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IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8(+) T cell responses to influenza A virus
Open accessAbstract
Immune responses to vaccines require direct recognition of pathogen-associated molecular patterns (PAMPs) through pattern-recognition receptors (PRRs) on dendritic cells (DCs). Unlike vaccination, infection by a live pathogen often impairs DC function and inflicts additional damage on the host. Here we found that after infection with live influenza A virus, signaling through the interleukin 1 receptor (IL-1R) was required for productive priming of CD8(+) T cells, but signaling through the PRRs TLR7 and RIG-I was not. DCs activated by IL-1 in trans were both required and sufficient for the generation of virus-specific CD8(+) T cell immunity. Our data demonstrate a critical role for a bystander cytokine in the priming of CD8(+) T cells during infection with a live virus.
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“Evidence has been provided previously that IL-1 can replace a need for PRRs in activation of DCs and promotion of CD8+ T cell responses.50”
From TLR9-independent CD8+ T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling (2024) · cites this paper as [50]
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Cites
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H., & Bauer, S. (2004) · Science · doi:10.1126/science.1093620 · Cited by 3,947
Immunological and inflammatory functions of the interleukin-1 family
Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444
Approaching the asymptote? Evolution and revolution in immunology.Preprint
Janeway, C. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.003 · Cited by 3,396
5'-Triphosphate RNA Is the Ligand for RIG-I
Hornung, V., Ellegast, J., Kim, S., Brzózka, K., Jung, A., Kato, H., Poeck, H., Akira, S., Conzelmann, K.-K., Schlee, M., et al. (2006) · Science · doi:10.1126/science.1132505 · Cited by 2,474
The Inflammasomes: Guardians of the Body
Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K., & Akira, S. (1998) · Immunity · doi:10.1016/s1074-7613(00)80596-8 · Cited by 2,358
Regulation of Adaptive Immunity by the Innate Immune System
Iwasaki, A., & Medzhitov, R. M. (2010) · Science · doi:10.1126/science.1183021 · Cited by 2,220
Self-citationRIG-I-mediated antiviral responses to single-stranded RNA bearing 5’-phosphates
Pichlmair, A., Schulz, O., Tan, C. P., Näslund, T. I., Liljeström, P., Weber, F., & Reis e Sousa, C. (2006) · Science · doi:10.1126/science.1132998 · Cited by 2,210
Recognition of single-stranded RNA viruses by Toll-like receptor 7
Lund, J. M., Alexopoulou, L., Sato, A., Karow, M. L., Adams, N. C., Gale, N. W., Iwasaki, A., & Flavell, R. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400937101 · Cited by 1,854
Self-citationMicrobiota regulates immune defense against respiratory tract influenza A virus infection
Ichinohe, T., Pang, I. K., Kumamoto, Y., Peaper, D. R., Ho, J. H., Murray, T. S., & Iwasaki, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019378108 · Cited by 1,502
Self-citationAllen, I. C., Scull, M. A., Moore, C. B., Holl, E. K., McElvania-TeKippe, E., Taxman, D. J., Guthrie, E. H., Pickles, R. J., & Ting, J. P.-Y. (2009) · Immunity · doi:10.1016/j.immuni.2009.02.005 · Cited by 1,113
Sensing and reacting to microbes through the inflammasomes
Franchi, L., Muñoz-Planillo, R., & Núñez, G. (2012) · Nature Immunology · doi:10.1038/ni.2231 · Cited by 1,046
Thomas, P. G., Dash, P., Aldridge, J. R., Ellebedy, A. H., Reynolds, C., Funk, A. J., Martin, W. J., Lamkanfi, M., Webby, R. J., Boyd, K. L., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.02.006 · Cited by 769
Control of B-cell responses by Toll-like receptors
Pasare, C., & Medzhitov, R. M. (2005) · Nature · doi:10.1038/nature04267 · Cited by 752
Inflammasome recognition of influenza virus is essential for adaptive immune responses
Ichinohe, T., Lee, H. K., Ogura, Y., Flavell, R. A., & Iwasaki, A. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081667 · Cited by 701
Self-citationInfluenza virus activates inflammasomes via its intracellular M2 ion channel
Ichinohe, T., Pang, I. K., & Iwasaki, A. (2010) · Nature Immunology · doi:10.1038/ni.1861 · Cited by 632
Self-citationSpörri, R., & Sousa, C. R. E. (2005) · Nature Immunology · doi:10.1038/ni1162 · Cited by 618
The Specific and Essential Role of MAVS in Antiviral Innate Immune Responses
Sun, Q., Sun, L., Liu, H.-H., Chen, X., Seth, R. B., Forman, J., & Chen, Z. J. (2006) · Immunity · doi:10.1016/j.immuni.2006.04.004 · Cited by 604
Geurtsvankessel, C., Willart, M., van Rijt, L. V., Muskens, F., Kool, M., Baas, C., Thielemans, K., Bennett, C. L., Clausen, B., Hoogsteden, H., et al. (2008) · Journal of Experimental Medicine · doi:10.1084/jem.20071365 · Cited by 541
Goffic, R. L., Balloy, V., Lagranderie, M., Alexopoulou, L., Escriou, N., Flavell, R. A., Chignard, M., & Si‐Tahar, M. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020053 · Cited by 531
TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection
Aldridge, J. R., Moseley, C. E., Boltz, D. A., Negovetich, N. J., Reynolds, C., Franks, J., Brown, S. A., Doherty, P. C., Webster, R. G., & Thomas, P. G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900655106 · Cited by 436
Role of Host Cytokine Responses in the Pathogenesis of Avian H5N1 Influenza Viruses in Mice
Szretter, K. J., Gangappa, S., Lu, X., Smith, C. S., Shieh, W., Zaki, S. R., Sambhara, S. R., Tumpey, T. M., & Katz, J. M. (2006) · Journal of Virology · doi:10.1128/jvi.02336-06 · Cited by 373
Belz, G. T., Smith, C. M., Kleinert, L., Reading, P. C., Brööks, A. G., Shortman, K., Carbone, F., & Heath, W. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402644101 · Cited by 369
Schmitz, N., Kurrer, M. O., Bachmann, M. F., & Köpf, M. (2005) · Journal of Virology · doi:10.1128/jvi.79.10.6441-6448.2005 · Cited by 364
Koyama, S., Ishii, K. J., Kumar, H., Tanimoto, T., Coban, C., Uematsu, S., Kawai, T., & Akira, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4711 · Cited by 315
Influenza Virus Evades Innate and Adaptive Immunity via the NS1 Protein
Fernández-Sesma, A., Marukian, S., Ebersole, B. J., Kaminski, D. A., Park, M., Yuen, T., Sealfon, S. C., García‐Sastre, A., & Moran, T. M. (2006) · Journal of Virology · doi:10.1128/jvi.02381-05 · Cited by 305
Kim, T. S., & Braciale, T. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004204 · Cited by 293
Ballesteros‐Tato, A., León, B., Lund, F. E., & Randall, T. D. (2010) · Nature Immunology · doi:10.1038/ni.1838 · Cited by 268
Modulation of Dendritic Cell Trafficking to and from the Airways
Jakubzick, C., Tacke, F., Llodrá, J., van Rooijen, N., & Randolph, G. J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.6.3578 · Cited by 251
Heer, A. K., Shamshiev, A. T., Donda, A., Uematsu, S., Akira, S., Köpf, M., & Marsland, B. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2182 · Cited by 212
Inflammasomes as mediators of immunity against influenza virus
Pang, I. K., & Iwasaki, A. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.11.004 · Cited by 176
Self-citationEriksson, U., Kurrer, M. O., Sonderegger, I., Iezzi, G., Tafuri, A., Hunziker, L., Suzuki, S., Bachmaier, K., Bingisser, R. M., Penninger, J. M., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021788 · Cited by 158
Characterization of two TCR transgenic mouse lines specific for herpes simplex virus
Mueller, S. N., Heath, W. R., McLain, J. D., Carbone, F., & Jones, C. M. (2002) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2002.01071.x · Cited by 147
Smed‐Sörensen, A., Chalouni, C. M., Chatterjee, B., Cohn, L. B., Blattmann, P., Nakamura, N., Delamarre, L., & Mellman, I. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002572 · Cited by 107
Kratky, W., Sousa, C. R. E., Oxenius, A., & Spörri, R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108945108 · Cited by 101
Phagocytosis and antigen presentation: a partnership initiated by Toll-like receptors
Blander, J. M. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.097964 · Cited by 62
del Rio, M., Rodríguez-Barbosa, J.-I., Bölter, J., Ballmaier, M., Dittrich‐Breiholz, O., Kracht, M., Jung, S., & Förster, R. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.6178 · Cited by 48
Mueller, S. N., Langley, W. A., Li, G., García‐Sastre, A., Webby, R. J., & Ahmed, R. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001142 · Cited by 48
Jones, C., Taylor, T. J., & Knipe, D. M. (2000) · Virology · doi:10.1006/viro.2000.0628 · Cited by 47
Heer, A. K., Harris, N. L., Köpf, M., & Marsland, B. J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.6984 · Cited by 46
STAT6-independent production of IL-4 by mast cells
Sherman, M. A., Secor, V. H., Lee, S. K., Lopez, R. D., & Brown, M. A. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199904)29:04 · Cited by 45
Shornick, L. P., Bisarya, A. K., & Chaplin, D. (2001) · Cellular Immunology · doi:10.1006/cimm.2001.1834 · Cited by 36
Methods to Study Pulmonary Dendritic Cell Migration
Jakubzick, C., & Randolph, G. J. (2009) · Methods in molecular biology · doi:10.1007/978-1-60761-421-0_24 · Cited by 21
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Metadata
- Authors
- Pang, I. K., Ichinohe, T., & Iwasaki, A.
- Affiliations
- Yale University (US)
- Corresponding author
- Iwasaki, Akiko
- Venue
- Nature Immunology
- Published
- 2013-01-13
- Volume
- 14
- Issue
- 3
- Pages
- 246-253
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC3577947
- OpenAlex
- W2035396878
- Cited by
- 145
- References
- 44
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 5 · 2021: 15 · 2020: 8 · 2019: 10 · 2018: 11 · 2017: 19 · 2016: 13 · 2015: 21 · 2014: 12 · 2013: 10
- FWCI
- 10.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Japan Society for the Promotion of Science (23790506)
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases (R01AI062428, R56AI062428, AI062428 AND U54 AI057160, U54AI057160)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- IL-1 signaling, dendritic cells, CD8+ T cell priming, influenza A virus infection, pattern recognition receptors, TLR7, RIG-I, innate immunity
- MeSH terms
- Roundabout Proteins, Animals, Cell Differentiation, Cell Movement, Dendritic Cells, Interleukin-1, Lymphocyte Activation, Membrane Glycoproteins, Membrane Proteins, Mice, Inbred C57BL, Nerve Tissue Proteins, Orthomyxoviridae Infections, Influenza A virus, Receptors, Cell Surface, Signal Transduction, Receptors, Interleukin-1, Mice, Knockout, CD8-Positive T-Lymphocytes, Receptors, Pattern Recognition, Toll-Like Receptor 7, Mice, Myeloid Differentiation Factor 88, Receptors, CCR7
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