Cited by 544T-cell and B-cell ImmunologyHematopoietic Stem Cell TransplantationDevelopmental Biology and Gene Regulation

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Thymopoiesis independent of common lymphoid progenitors.

Allman, David, Sambandam, Arivazhagan, Kim, Sungjune, Miller, Juli P., Pagan, Antonio, Well, David, Meraz, Anita, Bhandoola, Avinash·2003·Nature Immunology

DOI 10.1038/ni878

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Abstract

Early T lineage progenitors (ETPs) in the thymus are thought to develop from common lymphoid progenitors (CLPs) in the bone marrow (BM). We compared thymic ETPs to BM CLPs in mice and found that they differed in several respects. Thymic ETPs were not interleukin 7 (IL-7)-responsive and generated B lineage progeny with delayed kinetics, whereas BM CLPs were IL-7-responsive and rapidly generated B cells. ETPs sustained production of T lineage progeny for longer periods of time than BM CLPs. Analysis of Ikaros-deficient mice that exhibit ongoing thymopoiesis without B lymphopoeisis revealed near-normal frequencies of thymic ETPs, yet undetectable numbers of BM CLPs. We conclude that ETPs can develop via a CLP-independent pathway.

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Authors: Allman, D., Sambandam, A., Kim, S., Miller, J. P., Pagan, A., Well, D., Meraz, A., & Bhandoola, A.
Affiliations: University of Pennsylvania (US)
ORCID: Allman, David
Bhandoola, Avinash
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2003-01-06
Volume: 4
Issue: 2
Pages: 168-174
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni878
OpenAlex: W2061307900
Cited by: 544
References: 41
Citations by year: 2026: 2 · 2025: 7 · 2024: 9 · 2023: 6 · 2022: 8 · 2021: 11 · 2020: 8 · 2019: 9 · 2018: 10 · 2017: 14 · 2016: 15 · 2015: 18 · 2014: 19 · 2013: 19 · 2012: 25
FWCI: 17.35
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: American Cancer Society
Concern Foundation
Abramson Cancer Center
National Institutes of Health (1r03ai053284-01, 1r03ag020818-01)
National Institute on Aging (AG 20818)
National Institute of Allergy and Infectious Diseases (AI 52861, AI053284, R01AI052861)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: thymopoiesis, common lymphoid progenitors, B cell development, Ikaros, thymus, bone marrow, T cell development
MeSH terms: Animals, B-Lymphocytes, Bone Marrow Cells, DNA-Binding Proteins, Female, Hematopoietic Stem Cells, Kinetics, Mice, Inbred C57BL, T-Lymphocytes, Thymus Gland, Transcription Factors, Gene Rearrangement, beta-Chain T-Cell Antigen Receptor, Interleukin-7, Mice, Knockout, Lymphopoiesis, Mice, Ikaros Transcription Factor

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Thymopoiesis independent of common lymphoid progenitors.

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