Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis
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Monocyte homing to the liver and adhesion to the liver sinusoidal endothelial cells (LSECs) are key elements in nonalcoholic steatohepatitis (NASH) pathogenesis. We reported previously that VCAM-1 mediates monocyte adhesion to LSECs. However, the pathogenic role of VCAM-1 in NASH is unclear. Herein, we report that VCAM-1 was a top upregulated adhesion molecule in the NASH mouse liver transcriptome. Open chromatin landscape profiling combined with genome-wide transcriptome analysis showed robust transcriptional upregulation of LSEC VCAM-1 in murine NASH. Moreover, LSEC VCAM-1 expression was significantly increased in human NASH. LSEC VCAM-1 expression was upregulated by palmitate treatment in vitro and reduced with inhibition of the mitogen-activated protein 3 kinase (MAP3K) mixed lineage kinase 3 (MLK3). Likewise, LSEC VCAM-1 expression was reduced in the Mlk3-/- mice with diet-induced NASH. Furthermore, VCAM-1 neutralizing Ab or pharmacological inhibition attenuated diet-induced NASH in mice, mainly via reducing the proinflammatory monocyte hepatic population as examined by mass cytometry by time of flight (CyTOF). Moreover, endothelium-specific Vcam1 knockout mice were also protected against NASH. In summary, lipotoxic stress enhances the expression of LSEC VCAM-1, in part, through MLK3 signaling. Inhibition of VCAM-1 was salutary in murine NASH and might serve as a potential therapeutic strategy for human NASH.
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During MASH, lipotoxic stimulation leads to increased expression of endothelial VCAM1.
“During MASH, lipotoxic stimulation leads to increased expression of endothelial vascular cell adhesion molecule 1 (VCAM1) [315].”
From Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells (2025) · cites this paper as [315]
LSEC activation involves VCAM-1 expression, which recruits pro-inflammatory and pro-fibrogenic immune cells and disrupts the quiescent state of HSCs.
“This activation involves the expression of adhesion proteins such as vascular cell adhesion molecule 1 (VCAM-1), which directly recruits pro-inflammatory and pro-fibrogenic immune cells into the liver, while also disrupting the quiescent state of HSCs (104) (105-109).”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [108]
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Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607 · see citing works
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386 · see citing works
Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332 · see citing works
Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention
Younossi, Z., Anstee, Q. M., Marietti, M., Hardy, T., Henry, L., Eslam, M., George, J., & Bugianesi, E. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.109 · Cited by 5,249 · see citing works
Getting to the site of inflammation: the leukocyte adhesion cascade updated
Ley, K., Laudanna, C., Cybulsky, M. I., & Nourshargh, S. (2007) · Nature Reviews Immunology · doi:10.1038/nri2156 · Cited by 4,354 · see citing works
Mechanisms of NAFLD development and therapeutic strategies
Friedman, S. L., Neuschwander-Tetri, B. A., Rinella, M., & Sanyal, A. J. (2018) · Nature Medicine · doi:10.1038/s41591-018-0104-9 · Cited by 4,354 · see citing works
An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues
Corces, M. R., Trevino, A. E., Hamilton, E. G., Greenside, P. G., Sinnott-Armstrong, N. A., Vesuna, S., Satpathy, A. T., Rubin, A. J., Montine, K. S., Wu, B., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4396 · Cited by 2,496 · see citing works
Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
Ross-Innes, C. S., Stark, R., Teschendorff, A. E., Holmes, K. A., Ali, H. R., Dunning, M., Brown, G. D., Gojiš, O., Ellis, I. O., Green, A. R., et al. (2012) · Nature · doi:10.1038/nature10730 · Cited by 2,182 · see citing works
Resolving the fibrotic niche of human liver cirrhosis at single-cell level
Ramachandran, P., Dobie, R., Wilson-Kanamori, J. R., Dora, E. F., Henderson, B. E. P., Luu, N. T., Portman, J. R., Matchett, K. P., Brice, M., Marwick, J. A., et al. (2019) · Nature · doi:10.1038/s41586-019-1631-3 · Cited by 1,784 · see citing works
Differential Oestrogen Receptor Binding is Associated with Clinical Outcome in Breast Cancer
Stark, R. (2012) · Lecture notes in computer science · doi:10.1007/978-3-642-29627-7_30 · Cited by 1,403 · see citing works
Liver sinusoidal endothelial cells: Physiology and role in liver diseases
Poisson, J., Lemoinne, S., Boulanger, C., Durand, F., Moreau, R., Valla, D., & Rautou, P.-E. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2016.07.009 · Cited by 1,047 · see citing works
The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
Kazankov, K., Jørgensen, S. M. D., Thomsen, K. L., Møller, H. J., Vilstrup, H., George, J., Schuppan, D., & Grønbæk, H. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0082-x · Cited by 941 · see citing works
Of lineage and legacy: the development of mammalian hematopoietic stem cells
Dzierzak, E., & Speck, N. A. (2008) · Nature Immunology · doi:10.1038/ni1560 · Cited by 707 · see citing works
Emerging Roles of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Immunological Disorders and Cancer
Kong, D.-H., Kim, Y., Kim, M. K., Jang, J. Y., & Lee, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041057 · Cited by 687 · see citing works
An improved mouse model that rapidly develops fibrosis in non‐alcoholic steatohepatitis
Matsumoto, M., Hada, N., Sakamaki, Y., Uno, A., Shiga, T., Tanaka, C., Ito, T., Katsume, A., & Sudoh, M. (2013) · International Journal of Experimental Pathology · doi:10.1111/iep.12008 · Cited by 523 · see citing works
Alva, J. A., Zovein, A. C., Monvoisin, A., Murphy, T. J., Salazar, A., Harvey, N. L., Carmeliet, P., & Iruela‐Arispe, M. L. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20643 · Cited by 455 · see citing works
Charlton, M., Krishnan, A., Viker, K., Sanderson, S. O., Cazanave, S. C., McConico, A. L., Masuoko, H., & Gores, G. J. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00145.2011 · Cited by 444 · see citing works
Seidman, J. S., Troutman, T. D., Sakai, M., Gola, A., Spann, N. J., Bennett, H., Bruni, C. M., Ouyang, Z., Li, R. Z., Sun, X., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.04.001 · Cited by 443 · see citing works
Epidemiology and natural history of non-alcoholic fatty liver disease
Fazel, Y., Koenig, A. B., Sayıner, M., Goodman, Z. D., & Younossi, Z. M. (2016) · Metabolism · doi:10.1016/j.metabol.2016.01.012 · Cited by 435 · see citing works
Inducible gene targeting in the neonatal vasculature and analysis of retinal angiogenesis in mice
Pitulescu, M. E., Schmidt, I., Benedito, R., & Adams, R. H. (2010) · Nature Protocols · doi:10.1038/nprot.2010.113 · Cited by 418 · see citing works
Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver disease
Hammoutene, A., & Rautou, P.-E. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.02.012 · Cited by 364 · see citing works
High-dimensional analysis of the murine myeloid cell system
Becher, B., Schlitzer, A., Chen, J.-M., Mair, F., Sumatoh, H., Teng, K., Low, D., Ruedl, C., Riccardi-Castagnoli, P., Poidinger, M., et al. (2014) · Nature Immunology · doi:10.1038/ni.3006 · Cited by 357 · see citing works
Cytofkit: A Bioconductor Package for an Integrated Mass Cytometry Data Analysis Pipeline
Chen, H., Lau, M. C., Wong, M. T., Newell, E. W., Poidinger, M., & Chen, J. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005112 · Cited by 343 · see citing works
An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis
Zhao, P., Sun, X., Chaggan, C., Liao, Z., Wong, K. I., He, F., Singh, S., Loomba, R. S., Karin, M., Witztum, J. L., et al. (2020) · Science · doi:10.1126/science.aay0542 · Cited by 308 · see citing works
Neish, A. S., Read, M. A., Thanos, D., Pine, R. I., Maniatis, T., & Collins, T. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.5.2558 · Cited by 298 · see citing works
Dietary Factors Alter Hepatic Innate Immune System in Mice With Nonalcoholic Ratty Liver Disease * #
Li, Z., Soloski, M. J., & Diehl, A. M. (2005) · Hepatology · doi:10.1002/hep.20826 · Cited by 294 · see citing works
Ibrahim, S. H., Hirsova, P., & Gores, G. J. (2018) · Gut · doi:10.1136/gutjnl-2017-315691 · Cited by 278 · see citing works
Self-citationTaooka, Y., Chen, J. L., Yednock, T. A., & Sheppard, D. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.2.413 · Cited by 261 · see citing works
Pivotal role of liver sinusoidal endothelial cells in NAFLD/NASH progression
Miyao, M., Kotani, H., Ishida, T., Kawai, C., Manabe, S., Abiru, H., & Tamaki, K. (2015) · Laboratory Investigation · doi:10.1038/labinvest.2015.95 · Cited by 255 · see citing works
VE‐cadherin‐CreER T2 transgenic mouse: A model for inducible recombination in the endothelium
Monvoisin, A., Alva, J. A., Hofmann, J. J., Zovein, A. C., Lane, T. F., & Iruela‐Arispe, M. L. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20982 · Cited by 255 · see citing works
Plasma total and free fatty acids composition in human non-alcoholic steatohepatitis
TAVARES DE ALMEIDA, I., CORTEZ-PINTO, H., FIDALGO, G., RODRIGUES, D., & CAMILO, M. E. (2002) · Clinical Nutrition · doi:10.1054/clnu.2001.0529 · Cited by 243 · see citing works
TGF-β-dependent induction of CD4+CD25+Foxp3+ Tregs by liver sinusoidal endothelial cells
Carambia, A., Freund, B., Schwinge, D., Heine, M., Laschtowitz, A., Huber, S., Wraith, D. C., Korn, T., Schramm, C., Lohse, A. W., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.04.027 · Cited by 241 · see citing works
Hilscher, M. B., Sehrawat, T., Arab, J. P., Zeng, Z., Gao, J., Liu, M., Kostallari, E., Gao, Y., Simonetto, D. A., Yaqoob, U., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.03.013 · Cited by 240 · see citing works
Self-citationIbrahim, S. H., Hirsova, P., Tomita, K., Bronk, S. F., Werneburg, N. W., Harrison, S. A., Goodfellow, V. S., Malhi, H., & Gores, G. J. (2016) · Hepatology · doi:10.1002/hep.28252 · Cited by 232 · see citing works
Self-citationTardif, J., McMurray, J. J. V., Klug, E., Small, R., Schumi, J., Choi, J., Cooper, J., Scott, R. C., Lewis, E. F., L’Allier, P. L., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60763-1 · Cited by 199 · see citing works
Ahmad, M., Theofanidis, P., & Medford, R. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.8.4616 · Cited by 190 · see citing works
Hammoutene, A., Biquard, L., Lasselin, J., Kheloufi, M., Tanguy, M., Vion, A.-C., Mérian, J., Colnot, N., Loyer, X., Tedgui, A., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2019.10.028 · Cited by 188 · see citing works
Guo, Q., Furuta, K., Lucien, F., Sanchez, L. H. G., Hirsova, P., Krishnan, A., Kabashima, A., Pavelko, K. D., Madden, B. J., Alhuwaish, H., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.07.019 · Cited by 181 · see citing works
Self-citationOntogeny and Polarization of Macrophages in Inflammation: Blood Monocytes Versus Tissue Macrophages
Dey, A., Allen, J., & Hankey-Giblin, P. A. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00683 · Cited by 126 · see citing works
Wong, M. T., Chen, J., Narayanan, S., Lin, W., Anicete, R., Tan, H. K. K., de Lafaille, M. A. C., Poidinger, M., & Newell, E. W. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.05.022 · Cited by 123 · see citing works
Sundell, C. L., Somers, P. K., Meng, C. Q., Hoong, L. K., Suen, K., Hill, R. R., Landers, L. K., Chapman, A., Butteiger, D. N., Jones, M., et al. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.048132 · Cited by 89 · see citing works
The Many Roles of Cell Adhesion Molecules in Hepatic Fibrosis
Hintermann, E., & Christen, U. (2019) · Cells · doi:10.3390/cells8121503 · Cited by 87 · see citing works
Park, J., Ryu, S. Y., Jung, I., Lee, Y.-H., Kang, K. J., Lee, M., Lee, M.-N., Sonn, S. K., Lee, J. H., Lee, H., et al. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.11.029 · Cited by 77 · see citing works
Self-citationMechanisms of endothelial dysfunction in rheumatoid arthritis: lessons from animal studies
Totoson, P., Maguin‐Gaté, K., Prati, C., Wendling, D., & Demougeot, C. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4450 · Cited by 75 · see citing works
HiChIP: a high-throughput pipeline for integrative analysis of ChIP-Seq data
Yan, H., Evans, J. M., Kalmbach, M., Moore, R. M., Middha, S., Luban, S., Wang, L., Bhagwate, A. V., Li, Y., Sun, Z., et al. (2014) · BMC Bioinformatics · doi:10.1186/1471-2105-15-280 · Cited by 75 · see citing works
Krishnan, A., Abdullah, T. S., Mounajjed, T., Hartono, S. P., McConico, A. L., White, T., LeBrasseur, N. K., Lanza, I. R., Nair, S., Gores, G., et al. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00213.2016 · Cited by 75 · see citing works
Miyachi, Y., Tsuchiya, K., Komiya, C., Shiba, K., Shimazu, N., Yamaguchi, S., Deushi, M., Osaka, M., Inoue, K., Sato, Y., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.039 · Cited by 73 · see citing works
Géraud, C., Mogler, C., Runge, A., Evdokimov, K., Lu, S., Schledzewski, K., Arnold, B., Hämmerling, G., Koch, P. S., Breuhahn, K., et al. (2013) · Liver International · doi:10.1111/liv.12262 · Cited by 69 · see citing works
Kunsch, C., Luchoomun, J., Grey, J. Y., Olliff, L. K., Saint, L. B., Arrendale, R. F., Wasserman, M. A., Saxena, U., & Medford, R. M. (2004) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.059733 · Cited by 66 · see citing works
New insights to the mechanisms underlying atherosclerosis in rheumatoid arthritis
Mahmoudi, M., Aslani, S., Fadaei, R., & Jamshidi, A. (2017) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.12999 · Cited by 62 · see citing works
Dynamic plasticity of macrophage functions in diseased liver
Ritz, T., Krenkel, O., & Tacke, F. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.12.007 · Cited by 58 · see citing works
Ibrahim, S. H., Gores, G. J., Hirsova, P., Kirby, M., Miles, L., Jaeschke, A., & Kohli, R. (2013) · Liver International · doi:10.1111/liv.12353 · Cited by 54 · see citing works
Self-citationCARTER, R. A., Campbell, I. K., O'DONNEL, K. L., & Wicks, I. P. (2002) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2002.01794.x · Cited by 54 · see citing works
Tomita, K., Kabashima, A., Freeman, B. L., Bronk, S. F., Hirsova, P., & Ibrahim, S. H. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25973 · Cited by 53 · see citing works
Self-citationLefere, S., de Velde, F. V., Devisscher, L., Bekaert, M., Raevens, S., Verhelst, X., Nieuwenhove, Y. V., Praet, M. M., Hoorens, A., Steenkiste, C. V., et al. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.102 · Cited by 53 · see citing works
Emerging Roles of Liver Sinusoidal Endothelial Cells in Nonalcoholic Steatohepatitis
Furuta, K., Guo, Q.-Q., Hirsova, P., & Ibrahim, S. (2020) · Biology · doi:10.3390/biology9110395 · Cited by 45 · see citing works
Self-citationMixed-lineage kinase 3 pharmacological inhibition attenuates murine nonalcoholic steatohepatitis
Tomita, K., Kohli, R., MacLaurin, B. L., Hirsova, P., Guo, Q., Sanchez, L. H. G., Gelbard, H. A., Blaxall, B. C., & Ibrahim, S. H. (2017) · JCI Insight · doi:10.1172/jci.insight.94488 · Cited by 34 · see citing works
Self-citationKar, S., Paglialunga, S., Jaycox, S. H., Islam, M. R., & Paredes, A. H. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217263 · Cited by 27 · see citing works
Rogers, G. W. T., Dobbs, B. R., & Fraser, R. (1992) · Liver International · doi:10.1111/j.1600-0676.1992.tb00581.x · Cited by 25 · see citing works
Recent and Emerging Therapeutic Medications in Type 2 Diabetes Mellitus
Lo, M. C., & Lansang, M. C. (2010) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e3181ec9eb2 · Cited by 12 · see citing works
Liu, Z., Shi, S., Zhu, H., Chen, Y., Zhang, Y., Zheng, Z., & Wang, X. (2018) · International Heart Journal · doi:10.1536/ihj.17-625 · Cited by 10 · see citing works
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A new perspective on NAFLD: Focusing on lipid droplets
Scorletti, E., & Carr, R. M. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.11.009 · Cited by 376 · see citing works
The evolving role of liver sinusoidal endothelial cells in liver health and disease
McConnell, M. J., Kostallari, E., Ibrahim, S. H., & Iwakiri, Y. (2023) · Hepatology · doi:10.1097/hep.0000000000000207 · Cited by 189 · see citing works
Self-citationMolecular mechanisms in MASLD/MASH-related HCC
Wang, X., Zhang, L., & Dong, B. (2024) · Hepatology · doi:10.1097/hep.0000000000000786 · Cited by 188 · see citing works
Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)
Wang, S., & Friedman, S. L. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adi0759 · Cited by 158 · see citing works
Endothelial Cell Dysfunction and Nonalcoholic Fatty Liver Disease (NAFLD): A Concise Review
Ansari, N. N., Ανδρουτσάκος, Θ., Flessa, C., Kyrou, I., Siasos, G., Randeva, H. S., Kassi, E. N., & Papavassiliou, A. G. (2022) · Cells · doi:10.3390/cells11162511 · Cited by 134 · see citing works
Zhao, Y., Jiang, J., Zhou, P., Deng, K., Liu, Z., Yang, M., Yang, X., Li, J., Li, R., & Xia, J. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116120 · Cited by 118 · see citing works
Qing, J., Ren, Y., Zhang, Y., Yan, M., Zhang, H., Wu, D., Ma, Y., Chen, Y., Huang, X., Wu, Q., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.09.032 · Cited by 103 · see citing works
Current Options and Future Directions for NAFLD and NASH Treatment
Zhang, C., & Yang, M. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147571 · Cited by 94 · see citing works
Lipotoxicity-driven metabolic dysfunction-associated steatotic liver disease (MASLD)
Iturbe-Rey, S., Maccali, C., Arrese, M. A., Aspichueta, P., de Oliveira, C. P. M. S., Castro, R. E., Lapitz, A., Izquierdo‐Sánchez, L., Bujanda, L., Perugorria, M. J., et al. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.119053 · Cited by 97 · see citing works
Pathophysiological underpinnings of metabolic dysfunction-associated steatotic liver disease
Kuchay, M. S., Choudhary, N. S., & Ramos‐Molina, B. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00951.2024 · Cited by 97 · see citing works
Greuter, T., Yaqoob, U., Gan, C., Jalan-Sakrikar, N., Kostallari, E., Lu, J., Gao, J., Sun, L., Liu, M., Sehrawat, T. S., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.03.029 · Cited by 92 · see citing works
Self-citationWang, L., Tang, Y., Tang, J., Liu, X., Zi, S., Li, S., Chen, H., Liu, A., Huang, W. C., Xie, J., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12423 · Cited by 88 · see citing works
Spatial transcriptomics identifies enriched gene expression and cell types in human liver fibrosis
Chung, B. K., Øgaard, J., Reims, H. M., Karlsen, T. H., & Melum, E. (2022) · Hepatology Communications · doi:10.1002/hep4.2001 · Cited by 85 · see citing works
Angiocrine signaling in sinusoidal homeostasis and liver diseases
Gao, J., Lan, T., Kostallari, E., Guo, Y., Lai, E., Guillot, A., Ding, B., Tacke, F., Tang, C., & Shah, V. H. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.05.014 · Cited by 90 · see citing works
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Mladenić, K., Lenartić, M., Marinović, S., Polić, B., & Wensveen, F. M. (2024) · European Journal of Immunology · doi:10.1002/eji.202149641 · Cited by 76 · see citing works
Guo, Q., Furuta, K., Islam, S., Caporarello, N., Kostallari, E., Dielis, K., Tschumperlin, D. J., Hirsova, P., & Ibrahim, S. H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.983255 · Cited by 73 · see citing works
Self-citationMcConnell, M., Kondo, R., Kawaguchi, N., & Iwakiri, Y. (2021) · Hepatology Communications · doi:10.1002/hep4.1843 · Cited by 60 · see citing works
Duan, J., Liu, J., Ruan, B., Ding, J. H., Fang, Z.-Q., Xu, H., Song, P., Chen, X., Li, Z., Du, W., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00348-z · Cited by 63 · see citing works
Gutiérrez‐Cuevas, J., Lucano‐Landeros, S., López-Cifuentes, D., Santos, A., & Armendáriz‐Borunda, J. (2022) · Cancers · doi:10.3390/cancers15010023 · Cited by 62 · see citing works
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He, Q., He, W., Dong, H., Guo, Y., Yuan, G., Shi, X., Wang, D., & Lu, F. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01720-9 · Cited by 61 · see citing works
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Rui, L., & Lin, J. D. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062220-105200 · Cited by 56 · see citing works
Tao, X., Zhang, R., Du, R., Yu, T., Yang, H., Li, J., Wang, Y., Liu, Q., Zuo, S., Wang, X., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20212414 · Cited by 55 · see citing works
Arelaki, S., Κoletsa, T., Sinakos, E., Papadopoulos, V. P., Arvanitakis, K., Skendros, P., Akriviadis, E. A., Ritis, K., Germanidis, G. S., & Hytiroglou, P. (2022) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-022-03330-7 · Cited by 50 · see citing works
Shen, B., Gu, T., Shen, Z., Zhou, C., Guo, Y., Wang, J., Li, B., Xu, X., Li, F., Zhang, Q., et al. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.08.001 · Cited by 47 · see citing works
MASLD development: From molecular pathogenesis toward therapeutic strategies
Yang, Z., Zhao, J., Xie, K., Tang, C., Gan, C., & Gao, J. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003629 · Cited by 47 · see citing works
Nonalcoholic fatty liver disease: Current therapies and future perspectives in drug delivery
Domingues, I., Leclercq, I. A., & Beloqui, A. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.09.040 · Cited by 44 · see citing works
Li, M., Cui, M., Li, G., Liu, Y., Xu, Y., Eftekhar, S. P., & Ala, M. (2024) · Hormone and Metabolic Research · doi:10.1055/a-2266-1503 · Cited by 37 · see citing works
Melchinger, I., Guo, K., Li, X., Guo, J.-K., Cantley, L. G., & Xu, L. (2024) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00076.2024 · Cited by 37 · see citing works
Gonzalez-Rellan, M. J., Riobello, C., Fang, S., da Silva, E. M., Koehler, J. A., Shang, R., Hammoud, R., Cao, X., Varela‐Rey, M., & Drucker, D. J. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.03.011 · Cited by 33 · see citing works
Analysis of miRNAs Profiles in Serum of Patients With Steatosis and Steatohepatitis
Vulf, M. A., Skuratovskaia, D., Komar, A., Bograya, M., Затолокин, П. А., Кириенкова, Е. В., Газатова, Н. Д., Kozlov, I. G., & Litvinova, L. S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.736677 · Cited by 34 · see citing works
Endotheliopathy in the metabolic syndrome: Mechanisms and clinical implications
Furuta, K., Tang, X., Islam, S., Tapia, A., Chen, Z., & Ibrahim, S. H. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108372 · Cited by 34 · see citing works
Self-citationSinusoidal endotheliopathy in nonalcoholic steatohepatitis: therapeutic implications
Ibrahim, S. H. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00009.2021 · Cited by 31 · see citing works
Self-citationPathophysiological Mechanisms in Non-Alcoholic Fatty Liver Disease: From Drivers to Targets
Santos-Laso, A., Gutiérrez-Larrañaga, M., Alonso-Peña, M., Medina, J. M., Iruzubieta, P., Arias-Loste, M., López-Hoyos, M., & Crespo, J. (2021) · Biomedicines · doi:10.3390/biomedicines10010046 · Cited by 31 · see citing works
Carr, R. M. (2021) · Journal of Clinical Investigation · doi:10.1172/jci147556 · Cited by 30 · see citing works
Molecular imaging of liver inflammation using an anti-VCAM-1 nanobody
Nachit, M., Montemagno, C., Clerc, R., Ahmadi, M., Briand, F., Bacot, S., Devoogdt, N., Serdjebi, C., Ghezzi, C., Sulpice, T., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36776-7 · Cited by 29 · see citing works
Çebi, M., & Yilmaz, Y. N. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1445634 · Cited by 29 · see citing works
Fan, W., Bradford, T. M., & Török, N. J. (2024) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.15184 · Cited by 25 · see citing works
Solleiro-Villavicencio, H., Viurcos-Sanabria, R., Aguayo-Guerrero, J. A., Pineda-Pérez, P. F., & Méndez-García, L. A. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1620585 · Cited by 25 · see citing works
Felli, É., Nulan, Y., Ortega‐Ribera, M., Fernández‐Iglesias, A., & Gracia‐Sancho, J. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.10.017 · Cited by 25 · see citing works
A Comparative Proteomic Analysis of Extracellular Vesicles Associated With Lipotoxicity
Nakao, Y., Fukushima, M., Mauer, A. S., Liao, C., Ferris, A., Dasgupta, D., Heppelmann, C. J. H., Vanderboom, P. M., Saraswat, M., Pandey, A., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.735001 · Cited by 25 · see citing works
Self-citationScavenger Receptors: Novel Roles in the Pathogenesis of Liver Inflammation and Cancer
Patten, D. A., Wilkinson, A. L., O'Keeffe, A., & Shetty, S. (2021) · Seminars in Liver Disease · doi:10.1055/s-0041-1733876 · Cited by 26 · see citing works
Dai, Q., Ain, Q., Seth, N., Rooney, M., & Zipprich, A. (2025) · Digestive and Liver Disease · doi:10.1016/j.dld.2025.01.189 · Cited by 24 · see citing works
Mao, T., Sun, Y., Xu, X., & He, K. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000234 · Cited by 24 · see citing works
Combined GIP receptor and GLP1 receptor agonism attenuates NAFLD in male APOE∗3-Leiden.CETP mice
Ying, Z., van Eenige, R., Ge, X., van Marwijk, C., Lambooij, J. M., Guigas, B., Giera, M. A., de Boer, J. F., Coşkun, T., Qu, H., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104684 · Cited by 23 · see citing works
Mesenchymal stem cells-based therapy in liver diseases
Han, H., Jin, W., & Li, X. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00088-x · Cited by 22 · see citing works
Wang, G., Zhang, X., Wang, C., & Guan, Y. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i1.75 · Cited by 21 · see citing works
Gan, C., Yaqoob, U., Lu, J., Xie, M., Anwar, A., Jalan-Sakrikar, N., Jerez, S., Sehrawat, T. S., Navarro-Corcuera, A., Kostallari, E., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.174775 · Cited by 21 · see citing works
Self-citationDual Role of Pregnane X Receptor in Nonalcoholic Fatty Liver Disease
Xu, Y., An, Z., Wang, S., Ni, Y., Zhou, M., Feng, Q., Gou, X., Xu, M., & Qi, Y. (2023) · Current Molecular Pharmacology · doi:10.2174/0118761429259143230927110556 · Cited by 19 · see citing works
Advances in Noninvasive Biomarkers for Nonalcoholic Fatty Liver Disease
Gîlcă-Blanariu, G.-E., Budur, D. S., Mitrică, D., Gologan, E., Timofte, O., Bălan, G. G., OLTEANU, V.-A., & Ștefănescu, G. (2023) · Metabolites · doi:10.3390/metabo13111115 · Cited by 21 · see citing works
Glycogen synthase kinase 3 activity enhances liver inflammation in MASH
Khoury, M., Guo, Q., Furuta, K., Correia, C., Meroueh, C., Kim Lee, H. S., Warasnhe, K., Valenzuela-Pérez, L., Mazar, A. P., Kim, I., et al. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101073 · Cited by 17 · see citing works
Self-citationThe role of liver sinusoidal endothelial cells in liver remodeling after injury
Li, Z., & Wang, L. (2022) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2022.09.007 · Cited by 17 · see citing works
Oliva, M. E., Ingaramo, P. I., Joubert, M. B. V., Ferreira, M. D. R., & D’Alessandro, M. E. (2021) · Food & Function · doi:10.1039/d1fo02274a · Cited by 17 · see citing works
RGS7-ATF3-Tip60 Complex Promotes Hepatic Steatosis and Fibrosis by Directly Inducing TNFα
Basak, M., Das, K., Mahata, T., Sengar, A. S., Verma, S. K., Biswas, S., Bhadra, K., Stewart, A., & Maity, B. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0174 · Cited by 15 · see citing works
Angiocrine Signaling in Sinusoidal Health and Disease
Cooper, S. A., Kostallari, E., & Shah, V. H. (2023) · Seminars in Liver Disease · doi:10.1055/a-2128-5907 · Cited by 15 · see citing works
Self-citationMo, H., Yue, P., Li, Q., Tan, Y., Yan, X., Liu, X., Xu, Y., Luo, Y., Palihati, S., Yi, C., et al. (2025) · Angiogenesis · doi:10.1007/s10456-025-09969-5 · Cited by 15 · see citing works
The many pathways driving liver inflammation in MASH
Tilg, H., Adolph, T. E., Romeo, S., & Loomba, R. S. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.02.018 · Cited by 15 · see citing works
Non-parenchymal cells: key targets for modulating chronic liver diseases
Yang, T., Gu, Z., Feng, J., Shan, J., Qian, C., & Zhuang, N. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1576739 · Cited by 13 · see citing works
Nonalcoholic Steatohepatitis Disrupts Diurnal Liver Transcriptome Rhythms in Mice
de Assis, L. V. M., Demir, M., & Oster, H. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.05.008 · Cited by 13 · see citing works
Lee, S.-W., Baek, S.-M., Lee, Y.-J., Kim, T., Yim, J.-H., Son, J.-H., Kim, H.-Y., Kang, K., Kim, J. H., Rhee, M. H., et al. (2022) · Journal of Ginseng Research · doi:10.1016/j.jgr.2022.10.005 · Cited by 12 · see citing works
From NAFLD to HCC: Advances in noninvasive diagnosis
Xu, Q., Feng, M., Ren, Y., Liu, X., Gao, H., Li, Z., Su, X., Wang, Q., & Wang, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115028 · Cited by 12 · see citing works
Karri, K., & Waxman, D. J. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116550 · Cited by 11 · see citing works
Research Progress on the Immune Function of Liver Sinusoidal Endothelial Cells in Sepsis
Wang, X.-R., Guo, Z., Xia, Y., Wang, X., & Wang, Z. (2025) · Cells · doi:10.3390/cells14050373 · Cited by 13 · see citing works
The RANK/RANKL axis controls vascular dynamics in the bone marrow
Kaneko, T., Yari, S., Kikuta, J., Omatsu, Y., Seno, S., Kikuchi, S., Sato, K., Fujii, K., Sudo, T., Hasegawa, T., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2425366122 · Cited by 10 · see citing works
Self-citationLi, M., Zhang, Y., Xiang, K., Su, Z., Li, X., Song, H., Wu, X., Mo, D., Ren, M., & Yang, S. L. (2025) · ACS Nano · doi:10.1021/acsnano.5c01730 · Cited by 10 · see citing works
Warasnhe, K., Sano, A., Guo, Q., Satthawiwat, N., Dai, X., Classon, P., Meroueh, C., Lee, H. S. K., Valenzuela-Pérez, L., Victorelli, S. G., et al. (2025) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2025.101633 · Cited by 9 · see citing works
Self-citationLarge-scale expansion of human umbilical cord-derived mesenchymal stem cells using PLGA@PLL scaffold
Liu, Y., Amissah, O. B., Huangfang, X., Wang, L., Habimana, J. D. D., Lv, L., Ding, X., Li, J., Chen, M., Zhu, J., et al. (2023) · Bioresources and Bioprocessing · doi:10.1186/s40643-023-00635-6 · Cited by 9 · see citing works
Interdisciplinary advances reshape the delivery tools for effective NASH treatment
Chen, L., & Wang, Y. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101730 · Cited by 9 · see citing works
Zhang, X., Zheng, Y., Zhou, C., Cao, J., Pan, D., Cai, Z., Wu, Z., & Xia, Q. (2024) · Food Microbiology · doi:10.1016/j.fm.2024.104563 · Cited by 8 · see citing works
C/EBPβ–VCAM1 axis in Kupffer cells promotes hepatic inflammation in MASLD
Lin, S., Xie, Y., Cheng, Y., Xue, R., Su, Y.-S., Liu, M., Chen, Y., & Fan, J. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101418 · Cited by 8 · see citing works
Rho-associated protein kinase 1 inhibition in hepatocytes attenuates nonalcoholic steatohepatitis
Dohnálková, E., Bayer, R. L., Guo, Q., Bamidele, A. O., Lee, H. S. K., Valenzuela-Pérez, L., Krishnan, A., Pavelko, K. D., Guisot, N. E. S., Bunyard, P., et al. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000171 · Cited by 8 · see citing works
Self-citationBrouwers, M. C. G. J., Simons, N., Kooi, M. E., de Ritter, R., DONGEN, M. C. J. M. V., Eussen, S. J. P. M., Bekers, O., Kooman, J. P., van Greevenbroek, M. M. J., Kallen, C., et al. (2022) · Digestive and Liver Disease · doi:10.1016/j.dld.2022.01.130 · Cited by 8 · see citing works
In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene
Giorgi, M. D., Park, S. H., Castoreno, A. B., Cao, M., Hurley, A. E., Saxena, L., Chuecos, M. A., Walkey, C. J., Doerfler, A. M., Furgurson, M. N., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adk3920 · Cited by 8 · see citing works
Analysis of the Role of Stellate Cell VCAM-1 in NASH Models in Mice
Chung, K., Legaki, A., Papadopoulos, G., Gercken, B., Gebler, J., Schwabe, R. F., Chavakis, T., & Chatzigeorgiou, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054813 · Cited by 8 · see citing works
Zaib, M., Malik, M. N. H., Shabbir, R., Mushtaq, M. N., Younis, W., Jahan, S., Ahmed, I. M., & Kharl, H. A. A. (2023) · ACS Omega · doi:10.1021/acsomega.3c00443 · Cited by 6 · see citing works
Isolation and Characterization of Mouse Primary Liver Sinusoidal Endothelial Cells
Guo, Q., Furuta, K., Aly, A., & Ibrahim, S. H. (2021) · Journal of Visualized Experiments · doi:10.3791/63062 · Cited by 6 · see citing works
Self-citationMullin, S. M., Kelly, A. J., Chathail, M. B. N., Norris, S., Shannon, C. E., & Roche, H. M. (2025) · Advances in Nutrition · doi:10.1016/j.advnut.2025.100375 · Cited by 3 · see citing works
Liu, J., Deng, L., Yao, B., Zhang, Y., Huang, J., Huang, S., Liang, C., Shen, Y., & Wang, X. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.03.021 · Cited by 5 · see citing works
Nanotherapy targeting liver sinusoidal endothelial cells in liver fibrosis
Zhang, L., Ru, J.-W., Liang, S.-Q., Zhang, M.-M., Zhang, C.-Y., Liu, J.-Q., Wang, Y., Zhou, T., Cheng, X. W., Xing, L., et al. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.114864 · Cited by 7 · see citing works
Li, Y., Ye, H., & Ding, Y.-X. (2022) · Children · doi:10.3390/children9050697 · Cited by 5 · see citing works
Endotheliopathy of liver sinusoidal endothelial cells in liver disease
Kondo, R., Iwakiri, Y., Kage, M., & Yano, H. (2023) · Pathology International · doi:10.1111/pin.13361 · Cited by 5 · see citing works
Fu, R., Zhang, F., Fu, J., Li, Y., Zhu, X., Ding, Q., & Zhu, Y. Z. (2025) · Metabolism and Target Organ Damage · doi:10.20517/mtod.2025.163 · Cited by 6 · see citing works
Wei, H., Yin, Y., Yang, W., Zhu, J., Chen, L., Guo, R., Yang, Z., & Li, S. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1264324 · Cited by 4 · see citing works
Ouyang, H., Miao, H., Zhang, H., Lu, B., Zhang, J., Zhang, T., Zhu, J., Wang, Z., & Ji, L. (2025) · Phytotherapy Research · doi:10.1002/ptr.70095 · Cited by 4 · see citing works
Ma, R., Gong, L., Dong, C., Utsumi, T., Qi, J., Zhuang, Z. W., Zhang, X., Yang, Y., McConnell, M. J., Huang, H., et al. (2026) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2026.101728 · Cited by 4 · see citing works
Wang, C., Hezam, K., Fu, E., Pan, K., Liu, Y., & Li, Z. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114013 · Cited by 5 · see citing works
Species differences of fatty liver diseases: comparisons between human and feline
Ling, L., Li, R., Xu, M., Zhou, J., Hu, M., Zhang, X., & Zhang, X.-J. (2024) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00014.2024 · Cited by 4 · see citing works
Panara, V., Monteiro, R. M., & Koltowska, K. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.891538 · Cited by 4 · see citing works
Yue, Y.-X., Huang, S., Weng, Y., Lu, Y., Jia, B., & Yang, Z. (2024) · Current Pharmaceutical Design · doi:10.2174/0113816128311596240723113624 · Cited by 4 · see citing works
Melchinger, I., Guo, K., Guo, J., & Xu, L. (2022) · bioRxiv · doi:10.1101/2022.09.15.508151 · Cited by 3 · see citing works
Wu, Y., Le, W., Zhang, H., & Zhu, Y. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123879 · Cited by 3 · see citing works
Huang, R., Deng, J., Wang, K., Zhu, C., Ding, C., Chen, F., Zhang, X., & Xie, W. (2025) · Liver International · doi:10.1111/liv.70227 · Cited by 3 · see citing works
Sen, D., Bisht, S., & Gupta, S. (2025) · Egyptian Liver Journal · doi:10.1186/s43066-025-00446-8 · Cited by 3 · see citing works
Ge, W., Ma, L., Huang, Y., Weigao, E., Lai, S., Cui, B., Wang, J., Ji, Y., Liu, D., Ye, S., et al. (2025) · Liver International · doi:10.1111/liv.70262 · Cited by 3 · see citing works
Role of miRNA signalling in the pathogenesis of MASLD
Cheng, S.-L., Hao, J.-S., & Qin, H.-Y. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1756805 · Cited by 3 · see citing works
Chen, W., Yang, A., Zhang, N., & You, H. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95262-0.00014-0 · Cited by 3 · see citing works
El-Sabawi, B., Tanriverdi, K., Gajjar, P., Nayor, M., Landman, J., Below, J., Haff, M. G., Long, M. T., Ezpeleta, M., Freedman, J. E., et al. (2025) · Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease · doi:10.1161/jaha.124.037100 · Cited by 3 · see citing works
Zhang, C., Sui, Y., Liu, S., & Yang, M. J. (2023) · Exploration of Digestive Diseases · doi:10.37349/edd.2023.00029 · Cited by 3 · see citing works
Zou, C., Cai, R., Li, Y., Yu, X., Zhang, G., Alitongbieke, G., Pan, Y., & Zhang, S. Q. (2024) · iScience · doi:10.1016/j.isci.2024.110766 · Cited by 3 · see citing works
- Authors
- Furuta, K., Guo, Q., Pavelko, K. D., Lee, J.-H., Robertson, K. D., Nakao, Y., Melek, J., Shah, V. H., Hirsova, P., & Ibrahim, S. H.
- Affiliations
- Mayo Clinic (US)
- Charles University (CZ)
- Corresponding author
- Ibrahim, Samar H.
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2021-03-15
- Volume
- 131
- Issue
- 6
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- PMC
- PMC7954604
- OpenAlex
- W3125313120
- Cited by
- 136
- References
- 61
- Citations by year
- 2026: 23 · 2025: 31 · 2024: 24 · 2023: 27 · 2022: 18 · 2021: 13
- FWCI
- 14.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Digestive And Kidney Diseases of the National Institutes of Health (DK 122948)
- American Association of Study of liver Disease (Pinnacle Research Award, Bridge Award)
- NIH Silvio O. Conte Digestive Diseases Research Core Centers P30 grant mechanism (DK084567)
- Japan Society for the Promotion of Science (202060532)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Keywords
- nonalcoholic steatohepatitis, VCAM-1, liver sinusoidal endothelial cells, monocyte adhesion, lipotoxicity, palmitate, MLK3, MAP3K signaling, endothelial adhesion molecules, diet-induced NASH, NASH therapy
- MeSH terms
- Animals, Disease Models, Animal, Humans, Liver, Mice, Inbred C57BL, Palmitates, RNA, Messenger, Up-Regulation, Mice, Knockout, Vascular Cell Adhesion Molecule-1, Gene Expression Profiling, MAP Kinase Signaling System, Endothelial Cells, Mice, Antibodies, Neutralizing, Non-alcoholic Fatty Liver Disease
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