The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways
Open accessAbstract
The NF-κB protein RelB controls dendritic cell (DC) maturation and may be targeted therapeutically to manipulate T cell responses in disease. Here we report that RelB promoted DC activation not as the expected RelB-p52 effector of the noncanonical NF-κB pathway, but as a RelB-p50 dimer regulated by canonical IκBs, IκBα and IκBɛ. IκB control of RelB minimized spontaneous maturation but enabled rapid pathogen-responsive maturation. Computational modeling of the NF-κB signaling module identified control points of this unexpected cell type–specific regulation. Fibroblasts that we engineered accordingly showed DC-like RelB control. Canonical pathway control of RelB regulated pathogen-responsive gene expression programs. This work illustrates the potential utility of systems analyses in guiding the development of combination therapeutics for modulating DC-dependent T cell responses.
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Cites
Crosstalk in NF-κB Signaling Pathways
Oeckinghaus, A., Hayden, M. S., & Ghosh, S. (2011) · Nature Immunology · doi:10.1038/ni.2065 · Cited by 1,942
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Metadata
- Authors
- Shih, V. F.-S., Davis-Turak, J., Macal, M., Huang, J. Q., Ponomarenko, J., Kearns, J. D., Yu, T., Fagerlund, R., Asagiri, M., Zuniga, E. I., & Hoffmann, A.
- Venue
- Nature Immunology
- Published
- 2012-10-21
- Volume
- 13
- Issue
- 12
- Pages
- 1162-1170
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1984387148
- Cited by
- 177
- References
- 1
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- green
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- Shih, V. F.-S., Davis-Turak, J., Macal, M., Huang, J. Q., Ponomarenko, J., Kearns, J. D., Yu, T., Fagerlund, R., Asagiri, M., Zuniga, E. I., & Hoffmann, A. (2012). Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways. Nature Immunology. https://doi.org/10.1038/ni.2446
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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