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MyD88 signalling plays a critical role in host defence by controlling pathogen burden and promoting epithelial cell homeostasis during Citrobacter rodentium-induced colitis

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Mesenchymal Stem Cells (MSC) Derived from Induced Pluripotent Stem Cells (iPSC) Equivalent to Adipose-Derived MSC in Promoting Intestinal Healing and Microbiome Normalization in Mouse Inflammatory Bowel Disease Model

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The Stromal Intervention: Regulation of Immunity and Inflammation at the Epithelial-Mesenchymal Barrier

Nowarski, R., Jackson, R., & Flavell, R. A. (2017) · Cell · doi:10.1016/j.cell.2016.11.040 · Cited by 191 · see citing works

Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism

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The stem cells of small intestinal crypts: where are they?

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The interleukin‐23 axis in intestinal inflammation

Ahern, P. P., Ízcue, A., Maloy, K. J., & Powrie, F. M. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00705.x · Cited by 180 · see citing works

IL-21 and T follicular helper cells

Spolski, R. J., & Leonard, W. J. (2009) · International Immunology · doi:10.1093/intimm/dxp112 · Cited by 182 · see citing works

Role of Toll-like receptors in gastrointestinal malignancies

Fukata, M., & Abreu, M. T. (2008) · Oncogene · doi:10.1038/sj.onc.1210908 · Cited by 178 · see citing works

Loss of Epithelial RelA Results in Deregulated Intestinal Proliferative/Apoptotic Homeostasis and Susceptibility to Inflammation

Steinbrecher, K. A., Harmel-Laws, E., Sitcheran, R., & Baldwin, A. S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2588 · Cited by 174 · see citing works

Intestinal myofibroblasts: targets for stem cell therapy

Mifflin, R. C., Pinchuk, I. V., Saada, J. I., & Powell, D. W. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00474.2010 · Cited by 169 · see citing works

Role of gut microbiota in intestinal wound healing and barrier function

Alam, A., & Neish, A. (2018) · Tissue Barriers · doi:10.1080/21688370.2018.1539595 · Cited by 166 · see citing works

Toll-Like Receptor–Gut Microbiota Interactions: Perturb at Your Own Risk!

Carvalho, F. A., Aitken, J. D., Vijay–Kumar, M., & Gewirtz, A. T. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020911-153330 · Cited by 164 · see citing works

Experimental Inflammatory Bowel Disease: Insights into the Host-Microbiota Dialog

Saleh, M., & Elson, C. O. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.008 · Cited by 158 · see citing works

Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors

Fukata, M., Hernandez, Y., Conduah, D. E., Cohen, J., Chen, A., Breglio, K. J., Goo, T., Hsu, D. S., Xu, R., & Abreu, M. T. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20880 · Cited by 157 · see citing works

Inflammatory pathways in the early steps of colorectal cancer development

Mariani, F. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i29.9716 · Cited by 156 · see citing works

The Life and Death of Epithelia During Inflammation: Lessons Learned from the Gut

Koch, S., & Nusrat, A. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011811-120905 · Cited by 153 · see citing works

Inflammasomes in Intestinal Inflammation and Cancer

Chen, G., & Núñez, G. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.10.002 · Cited by 151 · see citing works

MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands

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An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer

Asquith, M. J., & Powrie, F. M. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101330 · Cited by 136 · see citing works

Toll-like receptors, wound healing, and carcinogenesis

Kluwe, J., Mencin, A. M., & Schwabe, R. F. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0426-z · Cited by 133 · see citing works

Intraperitoneal injection (IP), Intravenous injection (IV) or anal injection (AI)? Best way for mesenchymal stem cells transplantation for colitis

Wang, M., Liang, C., Hu, H., Zhou, L., Xu, B., Wang, X., Han, Y., Nie, Y., Jia, S., Liang, J., et al. (2016) · Scientific Reports · doi:10.1038/srep30696 · Cited by 130 · see citing works

Pattern Recognition Receptor Signaling and Cytokine Networks in Microbial Defenses and Regulation of Intestinal Barriers: Implications for Inflammatory Bowel Disease

Abraham, C., Abreu, M. T., & Turner, J. R. (2022) · Gastroenterology · doi:10.1053/j.gastro.2021.12.288 · Cited by 127 · see citing works

Transforming Growth Factor–β Regulates Mammary Carcinoma Cell Survival and Interaction with the Adjacent Microenvironment

Bierie, B., Stover, D. G., Abel, T. W., Chytil, A. M., Gorska, A. E., Aakre, M. E., Forrester, E., Yang, H. H., Wagner, K., & Moses, H. L. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5597 · Cited by 124 · see citing works

The struggle within: Microbial influences on colorectal cancer

Arthur, J. C., & Jobin, C. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21354 · Cited by 121 · see citing works

Innate immune signaling in defense against intestinal microbes

Kinnebrew, M. A., & Pamer, E. G. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01081.x · Cited by 123 · see citing works

Regulation of Colonic Epithelial Repair in Mice by Toll-Like Receptors and Hyaluronic Acid

Zheng, L., Riehl, T. E., & Stenson, W. F. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.055 · Cited by 118 · see citing works

Intestinal stromal cells in mucosal immunity and homeostasis

Owens, B. M. J., & Simmons, A. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.125 · Cited by 117 · see citing works

Gnotobiotic IL-10−/−;NF-κBEGFP Mice Reveal the Critical Role of TLR/NF-κB Signaling in Commensal Bacteria-Induced Colitis

Karrasch, T., Kim, J.-S., Mühlbauer, M., Magness, S. T., & Jobin, C. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6522 · Cited by 117 · see citing works

Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk

Kutikhin, A. G. (2011) · Human Immunology · doi:10.1016/j.humimm.2011.07.307 · Cited by 116 · see citing works

NF-κB and the intestine: Friend or foe?

Karrasch, T., & Jobin, C. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20243 · Cited by 112 · see citing works

The intestinal microbiota in health and disease: the influence of microbial products on immune cell homeostasis

Abt, M. C., & Artis, D. (2009) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e328331b6b4 · Cited by 110 · see citing works

B Cell-Intrinsic MyD88 Signaling Prevents the Lethal Dissemination of Commensal Bacteria during Colonic Damage

Kirkland, D., Benson, A., Mirpuri, J., Pifer, R., Hou, B., DeFranco, A. L., & Yarovinsky, F. (2012) · Immunity · doi:10.1016/j.immuni.2011.11.019 · Cited by 109 · see citing works

Interactions between epithelial cells and leukocytes in immunity and tissue homeostasis

Shaykhiev, R., & Bals, R. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0207096 · Cited by 109 · see citing works

IL-6 Signaling Regulates Small Intestinal Crypt Homeostasis

Jeffery, V., Goldson, A. J., Dainty, J. R., Chieppa, M., & Sobolewski, A. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1600960 · Cited by 105 · see citing works

Intestinal Mesenchymal Cells

Pinchuk, I. V., Mifflin, R. C., Saada, J. I., & Powell, D. W. (2010) · Current Gastroenterology Reports · doi:10.1007/s11894-010-0135-y · Cited by 104 · see citing works

Bacteria- and host-derived mechanisms to control intestinal epithelial cell homeostasis: Implications for chronic inflammation

Clavel, T., & Haller, D. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20174 · Cited by 105 · see citing works

Regulation of intestinal homeostasis by innate and adaptive immunity

Kayama, H., & Takeda, K. (2012) · International Immunology · doi:10.1093/intimm/dxs094 · Cited by 101 · see citing works

Formylpeptide receptor-2 contributes to colonic epithelial homeostasis, inflammation, and tumorigenesis

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Induction of IDO-1 by Immunostimulatory DNA Limits Severity of Experimental Colitis

Ciorba, M. A., Bettonville, E. E., McDonald, K. G., Metz, R. A., Prendergast, G. C., Newberry, R. D., & Stenson, W. F. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0900291 · Cited by 99 · see citing works

The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage

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MyD88 and its divergent toll in carcinogenesis

Salcedo, R., Cataisson, C., Hasan, U. A., Yuspa, S. H., & Trinchieri, G. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.03.008 · Cited by 95 · see citing works

Intestinal myofibroblast-specific Tpl2-Cox-2-PGE 2 pathway links innate sensing to epithelial homeostasis

Roulis, M., Nikolaou, C., Kotsaki, E., Kaffe, E., Karagianni, N., Koliaraki, V., Salpea, K. D., Ragoussis, J., Aidinis, V., Martini, E., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415762111 · Cited by 93 · see citing works

Stem Cells in Repair of Gastrointestinal Epithelia

Andersson-Rolf, A., Zilbauer, M., Koo, B., & Clevers, H. C. (2017) · Physiology · doi:10.1152/physiol.00005.2017 · Cited by 91 · see citing works

The yin and yang of intestinal epithelial cells in controlling dendritic cell function

Iliev, I. D., Matteoli, G., & Rescigno, M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062535 · Cited by 91 · see citing works

Role of toll-like receptors in tissue repair and tumorigenesis

Rakoff-Nahoum, S., & Medzhitov, R. M. (2008) · Biochemistry (Moscow) · doi:10.1134/s0006297908050088 · Cited by 89 · see citing works

Extrinsic control of Wnt signaling in the intestine

Koch, S. (2017) · Differentiation · doi:10.1016/j.diff.2017.08.003 · Cited by 89 · see citing works

Microbial Patterns Signaling via Toll-Like Receptors 2 and 5 Contribute to Epithelial Repair, Growth and Survival

Shaykhiev, R., Behr, J., & Bals, R. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001393 · Cited by 87 · see citing works

Igf2bp1 Is Required for Full Induction of Ptgs2 mRNA in Colonic Mesenchymal Stem Cells in Mice

Manieri, N. A., Drylewicz, M. R., Miyoshi, H., & Stappenbeck, T. S. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.03.037 · Cited by 86 · see citing works

Pathogen recognition receptors, cancer and inflammation in the gut

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Role of eicosanoids on intestinal epithelial homeostasis

Ferrer, R., & Moreno, J. J. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.04.033 · Cited by 80 · see citing works

NOD-like receptors in intestinal homeostasis and epithelial tissue repair

Parlato, M., & Yeretssian, G. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15069594 · Cited by 79 · see citing works

Innate and adaptive mechanisms to control of pathological intestinal inflammation

Kelsall, B. L. (2007) · The Journal of Pathology · doi:10.1002/path.2286 · Cited by 77 · see citing works

Plasticity of Intestinal Epithelium: Stem Cell Niches and Regulatory Signals

Kurokawa, K., Hayakawa, Y., & Koike, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010357 · Cited by 76 · see citing works

Innate Sensing of the Gut Microbiota: Modulation of Inflammatory and Autoimmune Diseases

Ignácio, A., Morales, C., Câmara, N. O. S., & Almeida, R. R. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00054 · Cited by 74 · see citing works

Human Intestinal Epithelial Cells Express Interleukin-10 through Toll-Like Receptor 4-Mediated Epithelial-Macrophage Crosstalk

Hyun, J., Romero, L., Riveron, R., Flores, C., Kanagavelu, S. K., Chung, K. D., Alonso, A., Sotolongo, J. P., Ruiz, J. R., Manukyan, A., et al. (2014) · Journal of Innate Immunity · doi:10.1159/000365417 · Cited by 73 · see citing works

Mechanisms of Induction and Maintenance of Constitutive Ptgs2 Expression in Colonic Mesenchymal Stem Cells

Drylewicz, M. R. (2012) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7z60m1w

Colonic epithelial response to injury requires Myd88 signaling in myeloid cells

Malvin, N., Seno, H., & Stappenbeck, T. (2012) · Mucosal Immunology · doi:10.1038/mi.2011.65 · Cited by 54 · see citing works

Mechanisms for Colonic Mucosal Wound Repair

Manieri, N. A. (2015) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7s75dgx

Prostaglandin-secreting cells: a portable first aid kit for tissue repair

Rakoff-Nahoum, S., & Medzhitov, R. M. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30865 · Cited by 17 · see citing works

Prostaglandins prevent decreased epithelial cell proliferation associated with dextran sodium sulfate injury in mice

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