The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response
Open accessAbstract
The induction of type I interferons by the bacterial secondary messengers cyclic di-GMP (c-di-GMP) or cyclic di-AMP (c-di-AMP) is dependent on a signaling axis that involves the adaptor STING, the kinase TBK1 and the transcription factor IRF3. Here we identified the heliase DDX41 as a pattern-recognition receptor (PRR) that sensed both c-di-GMP and c-di-AMP. DDX41 specifically and directly interacted with c-di-GMP. Knockdown of DDX41 via short hairpin RNA in mouse or human cells inhibited the induction of genes encoding molecules involved in the innate immune response and resulted in defective activation of STING, TBK1 and IRF3 in response to c-di-GMP or c-di-AMP. Our results suggest a mechanism whereby c-di-GMP and c-di-AMP are detected by DDX41, which forms a complex with STING to signal to TBK1-IRF3 and activate the interferon response.
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Cites
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STING is a direct innate immune sensor of cyclic di-GMP
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The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation
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Cited by
DNA sensing by the cGAS–STING pathway in health and disease
Motwani, M., Pesiridis, S., & Fitzgerald, K. A. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0151-1 · Cited by 1,467
Paludan, S. R., & Bowie, A. G. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.004 · Cited by 759
STING and the innate immune response to nucleic acids in the cytosol
Burdette, D. L., & Vance, R. E. (2013) · Nature Immunology · doi:10.1038/ni.2491 · Cited by 501
Newly described pattern recognition receptors team up against intracellular pathogens
Broz, P., & Monack, D. M. (2013) · Nature Reviews Immunology · doi:10.1038/nri3479 · Cited by 462
Conlon, J., Burdette, D. L., Sharma, S., Bhat, N., Thompson, M., Jiang, Z., Rathinam, V. A. K., Monks, B., Jin, T., Xiao, T. S., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300097 · Cited by 434
Metadata
- Authors
- Parvatiyar, K., Zhang, Z., Teles, R. M., Ouyang, S., Jiang, Y., Iyer, S. S., Zaver, S. A., Schenk, M., Zeng, S., Zhong, W., Liu, Z.-J., Modlin, R. L., Liu, Y.-J., & Cheng, G.
- Venue
- Nature Immunology
- Published
- 2012-11-11
- Volume
- 13
- Issue
- 12
- Pages
- 1155-1161
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2099489128
- Cited by
- 406
- References
- 35
- FWCI
- 14.42
- Type
- journal article
- Language
- en
- Open access
- green
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- Parvatiyar, K., Zhang, Z., Teles, R. M., Ouyang, S., Jiang, Y., Iyer, S. S., Zaver, S. A., Schenk, M., Zeng, S., Zhong, W., Liu, Z.-J., Modlin, R. L., Liu, Y.-J., & Cheng, G. (2012). The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nature Immunology. https://doi.org/10.1038/ni.2460
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