The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques
van Gils, Janine M, Derby, Merran C, Fernandes, Luciana R, Ramkhelawon, Bhama, Ray, Tathagat D, Rayner, Katey J, Parathath, Sajesh, Distel, Emilie, Feig, Jessica L, Alvarez-Leite, Jacqueline I, Rayner, Alistair J, McDonald, Thomas O, O'Brien, Kevin D, Stuart, Lynda M, Fisher, Edward A, Lacy-Hulbert, Adam, Moore, Kathryn J·2012·Nature Immunology
DOI 10.1038/ni.2205
Cited by (364)
Items 301–364 of 364
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- Restoring compromised blood-retina-barrier integrity with Netrin-1 overexpressionJessica Furtado, Thomas E. Zapadka, Hyo‐Jin Park, Kevin Boyé, Jonathan B. Demb, Anne Eichmann · 2025 · Cellular and Molecular Life Sciences
- DAB2IP: unifying cardiovascular pathogenesis and cardiovascular brain crosstalkYufan Zhou, Peiwen Yang, Hanxun He, Hao Liu, Ping Ye, Jiahong Xia · 2026 · Frontiers in Cardiovascular Medicine
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- The year 2020 in AtherosclerosisChristoph J. Binder, Jan Borén, Alberico Luigi Catapano, Florian Kronenberg, Ziad Mallat, Simona Negrini, Katariina Öörni, Paolo Raggi, Arnold von Eckardstein · 2021 · Atherosclerosis
- The Role of Platelets in the Pathophysiology of Atherosclerosis and Its ComplicationsKerry A. Layne, Gabriella Passacquale, Albert Ferro · 2018 · Elsevier eBooks
- Roles of Macrophage Mitochondrial Oxidative Stress and Mitochondrial Fission in AtherosclerosisYing Wang · 2014
- Plasma netrin-1 levels in Familial Mediterranean fever: A potential biomarker?Ebru Atalar, Kevser Gök, Esra Fırat Oğuz, Ahmet Kor, Yüksel Maraş · 2022 · Journal of Experimental and Clinical Medicine
- "Netrin-slaying nanoparticles: A new frontier in cancer therapy"Vishakha Sherawat, Deepika Sharma · 2025 · BBA Advances
- ‘Emerging cell-specific therapies in cardiovascular disease’Amandeep Rashid Mondal, Ashish Misra · 2025 · Vascular Pharmacology
- Netrin-1 upregulates the its own gene expression and unc5b gene expression, but downregulates ccl19 gene expression in human macrophages THP-1 cell lineEkaterina V. Nekrasova, Sergey Orlov · 2025 · Medical Immunology (Russia)
- Purinergic Signaling, HIF, and ROS Interactions in Myocardial I/R Injury: Therapeutic Potential and Future ProspectiveManish Kumar Singh, Hyeong Rok Yun, Jyotsna Suresh Ranbhise, Sunhee Han, Hanjoon Seo, Seung Geun Yeo, Fu‐Shi Quan, Sung Soo Kim, Insug Kang · 2026 · Cells
- Synovial macrophage-targeted hierarchical microspheres achieve cartilage preservation and pain relief in osteoarthritisGuojiang Zhang, Laibo Zhang, Xiangdong Wen, Guangxian Liu, Dengju Li, Chuanhong Qin, Senbo An, Yawei Sun, Shui Sun · 2026 · Materials Today Bio
- Relationship Between Ox–LDL, Immune Cells, Atheroma Dimensions and Angiographic Measurements Assessed by Coronary Angiography and Intravascular UltrasoundCatarina Ramos, Patrícia Napoleão, Rui Cruz, Cristina Fondinho, Mafalda Selas, Miguel Mota, Ana María, Teresa Pinheiro · 2013 · InTech eBooks
- Clinical Relevance in Disease States: Heart Failure and Coronary DiseaseRebeca Alonso‐Arias, Raquel Marcos-Fernández, María Iglesias-Escudero, Marco Antonio Moro‐García · 2019 · Springer eBooks
- Role of macrophages in prevention and control of diseases and their upregulation through cowpathyRikhi Singh Chauhan, Divya Chauhan · 2022 · International Journal of Cow Science
- Atherosclerosis is the outcome of adaptive complexity in the Arterial Endothelial MicroenvironmentTrina Roy, Aleepta Guha Ray, Arun Bandyopadhyay · 2024 · Elsevier eBooks
- Axon guidance: NetrinsMarc Tessier‐Lavigne · 2020 · Elsevier eBooks
- Mechanisms of Myeloid Cell Modulation of AtherosclerosisFilip K. Świrski, Matthias Nahrendorf, Peter Libby · 2017 · ASM Press eBooks
- LipoproteinsPeter Libby · 2015 · Elsevier eBooks
- Editorial: Misguided Macrophage and Risk of Coronary AtherosclerosisAfaque Alam Md · 2016 · Journal of Vascular Medicine & Surgery
- AtherosclerosisHong S. Lu, Alan Daugherty · 2013 · Current Opinion in Lipidology
- The role of syndecan-1 in the resolution of chronic inflammatory responsesJulianty Angsana · 2013 · SMARTech Repository (Georgia Institute of Technology)
- Atherogenesis and Lymphstasis...Connecting the Dots.Lemole Gm · 2016 · PubMed
- The Effects of Discoidin Domain Receptor 1 on Macrophage Phenotype in Vascular Inflammatory DiseaseWinnie Cheuk-Yan Fung · 2015 · TSpace (University of Toronto)
- Cholesterol, HDL and Lymphatic Clearance of the Arterial WallG. Lemole · 2017 · Journal of Cardiology & Cardiovascular Therapy
- Clinical Relevance in Disease States: Heart Failure and Coronary DiseaseRebeca Alonso‐Arias, Raquel Marcos-Fernández, María Iglesias-Escudero, Marco Antonio Moro‐García · 2017 · Springer eBooks
- Rings of FireFilip K. Świrski · 2018 · Arteriosclerosis Thrombosis and Vascular Biology
- Níveis Elevados de Netrina-1 e IL-1β em Mulheres Idosas com SCA: Pior Prognóstico no Acompanhamento de Dois AnosPaola Caroline Lacerda Leocádio, Penélope Lacrísio dos Reis Menta, Melissa Dias, Julia Merladete Fraga, Alessandra Carvalho Goulart, Itamar S Santos, Paulo A. Lotufo, Isabela M Benseñor, Jacqueline Isaura Alvarez-Leite · 2020 · Arquivos Brasileiros de Cardiologia
- RETRACTED: Levetiracetam inhibits THP-1 monocyte chemotaxis and adhesion via the synaptic vesicle 2AYue Zhang, Min Hu, Yue-yu Tang, Bei Zhang, Yinyin Han, Zheng-yu Huang, Chen Chen, Gang Li · 2020 · Biochemical and Biophysical Research Communications · Retracted
- Macrophage-derived Netrin-1 participates in endometriosis-associated painShaojie Ding, Xinyue Guo, Libo Zhu, Jianzhang Wang, Tiantian Li, Qin Ping Yu, Xinmei Zhang · 2019
- Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1Weiyi Qian, Tarik Hadi, Xiao Ma, Michele Silvestro, Cristobal F. Rivera, Apratim Bajpai, Zijing Zhang, Hengdong Qu, Annanina Corsica, Bradley Miscovich et al. · 2020
- 国際生活機能分類(国際障害分類改定版)を障害者のための臨床現場にいかに生かすか--身体障害者リハビリテーションの立場から (特集 WHO国際障害分類改定の意義を考える(上))弥生 大川 · 2002 · リハビリテ-ション研究
- Is Netrin-1 Associated With the Development of Fibrosis in Systemic Sclerosis?Yüksel Maraş, Ahmet Kor, Esra Fırat Oğuz, Alper Sarı, KEVSER GOK, Ali Akdoğan · 2022 · medRxiv
- 2014 Hot Topics2015 · Japanese Journal of Thrombosis and Hemostasis
- Les macrophages piégés par l’athérome2012 · Revue Francophone des Laboratoires
- AtherosclerosisCaitríona Grönberg, Harry Björkbacka · 2012 · Current Opinion in Lipidology
- Genetic Rare Variants Affecting Multiple Pathways in Japanese Patients with Palindromic Rheumatism.Taketo Kawara, Koji Inoue, Shunichi Shiozawa, Kayo Osawa, Koichiro Komai · 2024 · PubMed Central
- Immunomodulation by allograft endothelial cellsSayantan Bose, Vicki Do, Chiara Testini, Suchita Suryakant Jadhav, Nicolas Sailliet, Alvin T. Kho, Masaaki Komatsu, Leo Boneschansker, Sek Won Kong, Johannes Wedel et al. · 2025 · Frontiers in Transplantation
- Proteomics for Novel Biomarker and Drug Target Discovery in Alzheimer DiseaseHuiming Zhu, Minqi Cai, Dezhu Chen, Jiaojiao Sha, Liang Du, Yiqiang Chen, Siyuan Liu, Qian Zheng, Xuefei Wei, Bing Bai · 2025 · Springer eBooks
- Additional file 2 of Hypofucosylation of Unc5b regulated by Fut8 enhances macrophage emigration and prevents atherosclerosisYang, Xi, Ma, Limei, Jun Zhang, Chen, Linmu, Zou, Zhen, Shen, Di, Hui He, Zhang, Lei, Chen, Jun, Yuan, Zhiyi et al. · 2024 · Figshare
- Additional file 1 of Hypofucosylation of Unc5b regulated by Fut8 enhances macrophage emigration and prevents atherosclerosisYang, Xi, Ma, Limei, Jun Zhang, Chen, Linmu, Zou, Zhen, Shen, Di, He, Hui, Zhang, Lei, Chen, Jun, Yuan, Zhiyi et al. · 2024 · Figshare
- Dehydrocorydaline Promotes STAT3 /Bcl‐2 Axis‐Mediated Macrophage Efferocytosis to Attenuate Apoptosis in Atherosclerotic PlaquesLi Hongzheng, Zucheng Shang, Aimei Lu, Yang Wenwen, Mengfan Li, Jiang Wenrui, Lian Wenjing, Zhao Xin, Yu Zikai, Lu Yingdong et al. · 2026 · Phytotherapy Research
- Synthesis of Apolipoprotein A-I in Human Macrophages Enhances their Migratory ActivityE. V. Nekrasova, Ekaterina E. Larionova, M.K. Serebriakova, D. O. Kuzmina, Alexandra Burnusuz, N. P. Gorbunov, S. V. Orlov · 2026 · Cell Biochemistry and Biophysics
- Novel netrin-1–Unc5b–Klf4 axis balances AT2 survival in experimental bronchopulmonary dysplasiaOleksiy Klymenko, Jasmine Mohr, Soula Danopoulos, Ivana Mižik, Celien Kuiper-Makris, Stephanie Stephan, Mohammad A Mahjoub, Cristina M. Alvira, Daniela Rheindorf, Thomas Imhof et al. · 2026 · American Journal of Respiratory Cell and Molecular Biology
- Rôle de CD146 dans l'athéroscléroseMuriel G. Blin · 2016 · theses.fr (ABES)
- Virus de l'hépatite C, Nétrine-1 et réponse aux protéines mal repliées en contexte hépatiqueThomas Lahlali · 2014 · theses.fr (ABES)
- Implication des phagocytes mononuclées dans l'évolution de la plaque d'athérosclérose et relation avec l'homéostasie du cholestérol et des lipoprotéinesLaura Bouchareychas · 2014 · theses.fr (ABES)
- Study of the pair Netrin-1/DCC in Parkinson's diseasMarie Jasmin · 2018 · theses.fr (ABES)
- La nétrine-1 et son récepteur UNC5A en contexte de stress réticulaire et d'inflammation hépatiquesRomain Barnault · 2020 · theses.fr (ABES)
- Netrin-1 in extracellular vesicles : a new secretory pathwayStephany Fiore · 2019 · theses.fr (ABES)
- Effets des faibles doses de rayonnements ionisants γ dans la pathologie athéromateuse : étude des mécanismes de modulation de l’inflammation.Nicolas Rey · 2021 · theses.fr (ABES)
- Étude de l’influence de la glutaminolyse des macrophages dans les maladies cardio-métaboliquesJohanna Merlin · 2020 · theses.fr (ABES)
- Développement d’un modèle physiopathologique de macrophages spumeux de l’athérosclérose : caractérisation phénotypique et fonctionnelle et sélection d’anticorps humains spécifiquesCoraline Borowczyk · 2020 · theses.fr (ABES)
- Rôle de la phosphatase alcaline non spécifique du tissu "TNAP" dans la calcification des plaques d’athéroscléroseLynn Kawtharany · 2022 · theses.fr (ABES)
- Netrin-1 and neurons in hepatocellular carcinomaIevgeniia Chicherova · 2022 · theses.fr (ABES)
- Génétique des mouvements en miroir congénitaux : recherche de nouvelles causes génétiques et étude in vitro de l’impact des variants RAD51 et NTN1Oriane Trouillard · 2023 · theses.fr (ABES)
- Caractérisation d’un facteur de guidage axonal, la Draxine, en tant que nouvelle cible thérapeutique dans le glioblastomeVerena Neururer · 2022 · theses.fr (ABES)
- Deciphering the mechanisms of nerve/tumor Interaction : role of the axon guidance signaling Netrin-1/DCCHiba Haidar · 2024 · theses.fr (ABES)
- Biomarkers and Endothelial Damage in Obesity: An Insight into the Pharmacological ModulationArturo Yonatan Bojórquez-González, Eduardo Gómez-Sánchez, Daniel Osmar Suárez-Rico, Alberto Beltrán-Ramírez, Luis Ricardo Balleza-Alejandri, Luis Daniel López-Murillo, Ernesto Javier Ramírez-Lizardo, Jesús Jonathan García-Galindo · 2026 · International Journal of Molecular Sciences
- Macrophage trafficking and efferocytosis in atherosclerotic plaque regression: Molecular mechanisms and therapeutic perspectivesKeivan Sahebi, Maedeh Bordbar, Saghi Eslamzadeh, Fatemeh Hosseinpour-Soleimani, Amir Tajbakhsh, Amir Savardashtaki, Armin Attar · 2026 · Biomedicine & Pharmacotherapy
- Netrin-1 suppresses CCL2-driven macrophage migration: implications for modulating vascular inflammation and aortic sinus enlargement in hyperlipidaemic miceVasco Claro, Yanira Riffo‐Vasquez, Fulye Argunhan, Albert Ferro · 2026 · Journal of Molecular and Cellular Cardiology Plus
- Editorial for the Special Issue “Molecular Mechanisms and Innovative Therapeutic Approaches in Inflammatory Diseases, Pioneering Precision Medicine Solutions”Héctor A. Cabrera-Fuentes, Elisabeth Deindl, Klaus T. Preissner · 2026 · Current Issues in Molecular Biology