The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease
Open accessAbstract
Cyclophilin D (CypD, encoded by Ppif) is an integral part of the mitochondrial permeability transition pore, whose opening leads to cell death. Here we show that interaction of CypD with mitochondrial amyloid-β protein (Aβ) potentiates mitochondrial, neuronal and synaptic stress. The CypD-deficient cortical mitochondria are resistant to Aβ- and Ca2+-induced mitochondrial swelling and permeability transition. Additionally, they have an increased calcium buffering capacity and generate fewer mitochondrial reactive oxygen species. Furthermore, the absence of CypD protects neurons from Aβ- and oxidative stress–induced cell death. Notably, CypD deficiency substantially improves learning and memory and synaptic function in an Alzheimer's disease mouse model and alleviates Aβ-mediated reduction of long-term potentiation. Thus, the CypD-mediated mitochondrial permeability transition pore is directly linked to the cellular and synaptic perturbations observed in the pathogenesis of Alzheimer's disease. Blockade of CypD may be a therapeutic strategy in Alzheimer's disease.
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“Moreover, recent studies show that a genetic deficiency in CypD protects from Ca 2+ - and oxidative stress–induced cell death and that CypD functions as a necessary component of the mPT”
ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease
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Metadata
- Authors
- Du, H., Guo, L., Fang, F., Chen, D., A Sosunov, A., M McKhann, G., Yan, Y., Wang, C., Zhang, H., Molkentin, J. D., Gunn-Moore, F. J., Vonsattel, J. P., Arancio, O., Chen, J. X., & Yan, S. D.
- Venue
- Nature Medicine
- Published
- 2008-09-21
- Volume
- 14
- Issue
- 10
- Pages
- 1097-1105
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1968257316
- Cited by
- 932
- References
- 15
- FWCI
- 36.59
- Type
- journal article
- Language
- en
- Open access
- green
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