The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens
Open accessAbstract
Defense against attaching-and-effacing bacteria requires the sequential generation of interleukin 23 (IL-23) and IL-22 to induce protective mucosal responses. Although CD4+ and NKp46+ innate lymphoid cells (ILCs) are the critical source of IL-22 during infection, the precise source of IL-23 is unclear. We used genetic techniques to deplete mice of specific subsets of classical dendritic cells (cDCs) and analyzed immunity to the attaching-and-effacing pathogen Citrobacter rodentium. We found that the signaling receptor Notch2 controlled the terminal stage of cDC differentiation. Notch2-dependent intestinal CD11b+ cDCs were an obligate source of IL-23 required for survival after infection with C. rodentium, but CD103+ cDCs dependent on the transcription factor Batf3 were not. Our results demonstrate a nonredundant function for CD11b+ cDCs in the response to pathogens in vivo.
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Transforming growth factor-β induces development of the TH17 lineage
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Regional specialization within the intestinal immune system
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Metadata
- Authors
- Satpathy, A. T., Briseño, C. G., Lee, J. S., Ng, D., Manieri, N. A., KC, W., Wu, X., Thomas, S. R., Lee, W.-L., Turkoz, M., McDonald, K. G., Meredith, M. M., Song, C., Guidos, C. J., Newberry, R. D., Ouyang, W., Murphy, T. L., Stappenbeck, T. S., Gommerman, J. L., Nussenzweig, M. C., Colonna, M., Kopan, R., & Murphy, K. M.
- Venue
- Nature Immunology
- Published
- 2013-08-04
- Volume
- 14
- Issue
- 9
- Pages
- 937-948
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2049909747
- Cited by
- 468
- References
- 9
- FWCI
- 20.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Satpathy, A. T., Briseño, C. G., Lee, J. S., Ng, D., Manieri, N. A., KC, W., Wu, X., Thomas, S. R., Lee, W.-L., Turkoz, M., McDonald, K. G., Meredith, M. M., Song, C., Guidos, C. J., Newberry, R. D., Ouyang, W., Murphy, T. L., Stappenbeck, T. S., Gommerman, J. L., . . . Murphy, K. M. (2013). Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nature Immunology. https://doi.org/10.1038/ni.2679
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
