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Cited by 332

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking

Open access
Sigmundsdottir, Hekla, Butcher, Eugene C·2008·Nature Immunology

Abstract

Lymphocytes are imprinted during activation with trafficking programs (combinations of adhesion and chemoattractant receptors) that target their migration to specific tissues and microenvironments. Cytokines contribute, but, for gut and skin, evolution has cleverly adapted external cues from food (vitamin A) and sunlight (ultraviolet-induced vitamin D3) to imprint lymphocyte homing to the small intestines and T cell migration into the epidermis. Dendritic cells are essential: they process the vitamins to their active metabolites (retinoic acid and 1,25(OH)2D3) for presentation with antigen to lymphocytes, and they help export environmental cues through lymphatics to draining lymph nodes, to program the trafficking and effector functions of naive T and B cells.

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Crossref · 10.1038/ni.f.208

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Metadata

Authors
Sigmundsdottir, H., & Butcher, E. C.
Venue
Nature Immunology
Published
2008-08-19
Volume
9
Issue
9
Pages
981-987
ISSN
  • 1529-2908 (ISSN-L)
  • 1529-2916
OpenAlex
W2086226733
Cited by
332
References
4
FWCI
12.23
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking. https://app.cochat.ai/papers/10.1038/ni.f.208
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Sigmundsdottir, H., & Butcher, E. C. (2008). Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking. Nature Immunology. https://doi.org/10.1038/ni.f.208

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.