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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

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Transforming growth factor-β induces development of the TH17 lineage

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The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

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Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation

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TH-17 cells in the circle of immunity and autoimmunity

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Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation

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Reprogramming the tumor metastasis cascade by targeting galectin-driven networks

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Galectins in Regulation of Apoptosis

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An adaptive workflow coupled with Random Forest algorithm to identify intact N-glycopeptides detected from mass spectrometry

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Galectins as New Prognostic Markers and Potential Therapeutic Targets for Advanced Prostate Cancers

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Lack of galectin‐1 exacerbates chronic hepatitis, liver fibrosis, and carcinogenesis in murine hepatocellular carcinoma model

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Absence of Galectin‐1 accelerates CD8+ T cell‐mediated graft rejection

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Circulating galectin‐1 concentrations in systemic sclerosis: potential contribution to digital vasculopathy

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Cell- and stage-specific localization of galectin-3, a β-galactoside-binding lectin, in a mouse model of experimental autoimmune encephalomyelitis

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Expression profiling and functional characterization of galectin-3 of turbot (Scophthalmus maximus L.) in host mucosal immunity

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Presentation of immunoregulatory sialoglycans on T cells is divergent between mice and humans

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KLF12 overcomes anti-PD-1 resistance by reducing galectin-1 in cancer cells

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Do galectins serve as soluble ligands for immune checkpoint receptors?

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Expression of galectin-1 in immune cells and glial cells after spinal cord injury

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IgG and leukocytes: Targets of immunomodulatory α2,6 sialic acids

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Relevance of glycans in the interaction between T lymphocyte and the antigen presenting cell

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Tumor-specific protein human galectin-1 interacts with anticancer agents

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Nuclear Galectin-1 promotes KRAS -dependent activation of pancreatic cancer stellate cells

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The role of galectins‑1, 3, 7, 8 and 9 as potential diagnostic and therapeutic markers in ovarian cancer (Review)

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Galectin-1 is associated with the severity of coronary artery disease and adverse cardiovascular events in patients undergoing coronary angiography

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Identification of galectins as novel regulators of platelet signaling and function

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N-linked glycans: an underappreciated key determinant of T cell development, activation, and function

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Galectin 7 leads to a relative reduction in CD4+ T cells, mediated by PD-1

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Regulation of T Cell Glycosylation by MXene/β‐TCP Nanocomposite for Enhanced Mandibular Bone Regeneration

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In Search of a Solution to the Sphinx-Like Riddle of GM1

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Aspects immunologiques de la grossesse

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Polysialic acid is expressed in human naïve CD4+ T cells and is involved in modulating activation

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Re-Expression of Poly/Oligo-Sialylated Adhesion Molecules on the Surface of Tumor Cells Disrupts Their Interaction with Immune-Effector Cells and Contributes to Pathophysiological Immune Escape

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Engineering Reactive Oxygen Species-Resistant Galectin-1 Dimers with Enhanced Lectin Activity

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Glycan-Binding Proteins in Immunity

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Placental galectins regulate innate and adaptive immune responses in pregnancy

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The immune interactions of gut glycans and microbiota in health and disease

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Single-cell RNA and T-cell receptor sequencing unveil mycosis fungoides heterogeneity and a possible gene signature

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Generation and Use of Recombinant Galectins

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A roadmap for translational cancer glycoimmunology at single cell resolution

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Profiling of IgG N-glycome during mouse aging: Fucosylated diantennary glycans containing one Neu5Gc-linked LacNAc are associated with age

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Chemokines modulate glycan binding and the immunoregulatory activity of galectins

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Targeting Sialylation Enhances the Therapeutic Efficacy of the Nectin-4–Targeted Antibody–Drug Conjugate Enfortumab Vedotin in Bladder Cancer

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Galectin Regulation of Host Microbial Interactions

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Galectin-1-induced tolerogenic dendritic cells combined with apoptotic lymphocytes prolong liver allograft survival

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A Dynamic Interplay of Circulating Extracellular Vesicles and Galectin-1 Reprograms Viral Latency during HIV-1 Infection

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Prohibitins function as endogenous ligands for Siglec-9 and negatively regulate TCR signaling upon ligation

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The effects of galectin-1 on the gene expression of the transcription factors TBX21, GATA-3, FOXP3 and RORC

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Resolution of inflammation: examples of peptidergic players and pathways

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Epigenetic mechanisms of myeloid differentiation in the tumor microenvironment

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Sweet tailoring of glyco-modulatory extracellular matrix-inspired biomaterials to target neuroinflammation

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Duodenal Intraepithelial Lymphocytes of Children with Cow Milk Allergy Preferentially Bind the Glycan-Binding Protein Galectin-3

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Sialic acid in the regulation of blood cell production, differentiation and turnover

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Identification of immune subsets with distinct lectin binding signatures using multi-parameter flow cytometry: correlations with disease activity in systemic lupus erythematosus

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Galectins and Liver Diseases

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Post-translational modifications in T cells in systemic erythematosus lupus

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Glycobiology of cellular expiry: Decrypting the role of glycan-lectin regulatory complex and therapeutic strategies focusing on cancer

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The trans-Sialidase from Trypanosoma cruzi a Putative Target for Trypanocidal Agents

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Expression, purification and characterization of galectin-1 in Escherichia coli

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Tetracycline treatment targeting Wolbachia affects expression of an array of proteins in Brugia malayi parasite

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Galectin-1 synthesis in type 1 diabetes by different immune cell types: Reduced synthesis by monocytes and Th1 cells

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Spatiotemporal regulation of galectin-1-induced T-cell death in lamina propria from Crohn’s disease and ulcerative colitis patients

Papa‐Gobbi, R., Muglia, C. I., Rocca, A., Curciarello, R., Sambuelli, A. M., Yantorno, M., Correa, G. J., Morosi, L. G., Sabatino, A. D., Biancheri, P., et al. (2021) · APOPTOSIS · doi:10.1007/s10495-021-01675-z · Cited by 10

Galectin-1 and galectin-3 in male reproduction - impact in health and disease

Fijak, M., Hasan, H., & Meinhardt, A. (2025) · Seminars in Immunopathology · doi:10.1007/s00281-024-01032-7 · Cited by 10

Galectin-1 Impairs the Generation of Anti-Parasitic Th1 Cell Responses in the Liver during Experimental Visceral Leishmaniasis

Bunn, P. T., de, M. M., Rivera, F. D. L., Kumar, R., Edwards, C. L., Faleiro, R. J., Ng, S. S., Sheel, M., Wang, Y., Amante, F. H., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01307 · Cited by 10

Oral administration of Helianthus annuus leaf extract ameliorates atopic dermatitis by modulation of T cell activity in vivo

Lee, H., Kim, E., & Jeong, G. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154443 · Cited by 10

The sweet side of wound healing: galectins as promising therapeutic targets in hemostasis, inflammation, proliferation, and maturation/remodeling

Čoma, M., Manning, J. C., Kaltner, H., & Gál, P. (2023) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2023.2175318 · Cited by 10

Harnessing aptamers for the biosensing of cell surface glycans – A review

Liu, S., Zhao, F., Xu, K., Cao, M., Sohail, M., Li, B., & Zhang, X. (2023) · Analytica Chimica Acta · doi:10.1016/j.aca.2023.342044 · Cited by 10

Knockdown of Core 1 Beta 1, 3-galactosyltransferase Prolongs Skin Allograft Survival with Induction of Galectin-1 Secretion and Suppression of CD8+T Cells

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Role of EBAG9 protein in coat protein complex I‐dependent glycoprotein maturation and secretion processes in tumor cells

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Effects of galectin-1 on immunomodulatory properties of human monocyte-derived dendritic cells

Džopalić, T., Kostić, M. S., Kostić, M., Marjanović, G., Guzina, J., Jurišić, V., & Nedeljković, B. B. (2020) · Growth Factors · doi:10.1080/08977194.2021.1947267 · Cited by 10

Systemic lupus erythematosus in the light of the regulatory effects of galectin-1 on T-cell function

Hornung, Á., Monostori, É., & Kovács, L. (2017) · Lupus · doi:10.1177/0961203316686846 · Cited by 10

SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis

Alves, I., Vicente, M. M., Gaifem, J., Fernandes, Â., Dias, A. M., Rodrigues, C. S., Oliveira, J. C., Seixas, N., Malheiro, L., Abreu, M. A., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100131 · Cited by 10

α2,6 sialylation distinguishes a novel active state in CD4+ and CD8+ cells during acute Toxoplasma gondii infection

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The Role of Glycans in Human Immunity—A Sweet Code

Tvaroška, I. (2025) · Molecules · doi:10.3390/molecules30132678 · Cited by 9

Biomarkers and Their Possible Functions in the Intestinal Microenvironment of Chagasic Megacolon: An Overview of the (Neuro)inflammatory Process

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Galectin-7 in Cardiac Allografts in Mice: Increased Expression Compared With Isografts and Localization in Infiltrating Lymphocytes and Vascular Endothelial Cells

Luo, Z., Ji, Y., Zhou, H., Huang, X., Fang, J., Guo, H., Pan, T., & Chen, Z. K. (2013) · Transplantation Proceedings · doi:10.1016/j.transproceed.2012.12.005 · Cited by 9

Size does not matter: commensal microorganisms forge tumor-promoting inflammation and anti-tumor immunity

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Emerging glycobiology tools: A renaissance in accessibility

Oswald, D. M., & Cobb, B. A. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.04.010 · Cited by 9

The Role of Glycosylation in Inflammatory Diseases

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Galectins in Chagas Disease: A Missing Link Between Trypanosoma cruzi Infection, Inflammation, and Tissue Damage

Poncini, C. V., Benatar, A. F., Gómez, K. A., & Rabinovich, G. A. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.794765 · Cited by 8

Identification of galectin-1 and other cellular targets of alpha,beta-unsaturated carbonyl compounds, including dimethylfumarate, by use of click-chemistry probes

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Leveraging fluorinated glucosamine action to boost antitumor immunity

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Differential Expression of O-Glycans in CD4+ T Lymphocytes from Patients with Systemic Lupus Erythematosus

Ramos-Martínez, E. G., Lascuraín, R., Tenorio, E. P., Sánchez-González, A., Chávez-Rueda, A. K., Chávez-Sanchéz, L., Jara-Quezada, L. J., Chávez-Sánchez, R., Zenteno, E., & Blanco-Favela, F. A. (2016) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.240.79 · Cited by 8

TrkB-Target Galectin-1 Impairs Immune Activation and Radiation Responses in Neuroblastoma: Implications for Tumour Therapy

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Alkylation of Galectin-1 with Iodoacetamide and Mass Spectrometric Mapping of the Sites of Incorporation

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Study of Galectins in Tumor Immunity: Strategies and Methods

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The role of N-glycans in regulatory T cells in autoimmunity

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The Exploitation of the Glycosylation Pattern in Asthma: How We Alter Ancestral Pathways to Develop New Treatments

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Differential expression patterns of glycosphingolipids and C‐type lectin receptors on immune cells in absence of functional regulatory T cells

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Persistent immune response: Twice tumor exfoliation induced by sialic acid–modified vincristine sulfate liposomes

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Mechanisms of immunological tolerance in central nervous system inflammatory demyelination

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The aggressiveness of murine lymphomas selected in vivo by growth rate correlates with galectin-1 expression and response to cyclophosphamide

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Enhanced Susceptibility of Galectin-1 Deficient Mice to Experimental Colitis

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Increased CD69+CCR7+ circulating activated T cells and STAT3 expression in cutaneous lupus erythematosus patients recalcitrant to antimalarials

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Galectins

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Placental galectins: a subfamily of galectins lose the ability to bind β-galactosides with new structural features

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Maternal and placental galectins: key players in the feto-maternal symbiotic tango

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Age-related remodeling of the sialoglycans dampens murine CD8 + T cell function

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Galectins in Esophageal Cancer: Current Knowledge and Future Perspectives

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The Contribution of Complement System in Multiple Sclerosis: Mechanisms and Therapeutic Potentials

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Galectins - Important players of the immune response to CNS parasitic infection

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T‐helper cell regulation of CD45 phosphatase activity by galectin‐1 and CD43 governs chronic lymphocytic leukaemia proliferation

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Inflammation and arthritis: perspectives of the glycobiologist

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"Time sweet time": circadian characterization of galectin-1 null mice

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Human multipotent adult progenitor cells transcriptionally regulate fucosyltransferase VII

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Vitamin D and Multiple Sclerosis

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In Brief

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Galectin‐1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function

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Galectin-1 Binds Different CD43 Glycoforms to Cluster CD43 and Regulate T Cell Death

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Regulated glycosylation controls the fate and function of regulatory T cells

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Dimeric galectin-1 alters the plasticity and commitment of Th1 and Th17 cells by promoting IL-10 expression. (152.20)

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