The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
RNA-mediated interference and reverse transcription control the persistence of RNA viruses in the insect model Drosophila
Open accessAbstract
How persistent viral infections are established and maintained is widely debated and remains poorly understood. We found here that the persistence of RNA viruses in Drosophila melanogaster was achieved through the combined action of cellular reverse-transcriptase activity and the RNA-mediated interference (RNAi) pathway. Fragments of diverse RNA viruses were reverse-transcribed early during infection, which resulted in DNA forms embedded in retrotransposon sequences. Those virus-retrotransposon DNA chimeras produced transcripts processed by the RNAi machinery, which in turn inhibited viral replication. Conversely, inhibition of reverse transcription hindered the appearance of chimeric DNA and prevented persistence. Our results identify a cooperative function for retrotransposons and antiviral RNAi in the control of lethal acute infection for the establishment of viral persistence.
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Cited by
Host Biology in Light of the Microbiome: Ten Principles of Holobionts and Hologenomes
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Small RNA-based antimicrobial immunity
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Metadata
- Authors
- Goic, B., Vodovar, N., Mondotte, J. A., Monot, C., Frangeul, L., Blanc, H., Gausson, V., Vera-Otarola, J., Cristofari, G., & Saleh, M.-C.
- Venue
- Nature Immunology
- Published
- 2013-02-24
- Volume
- 14
- Issue
- 4
- Pages
- 396-403
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2159086136
- Cited by
- 265
- References
- 38
- FWCI
- 11.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Goic, B., Vodovar, N., Mondotte, J. A., Monot, C., Frangeul, L., Blanc, H., Gausson, V., Vera-Otarola, J., Cristofari, G., & Saleh, M.-C. (2013). RNA-mediated interference and reverse transcription control the persistence of RNA viruses in the insect model Drosophila. Nature Immunology. https://doi.org/10.1038/ni.2542
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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