mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H + -ATPase

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351 · see citing works

mTOR: from growth signal integration to cancer, diabetes and ageing

Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941 · see citing works

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., & Sabatini, D. M. (2008) · Science · doi:10.1126/science.1157535 · Cited by 2,773 · see citing works

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., & Sabatini, D. M. (2010) · Cell · doi:10.1016/j.cell.2010.02.024 · Cited by 2,464 · see citing works

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Inoki, K., Li, Y., Xu, T., & Guan, K.-L. (2003) · Genes & Development · doi:10.1101/gad.1110003 · Cited by 1,911 · see citing works

Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology

Forgac, M. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2272 · Cited by 1,626 · see citing works

Regulation of TORC1 by Rag GTPases in nutrient response

Kim, E., Goraksha-Hicks, P., Li, L., Neufeld, T. P., & Guan, K.-L. (2008) · Nature Cell Biology · doi:10.1038/ncb1753 · Cited by 1,349 · see citing works

Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

Tee, A. R., Manning, B. D., Roux, P. P., Cantley, L. C., & Blenis, J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00506-2 · Cited by 1,211 · see citing works

Requirement of Prorenin Receptor and Vacuolar H + -ATPase–Mediated Acidification for Wnt Signaling

Cruciat, C., Ohkawara, B., Acebrón, S. P., Karaulanov, E., Reinhard, C., Ingelfinger, D., Boutros, M., & Niehrs, C. (2010) · Science · doi:10.1126/science.1179802 · Cited by 548 · see citing works

Trans-complex formation by proteolipid channels in the terminal phase of membrane fusion

Peters, C., Bayer, M. J., Bühler, S., Andersen, J., Mann, M., & Mayer, A. (2001) · Nature · doi:10.1038/35054500 · Cited by 501 · see citing works

Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: a dose-response study

Bohé, J., Low, A., Wolfe, R. R., & Rennie, M. J. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.050674 · Cited by 496 · see citing works

V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway

Hurtado‐Lorenzo, A., Skinner, M. A., Annan, J. E., Futai, M., Sun‐Wada, G., Bourgoin, S. G., Casanova, J. E., Wildeman, A. G., Bechoua, S., Ausiello, D. A., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1348 · Cited by 469 · see citing works

Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability

BEUGNET, A., TEE, A. R., TAYLOR, P. M., & PROUD, C. G. (2003) · Biochemical Journal · doi:10.1042/bj20021266 · Cited by 307 · see citing works

The v-ATPase V 0 Subunit a1 Is Required for a Late Step in Synaptic Vesicle Exocytosis in Drosophila

Hiesinger, P. R., Fayyazuddin, A., Mehta, S., Rosenmund, T., Schulze, K. L., Zhai, R. G., Verstreken, P., Cao, Y., Zhou, Y., Kunz, J., et al. (2005) · Cell · doi:10.1016/j.cell.2005.03.012 · Cited by 295 · see citing works

A cation counterflux supports lysosomal acidification

Steinberg, B. E., Huynh, K. K., Brodovitch, A., Jabs, S., Stauber, T., Jentsch, T. J., & Grinstein, S. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200911083 · Cited by 280 · see citing works

Concanamycin A, the Specific Inhibitor of V-ATPases, Binds to the Vo Subunit c

Huss, M., Ingenhorst, G., König, S., Gaßel, M., Dröse, S., Zeeck, A., Altendorf, K., & Wieczorek, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207345200 · Cited by 278 · see citing works

Identification and characterization of a lysosomal transporter for small neutral amino acids

Sagné, C., Agulhon, C., Ravassard, P., Darmon, M. C., Hamon, M., Mestikawy, S. E., Gasnier, B., & Bruno Giros, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121183498 · Cited by 233 · see citing works

The Vacuolar Proton Pump, V-ATPase, Is Required for Notch Signaling and Endosomal Trafficking in Drosophila

Yan, Y., Denef, N., & Schüpbach, T. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.07.001 · Cited by 220 · see citing works

Discovery of a Novel Antitumor Benzolactone Enamide Class That Selectively Inhibits Mammalian Vacuolar-Type (H+)-ATPases

Boyd, M. R., Farina, C., Belfiore, P., Gagliardi, S., Kim, J. W., Hayakawa, Y., Beutler, J. A., McKee, T. C., Bowman, B. J., & Bowman, E. J. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29517-3 · Cited by 143 · see citing works

Accumulation of amino acids by lysosomes incubated with amino acid methyl esters.

Reeves, J. P. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86787-x · Cited by 137 · see citing works

Purification of a Hepatic S6 Kinase from Cycloheximide-treated Rats

Price, D. J., Nemenoff, R. A., & Avruch, J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)80075-8 · Cited by 128 · see citing works

Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner

Christie, G. R., Hajduch, E., Hundal, H. S., Proud, C. G., & Taylor, P. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107694200 · Cited by 125 · see citing works

Salicylihalamide A Inhibits the V0 Sector of the V-ATPase through a Mechanism Distinct from Bafilomycin A1

Xie, X., Padrón, D., Liao, X., Wang, J., Roth, M. G., & Brabander, J. K. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313796200 · Cited by 113 · see citing works

The Ras/cAMP/Protein Kinase A Pathway Regulates Glucose-dependent Assembly of the Vacuolar (H+)-ATPase in Yeast

Bond, S., & Forgac, M. D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805232200 · Cited by 87 · see citing works

Competitive intra- and extracellular nutrient sensing by the transporter homologue Ssy1p

Wu, B., Ottow, K. E., Poulsen, P., Gaber, R. F., Albers, E., & Kielland‐Brandt, M. C. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200602089 · Cited by 78 · see citing works

A Model for the Proteolipid Ring and Bafilomycin/Concanamycin-binding Site in the Vacuolar ATPase of Neurospora crassa

Bowman, B. J., McCall, M. E., Baertsch, R., & Bowman, E. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605532200 · Cited by 75 · see citing works

mTOR Signaling in Growth Control and Disease

Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509 · see citing works

mTOR Signaling in Growth, Metabolism, and Disease

Saxton, R. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.02.004 · Cited by 7,555 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996 · see citing works

mTOR at the nexus of nutrition, growth, ageing and disease

Liu, G. Y., & Sabatini, D. M. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0199-y · Cited by 2,737 · see citing works

Dynamics and functions of lipid droplets

Olzmann, J. A., & Carvalho, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0085-z · Cited by 2,740 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) ¹

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,622 · see citing works

Oxidative stress and autophagy: The clash between damage and metabolic needs

Filomeni, G., De Zio, D., & Cecconi, F. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.150 · Cited by 2,195 · see citing works

MTOR: a pharmacologic target for autophagy regulation

Kim, Y. C., & Guan, K.-L. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73939 · Cited by 2,126 · see citing works

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

Mauthe, M., Orhon, I., Rocchi, C., Zhou, X., Luhr, M., Hijlkema, K.-J., Coppes, R. P., Engedal, N., Mari, M., & Reggiori, F. (2018) · Autophagy · doi:10.1080/15548627.2018.1474314 · Cited by 2,122 · see citing works

A lysosome‐to‐nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

Settembre, C., Zoncu, R., Medina, D. L., Vetrini, F., Erdin, S., Erdin, S. U., Huynh, T., Ferron, M., Karsenty, G., Vellard, M. C., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.32 · Cited by 1,932 · see citing works

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

Settembre, C., Fraldi, A., Medina, D. L., & Ballabio, A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3565 · Cited by 1,689 · see citing works

Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638 · see citing works

Mechanisms regulating skeletal muscle growth and atrophy

Schiaffino, S., Dyar, K. A., Ciciliot, S., Blaauw, B., & Sandri, M. (2013) · The FEBS Journal · doi:10.1111/febs.12253 · Cited by 1,492 · see citing works

Autophagy modulation as a potential therapeutic target for diverse diseases

Rubinsztein, D. C., Codogno, P., & Levine, B. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3802 · Cited by 1,429 · see citing works

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

Medina, D. L., Paola, S. D., Peluso, I., Armani, A., Stefani, D. D., Venditti, R., Montefusco, S., Rosato, A. S., Prezioso, C., Forrester, A. R., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3114 · Cited by 1,405 · see citing works

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

Roczniak-Ferguson, A., Petit, C. S. V., Froehlich, F., Qian, S., Ky, J., Angarola, B. L., Walther, T. C., & Ferguson, S. M. (2012) · Science Signaling · doi:10.1126/scisignal.2002790 · Cited by 1,358 · see citing works

The autophagosome: origins unknown, biogenesis complex

Lamb, C. A., Yoshimori, T., & Tooze, S. A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3696 · Cited by 1,307 · see citing works

Sestrin2 is a leucine sensor for the mTORC1 pathway

Wolfson, R. L., Chantranupong, L., Saxton, R. A., Shen, K., Scaria, S. M., Cantor, J. R., & Sabatini, D. M. (2016) · Science · doi:10.1126/science.aab2674 · Cited by 1,306 · see citing works

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

Yamamoto, K., Venida, A., Yano, J., Biancur, D. E., Kakiuchi, M., Gupta, S., Sohn, A. S. W., Mukhopadhyay, S., Lin, E. Y., Parker, S. J., et al. (2020) · Nature · doi:10.1038/s41586-020-2229-5 · Cited by 1,240 · see citing works

Emerging regulation and functions of autophagy

Boya, P., Reggiori, F., & Codogno, P. (2013) · Nature Cell Biology · doi:10.1038/ncb2788 · Cited by 1,216 · see citing works

AMPK: Sensing Glucose as well as Cellular Energy Status

Lin, S., & Hardie, D. G. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.10.009 · Cited by 1,195 · see citing works

Nutrient-sensing mechanisms and pathways

Efeyan, A., Comb, W. C., & Sabatini, D. M. (2015) · Nature · doi:10.1038/nature14190 · Cited by 1,110 · see citing works

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

Bar-Peled, L., Chantranupong, L., Cherniack, A. D., Chen, W. W., Ottina, K. A., Grabiner, B. C., Spear, E. D., Carter, S. L., Meyerson, M., & Sabatini, D. M. (2013) · Science · doi:10.1126/science.1232044 · Cited by 1,080 · see citing works

mTOR as a central hub of nutrient signalling and cell growth

Kim, J., & Guan, K. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0205-1 · Cited by 1,067 · see citing works

Making new contacts: the mTOR network in metabolism and signalling crosstalk

Shimobayashi, M., & Hall, M. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3757 · Cited by 1,053 · see citing works

Lysosomal Physiology

Xu, H., & Ren, D. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071649 · Cited by 1,028 · see citing works

Autophagy—a key player in cellular and body metabolism

Kim, K. H., & Lee, M. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.35 · Cited by 962 · see citing works

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

Sahay, G., Querbes, W., Alabi, C., Eltoukhy, A., Sarkar, S., Zurenko, C., Karagiannis, E., Love, K., Chen, D., Zoncu, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2614 · Cited by 948 · see citing works

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

Bar-Peled, L., Schweitzer, L. D., Zoncu, R., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.07.032 · Cited by 918 · see citing works

The lysosome as a cellular centre for signalling, metabolism and quality control

Lawrence, R. E., & Zoncu, R. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0244-7 · Cited by 920 · see citing works

Amino acid signalling upstream of mTOR

Jewell, J. L., Russell, R. C., & Guan, K.-L. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3522 · Cited by 894 · see citing works

Mechanisms and Functions of Long Non-Coding RNAs at Multiple Regulatory Levels

Zhang, X., Wang, W., Zhu, W., Dong, J., Cheng, Y., Yin, Z., & Shen, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225573 · Cited by 878 · see citing works

Metabolic control of autophagy

Galluzzi, L., Pietrocola, F., Levine, B., & Kroemer, G. (2014) · Cell · doi:10.1016/j.cell.2014.11.006 · Cited by 855 · see citing works

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

Chantranupong, L., Scaria, S. M., Saxton, R. A., Gygi, M. P., Shen, K., Wyant, G. A., Wang, T., Harper, J. W., Gygi, S. P., & Sabatini, D. M. (2016) · Cell · doi:10.1016/j.cell.2016.02.035 · Cited by 843 · see citing works

TFEB at a glance

Napolitano, G., & Ballabio, A. (2016) · Journal of Cell Science · doi:10.1242/jcs.146365 · Cited by 836 · see citing works

AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control

González, A., Hall, M. N., Lin, S.-C., & Hardie, D. G. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.015 · Cited by 797 · see citing works

The amino acid transporter SLC38A9 is a key component of a lysosomal membrane complex that signals arginine sufficiency to mTORC1

Wang, S., Tsun, Z., Wolfson, R. L., Shen, K., Wyant, G., Plovanich, M. E., Yuan, E. D., Jones, T. D., Chantranupong, L., Comb, W. C., et al. (2015) · Science · doi:10.1126/science.1257132 · Cited by 772 · see citing works

Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism

Perera, R. M., Stoykova, S., Nicolay, B. N., Ross, K. N., Fitamant, J., Boukhali, M., Lengrand, J., Deshpande, V., Selig, M. K., Ferrone, C. R., et al. (2015) · Nature · doi:10.1038/nature14587 · Cited by 799 · see citing works

Lysosome biology in autophagy

Yim, W. W., & Mizushima, N. (2020) · Cell Discovery · doi:10.1038/s41421-020-0141-7 · Cited by 800 · see citing works

Regulation of mTORC1 by amino acids

Bar-Peled, L., & Sabatini, D. M. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.03.003 · Cited by 773 · see citing works

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

Menon, S., Dibble, C. C., Talbott, G., Hoxhaj, G., Valvezan, A., Takahashi, H., Cantley, L., & Manning, B. (2014) · Cell · doi:10.1016/j.cell.2013.11.049 · Cited by 787 · see citing works

Differential regulation of mTORC1 by leucine and glutamine

Jewell, J. L., Kim, Y. C., Russell, R. C., Yu, F.-X., Park, H. W., Plouffe, S. W., Tagliabracci, V. S., & Guan, K.-L. (2015) · Science · doi:10.1126/science.1259472 · Cited by 757 · see citing works

The Neurology of mTOR

Lipton, J. O., & Şahin, M. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.034 · Cited by 732 · see citing works

Nutrient sensing and TOR signaling in yeast and mammals

González, A., & Hall, M. (2017) · EMBO Journal · doi:10.15252/embj.201696010 · Cited by 684 · see citing works

Glutaminolysis Activates Rag-mTORC1 Signaling

Durán, R. V., Oppliger, W., Robitaille, A. M., Heiserich, L., Skendaj, R., Gottlieb, E., & Hall, M. N. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.043 · Cited by 723 · see citing works

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

Dibble, C. C., & Manning, B. D. (2013) · Nature Cell Biology · doi:10.1038/ncb2763 · Cited by 716 · see citing works

Protein breakdown in muscle wasting: Role of autophagy-lysosome and ubiquitin-proteasome

Sandri, M. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.04.023 · Cited by 689 · see citing works

Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response

Olson, O. C., & Joyce, J. A. (2015) · Nature reviews. Cancer · doi:10.1038/nrc4027 · Cited by 703 · see citing works

Lysosomal storage disorders: The cellular impact of lysosomal dysfunction

Platt, F. M., Boland, B., & van der Spoel, A. C. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201208152 · Cited by 689 · see citing works

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

Abu-Remaileh, M., Wyant, G. A., Kim, C., Laqtom, N. N., Abbasi, M., Chan, S. H., Freinkman, E., & Sabatini, D. M. (2017) · Science · doi:10.1126/science.aan6298 · Cited by 665 · see citing works

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

Rebsamen, M., Pochini, L., Stasyk, T., de Araújo, M. E. G., Galluccio, M., Kandasamy, R. K., Snijder, B., Fauster, A., Rudashevskaya, E. L., Bruckner, M., et al. (2015) · Nature · doi:10.1038/nature14107 · Cited by 673 · see citing works

Regulation of mTORC1 and its impact on gene expression at a glance

Laplante, M., & Sabatini, D. M. (2013) · Journal of Cell Science · doi:10.1242/jcs.125773 · Cited by 665 · see citing works

The Lysosome as a Regulatory Hub

Perera, R. M., & Zoncu, R. (2016) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-125125 · Cited by 664 · see citing works

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide

Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A., Nakayama, K., Clohessy, J., & Pandolfi, P. (2016) · Nature · doi:10.1038/nature21034 · Cited by 594 · see citing works

mTORC1 signaling and the metabolic control of cell growth

Ben‐Sahra, I., & Manning, B. D. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.02.012 · Cited by 641 · see citing works

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

Martina, J. A., Diab, H. I., Lishu, L., Jeong-A, L., Patange, S., Raben, N., & Puertollano, R. (2014) · Science Signaling · doi:10.1126/scisignal.2004754 · Cited by 677 · see citing works

Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae

Conrad, M., Schothorst, J., Kankipati, H., Zeebroeck, G. V., Rubio‐Texeira, M., & Thevelein, J. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12065 · Cited by 616 · see citing works

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

Dibble, C. C., Elis, W., Menon, S., Qin, W., Klekota, J., Asara, J. M., Finan, P. M., Kwiatkowski, D. J., Murphy, L. O., & Manning, B. D. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.06.009 · Cited by 612 · see citing works

Disrupting proton dynamics and energy metabolism for cancer therapy

Parks, S. K., Chiche, J., & Pouysségur, J. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3579 · Cited by 613 · see citing works

The position of lysosomes within the cell determines their luminal pH

Johnson, D. E., Ostrowski, P., Jaumouillé, V., & Grinstein, S. (2016) · Journal of Cell Biology · doi:10.1083/jcb.201507112 · Cited by 590 · see citing works

Endosome maturation, transport and functions

Scott, C. C., Vacca, F., & Gruenberg, J. E. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.03.034 · Cited by 581 · see citing works

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

Tsun, Z.-Y., Bar-Peled, L., Chantranupong, L., Zoncu, R., Wang, T., Kim, C., Spooner, E., & Sabatini, D. M. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.09.016 · Cited by 565 · see citing works

An Autophagic Flux Probe that Releases an Internal Control

Kaizuka, T., Morishita, H., Hama, Y., Tsukamoto, S., Matsui, T., Toyota, Y., Kodama, A., Ishihara, T., Mizushima, T., & Mizushima, N. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.09.037 · Cited by 580 · see citing works

Autophagy: The spotlight for cellular stress responses

Ravanan, P., Florance, I., & Talwar, P. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.08.029 · Cited by 578 · see citing works

mTORC1 as the main gateway to autophagy

Rabanal-Ruiz, Y., Otten, E. G., & Korolchuk, V. (2017) · Essays in Biochemistry · doi:10.1042/ebc20170027 · Cited by 505 · see citing works

Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease

Colacurcio, D. J., & Nixon, R. A. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.05.004 · Cited by 548 · see citing works

Mechanisms and functions of lysosome positioning

Pu, J., Guardia, C. M. A., Keren‐Kaplan, T., & Bonifacino, J. S. (2016) · Journal of Cell Science · doi:10.1242/jcs.196287 · Cited by 542 · see citing works

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

Castellano, B. M., Thelen, A. M., Moldavski, O., Feltes, M., van der Welle, R. E. N., Mydock-McGrane, L., Jiang, X., van Eijkeren, R. J., Davis, O. B., Louie, S. M., et al. (2017) · Science · doi:10.1126/science.aag1417 · Cited by 562 · see citing works

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

Zhang, C., Jiang, B., Li, M., Zhu, M., Peng, Y., Zhang, Y., Wu, Y., Li, T. Y., Yu, L., Lu, Z., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.014 · Cited by 546 · see citing works

The dawn of the age of amino acid sensors for the mTORC1 pathway

Wolfson, R. L., & Sabatini, D. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.001 · Cited by 500 · see citing works

Where is mTOR and what is it doing there?

Betz, C., & Hall, M. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201306041 · Cited by 529 · see citing works

Twenty-five years of mTOR: Uncovering the link from nutrients to growth

Sabatini, D. (2017) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1716173114 · Cited by 448 · see citing works

Amino acid homeostasis and signalling in mammalian cells and organisms

Bröer, S., & Bröer, A. (2017) · Biochemical Journal · doi:10.1042/bcj20160822 · Cited by 496 · see citing works

Dendritic cell metabolism

Pearce, E. J., & Everts, B. (2014) · Nature reviews. Immunology · doi:10.1038/nri3771 · Cited by 482 · see citing works

Lysosome biogenesis: Regulation and functions

Yang, C., & Wang, X.-C. (2021) · Journal of Cell Biology · doi:10.1083/jcb.202102001 · Cited by 420 · see citing works

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

Chantranupong, L., Wolfson, R. L., Orozco, J. M., Saxton, R. A., Scaria, S. M., Bar-Peled, L., Spooner, E., Isasa, M., Gygi, S. P., & Sabatini, D. M. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.014 · Cited by 466 · see citing works

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

Saxton, R. A., Knockenhauer, K. E., Wolfson, R. L., Chantranupong, L., Pacold, M. E., Wang, T., Schwartz, T. U., & Sabatini, D. M. (2016) · Science · doi:10.1126/science.aad2087 · Cited by 457 · see citing works

Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome Acidification

Li, D. ‘., Wang, Z. V., Ding, G., Tan, W. H., Luo, X., Criollo, A., Xie, M., Jiang, N., May, H. I., Kyrychenko, V., et al. (2016) · Circulation · doi:10.1161/circulationaha.115.017443 · Cited by 466 · see citing works

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival

Efeyan, A., Zoncu, R., Chang, S. H., Gumper, I., Snitkin, H., Wolfson, R. L., Kirak, O., Sabatini, D. M., & Sabatini, D. M. (2012) · Nature · doi:10.1038/nature11745 · Cited by 457 · see citing works

TOR Signaling and Nutrient Sensing

Dobrenel, T., Caldana, C., Hanson, J., Robaglia, C., Vincentz, M., Veit, B. E., & Meyer, C. (2016) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-043014-114648 · Cited by 449 · see citing works

The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

Martini-Stoica, H., Xu, Y., Ballabio, A., & Zheng, H. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.02.002 · Cited by 436 · see citing works

Amino acids and mTORC1: from lysosomes to disease

Efeyan, A., Zoncu, R., & Sabatini, D. M. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.05.007 · Cited by 436 · see citing works

The ER–Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis

Ge, L., Melville, D., Zhang, M., & Schekman, R. W. (2013) · eLife · doi:10.7554/elife.00947 · Cited by 440 · see citing works

mTOR and autophagy: a dynamic relationship governed by nutrients and energy.

Dunlop, E., & Tee, A. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.08.006 · Cited by 428 · see citing works

TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress

Raben, N., & Puertollano, R. (2016) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-125407 · Cited by 437 · see citing works

The Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and Metabolism

Yoon, M.-S. (2016) · Nutrients · doi:10.3390/nu8070405 · Cited by 395 · see citing works

MITF-the first 25 years

Goding, C. R., & Arnheiter, H. (2019) · Genes & Development · doi:10.1101/gad.324657.119 · Cited by 430 · see citing works

Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases

Nixon, R. A., & Rubinsztein, D. C. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00757-5 · Cited by 435 · see citing works

Lysosomal storage diseases: from pathophysiology to therapy

Parenti, G., Andria, G., & Ballabio, A. (2015) · Annual Review of Medicine · doi:10.1146/annurev-med-122313-085916 · Cited by 404 · see citing works

Nutrient signaling to mTOR and cell growth

Jewell, J. L., & Guan, K. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.01.004 · Cited by 407 · see citing works

A multiprotein supercomplex controlling oncogenic signalling in lymphoma

Phelan, J. D., Young, R. M., Webster, D. E., Roulland, S., Wright, G. W., Kasbekar, M., Shaffer, A. L., Ceribelli, M., Wang, J. Q., Schmitz, R., et al. (2018) · Nature · doi:10.1038/s41586-018-0290-0 · Cited by 404 · see citing works

Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion

Zhou, J., Tan, S.-H., Nicolas, V., Bauvy, C., Yang, N., Zhang, J., Xue, Y., Codogno, P., & Shen, H. (2013) · Cell Research · doi:10.1038/cr.2013.11 · Cited by 391 · see citing works

Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma

Clark, C. A., Gupta, H. B., Sareddy, G. R., Pandeswara, S., Lao, S., Yuan, B., Drerup, J. M., Padron, A. S., Conejo-Garcia, J. R., Murthy, K., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0258 · Cited by 394 · see citing works

Endocytosis and CancerPreprint

Mellman, I., & Yarden, Y. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016949 · Cited by 391 · see citing works

A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation

Li, X., Rydzewski, N., Hider, A., Zhang, X., Yang, J., Wang, W., Gao, Q., Cheng, X., & Xu, H. (2016) · Nature Cell Biology · doi:10.1038/ncb3324 · Cited by 387 · see citing works

PtdIns(3,4,5) P 3-Dependent Activation of the mTORC2 Kinase Complex

Liu, P., Gan, W., Chin, Y. R., Ogura, K., Guo, J., Zhang, J., Wang, B., Blenis, J., Cantley, L. C., Toker, A., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0460 · Cited by 385 · see citing works

Autophagy: An Essential Degradation Program for Cellular Homeostasis and Life

Chun, Y., & Kim, J. (2018) · Cells · doi:10.3390/cells7120278 · Cited by 385 · see citing works

Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases

Petit, C. S., Roczniak-Ferguson, A., & Ferguson, S. M. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201307084 · Cited by 355 · see citing works

Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers

Sarkar, S. (2013) · Biochemical Society Transactions · doi:10.1042/bst20130134 · Cited by 367 · see citing works

Amino acid signalling upstream of mTOR

Jewell, J. L., Russell, R. C., & Guan, K.-L. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3522 · Cited by 894 · see citing works

PERSPECTIVES

(2011)

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., & Sabatini, D. M. (2010) · Cell · doi:10.1016/j.cell.2010.02.024 · Cited by 2,464 · see citing works

Rag–Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway

Valenstein, M. L., Lalgudi, P. V., Gu, X., Kedir, J. F., Taylor, M. S., Chivukula, R., & Sabatini, D. M. (2024) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2322755121 · Cited by 30 · see citing works

Deciphering the molecular mechanisms of amino acid sensing by mTOR

Angelidaki, D. D. (2023) · Kölner Universitäts PublikationsServer (Universität zu Köln)