Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell · doi:10.1016/0092-8674(91)90124-h · Cited by 4,116 · see citing works

The specificities of protein kinase inhibitors: an update

BAIN, J., McLAUCHLAN, H., ELLIOTT, M., & COHEN, P. (2003) · Biochemical Journal · doi:10.1042/bj20021535 · Cited by 1,369 · see citing works

A Small-Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog

Ichida, J. K., Blanchard, J., Lam, K., Son, E. Y., Chung, J. E., Egli, D., Loh, K. M., Carter, A. C., Di Giorgio, F. P., Koszka, K., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.09.012 · Cited by 808 · see citing works

Src kinases as therapeutic targets for cancer

Kim, L. C., Song, L., & Haura, E. B. (2009) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2009.129 · Cited by 700 · see citing works

A Logical Model Provides Insights into T Cell Receptor Signaling

Saez-Rodriguez, J., Simeoni, L., Lindquist, J. A., Hemenway, R., Bommhardt, U., Arndt, B., Haus, U.-U., Weismantel, R., Gilles, E. D., Klamt, S., et al. (2007) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0030163 · Cited by 352 · see citing works

Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor‐dependent, transcription‐independent mechanism

Croxtall, J. D., Choudhury, Q., & Flower, R. J. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703272 · Cited by 332 · see citing works

Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis

Sood, A. K., Armaiz-Pena, G. N., Halder, J., Nick, A. M., Stone, R. L., Hu, W., Carroll, A. R., Spannuth, W. A., Deavers, M. T., Allen, J. K., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40802 · Cited by 283 · see citing works

Tyrosine phosphatase STEP is a tonic brake on induction of long-term potentiation

Pelkey, K. A., Askalan, R., Paul, S., Kalia, L. V., Nguyen, T.-H., Pitcher, G. M., Salter, M. W., & Lombroso, P. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00633-5 · Cited by 208 · see citing works

Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells

Duxbury, M. S., Ito, H., Zinner, M. J., Ashley, S. W., & Whang, E. E. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-1183-3 · Cited by 192 · see citing works

Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus

Qiu, S., Zhao, L. F., Korwek, K. M., & Weeber, E. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2561-06.2006 · Cited by 186 · see citing works

Targeting Fyn Kinase in Alzheimer’s Disease

Nygaard, H. B. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.06.004 · Cited by 162 · see citing works

Proteinase-activated receptor 1 activation induces epithelial apoptosis and increases intestinal permeability

Chin, A. C., Vergnolle, N., MacNaughton, W. K., Wallace, J. L., Hollenberg, M. D., & Buret, A. G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1831452100 · Cited by 149 · see citing works

Molecular Mechanism of Hepcidin-Mediated Ferroportin Internalization Requires Ferroportin Lysines, Not Tyrosines or JAK-STAT

Ross, S. L., Tran, L., Winters, A., Lee, K.-J., Plewa, C., Foltz, I., King, C., Miranda, L. P., Allen, J., Beckman, H., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.017 · Cited by 145 · see citing works

HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib

Yang, G., Buhrlage, S. J., Tan, L., Liu, X., Chen, J., Xu, L., Tsakmaklis, N., Chen, J. G., Patterson, C. J., Brown, J. R., et al. (2016) · Blood · doi:10.1182/blood-2016-01-695098 · Cited by 135 · see citing works

Reelin, Very-Low-Density Lipoprotein Receptor, and Apolipoprotein E Receptor 2 Control Somatic NMDA Receptor Composition during Hippocampal Maturation<i>In Vitro</i>

Sinagra, M., Verrier, D., Frankova, D., Korwek, K. M., Blahos, J., Weeber, E. J., Manzoni, O. J., & Chavis, P. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1757-05.2005 · Cited by 128 · see citing works

Developmental Signaling in Hydra: What Does It Take to Build a “Simple” Animal?

Steele, R. E. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0744 · Cited by 129 · see citing works

Activated pp60c-Src Leads to Elevated Hypoxia-inducible Factor (HIF)-1α Expression under Normoxia

Karni, R., Dor, Y., Keshet, E., Meyuhas, O., & Levitzki, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206141200 · Cited by 116 · see citing works

Progesterone receptor membrane component-1 regulates hepcidin biosynthesis

Li, X., Rhee, D. K., Malhotra, R., Mayeur, C., Hurst, L. A., Ager, E., Shelton, G., Kramer, Y., McCulloh, D., Keefe, D., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci83831 · Cited by 112 · see citing works

Role of Src kinases and Syk in Fcγ receptor-mediated phagocytosis and phagosome-lysosome fusion

Majeed, M., Caveggion, E., Lowell, C. A., & Berton, G. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.70.5.801 · Cited by 97 · see citing works

Nr4a1 and Nr4a3 reporter mice are differentially sensitive to T cell receptor signal strength and duration

Jennings, E., Elliot, T. A. E., Thawait, N., Kanabar, S., Yam-Puc, J. C., Ono, M., Toellner, K.-M., Wraith, D. C., Anderson, G., & Bending, D. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108328 · Cited by 94 · see citing works

Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation

Leemhuis, J., Bouché, E., Frotscher, M., Henle, F., Hein, L., Herz, J., Meyer, D. K., Pichler, M., Roth, G., Schwan, C., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4036-10.2010 · Cited by 80 · see citing works

SHP-1 regulates Fcγ receptor–mediated phagocytosis and the activation of RAC

Kant, A. M., De, P., Peng, X., Yi, T., Rawlings, D. J., Kim, J. S., & Durden, D. L. (2002) · Blood · doi:10.1182/blood.v100.5.1852.h81702001852_1852_1859 · Cited by 81 · see citing works

Novel pyrazolopyrimidine derivatives as tyrosine kinase inhibitors with antitumoral activity in vitro and in vivo in papillary dedifferentiated thyroid cancer

Antonelli, A., Bocci, G., La Motta, C., Ferrari, S. M., Fallahi, P., Fioravanti, A., Sartini, S., Minuto, M., Piaggi, S., Corti, A., et al. (2011) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2010-1905 · Cited by 66 · see citing works

Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis

Griffiths, G. J., Koh, M. Y., Brunton, V. G., Cawthorne, C., Reeves, N. A., Greaves, M., Tilby, M. J., Pearson, D. G., Ottley, C. J., Workman, P., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408550200 · Cited by 60 · see citing works

Human Cytomegalovirus-Regulated Paxillin in Monocytes Links Cellular Pathogenic Motility to the Process of Viral Entry

Nogalski, M. T., Chan, G., Stevenson, E. V., Gray, S., & Yurochko, A. D. (2011) · Journal of Virology · doi:10.1128/jvi.02090-10 · Cited by 56 · see citing works

Amyloid precursor protein mediates proinflammatory activation of monocytic lineage cells

Sondag, C. M., & Combs, C. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313747200 · Cited by 56 · see citing works

Sodium l-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin

Hinek, A., Kim, H. J., Wang, Y., Wang, A., & Mitts, T. F. (2014) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2014.05.011 · Cited by 41 · see citing works

Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed

Mekonnen, Y. A., Gültas, M., Effa, K., Hanotte, O., & Schmitt, A. O. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01095 · Cited by 37 · see citing works

Extinction and reacquisition of a fear-motivated memory require activity of the Src family of tyrosine kinases in the CA1 region of the hippocampus

BEVILAQUA, L., DASILVA, W., MEDINA, J., IZQUIERDO, I., & CAMMAROTA, M. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.03.005 · Cited by 35 · see citing works

G-protein–coupled formyl peptide receptors play a dual role in neutrophil chemotaxis and bacterial phagocytosis

Wen, X., Xu, X., Sun, W., Chen, K., Pan, M., Wang, J. M., Bolland, S. M., & Jin, T. (2019) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-06-0358 · Cited by 30 · see citing works

Nonredundant roles of Src-family kinases and Syk in the initiation of B-cell antigen receptor signaling

Stepanek, O., Draber, P., Drobek, A., Horejsi, V., & Brdicka, T. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202401 · Cited by 31 · see citing works

The Src-family kinase inhibitor PP2 rescues inducible differentiation events in emergent retinoic acid-resistant myeloblastic leukemia cells

Jensen, H. A., Styskal, L. E., Tasseff, R., Bunaciu, R. P., Congleton, J., Varner, J. D., & Yen, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058621 · Cited by 18 · see citing works

Retina transduction by rAAV2 after intravitreal injection: Comparison between mouse and rat

Dias, M. S., Araujo, V. G., Vasconcelos, T., Li, Q., Hauswirth, W. W., Linden, R., & Petrs-Silva, H. (2019) · Gene Therapy · doi:10.1038/s41434-019-0100-9 · Cited by 17 · see citing works