Cited by 400Axon Guidance and Neuronal SignalingPhagocytosis and Immune RegulationChemokine receptors and signaling

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Semaphorins and their receptors in immune cell interactions

Suzuki, Kazuhiro, Kumanogoh, Atsushi, Kikutani, Hitoshi·2008·Nature Immunology

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Abstract

Semaphorins are newcomers to the growing panoply of immunoregulatory proteins. Members of this family were originally identified as proteins that provide axonal guidance cues during neuronal development. However, accumulating evidence indicates that several semaphorins, called 'immune semaphorins', are crucial to various phases of the immune response, from initiation to terminal inflammatory processes. Extensive studies of immune semaphorins have shown not only differences but also parallels in semaphorin functions among physiologically distinct systems, providing unexpected but meaningful insights into the biological activities of this protein family. Here we review the present knowledge of the function of semaphorins and their receptors in the immune system, including the most recent advances in this field.

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Authors: Suzuki, K., Kumanogoh, A., & Kikutani, H.
Affiliations: Japan Science and Technology Agency (JP)
Immunology Frontier Research Center, The University of Osaka (JP)
Corresponding author: Kikutani, Hitoshi
ORCID: Kumanogoh, Atsushi
Kikutani, Hitoshi
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2007-12-17
Volume: 9
Issue: 1
Pages: 17-23
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni1553
OpenAlex: W2055510343
Cited by: 400
References: 84
Citations by year: 2026: 13 · 2025: 14 · 2024: 12 · 2023: 18 · 2022: 16 · 2021: 17 · 2020: 16 · 2019: 17 · 2018: 18 · 2017: 21 · 2016: 15 · 2015: 11 · 2014: 13 · 2013: 21 · 2012: 94
FWCI: 1.64
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Keywords: semaphorins, semaphorin receptors, immune cell interactions, immune regulation, axon guidance, inflammation, immune response initiation
MeSH terms: Animals, B-Lymphocytes, Cell Communication, Cell Differentiation, Dendritic Cells, Humans, Immunity, Cellular, Inflammation, Lymphocyte Activation, T-Lymphocytes, Signal Transduction, Antigens, CD, Semaphorins, Mice, GPI-Linked Proteins

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Semaphorins and their receptors in immune cell interactions

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