Cited by 641Sepsis Diagnosis and TreatmentInflammation biomarkers and pathwaysImmune Response and Inflammation

The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

Open access

Cheng, Shih-Chin, Scicluna, Brendon P, Arts, Rob J W, Gresnigt, Mark S, Lachmandas, Ekta, Giamarellos-Bourboulis, Evangelos J, Kox, Matthijs, Manjeri, Ganesh R, Wagenaars, Jori A L, Cremer, Olaf L, Leentjens, Jenneke, van der Meer, Anne J, van de Veerdonk, Frank L, Bonten, Marc J, Schultz, Marcus J, Willems, Peter H G M, Pickkers, Peter, Joosten, Leo A B, van der Poll, Tom, Netea, Mihai G·2016·Nature Immunology

DOI 10.1038/ni.3398

Open this paper in CoChat — free account

Abstract

The acute phase of sepsis is characterized by a strong inflammatory reaction. At later stages in some patients, immunoparalysis may be encountered, which is associated with a poor outcome. By transcriptional and metabolic profiling of human patients with sepsis, we found that a shift from oxidative phosphorylation to aerobic glycolysis was an important component of initial activation of host defense. Blocking metabolic pathways with metformin diminished cytokine production and increased mortality in systemic fungal infection in mice. In contrast, in leukocytes rendered tolerant by exposure to lipopolysaccharide or after isolation from patients with sepsis and immunoparalysis, a generalized metabolic defect at the level of both glycolysis and oxidative metabolism was apparent, which was restored after recovery of the patients. Finally, the immunometabolic defects in humans were partially restored by therapy with recombinant interferon-γ, which suggested that metabolic processes might represent a therapeutic target in sepsis.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/ni.3398

Cites

62 of 62 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
APACHE II
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1985) · Critical Care Medicine · doi:10.1097/00003246-198510000-00009 · Cited by 15,518
APACHE II-A Severity of Disease Classification System
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1986) · Critical Care Medicine · doi:10.1097/00003246-198608000-00028 · Cited by 13,379
Bioconductor: open software development for computational biology and bioinformatics
Gentleman, R. C., Carey, V. J., Bates, D. M., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004) · Genome biology · doi:10.1186/gb-2004-5-10-r80 · Cited by 12,082
Adjusting batch effects in microarray expression data using empirical Bayes methods
Johnson, W. E., Li, C., & Rabinovic, A. (2007) · Biostatistics · doi:10.1093/biostatistics/kxj037 · Cited by 8,658
A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
Bolstad, B. M., Irizarry, R. A., Åstrand, M., & Speed, T. P. (2003) · Bioinformatics · doi:10.1093/bioinformatics/19.2.185 · Cited by 8,328
APACHE II: a severity of disease classification system.
Knaus, W. A., Draper, E. S., Wagner, D. P., & Zimmerman, J. E. (1985) · PubMed · Cited by 6,034
affy—analysis of Affymetrix GeneChip data at the probe level
Gautier, L., Cope, L., Bolstad, B. M., & Irizarry, R. A. (2004) · Bioinformatics · doi:10.1093/bioinformatics/btg405 · Cited by 5,221
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., et al. (2013) · Nature · doi:10.1038/nature11986 · Cited by 4,176
Severe Sepsis and Septic Shock
Angus, D. C., & van der Poll, T. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1208623 · Cited by 4,119

Flagged first, then by citations

Show all 62 references

Research works printed but not linked: 1

Smyth, G.K. Bioinformatics and Computational Biology Solutions Using R. (eds. Gentleman, R., Carey, V., Huber, W., Irizarry, R. & Dudoit, S.) 397–420 (Springer, 2005).

Sorted by citations

Items 501–600 of 641

Immunosuppression in the Pathophysiology of Sepsis
Couwenbergh, T., van der Heijden, W. A., & Netea, M. G. (2026) · Critical Care Clinics · doi:10.1016/j.ccc.2026.05.010 · Cited by 2
Disturbed metabolic adaptation drives natural killer cell dysfunction in association with nosocomial infection during human sepsis
van der Wurff, A., Gambusz, M., Budeus, B., Claus, M., Watzl, C., Miteva, D., Scicluna, B. P., Rubio, I., Siakaeva, E., Zinsmeister, F., et al. (2026) · EBioMedicine · doi:10.1016/j.ebiom.2026.106345 · Cited by 2
Sepsis: Metabolomics and proteomics
Tan, Y. B., & Langley, R. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801496-7.00007-1 · Cited by 2
Compartment-Specific Differences in the Activation of Monocyte Subpopulations Are Not Affected by Nitric Oxide and Glucocorticoid Treatment in a Model of Resuscitated Porcine Endotoxemic Shock
Skirecki, T., Adamik, B., FROSTELL, C. G., Pasławska, U., Zieliński, S., Glatzel-Plucinska, N. M., Olbromski, M., Dzięgiel, P., & Goździk, W. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11092641 · Cited by 2
Potentiation of the axis involving pentose phosphate pathway/NADPH oxidase/reactive oxygen species drives higher IL‐10 production in monocytes of Sub‐Saharan Africans
Ongwe, M. E. B., Mouwenda, Y. D., Manurung, M. D., Heieis, G. A., Azimi, S., Adégnika, A. A., Kremsner, P. G., Kuijpers, T. W., Yazdanbakhsh, M., & Everts, B. (2024) · European Journal of Immunology · doi:10.1002/eji.202451029 · Cited by 2
Mediating role of blood metabolites in the relationship between immune cell traits and sepsis: a Mendelian randomization and mediation analysis
Liu, Y., & Cao, Y. J. (2025) · Inflammation Research · doi:10.1007/s00011-024-01971-9 · Cited by 2
Machine learning tools for deciphering the regulatory logic of enhancers in health and disease
Foutadakis, S., Bourika, V., Styliara, I., Koufargyris, P., Safarika, A., & Karakike, E. (2025) · Frontiers in Genetics · doi:10.3389/fgene.2025.1603687 · Cited by 2
The epigenetic landscape of innate immunity
Luca, M. D., Pels, K., Moleirinho, S., & Curtale, G. (2017) · AIMS molecular science · doi:10.3934/molsci.2017.1.110 · Cited by 2
Recombinant thrombomodulin alleviates oxidative stress without compromising host resistance to infection in rats infected with methicillin-resistant Staphylococcus aureus
Ito, T., Shrestha, B., Kakihana, Y., & Maruyama, I. (2020) · Scientific Reports · doi:10.1038/s41598-020-74529-4 · Cited by 2
The Role of Mitochondria in the Immune Response in Critical Illness
Wang, Y., & McLean, A. S. (2022) · Annual update in intensive care and emergency medicine · doi:10.1007/978-3-030-93433-0_1 · Cited by 2
Chronic Treatment with Aβ42 with a Toxic Conformer and LPS Induces Inflammatory Responses in BV-2 Microglia with Dysregulation of Hypoxia-Inducible Factor Expression
Maki, T., Sawahata, M., Uta, D., Irie, K., & Kume, T. (2023) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b22-00855 · Cited by 2
A novel anoikis-related gene signature predicts prognosis in patients with sepsis and reveals immune infiltration
Wang, Y., Chi, Y., Zhu, C., Zhang, Y., Li, K., Chen, J., Jiang, X., Chen, K., & Li, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-52742-9 · Cited by 2
Iron-related immune cell function in sepsis
Thorburn, T. (2019) · DalSpace (Dalhousie University) · Cited by 2
Editorial: An Omics Perspective on Fungal Infection: Toward Next-Generation Diagnosis and Therapy
Carvalho, A., & Goldman, G. H. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00085 · Cited by 2
Determination of Early Immune Function in Sepsis and Its Influence on Organ Dysfunction: Is a More Pragmatic Outcome on the Horizon?
Torres, L. K., & Choi, A. M. K. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201803-0470ed · Cited by 2
Hard to Remember
Netea, M. G. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313281 · Cited by 2
Coenzyme A governs proinflammatory macrophage metabolismPreprint
Timblin, G. A., Tharp, K. M., ten Hoeve, J., Kantner, D. S., Baydemir, İ., Noel, E. A., Khantwal, C. M., Singh, P. K., Farahzad, J. N., Domínguez‐Andrés, J., et al. (2025) · eLife · doi:10.7554/elife.106473.1 · Cited by 2
Pathogen-specific host responses define distinct pneumonia endotypes in the human lungPreprint
Markov, N. S., Możejko, M., Guggilla, V., Łazȩcka, M., Donnelly, H. K., Donayre, A., Fenske, S. W., Peltekian, A., Puczko-Szymański, B., Szymczak, P., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.12.724509 · Cited by 2
Association of 91 Inflammatory Factors and 1400 Metabolites with Sepsis: A Mendelian Randomization Analysis
Hu, N., Gan, J., Zhang, H., Lu, T., Tang, Q., Chen, Y., Yu, M., Ou, R., Huang, S., Zhao, H., et al. (2025) · Journal of Intensive Care Medicine · doi:10.1177/08850666241280385 · Cited by 1
A Retrospective Cohort Study on 28-Day Mortality in Immunosuppressed Sepsis: An Interpretability-Based Predictive Model Using MIMIC-IV V2.2
Zhong, Z., He, H., & Lin, Z. (2025) · Shock · doi:10.1097/shk.0000000000002721 · Cited by 1
Higher risk of viral infections in chronic obstructive pulmonary disease patients recovering from sepsis compared to non-sepsis patients: a propensity score-matched observational study
Chuang, T., & Chao, W. (2025) · Therapeutic Advances in Respiratory Disease · doi:10.1177/17534666251385679 · Cited by 1
Protection against Polymicrobial Sepsis by Chitin Oligomers is Fine-Tuned by N -Acetyl- d -Glucosamine Residues
Patel, P., Agnihotri, G., Siddappa, S., Ravindran, B., & Saiyed, T. (2025) · ACS Omega · doi:10.1021/acsomega.5c05936 · Cited by 1
Impaired peripheral mononuclear cell metabolism in patients at risk of developing sepsis: A cohort study
Herwanto, V., Wang, Y., Shojaei, M., Khan, A., Lai, K., Shetty, A., Huang, S., Chew, T., Teoh, S., Nalos, M., et al. (2026) · The Journal of Critical Care Medicine · doi:10.2478/jccm-2026-0010 · Cited by 1
Rare genetic variant risks in patients with sepsis-associated acute respiratory distress syndrome
Tosco-Herrera, E., Rubio‐Rodríguez, L. A., Muñoz‐Barrera, A., Jáspez, D., Suarez-Pajes, E., Corrales, A., Alonso-González, A., Prieto-González, M., Rodríguez, A., Carriedo, D., et al. (2026) · Respiratory Research · doi:10.1186/s12931-026-03588-4 · Cited by 1
Integrative Analysis Identifies Lactylation-Associated Hub Genes in Septic Cardiomyopathy
Jin, R., Dai, J., Zhang, X., Chen, Y., Xiong, W., & Qian, Z. (2026) · Shock · doi:10.1097/shk.0000000000002819 · Cited by 1
Interactions between Innate Immune Memory and the Central Nervous System
Valerio, R. R., Bernardi, A., Bonomo, A., & Frozza, R. L. (2026) · NeuroImmunoModulation · doi:10.1159/000551784 · Cited by 1
Identification of biomarkers for pediatric sepsis based on machine learning and bioinformatics analysis
Ye, W., Chen, S., Duan, Y. R., Shan, J., Wang, J., Xu, H., Li, Z., & Guo, C. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1768323 · Cited by 1
PRC1 impairs sepsis host defense by suppressing NF-κB/JAK-STAT signaling and macrophage glycolytic reprogramming
Wei, H., Meng, X., Fan, H., Xia, T., Wang, H., Yang, Y., Han, Y., Chen, D., Song, H., Peng, L., et al. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116816 · Cited by 1
Deficiency of FUNDC1-mediated mitophagy impairs macrophages immunometabolism to drive Sepsis-induced immunosuppression
Cai, M., Wang, Y., Zhong, Y., Wang, H., Li, Q., Dai, W., Xie, Y., Tang, M., Shen, L., Chen, W., et al. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116853 · Cited by 1
Integrated bioinformatics analysis reveals cytokine dysregulation, pathway alterations, and machine learning identification of diagnostic biomarkers in sepsis
Jiang, W., Rong, J., Han, W., & Fang, J. (2026) · Integrative Biology · doi:10.1093/intbio/zyag010 · Cited by 1
Macrophage metabolic reprogramming: A central hub linking multicellular crosstalk to organ vulnerability in sepsis
Zhang, B., Zhang, H., Cheng, L., & Wang, N. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103831 · Cited by 1
Role and prognostic value of N6-methyladenosine RNA modification regulators in glycolytic reprogramming during sepsis
Liu, X., Zhang, Y., Feng, L., Xiang, A., Kang, Z.-Q., Zhang, Q., & Kang, L. (2026) · Journal of Intensive Care · doi:10.1186/s40560-026-00920-4 · Cited by 1
Janus face of sepsis: a viewpoint
Bauer, M. W., & Wetzker, R. (2022) · Exploration of Immunology · doi:10.37349/ei.2022.00051 · Cited by 1
Inflammasomes in sepsis
Hurtado‐Navarro, L., García-Palenciano, C., & Pelegrı́n, P. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91802-2.00014-1 · Cited by 1
Inactivated vaccine dosage and serum IgG levels correlate with persistent COVID-19 infections in hematologic malignancy patients during the Omicron Surge in China
Li, Y., Yang, Y., Zhang, X., Wang, L., Zhu, L., Li, X., Zhou, Y., Zheng, X., Zhou, X., Ren, Y., et al. (2024) · BMC Infectious Diseases · doi:10.1186/s12879-024-10063-2 · Cited by 1
Outcomes, Characteristics, and Physiology of In-Hospital Cardiac Arrest in Children With Sepsis
Morgan, R. W., Reeder, R., Carcillo, J. A., Carpenter, T. C., Fitzgerald, J. C., Graham, K., Kilbaugh, T. J., Meert, K. L., Nadkarni, V., Palmer, C. A., et al. (2025) · Critical Care Medicine · doi:10.1097/ccm.0000000000006739 · Cited by 1
Inflammation, Hormones, and Metabolism
Khpal, M., & Singer, M. (2017) · Wiley-VCH eBooks · doi:10.1002/9783527692156.ch35 · Cited by 1
Genetic Predisposition for Acute Kidney Injury (AKI)
Payen, D. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-44942-7.00015-7 · Cited by 1
PDK1/mTOR Signaling in Myeloid Cells Differentially Regulates the Early and Late Stages of Sepsis
Du, J., Li, G., Hua, M., Han, J., Yu, H., Zeng, H., Li, A., & Kong, Y. (2020) · Mediators of Inflammation · doi:10.1155/2020/5437175 · Cited by 1
Estamos vivos: Reafirmación de la cultura maya
Morales, D. M. (1989) · Nueva sociedad · Cited by 1
ПРЕДПОСЫЛКИ И ОЖИДАНИЯ ВНЕДРЕНИЯ СИСТЕМЫ МЕНЕДЖМЕНТА КАЧЕСТВА В МУНИЦИПАЛЬНОМ БЮДЖЕТНОМ УЧРЕЖДЕНИИ ЗДРАВООХРАНЕНИЯ
Владимировна, Д. Я., Костомарова, Т. С., & Черкасс, Н. В. (2015) · Complex Issues of Cardiovascular Diseases · doi:10.17802/2306-1278-2014-1-11-15 · Cited by 1
Secondary Infection in Patients With Sepsis—Reply
van Vught, L. A., Klouwenberg, P. M. C. K., & van der Poll, T. (2016) · JAMA · doi:10.1001/jama.2016.9279 · Cited by 1
Efeito da riboflavina na disfunção orgânica e na mortalidade por sepse grave e choque séptico: estudo experimental
Vale, A. H. F. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2020.tde-05102020-105305 · Cited by 1
Single-cell profiling reveals monocyte mitochondrial dysfunction in patients with cirrhosis progressing to acute-on-chronic liver failurePreprint
Wirtz, T. H., Palomino‐Echeverría, S., Pollmanns, M. R., Huergo, E., Schreibing, F., Reißing, J., Sánchez-Garrido, C., López‐Vicario, C., Aransay, A. M., Baldassarre, M., et al. (2025) · medRxiv · doi:10.1101/2025.02.04.25321370 · Cited by 1
Rare genetic variant risks in patients with sepsis-associated acute respiratory distress syndromePreprint
Tosco-Herrera, E., Rubio‐Rodríguez, L. A., Muñoz‐Barrera, A., Jáspez, D., Suarez-Pajes, E., Corrales, A., Alonso-González, A., Prieto-González, M., Rodríguez, A., Carriedo, D., et al. (2025) · medRxiv · doi:10.1101/2025.03.10.25323600 · Cited by 1
Immunological Signatures of Sepsis in Solid Organ Transplant Recipients: A Multilayer and Multicentric Prospective Cohort StudyPreprint
Witowski, A., Bracht, T., Kröger, L., Rump, K., Nowak, H., Bergmann, L., Unterberg, M., Rahmel, T., Westhus, B., Wolf, A., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-9848253/v1 · Cited by 1
Perioperative neutrophil immune function
Cain, D. J. (2017) · UCL Discovery (University College London)
Metabolic Regulation of Innate Immunity to Fungal Infection
Rodrigues, C. S., Campos, C. F., Cunha, C., & Carvalho, A. (2018) · Experientia supplementum · doi:10.1007/978-3-319-74932-7_11
Understanding macrophage activation in the adipose tissue: at the crossroads of immunology and metabolism
Boutens, L. (2018) · doi:10.18174/438332
SOCS1: um regulador negativo da reprogramação metabólica e da inflamação sistêmica durante a sepse experimental
Piñeros, A. R. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2018.tde-29032018-111645
Actualités sur le sepsis et le choc septique de l’enfant
Morin, L., Pierre, A., Tissières, P., Miatello, J., & Durand, P. (2018) · Médecine Intensive Réanimation · doi:10.3166/rea-2018-0080
Reply to Nalos and Robergs and to De Backer and Vincent
Gattinoni, L. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201905-1090le
The JAK2-STAT pathway epigenetically regulates tolerized genes during the first encounter with bacterial antigensPreprint
Lorente‐Sorolla, C., Morante-Palacios, O., García-Gómez, A., Ciudad, L., Català‐Moll, F., Ruiz-Sanmartín, A., Martínez‐Gallo, M., Ferrer, R., Ruiz‐Rodríguez, J. C., Álvarez‐Errico, D., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.16.342717
Impaired peripheral mononuclear cell metabolism in patients at risk of developing sepsis: A cohort studyPreprint
Herwanto, V., Wang, Y., Shojaei, M., Khan, A., Lai, K., Shetty, A., Huang, S., Chew, T., Teoh, S., Nalos, M., et al. (2020) · medRxiv · doi:10.1101/2020.12.10.20244707
The Role of APOBEC3 A/G-induced RNA Editing in Stress Response of Immune cells
Alqassim, E. (2019)
Recombinant thrombomodulin does not promote bacterial propagation but alleviates oxidative stress in rats infected with methicillin-resistant Staphylococcus aureusPreprint
Ito, T., Shrestha, B., Kakihana, Y., & Maruyama, I. (2020) · doi:10.21203/rs.3.rs-29565/v1
Influencia del inmuno-metabolismo macrofágico en la sepsis humana: un nuevo paradigma
Agudelo, J. S. H., & Palomino, R. E. L. (2021) · Magna Scientia UCEVA · doi:10.54502/msuceva.v1n1a4
De-escalation Antibiotic Therapy Alleviates Organ Injury through Modulation of NET Formation during SepsisPreprint
Xie, T., Chu, C., Sun, S., Wang, X., Duan, Z., Ding, W., & Li, J. (2020) · doi:10.22541/au.160578728.89906739/v1
The Role of Ferroptosis-Related Gene in the Immune Activity and Prognosis of Sepsis
Dai, W., Tian, Y., Luo, D., Xie, Q., Liu, F., Shao, Q., Zhao, N., Zheng, P., & Qian, K. (2022) · Archives of Medical Science · doi:10.5114/aoms/145473
Faculty Opinions recommendation of Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection.
Gow, N. A. R., & Yadav, B. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733159930.793545575
Faculty Opinions recommendation of Metabolic competition between host and pathogen dictates inflammasome responses to fungal infection.
Hube, B., & Gresnigt, M. S. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.738437887.793577404
Faculty Opinions recommendation of Cellular metabolism constrains innate immune responses in early human ontogeny.
May, R. C. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734452199.793553631
Faculty Opinions recommendation of P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis.
Lien, E. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736028524.793561866
Research Progress of Sepsis
王, 晨. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.132366
Candida auris evades innate immunity by using metabolic strategies to escape and kill macrophages while avoiding antimicrobial inflammationPreprint
Weerasinghe, H., Simm, C., Djajawi, T. M., Tedja, I., Lo, T. L., Shasha, D., Mizrahi, N., Olivier, F. A. B., Speir, M., Lawlor, K. E., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.28.529319
Manejo de shock séptico refractario con Glucocorticoides en pacientes adultos ingresados en Unidades de Cuidados Intensivos
Pérez, G. F. F., Pulgarín, G. A. Z., & Cevallos, J. F. N. (2023) · Brazilian Journal of Health Review · doi:10.34119/bjhrv6n1-341 · Cited by 1
The Dysregulated Host Response
Payen, D. M., Carlès, M., & Seitz‐Polski, B. (2023) · Lessons from the ICU · doi:10.1007/978-3-031-17572-5_2
Severe acute malnutrition promotes bacterial binding over pro-inflammatory cytokine secretion by circulating innate immune cellsPreprint
Phiri, T. N., Mutasa, K., Rukobo, S., Govha, M., Mushayanembwa, P., Mwakamui, S., Haider, T., Zyambo, K., Dumbura, C., Tome, J., et al. (2023) · medRxiv · doi:10.1101/2023.04.10.23288163
DYNAMICS OF CHANGES IN THE FUNCTIONAL ACTIVITY OF NONSPECIFIC INFLAMMATORY FACTORS IN WIDESPREAD PERITONITIS
Bilyayeva, O. O., Kryzhevsky, V. V., Karol, I. V., & Osadchay, O. I. (2023) · Kharkiv Surgical School · doi:10.37699/2308-7005.1-2.2023.23
The 1926 novel, “One, no one, one hundred thousand”, metaphorizes the potential danger when the immune system is exposed to a repetitive antigen stimulation
Ferrazzo, F., Leto, S., & Malara, N. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1254853
Phosphoproteomic analysis of Fc gamma receptor Iib deficient macrophages in enhancing the severity of endotoxin tolerance
Ondee, T., & Leelahavanichkul, A. (2018) · doi:10.58837/chula.the.2018.356
Epigenetic regulation in trained and tolerized macrophages
Benjaskulluecha, S. (2022) · doi:10.58837/chula.the.2022.236
O impacto da exposição química sobre o transcriptoma de trabalhadores formais e informais
Salles, F. J. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.6.2023.tde-31012024-183620
Integrated Analysis of Bulk transcriptomics and Single-Cell RNA Sequencing Data identifies Glycolysis-Related Prognostic Gene signature of sepsisPreprint
Zhang, W., Liu, Z., Zheng, S., Liu, S., Ren, S., Wang, W., Shao, H., & Qin, B. (2024) · Research Square · doi:10.21203/rs.3.rs-3992959/v1
Exploring the interactions between mitochondria-related genes and the immune microenvironment in sepsis: a bioinformatics studyPreprint
Li, H., Ma, W., Liu, X., Song, J., yu, R., Hou, L., Guo, Y., Wu, J., Shi, B., Zhou, Q., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-3993097/v1
Inactivated Vaccine Dosage and Serum IgG Levels Correlate with Persistent COVID-19 Infection in Hematologic Malignancy Patients During the Omicron Surge in ChinaPreprint
Li, Y., Yang, Y., Zhang, X., Wang, L., Zhu, L., Li, X., Zhou, Y., Zheng, X., Zhou, X., Ren, Y., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-3951004/v1
“Mitolocalization”
Kraft, B. D. (2024) · CHEST Critical Care · doi:10.1016/j.chstcc.2024.100073
N-ACETILCISTEÍNA E HIDROCORTISONA NO MANEJO DA SEPSE
Gomes, L., Bortoleto, M. M., Lopes, L. B. V., & da Rocha, B. A. (2023) · Revista Omnia Saúde · doi:10.29327/2272174.6.1-26
One bite at a time : Exploring the immune-enhancing potential of dietary fiber for human health
Moerings, B. G. J. (2024) · doi:10.18174/654203
Les bases de la réponse immunitaire innée pour le réanimateur
Stiel, L., & Blot, M. (2024) · Médecine Intensive Réanimation · doi:10.37051/mir-00221
Aloe-emodin plus TIENAM ameliorate cecal ligation and puncture-induced sepsis in mice by attenuating inflammation and modulating microbiota
Su, J., Deng, X., Hu, S., Lin, X., Xie, L., Ye, H., Lin, C., Zhou, F., Wu, S., & Zheng, L. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1491169
Nomogram model for predicting secondary infection in critically ill patients with heatstroke: A pilot study from China
Lin, G., Peng, H., Yin, B., Xu, C., Zhao, Y., Liu, A., Guo, H., & Pan, Z. (2024) · PLoS ONE · doi:10.1371/journal.pone.0316254
Pasteur effect in leukocyte energy metabolism of patients with mild, moderate, and severe COVID-19
Ortatatlı, M., Sengul, G. F., Fatsa, T., Sertoğlu, E., Boyunağa, H., & Kenar, L. (2025) · Turkish Journal of Biochemistry · doi:10.1515/tjb-2024-0301
Melatonin-Mediated Protection against Sepsis-Induced Organ Dysfunction
Üstündağ, H., & Doğanay, S. (2025) · IntechOpen eBooks · doi:10.5772/intechopen.1009751
Branched-chain ketoacid antioxidants mediate disease tolerance to sepsisPreprint
Misra, A., Weitman, E. M., Weitman, M., Brook, J. R., Rone, J. M., Petrova, B., Mertens, R. T., Hwang, N., Vera, K. Z., Perrella, M. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.22.654748
Exploring ENPP5 as a diagnostic biomarker for sepsis: a comprehensive bioinformatics analysis
Gao, J., Li, Y., Huang, J., Wei, C., Chen, J., Huang, A., Liu, N., Lu, Y., & Yang, S. (2025) · BMC Infectious Diseases · doi:10.1186/s12879-025-11152-6
Coenzyme A governs proinflammatory macrophage metabolismPreprint
Timblin, G. A., Tharp, K. M., ten Hoeve, J., Kantner, D. S., Baydemir, İ., Noel, E. A., Khantwal, C. M., Singh, P. K., Farahzad, J. N., Domínguez‐Andrés, J., et al. (2025) · eLife · doi:10.7554/elife.106473
Clinical Research Progress of Pediatric Sepsis
许, 峰. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.1572061
Metabolic immune regulation of macrophages by melanized fungus Fonsecaea monophora
Pan, Q., Xin, T., Zhang, J., Lin, L., & Zhang, J. (2025) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2025.101571
Therapeutic Salmonella induces long-term protective trained immunity in NK cells against cancer metastasisPreprint
Li, R., Hu, J., Jin, W., Li, R., Wu, Y., Zhou, N., Zhou, Z., Shakhawat, H. M., Wang, X., Han, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.29.673007
Mémoire de l’immunité innée macrophagique. Application à la modulation des maladies inflammatoires et infectieuses
Jeljeli, M. M., Toullec, L., Durand, G., & Batteux, F. (2025) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/j.banm.2025.09.004
Additional file 3 of Mortality of septic shock patients is associated with impaired mitochondrial oxidative coupling efficiency in lymphocytes: a prospective cohort study
Nedel, W. L., Kopczynski, A., Rodolphi, M. S., Strogulski, N. R., De Bastiani, M., Montes, T. H. M., Abruzzi Jr, J., Galina, A., Horvath, T. L., & Portela, L. V. (2021) · Figshare · doi:10.6084/m9.figshare.15049004
Additional file 1 of PKM2/STAT1-mediated PD-L1 upregulation on neutrophils during sepsis promotes neutrophil organ accumulation by serving an anti-apoptotic role
Li, Y., 谭若铭, Li, R., Tian, R., Liu, Z., Wang, X., Chen, E., Pan, T., & Qu, H. (2023) · Figshare · doi:10.6084/m9.figshare.22735471
Additional file 2 of PKM2/STAT1-mediated PD-L1 upregulation on neutrophils during sepsis promotes neutrophil organ accumulation by serving an anti-apoptotic role
Li, Y., 谭若铭, Li, R., Tian, R., Liu, Z., Wang, X., Chen, E., Pan, T., & Qu, H. (2023) · Figshare · doi:10.6084/m9.figshare.22735474
Additional file 4 of The serum proteome of VA-ECMO patients changes over time and allows differentiation of survivors and non-survivors: an observational study
Siegel, P. M., Barta, B. A., Orlean, L., Steenbuck, I. D., Cosenza‐Contreras, M., Wengenmayer, T., Trummer, G., Wolf, D., Westermann, D., Schilling, O., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26589156
Additional file 1 of The serum proteome of VA-ECMO patients changes over time and allows differentiation of survivors and non-survivors: an observational study
Siegel, P. M., Barta, B. A., Orlean, L., Steenbuck, I. D., Cosenza‐Contreras, M., Wengenmayer, T., Trummer, G., Wolf, D., Westermann, D., Schilling, O., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26589147
Additional file 1 of Hippocampal glucose uptake as a surrogate of metabolic change of microglia in Alzheimer’s disease
Choi, H., Choi, Y., Lee, E. J., Kim, H., Lee, Y., Kwon, S., Hwang, D. W., & Lee, D. S. (2021) · Figshare · doi:10.6084/m9.figshare.16551264
Additional file 1 of A breakdown in microglial metabolic reprogramming causes internalization dysfunction of α-synuclein in a mouse model of Parkinson’s disease
Lu, J., Wang, C., Cheng, X., Wang, R., Yan, X., He, P., Chen, H., & Yu, Z. (2022) · Figshare · doi:10.6084/m9.figshare.19817898
Additional file 3 of The serum proteome of VA-ECMO patients changes over time and allows differentiation of survivors and non-survivors: an observational study
Siegel, P. M., Barta, B. A., Orlean, L., Steenbuck, I. D., Cosenza‐Contreras, M., Wengenmayer, T., Trummer, G., Wolf, D., Westermann, D., Schilling, O., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26589153
Additional file 5 of The serum proteome of VA-ECMO patients changes over time and allows differentiation of survivors and non-survivors: an observational study
Siegel, P. M., Barta, B. A., Orlean, L., Steenbuck, I. D., Cosenza‐Contreras, M., Wengenmayer, T., Trummer, G., Wolf, D., Westermann, D., Schilling, O., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26589159

Authors: Cheng, S.-C., Scicluna, B. P., Arts, R. J. W., Gresnigt, M. S., Lachmandas, E., Giamarellos-Bourboulis, E. J., Kox, M., Manjeri, G. R., Wagenaars, J. A. L., Cremer, O. L., Leentjens, J., van der Meer, A. J., van de Veerdonk, F. L., Bonten, M. J., Schultz, M. J., Willems, P. H. G. M., Pickkers, P., Joosten, L. A. B., van der Poll, T., & Netea, M. G.
Affiliations: Radboud University Medical Center (NL)
Amsterdam UMC Location University of Amsterdam (NL)
Radboud University Nijmegen (NL)
Radboud Institute for Molecular Life Sciences (NL)
University Medical Center Utrecht (NL)
Corresponding author: Netea, Mihai G
ORCID: Cheng, Shih-Chin
Scicluna, Brendon P
Arts, Rob J W
Gresnigt, Mark S
Giamarellos-Bourboulis, Evangelos J
Kox, Matthijs
Cremer, Olaf L
Leentjens, Jenneke
Bonten, Marc J
Schultz, Marcus J
Willems, Peter H G M
Pickkers, Peter
Joosten, Leo A B
Netea, Mihai G
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2016-03-07
Volume: 17
Issue: 4
Pages: 406-413
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni.3398
OpenAlex: W2296531152
Cited by: 637
References: 62
Citations by year: 2026: 63 · 2025: 66 · 2024: 65 · 2023: 61 · 2022: 59 · 2021: 73 · 2020: 83 · 2019: 54 · 2018: 59 · 2017: 39 · 2016: 13
FWCI: 51.49
Type: journal article
Language: en
Open access: green
pure.amsterdamumc.nl
Licence: other-oa
www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion, other-oa)
Radboud Repository (Radboud University) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Utrecht University Repository (Utrecht University) (submittedVersion)
Funders: Center for Translational Molecular Medicine (04I-201)
FP7 Ideas: European Research Council (310372)
Topics: Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: sepsis, immunoparalysis, leukocyte metabolism, immunometabolism, oxidative phosphorylation, aerobic glycolysis, metformin, systemic fungal infection, lipopolysaccharide tolerance, interferon-gamma, cytokine production, metabolite profiling
MeSH terms: Adenosine Triphosphate, Adult, Animals, Antifungal Agents, Aspergillosis, Energy Metabolism, Escherichia coli Infections, Female, Glycolysis, Humans, Immune Tolerance, Immunity, Innate, Interferon-gamma, Leukocytes, Lipopolysaccharides, Macrophages, Male, Middle Aged, Monocytes, NAD, Oxidative Phosphorylation, Oxygen Consumption, Prospective Studies, Immunoblotting, Cytokines, Sepsis, Lactic Acid, Endotoxemia, Mice, Young Adult, Candidiasis, Invasive, Transcriptome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks