The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
RNA Interference Directs Innate Immunity Against Viruses in Adult Drosophila
Abstract
Innate immunity against bacterial and fungal pathogens is mediated by Toll and immune deficiency (Imd) pathways, but little is known about the antiviral response in Drosophila . Here, we demonstrate that an RNA interference pathway protects adult flies from infection by two evolutionarily diverse viruses. Our work also describes a molecular framework for the viral immunity, in which viral double-stranded RNA produced during infection acts as the pathogen trigger whereas Drosophila Dicer-2 and Argonaute-2 act as host sensor and effector, respectively. These findings establish a Drosophila model for studying the innate immunity against viruses in animals.
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Citations
Cites
The immune response of Drosophila
Hoffmann, J. A. (2003) · Nature · doi:10.1038/nature02021 · Cited by 1,553
Cited by
Biogenesis of small RNAs in animals
Kim, V. N., Han, J., & Siomi, M. C. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2632 · Cited by 2,814
The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race
Aravin, A. A., Hannon, G. J., & Brennecke, J. (2007) · Science · doi:10.1126/science.1146484 · Cited by 1,096
Le Thomas, A., Rogers, A. K., Webster, A., Marinov, G. K., Liao, S. E., Perkins, E. M., Hur, J. K., Aravin, A. A., & Tóth, K. F. (2013) · Genes & Development · doi:10.1101/gad.209841.112 · Cited by 508
Bolognesi, R., Ramaseshadri, P., Anderson, J., Bachman, P., Clinton, W., Flannagan, R., Ilagan, O., Lawrence, C., Levine, S., Moar, W., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047534 · Cited by 473
Förstemann, K., Horwich, M. D., Wee, L., Tomari, Y., & Zamore, P. D. (2007) · Cell · doi:10.1016/j.cell.2007.05.056 · Cited by 438
Metadata
- Authors
- Wang, X.-H., Aliyari, R., Li, W.-X., Li, H.-W., Kim, K., Carthew, R., Atkinson, P., & Ding, S.-W.
- Venue
- Science
- Published
- 2006-04-21
- Volume
- 312
- Issue
- 5772
- Pages
- 452-454
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2029433700
- Cited by
- 724
- References
- 1
- FWCI
- 20.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, X.-H., Aliyari, R., Li, W.-X., Li, H.-W., Kim, K., Carthew, R., Atkinson, P., & Ding, S.-W. (2006). RNA Interference Directs Innate Immunity Against Viruses in Adult Drosophila. Science. https://doi.org/10.1126/science.1125694
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
