Semaphorins and their receptors in immune cell interactions

Untitled work

Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606

Getting to the site of inflammation: the leukocyte adhesion cascade updated

Ley, K., Laudanna, C., Cybulsky, M. I., & Nourshargh, S. (2007) · Nature Reviews Immunology · doi:10.1038/nri2156 · Cited by 4,354

Immunobiology: the immune system in health and disease

(1995) · Choice Reviews Online · doi:10.5860/choice.32-3876 · Cited by 4,110

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000) · Cell · doi:10.1016/s0092-8674(00)80702-3 · Cited by 3,589

VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes

Hemler, M. E. (1990) · Annual Review of Immunology · doi:10.1146/annurev.iy.08.040190.002053 · Cited by 1,561

Neuropilin is a semaphorin III receptor.

Kolodkin, A., Levengood, D. V., Rowe, E. G., Tai, Y.-T., Giger, R., & Ginty, D. (1997) · Cell · doi:10.1016/s0092-8674(00)80535-8 · Cited by 1,262

Plexins Are a Large Family of Receptors for Transmembrane, Secreted, and GPI-Anchored Semaphorins in Vertebrates

Tamagnone, L., Artigiani, S., Chen, H., He, Z., Ming, G., Song, H., Chédotal, A., Winberg, M. L., Goodman, C. S., Poo, M.-M., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80063-x · Cited by 1,163

Neuropilin Is a Receptor for the Axonal Chemorepellent Semaphorin III

He, Z., & Tessier‐Lavigne, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80534-6 · Cited by 1,137

Germinal-Center Organization and Cellular Dynamics

Allen, C. D. C., Okada, T., & Cyster, J. G. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.009 · Cited by 1,025

The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules

Kolodkin, A. L., Matthes, D., & Goodman, C. S. (1993) · Cell · doi:10.1016/0092-8674(93)90625-z · Cited by 957

Identification of Semaphorin 4B as a Negative Regulator of Basophil-Mediated Immune Responses

Nakagawa, Y., Takamatsu, H., Okuno, T., Kang, S., Nojima, S., Kimura, T., Kataoka, T. R., Ikawa, M., Toyofuku, T., Katayama, I., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003485 · Cited by 45

A functional role for semaphorin 4D/plexin B1 interactions in epithelial branching morphogenesis during organogenesis

Korostylev, A., Worzfeld, T., Deng, S., Friedel, R. H., Swiercz, J. M., Vodrazka, P., Maier, V., Hirschberg, A., Ohoka, Y., Inagaki, S., et al. (2008) · Development · doi:10.1242/dev.019760 · Cited by 45

Class 3 semaphorins induce F-actin reorganization in human dendritic cells: Role in cell migration

Curreli, S., Wong, B. S., Latinovic, O., Κωνσταντόπουλος, Κ., & Stamatos, N. M. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.2a1114-534r · Cited by 44

Plexin-D1 Is a Novel Regulator of Germinal Centers and Humoral Immune Responses

Holl, E. K., O’Connor, B. P., Holl, T. M., Roney, K. E., Zimmermann, A. G., Jha, S., Kelsoe, G. H., & Ting, J. P. ‐. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003464 · Cited by 43

Sema4D/PlexinB1 inhibition ameliorates blood‐brain barrier damage and improves outcome after stroke in rats

Zhou, Y., Li, Y., Jin, H., Wu, J., He, Q., Wang, X., Lei, H. C., & Hu, B. (2017) · The FASEB Journal · doi:10.1096/fj.201700786rr · Cited by 43

Decreased Expression of Semaphorin3A/Neuropilin-1 Signaling Axis in Apical Periodontitis

Lin, Y., Xing, Q., Qin, W., Melo, M. A. S., Zou, R., Xu, M., Zhang, X., Xu, H. H. K., & Lin, Z. (2017) · BioMed Research International · doi:10.1155/2017/8724503 · Cited by 43

Semaphorin-7a reverses the ERF-induced inhibition of EMT in Ras-dependent mouse mammary epithelial cells

Allégra, M., Ζαραγκούλιας, Α., Vorgia, E., Ioannou, M., Litos, G., Beug, H., & Mavrothalassitis, G. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-04-0276 · Cited by 42

Morphogens and blood-brain barrier function in health and disease

Wevers, N. R., & de Vries, H. E. (2015) · Tissue Barriers · doi:10.1080/21688370.2015.1090524 · Cited by 42

Characterization of Class-3 Semaphorin Receptors, Neuropilins and Plexins, as Therapeutic Targets in a Pan-Cancer Study

Zhang, X., Shao, S., & Li, L. (2020) · Cancers · doi:10.3390/cancers12071816 · Cited by 43

The Role of Semaphorins and Their Receptors in Innate Immune Responses and Clinical Diseases of Acute Inflammation

Kanth, S. M., Gairhe, S., & Torabi‐Parizi, P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.672441 · Cited by 42

Class 4 Semaphorins and Plexin-B receptors regulate GABAergic and glutamatergic synapse development in the mammalian hippocampus

McDermott, J. E., Goldblatt, D., & Paradis, S. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.06.008 · Cited by 42

Regulation of mesenchymal stem cell differentiation on microstructured titanium surfaces by semaphorin 3A

Lotz, E. M., Berger, M. B., Boyan, B. D., & Schwartz, Z. (2020) · Bone · doi:10.1016/j.bone.2020.115260 · Cited by 41

The Role of Semaphorins in Metabolic Disorders

Lu, Q., & Zhu, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165641 · Cited by 41

A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system

Zielonka, M., Xia, J., Friedel, R. H., Offermanns, S., & Worzfeld, T. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.05.007 · Cited by 42

The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology

Simonetti, M., Paldy, E., Njoo, C., Bali, K. K., Worzfeld, T., Pitzer, C., Kuner, T., Offermanns, S., Mauceri, D., & Kuner, R. (2021) · Molecular Psychiatry · doi:10.1038/s41380-019-0491-4 · Cited by 41

Tertiary lymphoid structures correlate with enhancement of antitumor immunity in esophageal squamous cell carcinoma

Nakamura, S., Ohuchida, K., Hayashi, M., Katayama, N., Tsutsumi, C., Yamada, Y., Hisano, K., Okuda, S., Ohtsubo, Y., Iwamoto, C., et al. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02396-7 · Cited by 41

Semaphorin 7A promotes EGFR-TKI resistance in EGFR mutant lung adenocarcinoma cells

Kinehara, Y., Nagatomo, I., Koyama, S., Ito, D., Nojima, S., Kurebayashi, R., Nakanishi, Y., Suga, Y., Nishijima-Futami, Y., Osa, A., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.123093 · Cited by 40

Semaphorin 7A Contributes to West Nile Virus Pathogenesis through TGF-β1/Smad6 Signaling

Sultana, H., Neelakanta, G., Foellmer, H. G., Montgomery, R. R., Anderson, J. F., Koski, R. A., Medzhitov, R. M., & Fikrig, E. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201140 · Cited by 40

Role of Semaphorins in Immunopathologies and Rheumatic Diseases

García, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020374 · Cited by 39

PUMA: A Unified Framework for Penalized Multiple Regression Analysis of GWAS Data

Hoffman, G. E., Logsdon, B. A., & Mezey, J. G. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003101 · Cited by 40

Bone scaffolds loaded with siRNA-Semaphorin4d for the treatment of osteoporosis related bone defects

Zhang, Y., Wei, L., Miron, R. J., Shi, B., & Bian, Z. (2016) · Scientific Reports · doi:10.1038/srep26925 · Cited by 40

Axonal guidance molecules and the failure of axonal regeneration in the adult mammalian spinal cord

Bolsover, S. R., Fabes, J., & Anderson, P. N. (2008) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2008-00448 · Cited by 39

Potential Role of Semaphorin 3A and Its Receptors in Regulating Aberrant Sympathetic Innervation in Peritoneal and Deep Infiltrating Endometriosis

Liang, Y., Wang, W., Huang, J., Tan, H., Liu, T., Shang, C., Liu, D., Guo, L., & Yao, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0146027 · Cited by 38

Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain

Páldy, E., Simonetti, M., Worzfeld, T., Bali, K. K., Vicuña, L., Offermanns, S., & Kuner, R. (2017) · Nature Communications · doi:10.1038/s41467-017-00341-w · Cited by 38

Neuroimmune Semaphorin 4A in Cancer Angiogenesis and Inflammation: A Promoter or a Suppressor?

Iyer, A., & Chapoval, S. P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010124 · Cited by 38

Endogenous CD100 promotes glomerular injury and macrophage recruitment in experimental crescentic glomerulonephritis

Li, M., O’Sullivan, K. M., Jones, L. K., Lo, C., Semple, T. J., Kumanogoh, A., Kikutani, H., Holdsworth, S. R., & Kitching, A. R. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03098.x · Cited by 38

A regulatory role for CD72 expression on B cells in systemic lupus erythematosus

Vadasz, Z., Haj, T., Balbir, A., Peri, R., Rosner, I., Slobodin, G., Kessel, A., & Toubi, E. (2013) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2013.11.010 · Cited by 38

Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D

Wannemacher, K. M., Zhu, L., Jiang, H., Fong, K. P., Stalker, T. J., Lee, D., Tran, A. N., Neeves, K. B., Maloney, S. F., Kumanogoh, A., et al. (2010) · Blood · doi:10.1182/blood-2010-04-279943 · Cited by 37

RNA-based therapy for osteogenesis

Wang, P., Perche, F., Logeart‐Avramoglou, D., & Pichon, C. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118594 · Cited by 38

Role of Sema4C in TGF- 1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells

Zeng, R., Han, M. H., Luo, Y., Li, C., Pei, G., Liao, W., Bai, S., Sun, G., Liu, X., & Xu, G. (2010) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfq619 · Cited by 37

Semaphorin 3E Alleviates Hallmarks of House Dust Mite–Induced Allergic Airway Disease

Movassagh, H., Shan, L., Duke‐Cohan, J. S., Halayko, A. J., Uzonna, J. E., & GOUNNI, A. S. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.03.008 · Cited by 37

Neuronal guidance genes in health and diseases

Yuasa‐Kawada, J., Kinoshita-Kawada, M., Tsuboi, Y., & Wu, J. Y. (2022) · Protein & Cell · doi:10.1093/procel/pwac030 · Cited by 37

Semaphorin 4D correlates with increased bone resorption, hypercalcemia, and disease stage in newly diagnosed patients with multiple myeloma

Terpos, E., Ntanasis‐Stathopoulos, I., Christoulas, D., Bagratuni, T., Bakogeorgos, M., Gavriatopoulou, M., Eleutherakis‐Papaiakovou, E., Kanellias, N., Kastritis, E., & Dimopoulos, M. A. (2018) · Blood Cancer Journal · doi:10.1038/s41408-018-0075-6 · Cited by 36

Non-alcoholic steatohepatitis in morbidly obese patients

Tran, A., & Gual, P. (2013) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2012.07.005 · Cited by 42

Semaphorin 3A: an immunoregulator in systemic sclerosis

Rimar, D., Nov, Y., Rosner, I., Slobodin, G., Rozenbaum, M., Halasz, K., Haj, T., Jiries, N., Kaly, L., Boulman, N., et al. (2015) · Rheumatology International · doi:10.1007/s00296-015-3269-2 · Cited by 36

Semaphorin 4D Signaling Requires the Recruitment of Phospholipase Cγ into the Plexin-B1 Receptor Complex

Swiercz, J. M., Worzfeld, T., & Offermanns, S. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00103-09 · Cited by 38

Oxycodone Self-Administration Induces Alterations in Expression of Integrin, Semaphorin and Ephrin Genes in the Mouse Striatum

Yuferov, V. P., Zhang, Y., Liang, Y., Zhao, C., Randesi, M., & Kreek, M. J. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00257 · Cited by 35

Semaphorins and their receptors: Novel features of neural guidance molecules

Kumanogoh, A., & Kikutani, H. (2010) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.86.611 · Cited by 35

Neuroimmune semaphorin 4D is necessary for optimal lung allergic inflammation

Shanks, K., Nkyimbeng-Takwi, E., Smith, E., Lipsky, M. M., DeTolla, L. J., Scott, D. W., Keegan, A. D., & Chapoval, S. P. (2013) · Molecular Immunology · doi:10.1016/j.molimm.2013.05.228 · Cited by 34

The role of Sema4D/CD100 as a therapeutic target for tumor microenvironments and for autoimmune, neuroimmune and bone diseases

Wu, M., Li, J., Gao, Q., & Ye, F. (2016) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2016.1139083 · Cited by 35

Intact CD100–CD72 Interaction Necessary for TCR-Induced T Cell Proliferation

Jiang, X., Björkström, N. K., & Melum, E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00765 · Cited by 34

Sensing the microenvironment of the central nervous system: immune cells in the central nervous system and their pharmacological manipulation

Fábry, Z., Schreiber, H. A., Harris, M. G., & Sándor, M. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.07.009 · Cited by 34

Semaphorin 3A Contributes to Distal Pulmonary Epithelial Cell Differentiation and Lung Morphogenesis

Becker, P. M., Tran, T. S., Delannoy, M. J., He, C., Shannon, J. M., & McGrath‐Morrow, S. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027449 · Cited by 33

The role of semaphorin3A in myogenic regeneration and the formation of functional neuromuscular junctions on new fibres

Anderson, J. E., Do, M.-K. Q., Daneshvar, N., Suzuki, T., Dort, J., Mizunoya, W., & Tatsumi, R. (2017) · Biological Reviews of The Cambridge Philosophical Society · doi:10.1111/brv.12286 · Cited by 34

Prevention of Alveolar Bone Loss in an Osteoporotic Animal Model via Interference of Semaphorin 4d

Zhang, Y., Wei, L., Miron, R. J., Zhang, Q., & Bian, Z. (2014) · Journal of Dental Research · doi:10.1177/0022034514552676 · Cited by 32

Cells under siege: Viral glycoprotein interactions at the cell surface

Bowden, T. A., Jones, E. Y., & Stuart, D. I. (2011) · Journal of Structural Biology · doi:10.1016/j.jsb.2011.03.016 · Cited by 32

Involvement of Sema4D in the control of microglia activation

Toguchi, M., Gonzalez, D., Furukawa, S., & Inagaki, S. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.05.013 · Cited by 32

Axon responses of embryonic stem cell‐derived dopaminergic neurons to semaphorins 3A and 3C

Tamaríz, E., Diaz-Martinez, N. E., Díaz, N. F., García‐Peña, C. M., Velasco, I., & Varela‐Echavarría, A. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22268 · Cited by 31

VEGF signaling mediates bladder neuroplasticity and inflammation in response to BCG

Saban, M. R., Davis, C. A., Avelino, A., Cruz, F., Maier, J., Bjorling, D. E., Sferra, T. J., Hurst, R. E., & Saban, R. (2011) · BMC Physiology · doi:10.1186/1472-6793-11-16 · Cited by 31

An Inhibitory Role for Sema4A in Antigen-Specific Allergic Asthma

Morihana, T., Goya, S., Mizui, M., Yasui, T., Prasad, D. V. R., Kumanogoh, A., Tamura, M., Shikina, T., Maeda, Y., Iwamoto, Y., et al. (2012) · Journal of Clinical Immunology · doi:10.1007/s10875-012-9798-5 · Cited by 31

Peripheral blood lymphocytes analysis detects CD100/SEMA4D alteration in systemic sclerosis patients

Beşliu, A. N., Bănică, L. M., Predețeanu, D., Vlad, V. M., Ionescu, R., Pistol, G. C., Opriș-Belinski, D., Berghea, F., Stefănescu, M., & Matache, C. (2011) · Autoimmunity · doi:10.3109/08916934.2010.541171 · Cited by 30

The role of immune semaphorins in the pathogenesis of multiple sclerosis: Potential therapeutic targets

Lotfi, R., Kalmarzi, R. N., Rajabinejad, M., Hasani, S., & Zamani, F. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107556 · Cited by 31

Construction of a Hierarchical Micro-/Submicro-/Nanostructured 3D-Printed Ti6Al4V Surface Feature to Promote Osteogenesis: Involvement of Sema7A through the ITGB1/FAK/ERK Signaling Pathway

Zhang, J., Zhao, C., Sheng, R., Lin, K., Wang, X., & Zhang, S. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c06454 · Cited by 30

Semaphorin Signals Tweaking the Tumor Microenvironment

Muratori, C., & Tamagnone, L. (2012) · Advances in cancer research · doi:10.1016/b978-0-12-386503-8.00003-x · Cited by 30

The evolving role of semaphorins and plexins in the immune system: Plexin-A1 regulation of dendritic cell function

O’Connor, B. P., & Ting, J. P. ‐. (2008) · Immunologic Research · doi:10.1007/s12026-008-8026-0 · Cited by 30

Neuropilin-1: The Glue between Regulatory T Cells and Dendritic Cells?

Mizui, M., & Kikutani, H. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.012 · Cited by 29

The Subcommissural Organ and the Development of the Posterior Commissure

Grondona, J. M., Hoyo-Becerra, C., Visser, R., Fernández‐Llebrez, P., & López-Ávalos, M. D. (2012) · International review of cytology · doi:10.1016/b978-0-12-394307-1.00002-3 · Cited by 29

Emerging role of semaphorin-3A in autoimmune diseases

Liu, L., Li, X., Ye, D., & Pan, H. (2018) · Inflammopharmacology · doi:10.1007/s10787-018-0484-y · Cited by 29

Increased Levels of Plasma Soluble Sema4D in Patients with Heart Failure

Lu, Q., Dong, N., Wang, Q., Yi, W., Wang, Y., Zhang, S., Gu, H., Zhao, X., Tang, X., Jin, B., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064265 · Cited by 28

A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration

Nojima, S., Toyofuku, T., Kamao, H., Ishigami, C., Kaneko, J., Okuno, T., Takamatsu, H., Ito, D., Kang, S., Kimura, T., et al. (2013) · Nature Communications · doi:10.1038/ncomms2420 · Cited by 27

Involvement of Sema4A in the progression of experimental autoimmune myocarditis

Makino, N., Toyofuku, T., Takegahara, N., Takamatsu, H., Okuno, T., Nakagawa, Y., Kang, S., Nojima, S., Hori, M., Kikutani, H., et al. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.10.040 · Cited by 27

Focused Examination of the Intestinal lamina Propria Yields Greater Molecular Insight into Mechanisms Underlying SIV Induced Immune Dysfunction

Mohan, M., Kaushal, D., Aye, P. P., Alvarez, X. A., Veazey, R. S., & Lackner, A. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034561 · Cited by 26

Multifaceted Functional Role of Semaphorins in Glioblastoma

Angelucci, C., Lama, G., & Sica, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092144 · Cited by 27

SEMA6A/RhoA/YAP axis mediates tumor-stroma interactions and prevents response to dual BRAF/MEK inhibition in BRAF-mutant melanoma

Loria, R., Laquintana, V., Scalera, S., Fraioli, R., Caprara, V., Falcone, I., Bazzichetto, C., Martile, M. D., Rosanò, L., Bufalo, D. D., et al. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02354-w · Cited by 26

Semaphorin 4A enhances lung fibrosis through activation of Akt via PlexinD1 receptor

Peng, H., Gao, W., Chong, F.-R., Liu, H., & Zhang, J. (2015) · Journal of Biosciences · doi:10.1007/s12038-015-9566-9 · Cited by 26

Role of Semaphorin Signaling During Cardiovascular Development

Sun, Q., Liu, S., Liu, K., & Jiao, K. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.008853 · Cited by 26

Semaphorin4A-Plexin D1 Axis Induces Th2 and Th17 While Represses Th1 Skewing in an Autocrine Manner

Carvalheiro, T., Rafael‐Vidal, C., Malvar‐Fernández, B., Lopes, A. P., Pego‐Reigosa, J. M., Radstake, T. R. D. J., & García, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186965 · Cited by 26

Immune semaphorins: Crucial regulatory signals and novel therapeutic targets in asthma and allergic diseases

Kalmarzi, R. N., Rajabinejad, M., & Lotfi, R. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173209 · Cited by 25

Saturation monitoring of VX 15/2503, a novel semaphorin 4 D ‐specific antibody, in clinical trials

Fisher, T. L., Seils, J., Reilly, C. A., Litwin, V., Green, L., Salkowitz‐Bokal, J., Walsh, R., Harville, S., Leonard, J. E., Smith, E., et al. (2015) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.21338 · Cited by 25

FUT8-mediated aberrant N-glycosylation of SEMA7A promotes head and neck squamous cell carcinoma progression

Liu, Z., Meng, X., Zhang, Y., Sun, J., Tang, X., Zhang, Z., Liu, L., & He, Y. (2024) · International Journal of Oral Science · doi:10.1038/s41368-024-00289-w · Cited by 24

Glucocorticoids suppressed osteoblast differentiation by decreasing Sema3A expression via the PIK3/Akt pathway

Xing, Q., Feng, J., & Zhang, X. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112595 · Cited by 24

Mice lacking Plexin-B3 display normal CNS morphology and behaviour

Worzfeld, T., Rauch, P. J., Karram, K., Trotter, J., Kuner, R., & Offermanns, S. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.08.008 · Cited by 25

Expression of semaphorin 6D and its receptor plexin-A1 in gastric cancer and their association with tumor angiogenesis

Lu, Y., Xu, Q., Chen, L., Zuo, Y., Liu, S., Hu, Y.-T., Li, X., Li, Y., & Zhao, X. (2016) · Oncology Letters · doi:10.3892/ol.2016.5208 · Cited by 24

Galunisertib Drives Treg Fragility and Promotes Dendritic Cell-Mediated Immunity against Experimental Lymphoma

Hira, S. K., Rej, A., Paladhi, A., Singh, R. K., Saha, J., Mondal, I., Bhattacharyya, S., & Manna, P. P. (2020) · iScience · doi:10.1016/j.isci.2020.101623 · Cited by 23

A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis

Jiang, X., Bergquist, A. M., Löscher, B.-S., Venkatesh, G., Mold, J. E., Holm, K., Laerdahl, J. K., Skånland, S. S., Maleki, K. T., Cornillet, M., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abb0036 · Cited by 24

Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium

Shoda, J., Tanaka, S., Etori, K., Hattori, K., Kasuya, T., Ikeda, K., Maezawa, Y., Suto, A., Suzuki, K., Nakamura, J., et al. (2022) · Arthritis Research & Therapy · doi:10.1186/s13075-022-02817-7 · Cited by 23

Axon Guidance Molecules and Pain

Damo, E., & Simonetti, M. (2022) · Cells · doi:10.3390/cells11193143 · Cited by 25

An increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in an in vitro model of human neural progenitor differentiation

Ferretti, G., Romano, A., Sirabella, R., Serafini, S., Maier, T. J., & Matrone, C. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00916-1 · Cited by 24

LDL Receptor-Related Protein 1 Regulates the Abundance of Diverse Cell-Signaling Proteins in the Plasma Membrane Proteome

Gaultier, A., Simon, G. M., Niessen, S., Dix, M. M., Takimoto, S., Cravatt, B. F., & Gonias, S. L. (2010) · Journal of Proteome Research · doi:10.1021/pr1008288 · Cited by 23

Semaphorins as Potential Immune Therapeutic Targets for Cancer

Jiang, J., Zhang, F., Wan, Y., Fang, K., Yan, Z., Ren, X., & Zhang, R. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.793805 · Cited by 21

Novel role of semaphorin 3A in the growth and progression of hepatocellular carcinoma

Li, X., Chen, Q., Yin, D., Shi, S., Yu, L., Zhou, S., Chen, E., Zhou, Z., Shi, Y., Fan, J., et al. (2017) · Oncology Reports · doi:10.3892/or.2017.5616 · Cited by 21

Semaphorins in immune cell function, inflammatory and infectious diseases

Thomas, R., & Yang, X. (2023) · Current Research in Immunology · doi:10.1016/j.crimmu.2023.100060 · Cited by 20

Smoking aggravates neovascular age-related macular degeneration via Sema4D-PlexinB1 axis-mediated activation of pericytes

He, K., Dong, X., Yang, T., Li, Z., Liu, Y., He, J., Wu, M., Wei-Zhang, S., Kaysar, P., Cui, B., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58074-0 · Cited by 20

Changes in expression of Class 3 Semaphorins and their receptors during development of the rat retina and superior colliculus

Sharma, A., LeVaillant, C. J., Plant, G. W., & Harvey, A. R. (2014) · BMC Developmental Biology · doi:10.1186/s12861-014-0034-9 · Cited by 22

Semaphorin3A: A potential therapeutic tool in immune-mediated diseases

Vadasz, Z., & Toubi, E. (2017) · European Journal of Rheumatology · doi:10.5152/eurjrheum.2017.17076 · Cited by 20

Measles virus modulates dendritic cell/T‐cell communication at the level of plexinA1/neuropilin‐1 recruitment and activity

Tran‐Van, H., Avota, E., Börtlein, C., Mueller, N., & Schneider‐Schaulies, S. (2010) · European Journal of Immunology · doi:10.1002/eji.201040847 · Cited by 19

Functional Genomic Assessment of Phosgene-Induced Acute Lung Injury in Mice

Leikauf, G. D., Concel, V. J., Bein, K., Liu, P., Berndt, A., Martin, T. M., Ganguly, K., Jang, A., Brant, K. A., Dopico, R. A., et al. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0337oc · Cited by 19

Sema3a inhibits the differentiation of Raw264.7 cells to osteoclasts under 2Gy radiation by reducing inflammation

Huang, B., Zhang, Q., Yuan, Y., Xin, N., He, K., Huang, Y. H., Tang, H., & Gong, P. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200000 · Cited by 19

Semaporin3A inhibitor ameliorates renal fibrosis through the regulation of JNK signaling

Sang, Y., Tsuji, K., Fukushima, K., Takahashi, K., Kitamura, S., & Wada, J. (2021) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00234.2021 · Cited by 19

Endothelial semaphorin 7A promotes seawater aspiration-induced acute lung injury through plexin C1 and β1 integrin

Zhang, M., Yan, X., Liu, W., Sun, R., Xie, Y., & Jin, F. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7097 · Cited by 19

The Semaphorin 4D-RhoA-Akt Signal Cascade Regulates Enamel Matrix Secretion in Coordination With Cell Polarization During Ameloblast Differentiation

Otsu, K., Ida‐Yonemochi, H., Fujiwara, N., & Harada, H. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2876 · Cited by 19

The identification and function of a Netrin-1 mutation in a pedigree with premature atherosclerosis

Bruikman, C. S., Vreeken, D., Zhang, H., van Gils, M. J., Peter, J., van Zonneveld, A. J., Hovingh, G. K., & van Gils, J. M. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.02.015 · Cited by 19

Locally Secreted Semaphorin 4D Is Engaged in Both Pathogenic Bone Resorption and Retarded Bone Regeneration in a Ligature-Induced Mouse Model of Periodontitis

Ishii, T., Ruiz‐Torruella, M., Yamamoto, K., Yamaguchi, T., Heidari, A., Pierrelus, R., Leon, E., Shindo, S., Rawas-Qalaji, M., Pastore, M. R., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105630 · Cited by 18

Decreased Expression of Semaphorin 3A and Semaphorin 7A Levels and Its Association with Systemic Lupus Erythematosus

Wang, P., Mao, Y., Liu, L., Zhao, C., Li, X., & Pan, H. (2019) · Immunological Investigations · doi:10.1080/08820139.2019.1649280 · Cited by 18

GI-REASONS: a novel 6-month, prospective, randomized, open-label, blinded end point (PROBE) trial

Cryer, B., Li, C., Simon, L. S., Singh, G., Stillman, M. J., & Berger, M. F. (2012) · Arthritis Research & Therapy · doi:10.1186/ar3664 · Cited by 17

Interferon-α-induced CD100 on naïve CD8 + T cells enhances antiviral responses to hepatitis C infection through CD72 signal transduction

Li, B. J., He, Y., Zhang, Y., Guo, Y. H., Zhou, Y., Zhang, P. X., Wang, W., Zhao, J., Li, J. G., Zuo, W., et al. (2017) · Journal of International Medical Research · doi:10.1177/0300060516676136 · Cited by 17

Viral Semaphorin Inhibits Dendritic Cell Phagocytosis and Migration but Is Not Essential for Gammaherpesvirus-Induced Lymphoproliferation in Malignant Catarrhal Fever

Myster, F., Palmeira, L., Sorel, O., Bouillenne, F., Pauw, E. D., Schwartz-Cornil, I., Vanderplasschen, A. F. C., & Dewals, B. G. (2015) · Journal of Virology · doi:10.1128/jvi.03634-14 · Cited by 17

Endogenous Regulators of the Immune System (sCD100, Malonic Dialdehyde, and Arginase)

Казимирский, А. Н., Poryadin, G. V., Салмаси, Ж. М., & Semenova, L. Y. (2018) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-018-4061-6 · Cited by 16

sSema4D levels are increased in coronary heart disease and associated with the extent of coronary artery stenosis

Gong, H., Lyu, X., Li, S., Chen, R., Hu, M., & Zhang, X. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.01.021 · Cited by 16

Semaphorin 7A interacts with nuclear factor NF-kappa-B p105 via integrin β1 and mediates inflammation

Li, X., Xie, W., Pan, Q., Zhang, X., Zhang, L., Zhao, N., Xie, Q., Ding, J., & Chai, J. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-022-01024-w · Cited by 16

Regulation of immune cell responses by semaphorins and their receptors

Takamatsu, H., Okuno, T., & Kumanogoh, A. (2010) · Cellular and Molecular Immunology · doi:10.1038/cmi.2009.111 · Cited by 108

Immune Semaphorins: Increasing Members and Their Diverse Roles

Kikutani, H., Suzuki, K., & Kumanogoh, A. (2007) · Advances in immunology · doi:10.1016/s0065-2776(06)93003-x · Cited by 37

Semaphorins: a new class of immunoregulatory molecules

Takegahara, N., Kumanogoh, A., & Kikutani, H. (2005) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2005.1696 · Cited by 45

The role of Semaphorin family in immune systems

Ito, D., Nojima, S., & Kumanogoh, A. (2014) · Japanese Journal of Clinical Immunology · doi:10.2177/jsci.37.1 · Cited by 5

Diverse roles for semaphorin−plexin signaling in the immune system

Takamatsu, H., & Kumanogoh, A. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.01.008 · Cited by 167