The DOI matches its Crossref record; 242 of the 242 references it cites were found in a registry or an index.
Regulation of NF-κB by TNF family cytokines
Open accessAbstract
The NF-κB family of inducible transcription factors is activated in response to a variety of stimuli. Amongst the best-characterized inducers of NF-κB are members of the TNF family of cytokines. Research on NF-κB and TNF have been tightly intertwined for more than 25 years. Perhaps the most compelling examples of the interconnectedness of NF-κB and the TNF have come from analysis of knock-out mice that are unable to activate NF-kB. Such mice die embryonically, however, deletion of TNF or TNFR1 can rescue the lethality thereby illustrating the important role of NF-κB as the key regulator of transcriptional responses to TNF. The physiological connections between NF-κB and TNF cytokines are numerous and best explored in articles focusing on a single TNF family member. Instead, in this review, we explore general mechanisms of TNF cytokine signaling, with a focus on the upstream signaling events leading to activation of the socalled canonical and noncanonical NF-κB pathways by TNFR1 and CD40 respectively.
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1 retracted
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Metadata
- Authors
- Hayden, M. S., & Ghosh, S.
- Venue
- Seminars in Immunology
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 26
- Issue
- 3
- Pages
- 253-266
- ISSN
- 1044-5323 (ISSN-L)
- OpenAlex
- W1998812648
- Cited by
- 1,115
- References
- 242
- FWCI
- 9.91
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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