The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques

van Gils, Janine M, Derby, Merran C, Fernandes, Luciana R, Ramkhelawon, Bhama, Ray, Tathagat D, Rayner, Katey J, Parathath, Sajesh, Distel, Emilie, Feig, Jessica L, Alvarez-Leite, Jacqueline I, Rayner, Alistair J, McDonald, Thomas O, O'Brien, Kevin D, Stuart, Lynda M, Fisher, Edward A, Lacy-Hulbert, Adam, Moore, Kathryn J·2012·Nature Immunology

Cited by (364)

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    Kosuke Inoue, Kentaro Uchida, Mitsuyoshi Matsumoto, Ryo Tazawa, Etsuro Ohta, A Hattori, Tomonori Kenmoku, Yuka Ito, Yui Uekusa, Gen Inoue et al. · 2025 · Current Issues in Molecular Biology
  3. Restoring compromised blood-retina-barrier integrity with Netrin-1 overexpression
    Jessica Furtado, Thomas E. Zapadka, Hyo‐Jin Park, Kevin Boyé, Jonathan B. Demb, Anne Eichmann · 2025 · Cellular and Molecular Life Sciences
  4. DAB2IP: unifying cardiovascular pathogenesis and cardiovascular brain crosstalk
    Yufan Zhou, Peiwen Yang, Hanxun He, Hao Liu, Ping Ye, Jiahong Xia · 2026 · Frontiers in Cardiovascular Medicine
  5. Long-Term Prognostic Value of Adipocytokines in Patients with Acute Coronary Syndrome: An 8-Year Clinical Prospective Cohort Study
    Xinchen Wang, Haiwei Bu, Chen Wei, Jingyi Liu, Yuewen Qi, Weichao Shan, Ying Zhang, Lixian Sun · 2024 · Journal of Inflammation Research
  6. The year 2020 in Atherosclerosis
    Christoph J. Binder, Jan Borén, Alberico Luigi Catapano, Florian Kronenberg, Ziad Mallat, Simona Negrini, Katariina Öörni, Paolo Raggi, Arnold von Eckardstein · 2021 · Atherosclerosis
  7. The Role of Platelets in the Pathophysiology of Atherosclerosis and Its Complications
    Kerry A. Layne, Gabriella Passacquale, Albert Ferro · 2018 · Elsevier eBooks
  8. Roles of Macrophage Mitochondrial Oxidative Stress and Mitochondrial Fission in Atherosclerosis
    Ying Wang · 2014
  9. Plasma netrin-1 levels in Familial Mediterranean fever: A potential biomarker?
    Ebru Atalar, Kevser Gök, Esra Fırat Oğuz, Ahmet Kor, Yüksel Maraş · 2022 · Journal of Experimental and Clinical Medicine
  10. "Netrin-slaying nanoparticles: A new frontier in cancer therapy"
    Vishakha Sherawat, Deepika Sharma · 2025 · BBA Advances
  11. ‘Emerging cell-specific therapies in cardiovascular disease’
    Amandeep Rashid Mondal, Ashish Misra · 2025 · Vascular Pharmacology
  12. Netrin-1 upregulates the its own gene expression and unc5b gene expression, but downregulates ccl19 gene expression in human macrophages THP-1 cell line
    Ekaterina V. Nekrasova, Sergey Orlov · 2025 · Medical Immunology (Russia)
  13. Purinergic Signaling, HIF, and ROS Interactions in Myocardial I/R Injury: Therapeutic Potential and Future Prospective
    Manish Kumar Singh, Hyeong Rok Yun, Jyotsna Suresh Ranbhise, Sunhee Han, Hanjoon Seo, Seung Geun Yeo, Fu‐Shi Quan, Sung Soo Kim, Insug Kang · 2026 · Cells
  14. Synovial macrophage-targeted hierarchical microspheres achieve cartilage preservation and pain relief in osteoarthritis
    Guojiang Zhang, Laibo Zhang, Xiangdong Wen, Guangxian Liu, Dengju Li, Chuanhong Qin, Senbo An, Yawei Sun, Shui Sun · 2026 · Materials Today Bio
  15. Relationship Between Ox–LDL, Immune Cells, Atheroma Dimensions and Angiographic Measurements Assessed by Coronary Angiography and Intravascular Ultrasound
    Catarina Ramos, Patrícia Napoleão, Rui Cruz, Cristina Fondinho, Mafalda Selas, Miguel Mota, Ana María, Teresa Pinheiro · 2013 · InTech eBooks
  16. Clinical Relevance in Disease States: Heart Failure and Coronary Disease
    Rebeca Alonso‐Arias, Raquel Marcos-Fernández, María Iglesias-Escudero, Marco Antonio Moro‐García · 2019 · Springer eBooks
  17. Role of macrophages in prevention and control of diseases and their upregulation through cowpathy
    Rikhi Singh Chauhan, Divya Chauhan · 2022 · International Journal of Cow Science
  18. Atherosclerosis is the outcome of adaptive complexity in the Arterial Endothelial Microenvironment
    Trina Roy, Aleepta Guha Ray, Arun Bandyopadhyay · 2024 · Elsevier eBooks
  19. Axon guidance: Netrins
    Marc Tessier‐Lavigne · 2020 · Elsevier eBooks
  20. Mechanisms of Myeloid Cell Modulation of Atherosclerosis
    Filip K. Świrski, Matthias Nahrendorf, Peter Libby · 2017 · ASM Press eBooks
  21. Lipoproteins
    Peter Libby · 2015 · Elsevier eBooks
  22. Editorial: Misguided Macrophage and Risk of Coronary Atherosclerosis
    Afaque Alam Md · 2016 · Journal of Vascular Medicine & Surgery
  23. Atherosclerosis
    Hong S. Lu, Alan Daugherty · 2013 · Current Opinion in Lipidology
  24. The role of syndecan-1 in the resolution of chronic inflammatory responses
    Julianty Angsana · 2013 · SMARTech Repository (Georgia Institute of Technology)
  25. Atherogenesis and Lymphstasis...Connecting the Dots.
    Lemole Gm · 2016 · PubMed
  26. The Effects of Discoidin Domain Receptor 1 on Macrophage Phenotype in Vascular Inflammatory Disease
    Winnie Cheuk-Yan Fung · 2015 · TSpace (University of Toronto)
  27. Cholesterol, HDL and Lymphatic Clearance of the Arterial Wall
    G. Lemole · 2017 · Journal of Cardiology & Cardiovascular Therapy
  28. Clinical Relevance in Disease States: Heart Failure and Coronary Disease
    Rebeca Alonso‐Arias, Raquel Marcos-Fernández, María Iglesias-Escudero, Marco Antonio Moro‐García · 2017 · Springer eBooks
  29. Rings of Fire
    Filip K. Świrski · 2018 · Arteriosclerosis Thrombosis and Vascular Biology
  30. Níveis Elevados de Netrina-1 e IL-1β em Mulheres Idosas com SCA: Pior Prognóstico no Acompanhamento de Dois Anos
    Paola Caroline Lacerda Leocádio, Penélope Lacrísio dos Reis Menta, Melissa Dias, Julia Merladete Fraga, Alessandra Carvalho Goulart, Itamar S Santos, Paulo A. Lotufo, Isabela M Benseñor, Jacqueline Isaura Alvarez-Leite · 2020 · Arquivos Brasileiros de Cardiologia
  31. RETRACTED: Levetiracetam inhibits THP-1 monocyte chemotaxis and adhesion via the synaptic vesicle 2A
    Yue Zhang, Min Hu, Yue-yu Tang, Bei Zhang, Yinyin Han, Zheng-yu Huang, Chen Chen, Gang Li · 2020 · Biochemical and Biophysical Research Communications · Retracted
  32. Macrophage-derived Netrin-1 participates in endometriosis-associated pain
    Shaojie Ding, Xinyue Guo, Libo Zhu, Jianzhang Wang, Tiantian Li, Qin Ping Yu, Xinmei Zhang · 2019
  33. Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1
    Weiyi Qian, Tarik Hadi, Xiao Ma, Michele Silvestro, Cristobal F. Rivera, Apratim Bajpai, Zijing Zhang, Hengdong Qu, Annanina Corsica, Bradley Miscovich et al. · 2020
  34. 国際生活機能分類(国際障害分類改定版)を障害者のための臨床現場にいかに生かすか--身体障害者リハビリテーションの立場から (特集 WHO国際障害分類改定の意義を考える(上))
    弥生 大川 · 2002 · リハビリテ-ション研究
  35. Is Netrin-1 Associated With the Development of Fibrosis in Systemic Sclerosis?
    Yüksel Maraş, Ahmet Kor, Esra Fırat Oğuz, Alper Sarı, KEVSER GOK, Ali Akdoğan · 2022 · medRxiv
  36. 2014 Hot Topics
    2015 · Japanese Journal of Thrombosis and Hemostasis
  37. Les macrophages piégés par l’athérome
    2012 · Revue Francophone des Laboratoires
  38. Atherosclerosis
    Caitríona Grönberg, Harry Björkbacka · 2012 · Current Opinion in Lipidology
  39. Genetic Rare Variants Affecting Multiple Pathways in Japanese Patients with Palindromic Rheumatism.
    Taketo Kawara, Koji Inoue, Shunichi Shiozawa, Kayo Osawa, Koichiro Komai · 2024 · PubMed Central
  40. Immunomodulation by allograft endothelial cells
    Sayantan Bose, Vicki Do, Chiara Testini, Suchita Suryakant Jadhav, Nicolas Sailliet, Alvin T. Kho, Masaaki Komatsu, Leo Boneschansker, Sek Won Kong, Johannes Wedel et al. · 2025 · Frontiers in Transplantation
  41. Proteomics for Novel Biomarker and Drug Target Discovery in Alzheimer Disease
    Huiming Zhu, Minqi Cai, Dezhu Chen, Jiaojiao Sha, Liang Du, Yiqiang Chen, Siyuan Liu, Qian Zheng, Xuefei Wei, Bing Bai · 2025 · Springer eBooks
  42. Additional file 2 of Hypofucosylation of Unc5b regulated by Fut8 enhances macrophage emigration and prevents atherosclerosis
    Yang, Xi, Ma, Limei, Jun Zhang, Chen, Linmu, Zou, Zhen, Shen, Di, Hui He, Zhang, Lei, Chen, Jun, Yuan, Zhiyi et al. · 2024 · Figshare
  43. Additional file 1 of Hypofucosylation of Unc5b regulated by Fut8 enhances macrophage emigration and prevents atherosclerosis
    Yang, Xi, Ma, Limei, Jun Zhang, Chen, Linmu, Zou, Zhen, Shen, Di, He, Hui, Zhang, Lei, Chen, Jun, Yuan, Zhiyi et al. · 2024 · Figshare
  44. Dehydrocorydaline Promotes STAT3 /Bcl‐2 Axis‐Mediated Macrophage Efferocytosis to Attenuate Apoptosis in Atherosclerotic Plaques
    Li Hongzheng, Zucheng Shang, Aimei Lu, Yang Wenwen, Mengfan Li, Jiang Wenrui, Lian Wenjing, Zhao Xin, Yu Zikai, Lu Yingdong et al. · 2026 · Phytotherapy Research
  45. Synthesis of Apolipoprotein A-I in Human Macrophages Enhances their Migratory Activity
    E. V. Nekrasova, Ekaterina E. Larionova, M.K. Serebriakova, D. O. Kuzmina, Alexandra Burnusuz, N. P. Gorbunov, S. V. Orlov · 2026 · Cell Biochemistry and Biophysics
  46. Novel netrin-1–Unc5b–Klf4 axis balances AT2 survival in experimental bronchopulmonary dysplasia
    Oleksiy Klymenko, Jasmine Mohr, Soula Danopoulos, Ivana Mižik, Celien Kuiper-Makris, Stephanie Stephan, Mohammad A Mahjoub, Cristina M. Alvira, Daniela Rheindorf, Thomas Imhof et al. · 2026 · American Journal of Respiratory Cell and Molecular Biology
  47. Rôle de CD146 dans l'athérosclérose
    Muriel G. Blin · 2016 · theses.fr (ABES)
  48. Virus de l'hépatite C, Nétrine-1 et réponse aux protéines mal repliées en contexte hépatique
    Thomas Lahlali · 2014 · theses.fr (ABES)
  49. Implication des phagocytes mononuclées dans l'évolution de la plaque d'athérosclérose et relation avec l'homéostasie du cholestérol et des lipoprotéines
    Laura Bouchareychas · 2014 · theses.fr (ABES)
  50. Study of the pair Netrin-1/DCC in Parkinson's diseas
    Marie Jasmin · 2018 · theses.fr (ABES)
  51. La nétrine-1 et son récepteur UNC5A en contexte de stress réticulaire et d'inflammation hépatiques
    Romain Barnault · 2020 · theses.fr (ABES)
  52. Netrin-1 in extracellular vesicles : a new secretory pathway
    Stephany Fiore · 2019 · theses.fr (ABES)
  53. Effets des faibles doses de rayonnements ionisants γ dans la pathologie athéromateuse : étude des mécanismes de modulation de l’inflammation.
    Nicolas Rey · 2021 · theses.fr (ABES)
  54. Étude de l’influence de la glutaminolyse des macrophages dans les maladies cardio-métaboliques
    Johanna Merlin · 2020 · theses.fr (ABES)
  55. Développement d’un modèle physiopathologique de macrophages spumeux de l’athérosclérose : caractérisation phénotypique et fonctionnelle et sélection d’anticorps humains spécifiques
    Coraline Borowczyk · 2020 · theses.fr (ABES)
  56. Rôle de la phosphatase alcaline non spécifique du tissu "TNAP" dans la calcification des plaques d’athérosclérose
    Lynn Kawtharany · 2022 · theses.fr (ABES)
  57. Netrin-1 and neurons in hepatocellular carcinoma
    Ievgeniia Chicherova · 2022 · theses.fr (ABES)
  58. Génétique des mouvements en miroir congénitaux : recherche de nouvelles causes génétiques et étude in vitro de l’impact des variants RAD51 et NTN1
    Oriane Trouillard · 2023 · theses.fr (ABES)
  59. Caractérisation d’un facteur de guidage axonal, la Draxine, en tant que nouvelle cible thérapeutique dans le glioblastome
    Verena Neururer · 2022 · theses.fr (ABES)
  60. Deciphering the mechanisms of nerve/tumor Interaction : role of the axon guidance signaling Netrin-1/DCC
    Hiba Haidar · 2024 · theses.fr (ABES)
  61. Biomarkers and Endothelial Damage in Obesity: An Insight into the Pharmacological Modulation
    Arturo Yonatan Bojórquez-González, Eduardo Gómez-Sánchez, Daniel Osmar Suárez-Rico, Alberto Beltrán-Ramírez, Luis Ricardo Balleza-Alejandri, Luis Daniel López-Murillo, Ernesto Javier Ramírez-Lizardo, Jesús Jonathan García-Galindo · 2026 · International Journal of Molecular Sciences
  62. Macrophage trafficking and efferocytosis in atherosclerotic plaque regression: Molecular mechanisms and therapeutic perspectives
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  63. Netrin-1 suppresses CCL2-driven macrophage migration: implications for modulating vascular inflammation and aortic sinus enlargement in hyperlipidaemic mice
    Vasco Claro, Yanira Riffo‐Vasquez, Fulye Argunhan, Albert Ferro · 2026 · Journal of Molecular and Cellular Cardiology Plus
  64. Editorial for the Special Issue “Molecular Mechanisms and Innovative Therapeutic Approaches in Inflammatory Diseases, Pioneering Precision Medicine Solutions”
    Héctor A. Cabrera-Fuentes, Elisabeth Deindl, Klaus T. Preissner · 2026 · Current Issues in Molecular Biology