Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells

Notch Signaling: Cell Fate Control and Signal Integration in Development

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Osteoblastic cells regulate the haematopoietic stem cell niche

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SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells

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Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.

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A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

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The stem-cell niche as an entity of action

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Stem Cells and Their Niches

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Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

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Signalling downstream of activated mammalian Notch

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Bone-marrow haematopoietic-stem-cell niches

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Induction of T Cell Development from Hematopoietic Progenitor Cells by Delta-like-1 In Vitro

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The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype

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Biology of Hematopoietic Stem Cells and Progenitors: Implications for Clinical Application

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Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphomaPreprint

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c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

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NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

Palomero, T., Lim, W. K., Odom, D. T., Sulis, M. L., Real, P. J., Margolin, A. A., Barnes, K., O’Neil, J., Neuberg, D. S., Weng, A. P., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606108103 · Cited by 821 · see citing works

Flk-2 is a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells

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Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance

Duncan, A. W., Rattis, F. M., DiMascio, L. N., Congdon, K. L., Pazianos, G., Zhao, C., Yoon, K., Cook, J. M., Willert, K., Gaiano, N., et al. (2005) · Nature Immunology · doi:10.1038/ni1164 · Cited by 770 · see citing works

Upregulation of Flt3 Expression within the Bone Marrow Lin−Sca1+c-kit+ Stem Cell Compartment Is Accompanied by Loss of Self-Renewal Capacity

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Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

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Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

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Inducible gene knockout of transcription factor recombination signal binding protein‐J reveals its essential role in T versus B lineage decision

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MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors

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Notch2 Is Preferentially Expressed in Mature B Cells and Indispensable for Marginal Zone B Lineage Development

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Notch regulation of lymphocyte development and function

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Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells

Tanigaki, K., Han, H., Yamamoto, N., Tashiro, K., Ikegawa, M., Kuroda, K., Suzuki, A., Nakano, T., & Honjo, T. (2002) · Nature Immunology · doi:10.1038/ni793 · Cited by 478 · see citing works

Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jκ/Su(H)

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Notch1 but Not Notch2 Is Essential for Generating Hematopoietic Stem Cells from Endothelial Cells

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Structural Basis for Cooperativity in Recruitment of MAML Coactivators to Notch Transcription Complexes

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Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy.

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REGULATION OF LYMPHOID DEVELOPMENT, DIFFERENTIATION, AND FUNCTION BY THE NOTCH PATHWAY

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Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome

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Dimorphic effects of Notch signaling in bone homeostasis

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Hematopoietic stem cell fate is established by the Notch-Runx pathway

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Concise Review: Notch Signaling in Stem Cell Systems

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Crystal Structure of the CSL-Notch-Mastermind Ternary Complex Bound to DNA

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Growth Suppression of Pre-T Acute Lymphoblastic Leukemia Cells by Inhibition of Notch Signaling

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Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway

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Notch signaling controls the generation and differentiation of early T lineage progenitors

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The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells

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Notch1 Signaling Promotes the Maturation of CD4 and CD8 SP Thymocytes

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Regulation of αβ/γδ T Cell Lineage Commitment and Peripheral T Cell Responses by Notch/RBP-J Signaling

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Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation

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Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts

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Mastermind critically regulates Notch-mediated lymphoid cell fate decisions

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Notch signaling is an important regulator of type 2 immunity

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Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability

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Identification of a Family of Mastermind-Like Transcriptional Coactivators for Mammalian Notch Receptors

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Notch1 Contributes to Mouse T-Cell Leukemia by Directly Inducing the Expression of c-myc

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Notch1-Induced Delay of Human Hematopoietic Progenitor Cell Differentiation Is Associated With Altered Cell Cycle Kinetics

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A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development

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Regulation of B Versus T Lymphoid Lineage Fate Decision by the Proto-Oncogene LRF

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CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?

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Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice

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The requirement for Notch signaling at the β-selection checkpoint in vivo is absolute and independent of the pre–T cell receptor

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E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment

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A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors

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Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells

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Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signalingPreprint

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HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo

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Characterization of a High-Molecular-Weight Notch Complex in the Nucleus of Notch ic -Transformed RKE Cells and in a Human T-Cell Leukemia Cell Line

Jeffries, S., Robbins, D. J., & Capobianco, A. J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3927-3941.2002 · Cited by 145 · see citing works

HES1 Inhibits Cycling of Hematopoietic Progenitor Cells via DNA Binding

Yu, X., Alder, J. K., Chun, J. H., Friedman, A. D., Heimfeld, S., Cheng, L., & Civin, C. I. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0598 · Cited by 116 · see citing works

Highly Efficient Ex Vivo Expansion of Human Hematopoietic Stem Cells Using Delta1‐Fc Chimeric Protein

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T/B lineage choice occurs prior to intrathymic Notch signaling

Harman, B. C., Jenkinson, W. E., Parnell, S. M., Rossi, S. W., Jenkinson, E. J., & Anderson, G. (2005) · Blood · doi:10.1182/blood-2004-12-4881 · Cited by 80 · see citing works

Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation

Maillard, I. P., Schwarz, B. A., Sambandam, A., Fang, T., Shestova, O. E., Xu, L., Bhandoola, A., & Pear, W. S. (2006) · Blood · doi:10.1182/blood-2005-08-3454 · Cited by 76 · see citing works

Regulation of intrathymic T‐cell development by Lunatic Fringe– Notch1 interactions

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Molecular regulation of stem cell quiescence

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Hematopoiesis: a human perspective

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A Critical Requirement for Notch Signaling in Maintenance of the Quiescent Skeletal Muscle Stem Cell State

Mourikis, P., Sambasivan, R., Castel, D., Rocheteau, P., Bizzarro, V., & Tajbakhsh, S. (2012) · Stem Cells · doi:10.1002/stem.775 · Cited by 526 · see citing works

Stem cells living with a Notch

Koch, U., Lehal, R., & Radtke, F. (2013) · Development · doi:10.1242/dev.080614 · Cited by 283 · see citing works

Notch activation inhibits AML growth and survival: a potential therapeutic approach

Kannan, S., Sutphin, R. M., Hall, M. G., Golfman, L. S., Fang, W., Nolo, R. M., Akers, L. J., Hammitt, R. A., McMurray, J. S., Kornblau, S. M., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20121527 · Cited by 152 · see citing works

Haematopoietic stem cells in perisinusoidal niches are protected from ageing

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Adult Hematopoiesis is Regulated by TIF1γ, a Repressor of TAL1 and PU.1 Transcriptional Activity

Kusy, S., Gault, N., Ferri, F., Lewandowski, D., Barroca, V., Jaracz-Ros, A., Losson, R., & Romeo, P.-H. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.02.005 · Cited by 47 · see citing works

Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy

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From haematopoietic stem cells to complex differentiation landscapes

Laurenti, E., & Göttgens, B. (2018) · Nature · doi:10.1038/nature25022 · Cited by 830 · see citing works

Properties of haematopoietic stem cells surviving 5-fluorouracil treatment: evidence for a pre-CFU-S cell?

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Sex specificity in the blood

Leeman, D. S., & Brunet, A. (2014) · Nature · doi:10.1038/505488a · Cited by 12 · see citing works

Autophagy maintains the metabolism and function of young and old stem cells

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