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Cited by 71Dermatology and Skin DiseasesAir Quality and Health ImpactsAsthma and respiratory diseases

Air Pollution and Atopic Dermatitis, from Molecular Mechanisms to Population-Level Evidence: A Review

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Fadadu, Raj P., Abuabara, Katrina, Balmes, John R., Hanifin, Jon M., Wei, Maria L.·2023·International Journal of Environmental Research and Public Health
DOI 10.3390/ijerph20032526PMC PMC9916398
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Abstract

Atopic dermatitis (AD) has increased in prevalence to become the most common inflammatory skin condition globally, and geographic variation and migration studies suggest an important role for environmental triggers. Air pollution, especially due to industrialization and wildfires, may contribute to the development and exacerbation of AD. We provide a comprehensive, multidisciplinary review of existing molecular and epidemiologic studies on the associations of air pollutants and AD symptoms, prevalence, incidence, severity, and clinic visits. Cell and animal studies demonstrated that air pollutants contribute to AD symptoms and disease by activating the aryl hydrocarbon receptor pathway, promoting oxidative stress, initiating a proinflammatory response, and disrupting the skin barrier function. Epidemiologic studies overall report that air pollution is associated with AD among both children and adults, though the results are not consistent among cross-sectional studies. Studies on healthcare use for AD found positive correlations between medical visits for AD and air pollutants. As the air quality worsens in many areas globally, it is important to recognize how this can increase the risk for AD, to be aware of the increased demand for AD-related medical care, and to understand how to counsel patients regarding their skin health. Further research is needed to develop treatments that prevent or mitigate air pollution-related AD symptoms.

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  • A review of the research on the link between AD and industrial and traffic air pollution suggests a role in the increasing incidence and exacerbation of AD.

    “A review of the research on the link between AD and industrial and traffic air pollution suggests a role in the increasing incidence and exacerbation of AD [58].”

    From Wildfires and Atopic Diseases: A Review (2026) · cites this paper as [58]

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Cited by

Sorted by citations

Authors
Fadadu, R. P., Abuabara, K., Balmes, J. R., Hanifin, J. M., & Wei, M. L.
Affiliations
  • San Francisco VA Medical Center (US)
  • University of California, San Francisco (US)
  • Oregon Health & Science University (US)
Corresponding author
Wei, Maria L.
ORCID
Venue
International Journal of Environmental Research and Public Health
Publisher
MDPI AG
Published
2023-01-31
Volume
20
Issue
3
Pages
2526
ISSN
1660-4601 (ISSN-L)
DOI
10.3390/ijerph20032526
PMC
PMC9916398
OpenAlex
W4318823816
Cited by
71
References
28
Citations by year
2026: 19 · 2025: 17 · 2024: 28 · 2023: 7
FWCI
3.27
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Environmental Research and Public Health (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
  • RePEc: Research Papers in Economics (submittedVersion)
Funders
  • University of California, San Francisco Summer Explore Fellowship, Marguerite Schoeneman Grant
  • Joint Medical Program Thesis Grant
Topics
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Keywords
atopic dermatitis, air pollution, aryl hydrocarbon receptor, oxidative stress, skin barrier function, pro-inflammatory response, forest fires, industrialization, health care utilization, children, adults, environmental triggers
MeSH terms
Air Pollutants, Air Pollution, Animals, Cross-Sectional Studies, Dermatitis, Atopic, Environmental Exposure, Skin, Particulate Matter

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