 22
Macrophages, dendritic cells, and regression of atherosclerosis
Feig, J. E., & Feig, J. L. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00286 · Cited by 22
Self-citationThe dynamic lives of macrophage and dendritic cell subsets in atherosclerosis
Taghavie-Moghadam, P. L., Butcher, M. J., & Galkina, E. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12392 · Cited by 21
Muñoz, J. C., Martín, R., Alonso, C., Gutiérrez, B., & Nieto, M. L. (2017) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2017.08.012 · Cited by 22
Xiong, W., Wang, H., Lü, L., Xi, R., Wang, F., Gu, G., & Tao, R. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1336-z · Cited by 22
Neuronal guidance proteins in cardiovascular inflammation
Keller, M., Mirakaj, V., Koeppen, M., & Rosenberger, P. (2021) · Basic Research in Cardiology · doi:10.1007/s00395-021-00847-x · Cited by 22
Association between Inflammation and New-Onset Atrial Fibrillation in Acute Coronary Syndromes
Băghină, R.-M., Crișan, S., Luca, S. A., Pătru, O., Lazăr, M.-A., Văcărescu, C., Negru, A. G., Luca, C. T., & Gaiță, D. I. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13175088 · Cited by 23
Metadata
- Authors
- van Gils, J. M., Derby, M. C., Fernandes, L. R., Ramkhelawon, B., Ray, T. D., Rayner, K. J., Parathath, S., Distel, E., Feig, J. L., Alvarez-Leite, J. I., Rayner, A. J., McDonald, T. O., O'Brien, K. D., Stuart, L. M., Fisher, E. A., Lacy-Hulbert, A., & Moore, K. J.
- Affiliations
- Harvard University (US)
- Universidade Federal de Minas Gerais (BR)
- New York University (US)
- University of Washington (US)
- Corresponding author
- Moore, Kathryn J
- ORCID
- Venue
- Nature Immunology
- Published
- 2012-01-08
- Volume
- 13
- Issue
- 2
- Pages
- 136-143
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC3262880
- OpenAlex
- W2044161694
- Cited by
- 365
- References
- 45
- Citations by year
- 2026: 11 · 2025: 19 · 2024: 30 · 2023: 13 · 2022: 29 · 2021: 28 · 2020: 29 · 2019: 23 · 2018: 21 · 2017: 23 · 2016: 32 · 2015: 30 · 2014: 27 · 2013: 30 · 2012: 17
- FWCI
- 14.48
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (acceptedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Funders
- American Heart Association
- Heart and Stroke Foundation of Canada
- Massachusetts General Hospital
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- National Institutes of Health
- Genentech
- National Heart, Lung, and Blood Institute (R01HL084312, P01HL092969, RC1HL100815)
- National Institute of Allergy and Infectious Diseases (R01AI079198, U01AI073871)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK043351)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cerebrovascular and Carotid Artery Diseases
- Keywords
- netrin-1, atherosclerosis, atherosclerotic plaque, MCP-1, CCL19, Rac1, actin polymerization, chronic inflammation, lipid-laden macrophages, LDL receptor
- MeSH terms
- Netrin Receptors, Netrin-1, Actins, Animals, Cell Movement, Cells, Cultured, Chimera, Humans, Macrophages, Nerve Growth Factors, Neuropeptides, Receptors, Cell Surface, Gene Deletion, Chemokine CCL2, rac GTP-Binding Proteins, rac1 GTP-Binding Protein, Tumor Suppressor Proteins, Atherosclerosis, Mice, Chemokine CCL19, Polymerization, Plaque, Atherosclerotic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
