The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Thymopoiesis independent of common lymphoid progenitors.
Abstract
Early T lineage progenitors (ETPs) in the thymus are thought to develop from common lymphoid progenitors (CLPs) in the bone marrow (BM). We compared thymic ETPs to BM CLPs in mice and found that they differed in several respects. Thymic ETPs were not interleukin 7 (IL-7)-responsive and generated B lineage progeny with delayed kinetics, whereas BM CLPs were IL-7-responsive and rapidly generated B cells. ETPs sustained production of T lineage progeny for longer periods of time than BM CLPs. Analysis of Ikaros-deficient mice that exhibit ongoing thymopoiesis without B lymphopoeisis revealed near-normal frequencies of thymic ETPs, yet undetectable numbers of BM CLPs. We conclude that ETPs can develop via a CLP-independent pathway.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Both αβ and γδ T cells arise from common multipotent DN precursors in the thymus that can be further separated into four DN subsets based on CD44 and CD25 expression [2], [3].”
From The Transcription Factor PU.1 Regulates γδ T Cell Homeostasis (2011) · cites this paper as [3]
Citations
Cites
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
Akashi, K., Traver, D., Miyamoto, T., & Weissman, I. L. (2000) · Nature · doi:10.1038/35004599 · Cited by 2,617
Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
Kondo, M., Weissman, I. L., & Akashi, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80453-5 · Cited by 2,253
Godfrey, D. I., Kennedy, J., Suda, T., & Zlotnik, A. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.10.4244 · Cited by 843
Christensen, J. L., & Weissman, I. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261562798 · Cited by 786
The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition
Kronenberg, M., Siu, G., Hood, L., & Shastri, N. (1986) · Annual Review of Immunology · doi:10.1146/annurev.iy.04.040186.002525 · Cited by 765
Adolfsson, J., Borge, O. J., Bryder, D., Theilgaard‐Mönch, K., Åstrand‐Grundström, I., Sitnicka, E., Sasaki, Y., & Jacobsen, S. E. W. (2001) · Immunity · doi:10.1016/s1074-7613(01)00220-5 · Cited by 712
Ikuta, K., & Weissman, I. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.4.1502 · Cited by 637
Wang, J., Nichogiannopoulou, A., Wu, L. J., Sun, L., Sharpe, A. H., Bigby, M. E., & Georgopoulos, K. (1996) · Immunity · doi:10.1016/s1074-7613(00)80269-1 · Cited by 614
Barresi, M. J. F., & Gilbert, S. F. (2023) · Oxford University Press eBooks · doi:10.1093/hesc/9780197574591.001.0001 · Cited by 600
Expression and function of the interleukin 7 receptor in murine lymphocytes.
Sudo, T., Nishikawa, S., Ohno, N., Akiyama, N., Tamakoshi, M., Yoshida, H., & Nishikawa, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.9125 · Cited by 482
Transcription from the RAG1 Locus Marks the Earliest Lymphocyte Progenitors in Bone Marrow
Igarashi, H., Gregory, S. C., Yokota, T., Sakaguchi, N., & Kincade, P. W. (2002) · Immunity · doi:10.1016/s1074-7613(02)00366-7 · Cited by 452
Early T Lymphocyte Progenitors
Shortman, K., & Wu, L. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.29 · Cited by 448
STRUCTURE AND FUNCTION OF THE PRE-T CELL RECEPTOR
von Boehmer, H., & Fehling, H. J. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.433 · Cited by 387
Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines
Kondo, M., Scherer, D. C., Miyamoto, T., King, A. G., Akashi, K., Sugamura, K., & Weissman, I. L. (2000) · Nature · doi:10.1038/35030112 · Cited by 382
Identification of the Earliest B Lineage Stage in Mouse Bone Marrow
Li, Y. S., Wasserman, R., Hayakawa, K., & Hardy, R. R. (1996) · Immunity · doi:10.1016/s1074-7613(00)80268-x · Cited by 376
CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus
Wu, L., Scollay, R. G., Egerton, M., Pearse, M. J., Spangrude, G. J., & Shortman, K. (1991) · Nature · doi:10.1038/349071a0 · Cited by 333
Kurosawa, Y., von Boehmer, H., Haas, W., Sakano, H., Traunecker, A., & Tonegawa, S. (1981) · Nature · doi:10.1038/290565a0 · Cited by 313
Developmental potential of the earliest precursor cells from the adult mouse thymus.
Wu, L., Antica, M., Johnson, G. R., Scollay, R. G., & Shortman, K. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.6.1617 · Cited by 293
Schlissel, M. S., Corcoran, L. M., & Baltimore, D. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.3.711 · Cited by 284
Defects in Hemopoietic Stem Cell Activity in Ikaros Mutant Mice
Nichogiannopoulou, A., Trevisan, M., Neben, S., Friedrich, C., & Georgopoulos, K. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.9.1201 · Cited by 232
Identification of very early lymphoid precursors in bone marrow and their regulation by estrogen
Medina, K. L., Garrett, K. P., Thompson, L. F., Rossi, M. I. D., Payne, K. J., & Kincade, P. W. (2001) · Nature Immunology · doi:10.1038/90659 · Cited by 231
Matsuzaki, Y., Gyotoku, J.-I., Ogawa, M., Nishikawa, S., Katsura, Y., Gachelin, G., & Nakauchi, H. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.4.1283 · Cited by 224
The Importation of Hematogenous Precursors by the Thymus Is a Gated Phenomenon in Normal Adult Mice
Foss, D. L., Donskoy, E., & Goldschneider, I. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.3.365 · Cited by 221
Rolink, A. G., ten Boekel, E., Melchers, F., Fearon, D. T., Krop, I. E., & Andersson, J. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.1.187 · Cited by 219
Miller, J. P., Izon, D., DeMuth, W., Gerstein, R., Bhandoola, A., & Allman, D. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020784 · Cited by 198
Self-citationRedefinition of lymphoid progenitors
Katsura, Y. (2002) · Nature reviews. Immunology · doi:10.1038/nri721 · Cited by 194
Rodewald, H.-R., Kretzschmar, K., Takeda, S., Hohl, C. M., & Dessing, M. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06743.x · Cited by 193
Phenotypic and functional characterization of c-kit expression during intrathymic T cell development
Godfrey, D. I., Zlotnik, A., & Suda, T. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.7.2281 · Cited by 185
Enrichment of hematopoietic precursor cells and cloning of multipotential B-lymphocyte precursors.
McKearn, J. P., McCubrey, J. A., & Fagg, B. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.21.7414 · Cited by 165
Donskoy, E., & Goldschneider, I. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.6.1604 · Cited by 162
Pre–T Cell Receptor (Tcr) and Tcr-Controlled Checkpoints in T Cell Differentiation Are Set by Ikaros
Winandy, S., Wu, L., Wang, J., & Georgopoulos, K. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.8.1039 · Cited by 161
Allman, D., Punt, J. A., Izon, D. J., Aster, J. C., & Pear, W. S. (2002) · Cell · doi:10.1016/s0092-8674(02)00689-x · Cited by 143
Self-citationTudor, K.-S. R. S., Payne, K. J., Yamashita, Y., & Kincade, P. W. (2000) · Immunity · doi:10.1016/s1074-7613(00)80186-7 · Cited by 123
King, A. G., Kondo, M., Scherer, D. C., & Weissman, I. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072087899 · Cited by 115
A Common Pathway for Dendritic Cell and Early B Cell Development
Izon, D. J., Rudd, K., DeMuth, W., Pear, W. S., Clendenin, C. J., Lindsley, R. C., & Allman, D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.3.1387 · Cited by 114
Self-citationNotch signaling in lymphopoiesis
Pear, W. S., & Radtke, F. (2003) · Seminars in Immunology · doi:10.1016/s1044-5323(03)00003-4 · Cited by 95
Rearrangement of IgH genes in normal thymocyte development.
Born, W. K., White, J., Kappler, J. W., & Marrack, P. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.9.3228 · Cited by 70
The role of IL-7 in thymic and extrathymic development of TCR gamma delta cells.
Laky, K., Lefrançois, L., von Freeden-Jeffry, U., Murray, R., & Puddington, L. (1998) · PubMed · Cited by 68
The Role of IL-7 in Thymic and Extrathymic Development of TCRγδ Cells
Laky, K., Lefrançois, L., von Freeden-Jeffry, U., Murray, R., & Puddington, L. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.2.707 · Cited by 67
Foss, D. L., Donskoy, E., & Goldschneider, I. (2002) · International Immunology · doi:10.1093/intimm/14.3.331 · Cited by 39
Transcription of the TCR- beta locus initiates in adult murine bone marrow.
Soloff, R. S., Wang, T. G., Lybarger, L. P., Dempsey, D., & Chervenak, R. P. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.8.3888 · Cited by 22
Flagged first, then by citations
Cited by
Sorted by citations
Age-related changes in lymphocyte development and function
Linton, P. J., & Dorshkind, K. A. (2004) · Nature Immunology · doi:10.1038/ni1033 · Cited by 1,199
Gruver, A., Hudson, L., & Sempowski, G. (2007) · The Journal of Pathology · doi:10.1002/path.2104 · Cited by 834
Causes, consequences, and reversal of immune system aging
Montecino-Rodriguez, E., Berent-Maoz, B., & Dorshkind, K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64096 · Cited by 793
Transcription factors in myeloid development: balancing differentiation with transformation
Rosenbauer, F., & Tenen, D. G. (2007) · Nature Reviews Immunology · doi:10.1038/nri2024 · Cited by 606
The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance
Fry, T. J., & Mackall, C. L. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.6571 · Cited by 563
Metadata
- Authors
- Allman, D., Sambandam, A., Kim, S., Miller, J. P., Pagan, A., Well, D., Meraz, A., & Bhandoola, A.
- Affiliations
- University of Pennsylvania (US)
- Venue
- Nature Immunology
- Published
- 2003-01-06
- Volume
- 4
- Issue
- 2
- Pages
- 168-174
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2061307900
- Cited by
- 544
- References
- 41
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 9 · 2023: 6 · 2022: 8 · 2021: 11 · 2020: 8 · 2019: 9 · 2018: 10 · 2017: 14 · 2016: 15 · 2015: 18 · 2014: 19 · 2013: 19 · 2012: 25
- FWCI
- 17.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Cancer Society
- Concern Foundation
- Abramson Cancer Center
- National Institutes of Health (1r03ai053284-01, 1r03ag020818-01)
- National Institute on Aging (AG 20818)
- National Institute of Allergy and Infectious Diseases (AI 52861, AI053284, R01AI052861)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- thymopoiesis, common lymphoid progenitors, B cell development, Ikaros, thymus, bone marrow, T cell development
- MeSH terms
- Animals, B-Lymphocytes, Bone Marrow Cells, DNA-Binding Proteins, Female, Hematopoietic Stem Cells, Kinetics, Mice, Inbred C57BL, T-Lymphocytes, Thymus Gland, Transcription Factors, Gene Rearrangement, beta-Chain T-Cell Antigen Receptor, Interleukin-7, Mice, Knockout, Lymphopoiesis, Mice, Ikaros Transcription Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
