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Thymopoiesis independent of common lymphoid progenitors.
Abstract
Early T lineage progenitors (ETPs) in the thymus are thought to develop from common lymphoid progenitors (CLPs) in the bone marrow (BM). We compared thymic ETPs to BM CLPs in mice and found that they differed in several respects. Thymic ETPs were not interleukin 7 (IL-7)-responsive and generated B lineage progeny with delayed kinetics, whereas BM CLPs were IL-7-responsive and rapidly generated B cells. ETPs sustained production of T lineage progeny for longer periods of time than BM CLPs. Analysis of Ikaros-deficient mice that exhibit ongoing thymopoiesis without B lymphopoeisis revealed near-normal frequencies of thymic ETPs, yet undetectable numbers of BM CLPs. We conclude that ETPs can develop via a CLP-independent pathway.
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“Both αβ and γδ T cells arise from common multipotent DN precursors in the thymus that can be further separated into four DN subsets based on CD44 and CD25 expression [2], [3].”
From The Transcription Factor PU.1 Regulates γδ T Cell Homeostasis (2011) · cites this paper as [3]
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Self-citation
Metadata
- Authors
- Allman, D., Sambandam, A., Kim, S., Miller, J. P., Pagan, A., Well, D., Meraz, A., & Bhandoola, A.
- Affiliations
- University of Pennsylvania (US)
- Venue
- Nature Immunology
- Published
- 2003-01-06
- Volume
- 4
- Issue
- 2
- Pages
- 168-174
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2061307900
- Cited by
- 544
- References
- 41
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 9 · 2023: 6 · 2022: 8 · 2021: 11 · 2020: 8 · 2019: 9 · 2018: 10 · 2017: 14 · 2016: 15 · 2015: 18 · 2014: 19 · 2013: 19 · 2012: 25
- FWCI
- 17.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Cancer Society
- Concern Foundation
- Abramson Cancer Center
- National Institutes of Health (1r03ai053284-01, 1r03ag020818-01)
- National Institute on Aging (AG 20818)
- National Institute of Allergy and Infectious Diseases (AI 52861, AI053284, R01AI052861)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- thymopoiesis, common lymphoid progenitors, B cell development, Ikaros, thymus, bone marrow, T cell development
- MeSH terms
- Animals, B-Lymphocytes, Bone Marrow Cells, DNA-Binding Proteins, Female, Hematopoietic Stem Cells, Kinetics, Mice, Inbred C57BL, T-Lymphocytes, Thymus Gland, Transcription Factors, Gene Rearrangement, beta-Chain T-Cell Antigen Receptor, Interleukin-7, Mice, Knockout, Lymphopoiesis, Mice, Ikaros Transcription Factor
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