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Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation
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Interferon-γ (IFN-γ) primes macrophages for enhanced microbial killing and inflammatory activation by Toll-like receptors (TLRs), but little is known about the regulation of cell metabolism or mRNA translation during this priming. We found that IFN-γ regulated the metabolism and mRNA translation of human macrophages by targeting the kinases mTORC1 and MNK, both of which converge on the selective regulator of translation initiation eIF4E. Physiological downregulation of mTORC1 by IFN-γ was associated with autophagy and translational suppression of repressors of inflammation such as HES1. Genome-wide ribosome profiling in TLR2-stimulated macrophages showed that IFN-γ selectively modulated the macrophage translatome to promote inflammation, further reprogram metabolic pathways and modulate protein synthesis. These results show that IFN-γ-mediated metabolic reprogramming and translational regulation are key components of classical inflammatory macrophage activation.
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“Although the IFN-γ and the mTOR pathways seem to be tightly interwoven, no data exist on the in vivo outcomes of mTORi on IFN-γ signaling and function38–40.”
From Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation (2019) · cites this paper as [40]
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Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364
mTOR Signaling in Growth Control and Disease
Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509
The M1 and M2 paradigm of macrophage activation: Time for reassessment
Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689
Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling
Ingolia, N. T., Ghaemmaghami, S., Newman, J. R. S., & Weissman, J. S. (2009) · Science · doi:10.1126/science.1168978 · Cited by 3,853
Regulation of type I interferon responses
Ivashkiv, L. B., & Donlin, L. T. (2013) · Nature reviews. Immunology · doi:10.1038/nri3581 · Cited by 3,442
Self-citationA diverse range of gene products are effectors of the type I interferon antiviral response
Schoggins, J. W., Wilson, S. J., Panis, M., Murphy, M. Y., Jones, C. T., Bieniasz, P. D., & Rice, C. M. (2011) · Nature · doi:10.1038/nature09907 · Cited by 2,412
Self-citationIdo expression by dendritic cells: tolerance and tryptophan catabolism
Mellor, A. L., & Munn, D. H. (2004) · Nature Reviews Immunology · doi:10.1038/nri1457 · Cited by 2,341
mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity
Cheng, S.-C., Quintin, J., Cramer, R. A., Shepardson, K. M., Saeed, S., Kumar, V., Giamarellos-Bourboulis, E. J., Martens, J. H. A., Rao, N. A., Aghajanirefah, A., et al. (2014) · Science · doi:10.1126/science.1250684 · Cited by 2,224
Autophagy in infection, inflammation and immunity
Deretic, V., Saitoh, T., & Akira, S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3532 · Cited by 1,919
Zoncu, R., Bar-Peled, L., Efeyan, A., Wang, S., Sancak, Y., & Sabatini, D. M. (2011) · Science · doi:10.1126/science.1207056 · Cited by 1,673
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Items 101–200 of 299
Zhang, H., Xue, C., Wang, Y., Shi, J., Zhang, X., Li, W., Núñez, S., Foulkes, A. S., Lin, J. J., Hinkle, C. C., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.007431 · Cited by 45
Mishra, B., & Ivashkiv, L. B. (2024) · Immunological Reviews · doi:10.1111/imr.13330 · Cited by 44
Self-citationHuynh, L., Kusnadi, A., Park, S. H., Murata, K., Park‐Min, K., & Ivashkiv, L. B. (2016) · Scientific Reports · doi:10.1038/srep31959 · Cited by 45
Self-citationCoccurello, R., Nazio, F., Rossi, C., Angelis, F. D., Vacca, V., Giacovazzo, G., Procacci, P., Magnaghi, V., Ciavardelli, D., & Marinelli, S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0208596 · Cited by 46
IFN-γ and TGF-β, Crucial Players in Immune Responses: A Tribute to Howard Young
Gauthier, T., & Chen, W. (2022) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2022.0132 · Cited by 45
Interferon-γ blocks signalling through PDGFRβ in human brain pericytes
Jansson, D., Scotter, E. L., Rustenhoven, J., Coppieters, N., Smyth, L. C. D., Oldfield, R. L., Bergin, P., Mee, E. W., Graham, E. S., Faull, R. L. M., et al. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0722-4 · Cited by 43
Viral Infections and Interferons in the Development of Obesity
Tian, Y., Jennings, J., Gong, Y., & Sang, Y. (2019) · Biomolecules · doi:10.3390/biom9110726 · Cited by 46
The role of cytokines in the evolution of cancer: IFN-γ paradigm
Todorović‐Raković, N. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155442 · Cited by 42
Jin, X., Merrett, J. E., Tong, S., Flower, B., Xie, J., Yu, R., Tian, S., Gao, L., Zhao, J., Wang, X., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.10.070 · Cited by 41
Cellular metabolism constrains innate immune responses in early human ontogeny
Kan, B., Michalski, C., Fu, H., Au, H. H. T., Lee, K., Marchant, E. A., Cheng, M. F., Anderson‐Baucum, E. K., Aharoni-Simon, M., Tilley, P. A. G., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07215-9 · Cited by 43
Estrella, B., Naumova, E. N., Cepeda, M., Voortman, T., Katsikis, P. D., & Drexhage, H. A. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16132347 · Cited by 41
The role of eIF4F-driven mRNA translation in regulating the tumour microenvironment
Bartish, M., Abraham, M. J., Gonçalves, C., Larsson, O. S., Rolny, C., & Rincon, S. V. D. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00567-5 · Cited by 42
Chen, K., Wang, H., Yang, Y., Tang, C., Sun, X., Zhou, J., Liu, S., Li, Q., Zhao, L., & Gao, Z. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02299-5 · Cited by 47
Braster, R., Bögels, M., Beelen, R. H. J., & van Egmond, M. (2015) · Immunobiology · doi:10.1016/j.imbio.2015.08.011 · Cited by 43
Chaparro, V., Leroux, L., Masvidal, L., Lorent, J., Graber, T. E., Zimmermann, A., Duque, G. A., Descoteaux, A., Alain, T., Larsson, O. S., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008291 · Cited by 39
Greene, C. J., Nguyen, J. A., Cheung, S., Arnold, C. R., Balce, D. R., Wang, Y., Söderholm, A., McKenna, N. T., Aggarwal, D., Campden, R. I., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30654-4 · Cited by 45
Kiritsy, M. C., Ankley, L. M., Trombley, J. D., Huizinga, G. P., Lord, A. E., Orning, P., Elling, R., Fitzgerald, K. A., & Olive, A. J. (2021) · eLife · doi:10.7554/elife.65110 · Cited by 34
Liang, S., Guo, X.-K., Ou, J., Huang, R., Xue, Q., Zhang, B., Chung, Y., Wu, W., Dong, C., Yang, X., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.03.012 · Cited by 40
Self-citationBush, S. J., Freem, L. J., MacCallum, A. J., O’Dell, J., Wu, C., Afrasiabi, C., Psifidi, A., Stevens, M. P., Smith, J., SUMMERS, K. M., et al. (2018) · BMC Genomics · doi:10.1186/s12864-018-4972-7 · Cited by 40
Myeloid effector cells in cancer
Schol, P. J., van Elsas, M. J., Middelburg, J., Twilhaar, M. K. N., van Hall, T., van der Sluis, T. C., & van der Burg, S. H. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.11.002 · Cited by 39
Epithelial Hes1 maintains gut homeostasis by preventing microbial dysbiosis
Guo, X.-K., Ou, J., Liang, S., Zhou, X., & Hu, X. (2018) · Mucosal Immunology · doi:10.1038/mi.2017.111 · Cited by 39
Self-citationSignaling by Type I Interferons in Immune Cells: Disease Consequences
Ζαννίκου, Μ., Fish, E. N., & Platanias, L. C. (2024) · Cancers · doi:10.3390/cancers16081600 · Cited by 43
Han, R., Gao, J., Zhai, H., Xiao, J., Ding, Y., & Hao, J. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.04.005 · Cited by 37
Wang, B., Cao, P., Wang, Z., Li, Z., Wang, Z., Ma, J., Liao, B., Deng, Y.-K., Long, X., Xu, K. L., et al. (2017) · Allergy · doi:10.1111/all.13153 · Cited by 36
Bogatu, A., Wysocka, M., Wysocki, O., Butterworth, H., Pillai, M. R., Allison, J., Landers, D., Kilgour, E., Thistlethwaite, F. C., & Freitas, A. (2023) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2023.104367 · Cited by 38
MNK2 governs the macrophage antiinflammatory phenotype
Bartish, M., Tong, D., Pan, Y., Wallerius, M., Liu, H., Ristau, J., Ferreira, S. D. S., Wallmann, T., van Hoef, V., Masvidal, L., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1920377117 · Cited by 34
Self-citationNakanishi, Y., Sato, T., Takahashi, K., & Ohteki, T. (2018) · Mucosal Immunology · doi:10.1038/mi.2017.104 · Cited by 35
Evaluating ribosomal frameshifting in CCR5 mRNA decoding
Khan, Y. A., Loughran, G., Steckelberg, A., Brown, K. A., Kiniry, S. J., Stewart, H., Baranov, P. V., Kieft, J. S., Firth, A. E., & Atkins, J. F. (2022) · Nature · doi:10.1038/s41586-022-04627-y · Cited by 34
Han, J., Dong, L., Wu, M., & Ma, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1160340 · Cited by 36
Mouse B2 SINE elements function as IFN-inducible enhancers
Horton, I., Kelly, C. J., Dziulko, A., Simpson, D. M., & Chuong, E. B. (2023) · eLife · doi:10.7554/elife.82617 · Cited by 33
Richard, K., Piepenbrink, K. H., Shirey, K. A., Gopalakrishnan, A., Nallar, S. C., Prantner, D., Perkins, D. J., Lai, W., Vlk, A., Toshchakov, V. Y., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20200675 · Cited by 33
Interferon regulates neural stem cell function at all ages by orchestrating mTOR and cell cycle
Ibañez, D. C., Skabkin, M. A., Hooli, J., Cerrizuela, S., Göpferich, M., Jolly, A., Volk, K., Zumwinkel, M., Bertolini, M., Figlia, G., et al. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202216434 · Cited by 37
Zhang, Y., Xing, X., Long, B., Cao, Y., Hu, S., Li, X., Yu, Y., Tian, D., Sui, B., Luo, Z., et al. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.700 · Cited by 30
Self-citationSchmidt, E. A., Fee, B. E., Henry, S. C., Nichols, A., Shinohara, M. L., Rathmell, J. C., MacIver, N. J., Coers, J., Ilkayeva, O., Koves, T. R., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.770735 · Cited by 30
Sanati, M., Pieterman, I., Levy, N., Akbari, T., Tavakoli, M., Najafabadi, A. H., & Yavari, S. A. (2025) · Biomaterials Science · doi:10.1039/d5bm00357a · Cited by 31
IFN-γ and LPS Induce Synergistic Expression of CCL2 in Monocytic Cells via H3K27 Acetylation
Akhter, N., Kochumon, S., Hasan, A., Wilson, A., Nizam, R., Madhoun, A. S. A., Al‐Rashed, F., Arefanian, H., Alzaïd, F., Sindhu, S. T. A. K., et al. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s368352 · Cited by 29
Chatterjee, S., Yabaji, S. M., Rukhlenko, O. S., Bhattacharya, B., Waligurski, E., Vallavoju, N., Ray, S., Kholodenko, B. Ν., Brown, L. E., Beeler, A. B., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102845 · Cited by 29
IL-6 translation is a therapeutic target of human cytokine release syndrome
Yang, Y., Zhang, Y., Xing, X., Xu, G., Lin, X., Wang, Y., Chen, M., Wang, C., Zhang, B., Han, W., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20230577 · Cited by 28
Self-citationWilliam, M., Leroux, L., Chaparro, V., Lorent, J., Graber, T. E., M’Boutchou, M.-N., Charpentier, T., Fabié, A., Dozois, C. M., Stäger, S., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701670 · Cited by 30
Zakaria, C., Sean, P., Hoang, H., Leroux, L., Watson, M., Workenhe, S. T., Hearnden, J., Pearl, D., Truong, V. T., Robichaud, N., et al. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007264 · Cited by 27
Pan, X.-Y., Wang, L., You, H.-M., Cheng, M., Yang, Y., Huang, C., & Li, J. (2021) · Laboratory Investigation · doi:10.1038/s41374-021-00531-7 · Cited by 26
The Role of mRNA Translational Control in Tumor Immune Escape and Immunotherapy Resistance
Cerezo, M., Robert, C., Liu, L., & Shen, S. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-1466 · Cited by 26
Nahle, S., Cassidy, H., Leroux, M. M., Mercier, R., Ghanbaja, J., Doumandji, Z., Matallanas, D., Rihn, B., Joubert, O., & Ferrari, L. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-0587-7 · Cited by 24
Halasz, H., Malekos, E., Covarrubias, S., Yitiz, S., Montano, C., Sudek, L. A., Katzman, S. J., Liu, S. J., Horlbeck, M. A., Namvar, L., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2322524121 · Cited by 25
Li, F., Sun, H., Li, Y., Bai, X., Dong, X., Zhao, N., Meng, J., Sun, B., & Zhang, D. (2021) · BMC Cancer · doi:10.1186/s12885-021-09010-0 · Cited by 26
Short open reading frame genes in innate immunity: from discovery to characterization
Malekos, E., & Carpenter, S. B. (2022) · Trends in Immunology · doi:10.1016/j.it.2022.07.005 · Cited by 25
Injectable Granular Hydrogels Enable Avidity-Controlled Biotherapeutic Delivery
D’Elia, A. M., Jones, O. L., Canziani, G., Sarkar, B., CHAIKEN, I. M., & Rodell, C. B. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c01906 · Cited by 24
mTOR Signaling in Macrophages: All Depends on the Context
Fedor, A., Bryniarski, K., & Nazimek, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157598 · Cited by 29
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Manneken, J. D., & Currie, P. D. (2023) · Development · doi:10.1242/dev.201510 · Cited by 27
William, M., Leroux, L., Chaparro, V., Graber, T. E., Alain, T., & Jaramillo, M. (2019) · European Journal of Immunology · doi:10.1002/eji.201847857 · Cited by 22
Santibáñez, Á., Paine‐Cabrera, D., Parra, M., Muñoz, C., Valdés, N., Zapata, C., Vargas, R. A., González, A., & Tello, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.696803 · Cited by 21
do Monte, E. R., Rossato, C., Pariona-Llanos, R., Russo, L. C., de Castro, L. M., Gozzo, F. C., de Araujo, C. B., Peron, J. P. S., Sant’Anna, O. A., Ferro, E. S., et al. (2016) · Journal of Proteomics · doi:10.1016/j.jprot.2016.08.003 · Cited by 21
Crisler, W. J., & Lenz, L. L. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.05.014 · Cited by 23
Bodhale, N. P., Ohms, M., Ferreira, C., Mesquita, I., Mukherjee, A., André, S., Sarkar, A., Estaquier, J., Laskay, T., Saha, B., et al. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155267 · Cited by 21
A Rapid Caspase-11 Response Induced by IFNγ Priming Is Independent of Guanylate Binding Proteins
Brubaker, S. W., Brewer, S. M., Massis, L. M., Napier, B. A., & Monack, D. M. (2020) · iScience · doi:10.1016/j.isci.2020.101612 · Cited by 20
Jou, E. (2023) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2023.00146 · Cited by 19
Yang, R., Du, Y., Zhang, M., Liu, Y., Feng, H., Liu, R., Yang, B., Xiao, J., He, P., & Niu, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1249731 · Cited by 21
Wu, C.-H., Guo, L., Hao, D., Wang, Q., Ye, X., Ito, M., Huang, B., Mineo, C., Shaul, P. W., & Li, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1110516 · Cited by 18
Type I and II interferons toward ideal vaccine and immunotherapy
Temizoz, B., & Ishii, K. J. (2021) · Expert Review of Vaccines · doi:10.1080/14760584.2021.1927724 · Cited by 18
Impaired interferon-γ signaling promotes the development of silicosis
Peng, Z., Duan, M., Tang, Y., Wu, J., Zhao, K., Zhong, Y., He, Z., Meng, J., Chen, F., Xiao, X., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104647 · Cited by 17
Self-citationLin, J., Liu, J., Ma, R., Hao, J., Liang, Y., Zhao, J., Zhang, A., Meng, H., & Lü, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.900826 · Cited by 18
Ferreira, P. T. M., Oliveira-Scussel, A. C. D. M., Sousa, R. A. P., Gomes, B. Q., Félix, J. E., da Silva, R. J., Milián, I. C. B., Farnesi-de-Assunção, T. S., Teixeira, S. C., Gomes, M. D. L. M., et al. (2023) · Immunobiology · doi:10.1016/j.imbio.2023.152357 · Cited by 17
Liu, Z., vonBargen, R. U., Kendricks, A. L., Wheeler, K., Leão, A. C., Sankaranarayanan, K., Dean, D. A., Kane, S. S., Hossain, E., Pollet, J. B. K., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42247-w · Cited by 17
mTORC1-mediated downregulation of COX2 restrains tumor growth caused by TSC2 deficiency
Li, H., Jin, F., Jiang, K., Ji, S., Wang, L., Ni, Z., Chen, X., Hu, Z., Zhang, H., Liu, Y., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8633 · Cited by 17
Autophagy gene-dependent intracellular immunity triggered by interferon-γ
McAllaster, M. R., Bhushan, J., Balce, D. R., Orvedahl, A., Park, A., Hwang, S., Sullender, M. E., Sibley, L. D., & Virgin, H. W. (2023) · mBio · doi:10.1128/mbio.02332-23 · Cited by 17
The Effect of Interferons on Presentation of Defective Ribosomal Products as HLA Peptides
Komov, L., Kadosh, D. M., Barnea, E., & Admon, A. (2021) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2021.100105 · Cited by 16
Genomic Circuitry Underlying Immunological Response to Pediatric Acute Respiratory Infection
Henrickson, S. E., Manne, S., Dolfi, D. V., Mansfield, K. D., Parkhouse, K., Mistry, R. D., Alpern, E. R., Hensley, S. E., Sullivan, K. E., Coffin, S. E., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.043 · Cited by 17
Yadav, S., Pandey, S. K., Goel, Y., Kujur, P. K., Maurya, B. N., Verma, A. K., Kumar, A., Singh, R. P., & Singh, S. M. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.01.149 · Cited by 16
Monocytes as suitable carriers for dissemination of dengue viral infection
Hwang, E.-H., Hur, G. H., Koo, B.-S., Oh, H., Kim, G., Jung, H., Baek, S. H., An, Y. J., Park, J.-H., & Hong, J. J. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e11212 · Cited by 15
Arefin, A., & Gage, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054785 · Cited by 17
Tamura, T., Cheng, C., Villaseñor-Altamirano, A. B., Yamada, K., Ikeda, K., Hayashida, K., Menon, J. A., Chen, X. D., Chung, H., Varon, J., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adq5796 · Cited by 16
Translation of TNFAIP2 is tightly controlled by upstream open reading frames
Scholz, A., Rappl, P., Böffinger, N. M., Mota, A. C., Brüne, B., & Schmid, T. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03265-4 · Cited by 16
PD-L1 near Infrared Photoimmunotherapy of Ovarian Cancer Model
Jin, J., Sivakumar, I., Mironchik, Y., Krishnamachary, B., Wildes, F. B., Barnett, J. D., Hung, C., Nimmagadda, S., Kobayashi, H., Bhujwalla, Z. M., et al. (2022) · Cancers · doi:10.3390/cancers14030619 · Cited by 15
Sonoafterglow nanoprobes for deep-tissue imaging of peroxynitrite
Xu, C., Huang, J., & Pu, K. (2025) · Nature Protocols · doi:10.1038/s41596-025-01202-3 · Cited by 16
Gunawan, C. K., Sumarpo, A., & Indrati, A. R. (2026) · Pathogens · doi:10.3390/pathogens15010051 · Cited by 14
Chen, Y., Liu, K., Qin, Y., Chen, S., Guan, G., Huang, Y., Chen, Y., & Mo, Z. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.869810 · Cited by 14
Fine-tuning of macrophage activation using synthetic rocaglate derivatives
Bhattacharya, B., Chatterjee, S., Devine, W. G., Kobzik, L., Beeler, A. B., Porco, J. A. J., & Kramnik, I. (2016) · Scientific Reports · doi:10.1038/srep24409 · Cited by 14
Minchenberg, S. B., & Massa, P. T. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.10.015 · Cited by 14
Autophagy machinery as exploited by viruses
Münz, C., Campbell, G. R., Esclatine, A., Faure, M., Labonté, P., Lussignol, M., Orvedahl, A., Altan‐Bonnet, N., Bartenschlager, R. F. W., Beale, R. C. L., et al. (2025) · Autophagy Reports · doi:10.1080/27694127.2025.2464986 · Cited by 14
Host Cell Amplification of Nutritional Stress Contributes To Persistence in Chlamydia trachomatis
Pokorzynski, N. D., Alla, M. R., & Carabeo, R. A. (2022) · mBio · doi:10.1128/mbio.02719-22 · Cited by 13
Monocyte/Macrophage: NK Cell Cooperation—Old Tools for New Functions
Wałajtys-Rode, E., & Dzik, J. M. (2017) · Results and problems in cell differentiation · doi:10.1007/978-3-319-54090-0_5 · Cited by 13
Qi, X., Shen, M., Fan, P., Guo, X., Wang, T., Feng, N., Zhang, M., Sweet, R. A., Kirisci, L., & Wang, L. (2020) · Molecules · doi:10.3390/molecules25122776 · Cited by 13
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Zhang, M., Che, Y., Zhao, S., Xia, X., Liu, H., Liu, J., Wang, Y., Han, W., Yang, Y., Zhou, C., et al. (2019) · Veterinary Microbiology · doi:10.1016/j.vetmic.2019.108420 · Cited by 11
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Du, W., Zhao, S., Gao, F., Wei, M., An, J., Jia, K., Li, F., Zhu, L., & Hao, J. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29510 · Cited by 11
Martin, A. T., Giri, S., Safronova, A., Eliseeva, S. I., Kwok, S. F., & Yarovinsky, F. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1011502 · Cited by 10
dos Santos, P. W. D. S., Rezende, C. P., Piraine, R. E. A., Oliveira, B., Ferreira, F. B., Carvalho, V. S., Calado, R. T., Pellegrini, M. A., & Almeida, F. B. D. R. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1468229 · Cited by 10
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Zhang, C., Jones, J. T., Chand, H. S., Wathelet, M. G., Evans, C. M., Dickey, B. F., Xiang, J., Mebratu, Y. A., & Tesfaigzi, Y. (2018) · Mucosal Immunology · doi:10.1038/mi.2017.117 · Cited by 9
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Chen, S., Zhao, Y., Jin, H., Qi, X., He, J., Huang, J., Ding, Y., Chen, W., Wu, C., Ding, X., et al. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.117207 · Cited by 9
Li, B., Liu, X., Long, Q., Zhuang, X., Gao, Y., Ali, B., Chen, H., Zhang, D., Wang, X., & Guo, W. (2023) · Nano Research · doi:10.1007/s12274-023-5743-6 · Cited by 9
Metadata
- Authors
- Su, X., Yu, Y., Zhong, Y., Giannopoulou, E. G., Hu, X., Liu, H., Cross, J. R., Rätsch, G., Rice, C. M., & Ivashkiv, L. B.
- Affiliations
- Hospital for Special Surgery (US)
- Rockefeller University (US)
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Ivashkiv, Lionel B
- Venue
- Nature Immunology
- Published
- 2015-06-29
- Volume
- 16
- Issue
- 8
- Pages
- 838-849
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC4509841
- OpenAlex
- W1550446004
- Cited by
- 298
- References
- 50
- Citations by year
- 2026: 25 · 2025: 25 · 2024: 22 · 2023: 31 · 2022: 29 · 2021: 30 · 2020: 26 · 2019: 24 · 2018: 39 · 2017: 15 · 2016: 27 · 2015: 5
- FWCI
- 12.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- CUNY Academic Works (City University of New York) (submittedVersion)
- Funders
- Hospital for Special Surgery
- National Institutes of Health (2r01ai046712-26)
- National Institute of Allergy and Infectious Diseases (R01-AI046712, R01AI044938)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR050401, R01AR046713)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- interferon-gamma, macrophage activation, metabolic reprogramming, mRNA translation, mTORC1, eIF4E, autophagy, Hes1, ribosome profiling, TLR2, inflammation, protein synthesis
- MeSH terms
- Transcription Factor HES-1, Mechanistic Target of Rapamycin Complex 1, Base Sequence, Cells, Cultured, Humans, Interferon-gamma, Macrophage Activation, Macrophages, Microscopy, Fluorescence, RNA, Messenger, Protein Biosynthesis, Blotting, Western, Signal Transduction, Protein Serine-Threonine Kinases, Homeodomain Proteins, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, RNA Interference, MicroRNAs, Eukaryotic Initiation Factor-4E, Multiprotein Complexes, Intracellular Signaling Peptides and Proteins, Toll-Like Receptor 2, Basic Helix-Loop-Helix Proteins, TOR Serine-Threonine Kinases
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