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Re‐wiring regulatory cell networks in immunity by galectin–glycan interactions

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Structural basis of redox-dependent modulation of galectin-1 dynamics and function

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State-of-the-art of regulatory dendritic cells in cancer

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Galectin-1 Facilitates Macrophage Reprogramming and Resolution of Inflammation Through IFN-β

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A Mechanism of Sialylation Functionally Silences the Hyaluronan Receptor LYVE-1 in Lymphatic Endothelium

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A galectin from shrimp Litopenaeus vannamei is involved in immune recognition and bacteria phagocytosis

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Predictive Biomarkers for Checkpoint Inhibitor-Based Immunotherapy: The Galectin-3 Signature in NSCLCs

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Suppression of age-related salivary gland autoimmunity by glycosylation-dependent galectin-1-driven immune inhibitory circuits

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Galectin‐8 promotes regulatory T‐cell differentiation by modulating IL‐2 and TGFβ signaling

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Tumor resistance mechanisms and their consequences on γδ T cell activation

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Nuclear factor (NF)-κB controls expression of the immunoregulatory glycan-binding protein galectin-1

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Lack of Galectin-3 Prevents Cardiac Fibrosis and Effective Immune Responses in a Murine Model ofTrypanosoma cruziInfection

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Foxp3+ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis

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Glycans in Immunologic Health and Disease

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Galectins in hematological malignancies

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Galectin-1 induces 12/15-lipoxygenase expression in murine macrophages and favors their conversion toward a pro-resolving phenotype

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Galectin-8 as an immunosuppressor in experimental autoimmune encephalomyelitis and a target of human early prognostic antibodies in multiple sclerosis

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Galectin-1 Tunes TCR Binding and Signal Transduction to Regulate CD8 Burst Size

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Role and therapeutic implications of protein glycosylation in neuroinflammation

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Polysialic Acid in the Immune System

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Galectin-1 and galectin-3: Plausible tumour markers for oral squamous cell carcinoma and suitable targets for screening high-risk population

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Apoptosis resistance in HIV-1 persistently-infected cells is independent of active viral replication and involves modulation of the apoptotic mitochondrial pathway

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Galectin 1—A Key Player between Tissue Repair and Fibrosis

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Dual roles of endogenous and exogenous galectin-1 in the control of testicular immunopathology

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Glycosyltransferase and sulfotransferase gene expression profiles in human monocytes, dendritic cells and macrophages

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Fragment-based development of triazole-substituted O-galactosyl aldoximes with fragment-induced affinity and selectivity for galectin-3

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Peripheral blood galectin-1-expressing T and natural killer cells in normal pregnancy and preeclampsia

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Dissecting the signal transduction pathways triggered by galectin–glycan interactions in physiological and pathological settings

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The interplay of galectins-1, -3, and -9 in the immune-inflammatory response underlying cardiovascular and metabolic disease

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Galectin-1 Prevents Infection and Damage Induced by Trypanosoma cruzi on Cardiac Cells

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Multivalent structure of galectin-1-nanogold complex serves as potential therapeutics for rheumatoid arthritis by enhancing receptor clustering

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Early Murine T-lymphocyte Activation Is Accompanied by a Switch from N-Glycolyl- to N-Acetyl-neuraminic Acid and Generation of Ligands for Siglec-E

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Roles of galectins in inflammatory bowel disease

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Application of Mono‐ and Disaccharides in Drug Targeting and Efficacy

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Galectin-1 enhances TNFα-induced inflammatory responses in Sertoli cells through activation of MAPK signalling

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The effect of galectins on leukocyte trafficking in inflammation: sweet or sour?

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Interaction of Polysialic Acid with CCL21 Regulates the Migratory Capacity of Human Dendritic Cells

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Psoriasis in humans is associated with down‐regulation of galectins in dendritic cells

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Increased plasma levels of galectin-1 in pancreatic cancer: potential use as biomarker

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Galectin-8 Ameliorates Murine Autoimmune Ocular Pathology and Promotes a Regulatory T Cell Response

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The role of integrin glycosylation in galectin-8-mediated trabecular meshwork cell adhesion and spreading

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Differences of glycocalyx composition in the structural elements of placenta in preeclampsia

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I-branched carbohydrates as emerging effectors of malignant progression

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‘Sweetening’ Pregnancy: Galectins at the Fetomaternal Interface

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Multifaceted roles of Galectins: from carbohydrate binding to targeted cancer therapy

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Dendritic cells: Functional aspects of glycosylation and lectins

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Binding of galectin‐1 to α IIb β 3 integrin triggers “outside‐in” signals, stimulates platelet activation, and controls primary hemostasis

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The emerging role of galectins in (re)myelination and its potential for developing new approaches to treat multiple sclerosis

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The effects of post-translational modifications on Th17/Treg cell differentiation

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Galectin-1 and -3 gene silencing in immature and mature dendritic cells enhances T cell activation and interferon-γ production

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A galectin‐specific signature in the gut delineates C rohn's disease and ulcerative colitis from other human inflammatory intestinal disorders

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Galectin-1–Mediated Suppression of Pseudomonas aeruginosa–Induced Corneal Immunopathology

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Cellular distribution of the C-type II lectin dendritic cell immunoreceptor (DCIR) and its expression in the rheumatic joint: identification of a subpopulation of DCIR+ T cells

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Endogenous Galectin-1 and Acute Inflammation

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Review: The function of regulatory T cells at the ocular surface

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Galectins in Intestinal Inflammation: Galectin-1 Expression Delineates Response to Treatment in Celiac Disease Patients

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Glycans as shapers of tumour microenvironment: A sweet driver of T‐cell‐mediated anti‐tumour immune response

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Immunosuppressive Tumor Microenvironment and Immunotherapy of Epstein–Barr Virus-Associated Malignancies

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Advances in glycopeptide enrichment methods for the analysis of protein glycosylation over the past decade

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Multiple Functional Targets of the Immunoregulatory Activity of Galectin-1

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Protein subtype-targeting through ligand epimerization: Talose-selectivity of galectin-4 and galectin-8

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Galectins in the Pathogenesis of Rheumatoid Arthritis

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Cell type–specific glycosylation of Orai1 modulates store-operated Ca 2+ entry

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Antibody-lectin chimeras for glyco-immune checkpoint blockade

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Galectin-1 signaling in leukocytes requires expression of complex-type N-glycans

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Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammation

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Characterization of a neutralizing anti-human galectin-1 monoclonal antibody with angioregulatory and immunomodulatory activities

Sáez, J. M. P., Hockl, P. F., Cagnoni, A. J., Méndez‐Huergo, S. P., García, P. A., Gatto, S. G., Cerliani, J. P., Croci, D. O., & Rabinovich, G. A. (2020) · Angiogenesis · doi:10.1007/s10456-020-09749-3 · Cited by 39

Th17 Cells Undergo Fas-Mediated Activation-Induced Cell Death Independent of IFN-γ

Zhang, Y., Xu, G., Zhang, L., Roberts, A. I., & Shi, Y. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.190 · Cited by 38

Endogenous Galectin-1 Exerts Tonic Inhibition on Experimental Arthritis

Iqbal, A. J., Cooper, D., Vugler, A., Gittens, B. R., Moore, A., & Perretti, M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203291 · Cited by 39

Galectin-1 circumvents lysolecithin-induced demyelination through the modulation of microglial polarization/phagocytosis and oligodendroglial differentiation

Rinaldi, M., Thomas, L., Mathieu, P., Carabias, P., Troncoso, M. F., Pasquini, J. M., Rabinovich, G. A., & Pasquini, L. A. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.09.003 · Cited by 38

The relationship between maternal 25-hydroxyvitamin D status in pregnancy and childhood adiposity and allergy: an observational study

Boyle, V. T., Thorstensen, E. B., Thompson, J., McCowan, L. M. E., Mitchell, E., Godfrey, K. M., Poston, L., Wall, C. R., Murphy, R., Cutfield, W. S., et al. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.182 · Cited by 40

Melanoma Cell Galectin-1 Ligands Functionally Correlate with Malignant Potential

Yazawa, E. M., Geddes-Sweeney, J., Cedeno‐Laurent, F., Walley, K. C., Barthel, S. R., Opperman, M. J., Liang, J., Lin, J. Y., Schatton, T., Laga, A. C., et al. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.95 · Cited by 38

MLL -Rearranged B Lymphoblastic Leukemias Selectively Express the Immunoregulatory Carbohydrate-Binding Protein Galectin-1

Juszczyński, P., Rodig, S. J., Ouyang, J., O’Donnell, E. A., Takeyama, K., Mlynarski, W. M., Mycko, K., Szczepański, T., Gaworczyk, A., Krivtsov, A. V., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2765 · Cited by 38

Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity

Vicente, M. M., Alves, I., Fernandes, Â., Dias, A. M., Santos‐Pereira, B., Pérez-Anton, E., Santos, S., Yang, T., Correia, A., Münster-Kühnel, A. K., et al. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01052-7 · Cited by 37

A novel miR1983-TLR7-IFNβ circuit licenses NK cells to kill glioma cells, and is under the control of galectin-1

Shah, D., Comba, A., Faisal, S. M., Kadiyala, P., Baker, G. J., Alghamri, M. S., Doherty, R., Zamler, D. B., Núñez, G., Castro, M. G., et al. (2021) · OncoImmunology · doi:10.1080/2162402x.2021.1939601 · Cited by 37

Mgat5 Deficiency in T Cells and Experimental Autoimmune Encephalomyelitis

Grigorian, A., & Demetriou, M. (2011) · ISRN Neurology · doi:10.5402/2011/374314 · Cited by 39

Galectin-1 is required for the regulatory function of B cells

Alhabbab, R. Y., Blair, P. A., Smyth, L. A., Ratnasothy, K., Peng, Q., Moreau, A., Lechler, R. I., Elgueta, R., & Lombardi, G. (2018) · Scientific Reports · doi:10.1038/s41598-018-19965-z · Cited by 36

The Galectin Family as Molecular Targets: Hopes for Defeating Pancreatic Cancer

Manero‐Rupérez, N., Martínez‐Bosch, N., Barranco, L. E., Visa, L., & Navarro, P. (2020) · Cells · doi:10.3390/cells9030689 · Cited by 36

Galectin-1-induced down-regulation of T lymphocyte activation protects (NZB x NZW) F1 mice from lupus-like disease

Liu, S., Lee, S., Cava, A. L., Motrán, C. C., Hahn, B., & Miceli, M. C. (2011) · Lupus · doi:10.1177/0961203310388444 · Cited by 36

Innate immunity against molecular mimicry: Examining galectin‐mediated antimicrobial activity

Arthur, C. M., Patel, S. R., Mener, A., Kamili, N. A., Fasano, R. M., Meyer, E., Winkler, A. M., Sola-Visner, M. C., Josephson, C. D., & Stowell, S. R. (2015) · BioEssays · doi:10.1002/bies.201500055 · Cited by 36

Galectins in Host Defense Against Microbial Infections

Li, F.-Y., Wang, S., Bernardes, E. S., & Liu, F. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1580-4_6 · Cited by 36

Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity

Qiu, J., Zhang, J., Ji, Y., Sun, H., Gu, Z., 孙强玲, Bai, M., Tang, J., Tang, J., Zhang, Y., et al. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00431-5 · Cited by 35

Human T Cell Activation Results in Extracellular Signal-regulated Kinase (ERK)-Calcineurin-dependent Exposure of Tn Antigen on the Cell Surface and Binding of the Macrophage Galactose-type Lectin (MGL)*

van Vliet, S. J., Vuist, I. M., Lenos, K., Tefsen, B., Kalay, H., García-Vallejo, J. J., & van Kooyk, Y. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.471045 · Cited by 35

Dissection of the Human Multipotent Adult Progenitor Cell Secretome by Proteomic Analysis

Burrows, G. G., Hof, W. V. ’., Newell, L. F., Reddy, A. P., Wilmarth, P. A., David, L. L., Raber, A., Bogaerts, A., Pinxteren, J., Deans, R., et al. (2013) · Stem Cells Translational Medicine · doi:10.5966/sctm.2013-0031 · Cited by 35

TCR-stimulated changes in cell surface CD46 expression generate type 1 regulatory T cells

Choileáin, S. N., Hay, J., Thomas, J., Williams, A., Vermeren, M., Bénézech, C., Gomez-Salazar, M. A., Hugues, O. R., Vermeren, S., Howie, S., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aah6163 · Cited by 38

Membrane organization by tetraspanins and galectins shapes lymphocyte function

Cano, L. Q., Dunlock, V.-M. E., Schwerdtfeger, F., & van Spriel, A. B. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00935-0 · Cited by 34

Galectin-1–Driven Tolerogenic Programs Aggravate Yersinia enterocolitica Infection by Repressing Antibacterial Immunity

Davicino, R. C., Méndez‐Huergo, S. P., Eliçabe, R. J., Stupirski, J. C., Autenrieth, I. B., Genaro, M. S. D., & Rabinovich, G. A. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700579 · Cited by 34

Extracellular galectins as controllers of cytokines in hematological cancer

Gordón‐Alonso, M., Bruger, A. M., & van der Bruggen, P. (2018) · Blood · doi:10.1182/blood-2018-04-846014 · Cited by 34

A Pro-resolving Role for Galectin-1 in Acute Inflammation

Law, H. L., Wright, R. D., Iqbal, A. J., Norling, L. V., & Cooper, D. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00274 · Cited by 34

Circulating galectin-1 delineates response to bevacizumab in melanoma patients and reprograms endothelial cell biology

Bannoud, N., Stupirski, J. C., Cagnoni, A. J., Hockl, P. F., Sáez, J. M. P., García, P. A., Mahmoud, Y. D., Tudela, J. G., Scheidegger, M. A., Marshall, A., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2214350120 · Cited by 34

Challenges of Regulated Cell Death: Implications for Therapy Resistance in Cancer

D’Amico, M., & Amicis, F. D. (2024) · Cells · doi:10.3390/cells13131083 · Cited by 34

Galectin-1 and HIV-1 Infection

St-Pierre, C., Ouellet, M., Tremblay, M. J., & Sato, S. (2010) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(10)80013-8 · Cited by 37

Imaging atherosclerotic plaques by targeting Galectin-3 and activated macrophages using (89Zr)-DFO- Galectin3-F(ab')2 mAb

Varasteh, Z., Rose, F. D., Mohanta, S. K., Li, Y., Zhang, X., Miritsch, B., Scafetta, G., Yin, C., Sager, H. B., Glasl, S., et al. (2020) · Theranostics · doi:10.7150/thno.50247 · Cited by 33

An integrative computational systems biology approach identifies differentially regulated dynamic transcriptome signatures which drive the initiation of human T helper cell differentiation

Äijö, T., Edelman, S., Lönnberg, T., Larjo, A., Kallionpää, H., Tuomela, S., Engström, E., Lahesmaa, R., & Lähdesmäki, H. J. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-572 · Cited by 34

In Brief

(2007) · Nature reviews. Immunology · doi:10.1038/nri2149

Galectin‐1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function

Motrán, C. C., Molinder, K. M., Liu, S. D., Poirier, F., & Miceli, M. C. (2008) · European Journal of Immunology · doi:10.1002/eji.200838295 · Cited by 108

Galectin-1 Binds Different CD43 Glycoforms to Cluster CD43 and Regulate T Cell Death

Hernandez, J. D., Nguyen, J. T., He, J., Wang, W., Ardman, B. M., Green, J. M., Fukuda, M., & Baum, L. G. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.5328 · Cited by 128

Regulated glycosylation controls the fate and function of regulatory T cells

Santiago, M.-H., Tomas, D.-M., Diego, C. R., Juan, C., Karina, M., Marta, T., & Gabriel, R. (2015) · Frontiers in Immunology · doi:10.3389/conf.fimmu.2015.05.00204

Dimeric galectin-1 alters the plasticity and commitment of Th1 and Th17 cells by promoting IL-10 expression. (152.20)

Cedeno‐Laurent, F., Opperman, M. J., Barthel, S. R., & Dimitroff, C. J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.186.supp.152.20 · Cited by 1