The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The non-canonical NF-κB pathway in immunity and inflammation
Open accessAbstract
The nuclear factor-κB (NF-κB) family of transcription factors is activated by canonical and non-canonical signalling pathways, which differ in both signalling components and biological functions. Recent studies have revealed important roles for the non-canonical NF-κB pathway in regulating different aspects of immune functions. Defects in non-canonical NF-κB signalling are associated with severe immune deficiencies, whereas dysregulated activation of this pathway contributes to the pathogenesis of various autoimmune and inflammatory diseases. Here we review the signalling mechanisms and the biological function of the non-canonical NF-κB pathway. We also discuss recent progress in elucidating the molecular mechanisms regulating non-canonical NF-κB pathway activation, which may provide new opportunities for therapeutic strategies.
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Cites
The Pathogenesis of Rheumatoid Arthritis
McInnes, I. B., & Schett, G. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1004965 · Cited by 5,514
Type 2 diabetes as an inflammatory disease
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IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis
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NF-κB in inflammation and renal diseases
Zhang, H., & Sun, S.-C. (2015) · Cell & Bioscience · doi:10.1186/s13578-015-0056-4 · Cited by 383
Self-citationChloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation
Xiu, Y., Xu, H., Zhao, C., Li, J., Morita, Y., Yao, Z., Xing, L., & Boyce, B. F. (2014) · Journal of Clinical Investigation · doi:10.1172/jci66947 · Cited by 164
The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling
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Metadata
- Authors
- Sun, S.-C.
- Venue
- Nature Reviews Immunology
- Published
- 2017-06-05
- Volume
- 17
- Issue
- 9
- Pages
- 545-558
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2620769476
- Cited by
- 1,891
- References
- 6
- FWCI
- 10.06
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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