Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482

APACHE II

Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1985) · Critical Care Medicine · doi:10.1097/00003246-198510000-00009 · Cited by 15,518

APACHE II-A Severity of Disease Classification System

Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1986) · Critical Care Medicine · doi:10.1097/00003246-198608000-00028 · Cited by 13,379

Bioconductor: open software development for computational biology and bioinformatics

Gentleman, R. C., Carey, V. J., Bates, D. M., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004) · Genome biology · doi:10.1186/gb-2004-5-10-r80 · Cited by 12,082

Adjusting batch effects in microarray expression data using empirical Bayes methods

Johnson, W. E., Li, C., & Rabinovic, A. (2007) · Biostatistics · doi:10.1093/biostatistics/kxj037 · Cited by 8,658

A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

Bolstad, B. M., Irizarry, R. A., Åstrand, M., & Speed, T. P. (2003) · Bioinformatics · doi:10.1093/bioinformatics/19.2.185 · Cited by 8,328

APACHE II: a severity of disease classification system.

Knaus, W. A., Draper, E. S., Wagner, D. P., & Zimmerman, J. E. (1985) · PubMed · Cited by 6,034

affy—analysis of Affymetrix GeneChip data at the probe level

Gautier, L., Cope, L., Bolstad, B. M., & Irizarry, R. A. (2004) · Bioinformatics · doi:10.1093/bioinformatics/btg405 · Cited by 5,221

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., et al. (2013) · Nature · doi:10.1038/nature11986 · Cited by 4,176

Severe Sepsis and Septic Shock

Angus, D. C., & van der Poll, T. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1208623 · Cited by 4,119

Population-Specific Metabolic Alterations in Professional Antigen-Presenting Cells Contribute to Sepsis-Associated Immunosuppression

Schenz, J., Tamulyte, S., Nußhag, C., Brenner, T., Poschet, G., Weigand, M. A., & Uhle, F. (2019) · Shock · doi:10.1097/shk.0000000000001337 · Cited by 20

Mechanisms of Ataxia Telangiectasia Mutated (ATM) Control in the DNA Damage Response to Oxidative Stress, Epigenetic Regulation, and Persistent Innate Immune Suppression Following Sepsis

Huff, L. A., Yan, S., & Clemens, M. G. (2021) · Antioxidants · doi:10.3390/antiox10071146 · Cited by 21

Shaping of the alveolar landscape by respiratory infections and long-term consequences for lung immunity

Rodriguez-Rodriguez, L., Gillet, L., & Machiels, B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1149015 · Cited by 23

PKM2/STAT1-mediated PD-L1 upregulation on neutrophils during sepsis promotes neutrophil organ accumulation by serving an anti-apoptotic role

Li, Y., Tan, R., Li, R., Tian, R., Liu, Z., Wang, X., Chen, E., Pan, T., & Qu, H. (2023) · Journal of Inflammation · doi:10.1186/s12950-023-00341-2 · Cited by 21

Proteomics of Rat Lungs Infected by Cryptococcus gattii Reveals a Potential Warburg-like Effect

da Rosa, R. L., Berger, M., Santi, L., Driemeier, D., Terraciano, P. B., Campos, A. R., Guimarães, J. A., Vainstein, M. H., Yates, J. R., & Beys‐da‐Silva, W. O. (2019) · Journal of Proteome Research · doi:10.1021/acs.jproteome.9b00326 · Cited by 20

Type IV pilus retraction enables sustained bacteremia and plays a key role in the outcome of meningococcal sepsis in a humanized mouse model

Barnier, J., Euphrasie, D., Join‐Lambert, O., Audry, M., Schönherr-Hellec, S., Schmitt, T., Bourdoulous, S., Coureuil, M., Nassif, X., & Behi, M. E. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009299 · Cited by 20

The role of hormones in sepsis: an integrated overview with a focus on mitochondrial and immune cell dysfunction

Melis, M. J., Khpal, M., Peters, V. B. M., & Singer, M. (2023) · Clinical Science · doi:10.1042/cs20220709 · Cited by 24

HIF1α-Induced Glycolysis in Macrophage Is Essential for the Protective Effect of Ouabain during Endotoxemia

Shao, C., Lin, S., Liu, S., Jin, P., Lu, W., Li, N., Zhang, Y., Bo, L., & Bian, J. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7136585 · Cited by 19

Age-related fatigue is associated with reduced mitochondrial function in peripheral blood mononuclear cells

Herpich, C., Franz, K., Klaus, S., Müller‐Werdan, U., Ost, M., & Norman, K. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111177 · Cited by 19

Innate Immune Memory in Macrophages

Maheshwari, A. (2023) · Newborn · doi:10.5005/jp-journals-11002-0058 · Cited by 18

Selective reconstitution of IFN‑γ gene function in Ncr1+ NK cells is sufficient to control systemic vaccinia virus infection

Borst, K., Flindt, S., Blank, P., Larsen, P., Chhatbar, C., Skerra, J., Spanier, J., Hirche, C., König, M. F., Alanentalo, T., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008279 · Cited by 20

The circular RNA landscape in specific peripheral blood mononuclear cells of critically ill patients with sepsis

Khan, H. N., Brands, X., Aufiero, S., Hoogendijk, A. J., Klarenbeek, A. M., van Engelen, T. S. R., Haak, B. W., van Vught, L. A., Horn, J., Schultz, M. J., et al. (2020) · Critical Care · doi:10.1186/s13054-020-03146-4 · Cited by 19

Modelling Microglial Innate Immune Memory In Vitro: Understanding the Role of Aerobic Glycolysis in Innate Immune Memory

Towriss, M., MacVicar, B. A., & Ciernia, A. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108967 · Cited by 19

Critical Role of IL1R2‐ENO1 Interaction in Inhibiting Glycolysis‐Mediated Pyroptosis for Protection Against Lethal Sepsis

Tan, C., Ma, H., Chen, J., Ma, G., Jha, A., Tan, S., Zhu, Y., Liu, M., Liu, K., Xiao, X., et al. (2025) · Advanced Science · doi:10.1002/advs.202502297 · Cited by 18

Effects of cobalt and chromium ions on glycolytic flux and the stabilization of hypoxia‐inducible factor‐1α in macrophages in vitro

Salloum, Z., Lehoux, E. A., Harper, M., & Catelas, I. (2020) · Journal of Orthopaedic Research® · doi:10.1002/jor.24758 · Cited by 19

Dynamic changes in macrophage metabolism modulate induction and suppression of Type I inflammatory responses

Luan, H., & Horng, T. (2021) · Current Opinion in Immunology · doi:10.1016/j.coi.2021.07.012 · Cited by 18

Rhodomeroterpene alleviates macrophage infiltration and the inflammatory response in renal tissue to improve acute kidney injury

Wu, Y., Shi, Q., Zhu, P., Ma, H., Cui, S., Li, J., Hou, A., & Li, J. (2021) · The FASEB Journal · doi:10.1096/fj.202100981rr · Cited by 18

Using RNA-Seq to Investigate Immune-Metabolism Features in Immunocompromised Patients With Sepsis

Cheng, P., Chen, H., Jiang, Y., Hsiao, T., Wang, C.-Y., Wu, C., Ko, T., & Chao, W. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.747263 · Cited by 18

Respiration supports intraphagosomal filamentation and escape of Candida albicans from macrophages

Case, N. T., Westman, J., Hallett, M. T., Plumb, J. D., Farheen, A., Maxson, M. E., MacAlpine, J., Liston, S. D., Hube, B., Robbins, N., et al. (2023) · mBio · doi:10.1128/mbio.02745-23 · Cited by 18

Train to Lose: Innate Immune Memory in Metaflammation

Charles‐Messance, H., & Sheedy, F. J. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900480 · Cited by 18

LBP Protects Hepatocyte Mitochondrial Function Via the PPAR-CYP4A2 Signaling Pathway in a Rat Sepsis Model

Song, Z., Meng, L., He, Z., Huang, J., Li, F., Feng, J., Jia, Z., Huang, Y., Liu, W., Liu, A., et al. (2021) · Shock · doi:10.1097/shk.0000000000001808 · Cited by 18

Nutrition and infection

Weiss, G. (2017) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2017.10.028 · Cited by 17

What every intensivist should know about the biphasic kinetics of lactate in septic shock

Castro, R., Glenn Hernández, P., Kattan, E., & Bakker, J. (2025) · Journal of Critical Care · doi:10.1016/j.jcrc.2025.155286 · Cited by 17

The Association of Premorbid Metformin Exposure With Mortality and Organ Dysfunction in Sepsis: A Systematic Review and Meta-Analysis

Tan, K., Simpson, A., Huang, S., Tang, B. M. P., McLean, A. S., & Nalos, M. (2019) · Critical Care Explorations · doi:10.1097/cce.0000000000000009 · Cited by 17

Monitoring immunomodulation in patients with sepsis

Kyriazopoulou, E., & Giamarellos‐Bourboulis, E. J. (2020) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2020.1851199 · Cited by 17

Immunomonitoring of Monocyte and Neutrophil Function in Critically Ill Patients: From Sepsis and/or Trauma to COVID-19

Udovičić, I., Stanojević, I., Djordjevic, D., Zeba, S., Rondović, G., Abazovic, T., Lazic, S., Vojvodić, D., To, K., Abazović, D., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10245815 · Cited by 19

Acyloxyacyl hydrolase promotes pulmonary defense by preventing alveolar macrophage tolerance

Cheng, X., Jiang, W., Chen, Y., Zou, B., Wang, Z., Gan, L., Xiao, Z., Li, C., Yu, C., Lu, Y., et al. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011556 · Cited by 17

Integrating genetic and immune factors to uncover pathogenetic mechanisms of viral-associated pulmonary aspergillosis

Gonçalves, S. M., Pereira, I. M., Feys, S., Cunha, C., Chamilos, G., Hoenigl, M., Wauters, J., van de Veerdonk, F. L., & Carvalho, A. (2024) · mBio · doi:10.1128/mbio.01982-23 · Cited by 18

Pathogenic, immunologic, and clinical aspects of sepsis – update 2016

Uhle, F., Chousterman, B. G., Grützmann, R., Brenner, T., & Weber, G. F. (2016) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2016.1224971 · Cited by 17

TnI and IL-18 levels are associated with prognosis of sepsis

Wu, Q., Xiao, Z., Pu, Y., Zhou, J., Wang, D., Huang, Z., & Hou, D. (2019) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2018-136371 · Cited by 18

A second C-reactive protein (CRP) test to detect inflammatory burst in patients with acute bacterial infections presenting with a first relatively low CRP

Goldberg, I., Shalmon, D., Shteinvil, R., Berliner, S. A., Paran, Y., Zeltser, D., Shapira, I., Shenhar‐Tsarfaty, S., Meilik, A., Wasserman, A., et al. (2020) · Medicine · doi:10.1097/md.0000000000022551 · Cited by 17

Cellular and Exosomal Regulations of Sepsis-Induced Metabolic Alterations

Appiah, M. G., Park, E. J., Akama, Y., Nakamori, Y., Kawamoto, E., Gaowa, A., & Shimaoka, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158295 · Cited by 19

Severe thermal and major traumatic injury results in elevated plasma concentrations of total heme that are associated with poor clinical outcomes and systemic immune suppression

Tullie, S., Nicholson, T., Bishop, J. R. B., McGee, K. C., Asiri, A., Sullivan, J., Chen, Y., Sardeli, A. V., Belli, A., Harrison, P., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1416820 · Cited by 16

α‐Ketoglutarate plays an inflammatory inhibitory role by regulating scavenger receptor class a expression through N6‐methyladenine methylation during sepsis

Liang, G., Hu, J., Liu, R., Chao, Y., Hu, Y., Zheng, H., Pan, X., Li, Y., Gong, Y., Lin, C., et al. (2024) · European Journal of Immunology · doi:10.1002/eji.202350655 · Cited by 16

Do microglia metabolize fructose in Alzheimer’s disease?

Sturno, A. M., Hassell, J. E., Lanaspa, M. A., & Bruce, K. D. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03401-x · Cited by 20

Single-cell multi-omics-based immune temporal network resolution in sepsis: unravelling molecular mechanisms and precise therapeutic targets

Liu, H., & Liang, Q. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1616794 · Cited by 19

Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis

Stier, M. T., Sewell, A. E., Mwizerwa, E. L., Sim, C. Y., Tanner, S., Nichols, C. M., Durai, H. H., Jennings, E. Q., Lindau, P., Wilfong, E. M., et al. (2026) · Nature Immunology · doi:10.1038/s41590-025-02390-6 · Cited by 21

Caspase‐1 inflammasome activity in patients with Staphylococcus aureus bacteremia

Rasmussen, G., Idosa, B. A., Bäckman, A., Monecke, S., Strålin, K., Särndahl, E., & Söderquist, B. (2019) · Microbiology and Immunology · doi:10.1111/1348-0421.12738 · Cited by 16

De-escalation antibiotic therapy alleviates organ injury through modulation of NETs formation during sepsis

Duan, Z., Xie, T., Chu, C., Chen, F., Wang, X., Li, J., & Ding, W. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00745-0 · Cited by 16

Mathematical modeling of septic shock based on clinical data

Yamanaka, Y., Uchida, K., Akashi, M., Watanabe, Y., Yaguchi, A., Shimamoto, S., Shimoda, S., Yamada, H., Yamashita, M., & Kimura, H. (2019) · Theoretical Biology and Medical Modelling · doi:10.1186/s12976-019-0101-9 · Cited by 16

Differential Roles of Dendritic Cells in Expanding CD4 T Cells in Sepsis

Darkwah, S. O., Nago, N., Appiah, M. G., Myint, P. K., Kawamoto, E., Shimaoka, M., & Park, E. J. (2019) · Biomedicines · doi:10.3390/biomedicines7030052 · Cited by 16

IL-10-producing regulatory B cells exhibit functional defects and play a protective role in severe endotoxic shock

Tao, L., Wang, Y., Xu, J., Su, J., Yang, Q. Z., Deng, W., Zou, B., Tan, Y., Ding, Z., & Li, X. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104457 · Cited by 16

MKP-1 Modulates Mitochondrial Transcription Factors, Oxidative Phosphorylation, and Glycolysis

Bauerfeld, C. P., Talwar, H. S., Zhang, K., Liu, Y., & Samavati, L. (2020) · ImmunoHorizons · doi:10.4049/immunohorizons.2000015 · Cited by 16

Psychological distress and lack of PINK1 promote bioenergetics alterations in peripheral blood mononuclear cells

Grigoruţă, M., Dagda, R. K., Díaz‐Sánchez, Á. G., & Martı́nez-Martı́nez, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-66745-9 · Cited by 16

Emerging roles of microRNAs in the metabolic control of immune cells

Yao, Q., Song, Z., Wang, B., & Zhang, J. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.06.024 · Cited by 17

Dichloroacetate-induced metabolic reprogramming improves lifespan in a Drosophila model of surviving sepsis

Bakalov, V., Reyes-Uribe, L., Deshpande, R., Maloy, A., Shapiro, S. D., Angus, D. C., Chang, C. H., Moyec, L. L., Wendell, S. G., & Kaynar, A. M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241122 · Cited by 17

Dysregulation of Host–Pathogen Interactions in Sepsis: Host-Related Factors

Joosten, S. C. M., Wiersinga, W. J., & van der Poll, T. (2024) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0044-1787554 · Cited by 16

The immunosuppressive mechanisms induced by sepsis and the corresponding treatment strategies

Gao, Q., Teng, Y., Zhu, L., Zhang, W., & Li, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1643194 · Cited by 18

Safety and recommendations for vaccinations of children with inborn errors of metabolism

Hady-Cohen, R., Dragoumi, P., Bârcă, D., Plecko, B., Lerman‐Sagie, T., & Zafeiriou, D. (2021) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2021.10.002 · Cited by 15

Detecting Critical Functional Ingredients Group and Mechanism of Xuebijing Injection in Treating Sepsis

Wu, Q., Yin, C., Li, Y., Cai, J., Yang, H., Huang, Y., Zheng, Y., Xiong, K., Yu, H., Lü, A., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.769190 · Cited by 15

Potential biomarkers used for risk estimation of pediatric sepsis-associated organ dysfunction and immune dysregulation

Jariyasakoolroj, T., Chattipakorn, S. C., & Chattipakorn, N. (2024) · Pediatric Research · doi:10.1038/s41390-024-03289-y · Cited by 15

A positive correlation between serum lactate dehydrogenase level and in-hospital mortality in ICU sepsis patients: evidence from two large databases

Yu, H., Yang, Q., Qian, Y., Luo, S., Kong, T., Yang, G., Chen, W., Xie, F., Chen, J., Xiong, X., et al. (2024) · European journal of medical research · doi:10.1186/s40001-024-02071-4 · Cited by 15

Identification of CD38 high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis

Hua, N., Kong, L., Fan, L., Bai, Y., Zhou, Y., Zhang, Y., Zhao, Q. D., Lu, X., Yang, H., Li, H., et al. (2025) · Advanced Science · doi:10.1002/advs.202500457 · Cited by 16

Analysis of mitochondrial respiratory function in tissue biopsies and blood cells

Ost, M., Doerrier, C., Gama-Pérez, P., & Moreno-Gomez, S. (2018) · Current opinion in clinical nutrition and metabolic care · doi:10.1097/mco.0000000000000486 · Cited by 14

Glucocorticoid-Induced Leucine Zipper: A Promising Marker for Monitoring and Treating Sepsis

He, Y., Xu, J., Sun, M., Fang, X., Peng, Z.-K., Pan, S., Zhou, T., Wang, Y., & Shang, Y. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.606649 · Cited by 14

Modulation of Metabolomic Profile in Sepsis According to the State of Immune Activation

Kranidioti, E., Ricaño-Ponce, I., Antonakos, N., Kyriazopoulou, E., Kotsaki, A., Tsangaris, I., Markopoulou, D., Rovina, N., Antoniadou, E., Koutsodimitropoulos, I., et al. (2024) · Critical Care Medicine · doi:10.1097/ccm.0000000000006391 · Cited by 14

The epigenetic regulator G9a attenuates stress-induced resistance and metabolic transcriptional programs across different stressors and species

Riahi, H., Fencková, M., Goruk, K. J., Schenck, A., & Kramer, J. M. (2021) · BMC Biology · doi:10.1186/s12915-021-01025-0 · Cited by 14

GLUT3 as an Intersection of Glycerophospholipid Metabolism and the Innate Immune Response to Candida albicans

Wu, X., Zhang, G., Yang, W., Cui, J., Zhang, L., Xiao, M., & Xu, Y. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.648988 · Cited by 14

Targeting immunometabolism in host-directed therapies to fungal disease

Gonçalves, S. M., Ferreira, A. V., Cunha, C., & Carvalho, A. (2021) · Clinical & Experimental Immunology · doi:10.1093/cei/uxab014 · Cited by 15

The impact of bacteremia on lipoprotein concentrations and patient’s outcome: a retrospective analysis

Pizzini, A., Kurz, K., Orth‐Höller, D., Fille, M., Rabensteiner, J., Lunger, F., Lunger, L., Tschurtschenthaler, C., Tancevski, I., Krause, R., et al. (2019) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-019-03543-w · Cited by 14

Mucosal anti-infections vaccines: Beyond conventional vaccines

Sánchez‐Ramón, S., Manzanares, M., & Candelas, G. (2019) · Reumatología Clínica (English Edition) · doi:10.1016/j.reumae.2018.10.020 · Cited by 14

Momordica charantia Suppresses Inflammation and Glycolysis in Lipopolysaccharide-Activated RAW264.7 Macrophages

Lee, S. Y., Wong, W. F., Dong, J., & Cheng, K. (2020) · Molecules · doi:10.3390/molecules25173783 · Cited by 14

Mitochondria at the Heart of Sepsis: Mechanisms, Metabolism, and Sex Differences

Yap, J. Q., Nikouee, A., Lau, J. E., Walsh, G., & Zang, Q. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094211 · Cited by 15

Identification of key genes related to immune cells in patients with gram-negative sepsis based on weighted gene co-expression network analysis

Zhu, D., Zhu, K., & Guo, S. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-3307 · Cited by 13

Mortality of septic shock patients is associated with impaired mitochondrial oxidative coupling efficiency in lymphocytes: a prospective cohort study

Nedel, W. L., Kopczynski, A., Rodolphi, M. S., Strogulski, N. R., Bastiani, M. D., Montes, T. H. M., Abruzzi, J., Galina, A., Horváth, T. L., & Portela, L. V. (2021) · Intensive Care Medicine Experimental · doi:10.1186/s40635-021-00404-9 · Cited by 13

MicroRNA-451a and Th1/Th2 ratio inform inflammation, septic organ injury, and mortality risk in sepsis patients

Geng, F., Liu, W., & Yu, L. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.947139 · Cited by 13

Identification of novel biomarkers involved in doxorubicin-induced acute and chronic cardiotoxicity, respectively, by integrated bioinformatics

Qian, H., Qian, Y., Liu, Y., Cao, J., Wang, Y., Yang, A., Zhao, W., Lu, Y., Liu, H., & Zhu, W. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.996809 · Cited by 13

Sustained Immunoparalysis in Endotoxin-Tolerized Monocytic Cells

Weisheit, C. K., Klüners, A., Wild, L. C., Casalter, A., Heilmann‐Heimbach, S., Sivalingam, S., Kleiner, J. L., Ehrentraut, S., Hoeft, A., Frede, S., et al. (2020) · Mediators of Inflammation · doi:10.1155/2020/8294342 · Cited by 13

Decreased Intestinal Microbiome Diversity in Pediatric Sepsis: A Conceptual Framework for Intestinal Dysbiosis to Influence Immunometabolic Function

Weiss, S. L., Bittinger, K. L., Lee, J., Friedman, E. S., Mattei, L. M., Graham, K., Zhang, D. “., Bush, J., Balamuth, F., McGowan, F. X. J., et al. (2021) · Critical Care Explorations · doi:10.1097/cce.0000000000000360 · Cited by 13

Current Insights into Glutathione Depletion in Adult Septic Patients

Gomar, S., Bou, R., Puertas, F. J., Miranda, M., Romero, F. J., & Romero, B. (2025) · Antioxidants · doi:10.3390/antiox14091033 · Cited by 15

A role for artificial intelligence in molecular imaging of infection and inflammation

Schwenck, J., Kneilling, M., Riksen, N. P., la Fougère, C., Mulder, D. J., Slart, R., & Aarntzen, E. H. J. G. (2022) · European Journal of Hybrid Imaging · doi:10.1186/s41824-022-00138-1 · Cited by 13

Macrophage Biology in Human Granulomatous Skin Inflammation

Klapproth, H., Arana, M. H., & Fabri, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054624 · Cited by 13

New Insights in Immunometabolism in Neonatal Monocytes and Macrophages in Health and Disease

de Jong, R., Tenbrock, K., & Ohl, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814173 · Cited by 14

Antibiotic-Induced Immunosuppression—A Focus on Cellular Immunity

Snow, T. A. C., Singer, M., & Arulkumaran, N. (2024) · Antibiotics · doi:10.3390/antibiotics13111034 · Cited by 17

An Inverse Relationship Between c-Kit/CD117 and mTOR Confers NK Cell Dysregulation Late After Severe Injury

Bösken, B., Hepner-Schefczyk, M., Vonderhagen, S., Dudda, M., & Flohé, S. B. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01200 · Cited by 12

Immunometabolic reprogramming in sepsis: mechanisms, clinical endotypes, and therapeutic opportunities

Liu, C., Cai, Y., Ma, Q., & Sun, W. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1731995 · Cited by 14

Persistent Monocytic Bioenergetic Impairment and Mitochondrial DNA Damage in PASC Patients with Cardiovascular Complications

Semo, D., Shomanova, Z., Sindermann, J. R., Möhr, M., Evers, G., Motloch, L. J., Reinecke, H., Godfrey, R., & Pistulli, R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104562 · Cited by 13

Epigenetic Modulation by Lactylation in Sepsis: Linking Metabolism to Immune Dysfunction

Chen, Y., Hu, H., Wang, C., Wu, J., Zan, J., & Liu, Y. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s522081 · Cited by 11

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Huang, M., Liu, X., Ye, H., Zhao, X., Zhao, J., Liu, Y., He, X., Qu, M., Pan, J., Hou, B., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03060-1 · Cited by 9

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Novakovic, B., Messina, N. L., & Curtis, N. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814603-3.00006-9 · Cited by 9

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Galbraith, N. J., Walker, S., Gardner, S. A., Bishop, C., Galandiuk, S., & Polk, H. C. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104197 · Cited by 10

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Fuchs, A. L., Miller, I. R., Schiller, S. M., Ammons, M. C. B., Eilers, B. J., Tripet, B., & Copié, V. (2020) · Cells · doi:10.3390/cells9102260 · Cited by 9

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Budikhina, A. S., & Pashenkov, M. V. (2021) · Immunologiya · doi:10.33029/0206-4952-2021-42-1-5-20 · Cited by 12

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Jędrzejewski, T., Piotrowski, J., Pawlikowska, M., Wrotek, S., & Kozak, W. (2019) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2019.05.005 · Cited by 9

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Gritte, R. B., Souza‐Siqueira, T., da Silva, E. B., dos Santos-Oliveira, L. C., Borges, R. C., de Oliveira, H. H., Masi, L. N., Murata, G. M., Gorjão, R., Levada‐Pires, A. C., et al. (2022) · Critical Care Explorations · doi:10.1097/cce.0000000000000734 · Cited by 8

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Yang, T., Liu, S., Jiang, Q., Wang, N., Zhang, L., Shi, X., Qiu, H., Lu, Y., Li, W. J., Ni, C., et al. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.151667 · Cited by 9

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Gupta, S., Amatullah, H., Tsoporis, J. N., Wei, K., Monteiro, A. P. T., Ektesabi, A. M., Varkouhi, A. K., Vaswani, C. M., Formosa, A., Fabro, A. T., et al. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00993-2 · Cited by 8

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Zhang, T., Li, X., Meng, Z., Fang, W. Y., Lian, G., Ma, W., Tian, L., Yang, H., Wang, C., Zhang, J., et al. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.03.009 · Cited by 7

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Torres, L. K., Mcconn, K., Gómez-Escobar, L. G., Cloonan, S. M., & Choi, A. M. K. (2022) · Journal of Clinical and Translational Science · doi:10.1017/cts.2022.271

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Arts, R. J. W., Gresnigt, M. S., Joosten, L. A. B., & Netea, M. G. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.4mr0216-066r · Cited by 126

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Liu, J., Zhou, G., Wang, X., & Liu, D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04490-0 · Cited by 161