Reduction in mitochondrial superoxide dismutase modulates Alzheimer’s disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice

Free radicals in biology and medicine

Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178 · see citing works

Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

Pellow, S., Chopin, P., File, S. E., & Briley, M. (1985) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(85)90031-7 · Cited by 5,822 · see citing works

Free radicals in biology and medicine

Halliwell, B. B., & Gutteridge, J. M. C. (1985) · Journal of Free Radicals in Biology & Medicine · doi:10.1016/0748-5514(85)90140-0 · Cited by 2,931 · see citing works

The use of a plus-maze to measure anxiety in the mouse

Lister, R. G. (1987) · Psychopharmacology · doi:10.1007/bf00177912 · Cited by 2,617 · see citing works

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516 · see citing works

High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

Mucke, L., Masliah, E., Yu, G.-Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., & McConlogue, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04050.2000 · Cited by 1,856 · see citing works

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

Tanzi, R. E., & Bertram, L. (2005) · Cell · doi:10.1016/j.cell.2005.02.008 · Cited by 1,849 · see citing works

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

Li, Y., Huang, T.-T., Carlson, E. J., Melov, S., Ursell, P. C., Olson, J. L., Noble, L. J., Yoshimura, M. P., Berger, C., Chan, P. H., et al. (1995) · Nature Genetics · doi:10.1038/ng1295-376 · Cited by 1,789 · see citing works

Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories

Braak, H., & Braak, E. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00056-0 · Cited by 1,656 · see citing works

Mitochondrial abnormalities in Alzheimer's disease

Hirai, K., Aliev, G., Nunomura, A., Fujioka, H., Russell, R. L., Atwood, C. S., Johnson, A. B., Kress, Y., Vinters, H. V., Tabaton, M., et al. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03017.2001 · Cited by 1,367 · see citing works

ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

Lustbader, J. W., Cirilli, M., Lin, C., Xu, H. W., Takuma, K., Wang, N., Caspersen, C., Chen, X., Pollak, S., Chaney, M., et al. (2004) · Science · doi:10.1126/science.1091230 · Cited by 1,303 · see citing works

Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease

DeMattos, R. B., Bales, K. R., Cummins, D. J., Dodart, J.-C., Paul, S. M., & Holtzman, D. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151261398 · Cited by 1,298 · see citing works

Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease

Simard, A. R., Soulet, D., Gowing, G., Julien, J.-P., & Rivest, S. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.022 · Cited by 1,265 · see citing works

Risk Factors for Alzheimer's Disease: A Prospective Analysis from the Canadian Study of Health and Aging

Lindsay, J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf074 · Cited by 1,261 · see citing works

Inflammation in Neurodegenerative Disease—A Double-Edged Sword

Wyss-Coray, T., & Mucke, L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00794-8 · Cited by 1,235 · see citing works

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

Cutler, R. G., Kelly, J., Storie, K., Pedersen, W. A., Tammara, A., Hatanpaa, K. J., Troncoso, J. C., & Mattson, M. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305799101 · Cited by 1,135 · see citing works

Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

Hsia, A. Y., Masliah, E., McConlogue, L., Yu, G.-Q., Tatsuno, G., Hu, K., Kholodenko, D., Malenka, R. C., Nicoll, R. A., & Mucke, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3228 · Cited by 1,123 · see citing works

Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide

Butterfield, D. A., Drake, J., Pocernich, C., & Castegna, A. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02173-6 · Cited by 1,114 · see citing works

Signal transduction through NF-κB

May, M. J., & Ghosh, S. (1998) · Immunology Today · doi:10.1016/s0167-5699(97)01197-3 · Cited by 1,098 · see citing works

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

Hensley, K., Carney, J. M., Mattson, M. P., Aksenova, M., Harris, M., Wu, J. F., Floyd, R. A., & Butterfield, D. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3270 · Cited by 1,086 · see citing works

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice

Lebovitz, R. M., Zhang, H., Vogel, H., Cartwright, J., Dionne, L., Lu, N., Huang, S., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9782 · Cited by 1,023 · see citing works

Mitochondria take center stage in aging and neurodegeneration

Beal, M. F. (2005) · Annals of Neurology · doi:10.1002/ana.20624 · Cited by 957 · see citing works

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

Staal, F. J. T., Roederer, M., Herzenberg, L. A., & Herzenberg, L. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9943 · Cited by 956 · see citing works

Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics

Selkoe, D. J., & Schenk, D. (2003) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.140248 · Cited by 816 · see citing works

SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling

Chen, J., Zhou, Y., Mueller-Steiner, S., Chen, L.-F., Kwon, H., Yi, S., Mucke, L., & Gan, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509329200 · Cited by 740 · see citing works

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

Van Remmen, H., Ikeno, Y., Hamilton, M., Pahlavani, M., Wolf, N., Thorpe, S. R., Alderson, N. L., Baynes, J. W., Epstein, C. J., Huang, T.-T., et al. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00122.2003 · Cited by 734 · see citing works

Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model

Calon, F., Lim, G. P., Yang, F., Morihara, T., Teter, B., Ubeda, O., Rostaing, P., Triller, A., Salem, N., Ashe, K. H., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.013 · Cited by 707 · see citing works

Amyloid precursor protein processing and Aβ 42 deposition in a transgenic mouse model of Alzheimer disease

Johnson‐Wood, K., Lee, M., Motter, R. N., Hu, K., Gordon, G., Barbour, R., Khan, K., Gordon, M. N., Tan, H. T., Games, D., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1550 · Cited by 634 · see citing works

TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice

Wyss-Coray, T., Lin, C., Yan, F., Yu, G.-Q., Rohde, M., McConlogue, L., Masliah, E., & Mucke, L. (2001) · Nature Medicine · doi:10.1038/87945 · Cited by 587 · see citing works

Redox Regulation of NF-κB Activation: Distinct Redox Regulation Between the Cytoplasm and the Nucleus

Kabe, Y., Ando, K., Hirao, S., Yoshida, M., & Handa, H. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.395 · Cited by 585 · see citing works

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

Anandatheerthavarada, H. K., Biswas, G., Robin, M.-A., & Avadhani, N. G. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200207030 · Cited by 571 · see citing works

Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication

Coskun, P. E., Beal, M. F., & Wallace, D. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403649101 · Cited by 556 · see citing works

Cortical Cytochrome Oxidase Activity Is Reduced in Alzheimer's Disease

Mutisya, E. M., Bowling, A. C., & Beal, M. F. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63062179.x · Cited by 531 · see citing works

Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice

Hovatta, I., Tennant, R. S., Helton, R., Marr, R. A., Singer, O., Redwine, J. M., Ellison, J. A., Schadt, E. E., Verma, I. M., Lockhart, D. J., et al. (2005) · Nature · doi:10.1038/nature04250 · Cited by 498 · see citing works

Increased mitochondrial oxidative stress in the Sod2 (+/−) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis

Kokoszka, J. E., Coskun, P. E., Esposito, L., & Wallace, D. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051627098 · Cited by 488 · see citing works

A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase

Melov, S., Schneider, J. A., Day, B. J., Hinerfeld, D. A., Coskun, P. E., Mirra, S. S., Crapo, J. D., & Wallace, D. C. (1998) · Nature Genetics · doi:10.1038/ng0298-159 · Cited by 487 · see citing works

Superoxide Radical and Iron Modulate Aconitase Activity in Mammalian Cells

Gardner, P. R., Raineri, I., Epstein, L. B., & White, C. W. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.13399 · Cited by 469 · see citing works

Increased Oxidative Damage Is Correlated to Altered Mitochondrial Function in Heterozygous Manganese Superoxide Dismutase Knockout Mice

Williams, M. D., Remmen, H. V., Conrad, C. C., Huang, T., Epstein, C. J., & Richardson, A. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.28510 · Cited by 453 · see citing works

Amyloidogenic role of cytokine TGF-β1 in transgenic mice and in Alzheimer's disease

Wyss-Coray, T., Masliah, E., Mallory, M., McConlogue, L., Johnson-Wood, K., Lin, C., & Mucke, L. (1997) · Nature · doi:10.1038/39321 · Cited by 417 · see citing works

Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid

Calhoun, M. E., Burgermeister, P., Phinney, A. L., Stalder, M., Tolnay, M., Wiederhold, K.-H., Abramowski, D., Sturchler-Pierrat, C., Sommer, B., Staufenbiel, M., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.14088 · Cited by 410 · see citing works

Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits

Palop, J. J., Jones, B., Kekonius, L., Chin, J., Yu, G.-Q., Raber, J., Masliah, E., & Mucke, L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1133381100 · Cited by 402 · see citing works

SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein

Iadecola, C., Zhang, F., Niwa, K., Eckman, C., Turner, S. K., Fischer, E., Younkin, S., Borchelt, D. R., Hsiao, K. K., & Carlson, G. A. (1999) · Nature Neuroscience · doi:10.1038/5715 · Cited by 399 · see citing works

Aβ is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis

Herzig, M. C., Winkler, D. T., Burgermeister, P., Pfeifer, M., Kohler, E., Schmidt, S. D., Danner, S., Abramowski, D., Stürchler-Pierrat, C., Bürki, K., et al. (2004) · Nature Neuroscience · doi:10.1038/nn1302 · Cited by 391 · see citing works

Altered Metabolism of the Amyloid β Precursor Protein Is Associated with Mitochondrial Dysfunction in Down's Syndrome

Busciglio, J., Pelsman, A., Wong, C., Pigino, G., Yuan, M., Mori, H., & Yankner, B. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00604-9 · Cited by 387 · see citing works

Expression of Human Apolipoprotein E3 or E4 in the Brains ofApoe−/−Mice: Isoform-Specific Effects on Neurodegeneration

Buttini, M., Orth, M., Bellosta, S., Akeefe, H., Pitas, R. E., Wyss‐Coray, T., Mucke, L., & Mahley, R. W. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-12-04867.1999 · Cited by 355 · see citing works

Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondria and rat hepatocytes.

García‐Ruiz, C., Colell, A., Morales, A., Kaplowitz, N., & Fernández-Checa, J. C. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10539-7 · Cited by 337 · see citing works

Copper-Dependent Inhibition of Human Cytochrome<i>c</i>Oxidase by a Dimeric Conformer of Amyloid-β_1-42

Crouch, P. J., Blake, R., Duce, J. A., Ciccotosto, G. D., Li, Q.-X., Barnham, K. J., Curtain, C. C., Cherny, R. A., Cappai, R., Dyrks, T., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4276-04.2005 · Cited by 327 · see citing works

Disrupted daily activity/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer's dementia

Hatfield, C. F. (2004) · Brain · doi:10.1093/brain/awh129 · Cited by 323 · see citing works

Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer’s disease

Chin, J., Palop, J. J., Puoliväli, J., Massaro, C., Bien-Ly, N., Gerstein, H., Scearce-Levie, K., Masliah, E., & Mucke, L. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2980-05.2005 · Cited by 312 · see citing works

Mitochondrial dysfunction, apoptotic cell death, and Alzheimer’s disease

Eckert, A., Keil, U., Marques, C. A., Bonert, A., Frey, C., Schüssel, K., & Müller, W. E. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00534-3 · Cited by 309 · see citing works

Amyloid Angiopathy–Related Vascular Cognitive Impairment

Greenberg, S. M., Gurol, M. E., Rosand, J., & Smith, E. E. (2004) · Stroke · doi:10.1161/01.str.0000143224.36527.44 · Cited by 298 · see citing works

Mouse genetic models for prepulse inhibition: an early review

Geyer, M. A., McIlwain, K. L., & Paylor, R. E. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001159 · Cited by 289 · see citing works

Amyloid β-induced Changes in Nitric Oxide Production and Mitochondrial Activity Lead to Apoptosis

Keil, U., Bonert, A., Marques, C. A., Scherping, I., Weyermann, J., Strosznajder, J. B., Müller-Spahn, F., Haass, C., Czech, C., Pradier, L., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405600200 · Cited by 287 · see citing works

Neuritic Beading Induced by Activated Microglia Is an Early Feature of Neuronal Dysfunction Toward Neuronal Death by Inhibition of Mitochondrial Respiration and Axonal Transport

Takeuchi, H., Mizuno, T., Zhang, G., Wang, J., Kawanokuchi, J., Kuno, R., & Suzumura, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413863200 · Cited by 285 · cited 1× · see citing works

Time sequence of maturation of dystrophic neurites associated with Aβ deposits in APP/PS1 transgenic mice

Blanchard, V., Moussaoui, S., Czech, C., Touchet, N., Bonici, B., Planche, M., Canton, T., Jedidi, I., Gohin, M., Wirths, O., et al. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00252-8 · Cited by 283 · see citing works

Human Apolipoprotein E4 Alters the Amyloid-β 40:42 Ratio and Promotes the Formation of Cerebral Amyloid Angiopathy in an Amyloid Precursor Protein Transgenic Model

Fryer, J. D., Simmons, K., Parsadanian, M., Bales, K. R., Paul, S. M., Sullivan, P. M., & Holtzman, D. M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5170-04.2005 · Cited by 278 · see citing works

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice

Li, F., Calingasan, N. Y., Yu, F., Mauck, W. M., Toidze, M., Almeida, C. G., Takahashi, R. H., Carlson, G. A., Beal, M. F., Lin, M. T. S., et al. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02455.x · Cited by 276 · see citing works

Transgenic animal models of Alzheimer's disease and related disorders: histopathology, behavior and therapy

Götz, J., Streffer, J. R., David, D. C., Schild, A., Hoerndli, F. J., Pennanen, L., Kurosinski, P., & Chen, F. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001508 · Cited by 272 · see citing works

Doxorubicin-dependent lipid peroxidation at low partial pressures of O2

Winterbourn, C. C., Gutteridge, J. M. C., & Halliwell, B. B. (1985) · Journal of Free Radicals in Biology & Medicine · doi:10.1016/0748-5514(85)90028-5 · Cited by 272 · see citing works

Identification of Glyoxalase-I as a Protein Marker in a Mouse Model of Extremes in Trait Anxiety

Krömer, S. A., Kessler, M. S., Milfay, D., Birg, I., Bunck, M., Czibere, L., Panhuysen, M., Pütz, B., Deussing, J. M., Holsboer, F., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0115-05.2005 · Cited by 263 · see citing works

Mitochondria dysfunction of Alzheimer's disease cybrids enhances Aβ toxicity

Cardoso, S. M., Santana, I. J., Swerdlow, R. H., & Oliveira, C. R. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02438.x · Cited by 262 · see citing works

Nicastrin, Presenilin, APH-1, and PEN-2 Form Active γ-Secretase Complexes in Mitochondria

Hansson, C. A., Frykman, S., Farmery, M. R., Tjernberg, L. O., Nilsberth, C., Pursglove, S. E., Ito, A., Winblad, B., Cowburn, R. F., Thyberg, J., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404500200 · Cited by 256 · see citing works

Sex-differences in age-related cognitive decline in C57BL/6J mice associated with increased brain microtubule-associated protein 2 and synaptophysin immunoreactivity

Benice, T. S., Rizk, A., Kohama, S., Pfankuch, T., & Raber, J. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.029 · Cited by 254 · see citing works

Manganese Superoxide Dismutase Deficiency Exacerbates Cerebral Infarction After Focal Cerebral Ischemia/Reperfusion in Mice

Kim, G. W., Kondo, T., Noshita, N., & Chan, P. H. (2002) · Stroke · doi:10.1161/hs0302.103745 · Cited by 251 · see citing works

Plaque-induced neurite abnormalities: Implications for disruption of neural networks in Alzheimer’s disease

Knowles, R. B., Wyart, C., Buldyrev, S. V., Cruz, L., Urbanc, B., Hasselmo, M. E., Stanley, H. E., & Hyman, B. T. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5274 · Cited by 241 · see citing works

Sporadic cerebral amyloid angiopathy: pathology, clinical implications, and possible pathomechanisms

Attems, J. (2005) · Acta Neuropathologica · doi:10.1007/s00401-005-1074-9 · Cited by 238 · see citing works

Apolipoprotein E and cognitive performance

Raber, J., Wong, D., Yu, G.-Q., Buttini, M., Mahley, R. W., Pitas, R. E., & Mucke, L. (2000) · Nature · doi:10.1038/35006165 · Cited by 237 · see citing works

Knockout mice heterozygous forSod2show alterations in cardiac mitochondrial function and apoptosis

Remmen, H. V., Williams, M. D., Guo, Z., Estlack, L. E., Yang, H. C., Carlson, E. J., Epstein, C. J., Huang, T., & Richardson, A. G. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.3.h1422 · Cited by 230 · see citing works

Chronic Overproduction of Transforming Growth Factor-β1 by Astrocytes Promotes Alzheimer's Disease-Like Microvascular Degeneration in Transgenic Mice

Wyss‐Coray, T., Lin, C., Sanan, D. A., Mucke, L., & Masliah, E. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64713-x · Cited by 224 · see citing works

Prominent Cerebral Amyloid Angiopathy in Transgenic Mice Overexpressing the London Mutant of Human APP in Neurons

Dorpe, J. V., Smeijers, L., Dewachter, I., Nuyens, D., Spittaels, K., den Haute, C. V., Mercken, M. H., Moechars, D., Laenen, I., Kuipéri, C., et al. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64644-5 · Cited by 223 · see citing works

Early formation of mature amyloid‐β protein deposits in a mutant APP transgenic model depends on levels of Aβ1–42

Rockenstein, E. M., Mallory, M. E., Mante, M., Sisk, A., & Masliaha, E. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1247 · Cited by 221 · see citing works

Role of Microglial-Derived Tumor Necrosis Factor in Mediating CD14 Transcription and Nuclear Factor κ B Activity in the Brain during Endotoxemia

Nadeau, S., & Rivest, S. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-09-03456.2000 · Cited by 217 · see citing works

β-Amyloid-Mediated Inhibition of NMDA Receptor-Dependent Long-Term Potentiation Induction Involves Activation of Microglia and Stimulation of Inducible Nitric Oxide Synthase and Superoxide

Wang, Q., Rowan, M. J., & Anwyl, R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0233-04.2004 · Cited by 192 · see citing works

Anti-Aβ antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice

Brendza, R. P., Bacskai, B. J., Cirrito, J. R., Simmons, K. A., Skoch, J. M., Klunk, W. E., Mathis, C. A., Bales, K. R., Paul, S. M., Hyman, B. T., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23269 · Cited by 190 · see citing works

Androgens Protect against Apolipoprotein E4-Induced Cognitive Deficits

Raber, J., Bongers, G., LeFevour, A., Buttini, M., & Mucke, L. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-12-05204.2002 · Cited by 187 · see citing works

Alzheimer’s disease and oxygen radicals: new insights

Praticò, D. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00919-4 · Cited by 186 · see citing works

Behavioral phenotypes of amyloid‐based genetically modified mouse models of Alzheimer's disease

Kobayashi, D. T., & Chen, K. S. (2005) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2005.00124.x · Cited by 175 · see citing works

Human T-Cell Leukemia Virus Type I Tax Activation of NF-ΝB/Rel Involves Phosphorylation and Degradation of IΙBκ and RelA (p65)-Mediated Induction of the italic to c-rel Gene

Sun, S., Elwood, J., Béraud, C., & Greene, W. C. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.11.7377-7384.1994 · Cited by 174 · see citing works

NEUROBEHAVIORAL AND NEUROPSYCHIATRIC SYMPTOMS IN ALZHEIMER'S DISEASE

Chung, J. A., & Cummings, J. L. (2000) · Neurologic Clinics · doi:10.1016/s0733-8619(05)70228-0 · Cited by 174 · see citing works

Macrophage/Microglia-specific Protein Iba1 Enhances Membrane Ruffling and Rac Activation via Phospholipase C-γ-dependent Pathway

Kanazawa, H., Ohsawa, K., Sasaki, Y., Kohsaka, S., & Imai, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109218200 · Cited by 170 · see citing works

Mitochondrial oxidative stress and increased seizure susceptibility in Sod2−/+ mice

Liang, L., & Patel, M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.11.029 · Cited by 168 · see citing works

A Molecular Switch in Amyloid Assembly: Met35and Amyloid β-Protein Oligomerization

Bitan, G., Tarus, B., Vollers, S. S., Lashuel, H. A., Condron, M. M., Straub, J. E., & Teplow, D. B. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0349296 · Cited by 158 · see citing works

Vascular Remodeling versus Amyloid β-Induced Oxidative Stress in the Cerebrovascular Dysfunctions Associated with Alzheimer's Disease

Tong, X., Nicolakakis, N., Kocharyan, A., & Hamel, É. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4031-05.2005 · Cited by 153 · see citing works

Increased Expression but Reduced Activity of Antioxidant Enzymes in Alzheimer's Disease

Omar, R., Chyan, Y., Andorn, A. C., Poeggeler, B., Robakis, N. K. R. K., & Pappolla, M. A. (1999) · Journal of Alzheimer s Disease · doi:10.3233/jad-1999-1301 · Cited by 149 · see citing works

Transgenic mouse models of Alzheimer's disease: phenotype and application.

(2003) · PubMed · doi:10.1097/01.fbp.0000088420.18414.ff · Cited by 147 · see citing works

Abnormal Glutamate Transport Function in Mutant Amyloid Precursor Protein Transgenic Mice

Masliah, E., Alford, M. F., Mallory, M. E., Rockenstein, E. M., Moechars, D., & LEUVEN, F. V. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7386 · Cited by 145 · see citing works

Vulnerability of Dentate Granule Cells to Disruption of Arc Expression in Human Amyloid Precursor Protein Transgenic Mice

Palop, J. J., Chin, J., Bien‐Ly, N., Massaro, C. M., Yeung, B. Z., Yu, G.-Q., & Mucke, L. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2829-05.2005 · Cited by 144 · see citing works

Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene.

Sun, S., Elwood, J., Beraud, C., & Greene, W. C. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.11.7377 · Cited by 143 · see citing works

Structural and Functional Disruption of Vascular Smooth Muscle Cells in a Transgenic Mouse Model of Amyloid Angiopathy

Christie, R. H., Yamada, M., Moskowitz, M. A., & Hyman, B. T. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64053-9 · Cited by 137 · see citing works

Causes of Alzheimer's disease.

Muñoz, D. G., & Feldman, H. (2000) · PubMed Central · Cited by 136 · see citing works

Hypothalamic–Pituitary–Adrenal Dysfunction inApoe−/−Mice: Possible Role in Behavioral and Metabolic Alterations

Raber, J., Akana, S. F., Bhatnagar, S., Dallman, M. F., Wong, D. T., & Mucke, L. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-05-02064.2000 · Cited by 131 · see citing works

Alzheimer’s amyloid β-peptide (1–42): involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide

Butterfield, D. A., & Bush, A. I. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.12.027 · Cited by 129 · see citing works

Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis

Farrer, L. A. (1997) · JAMA · doi:10.1001/jama.1997.03550160069041 · Cited by 124 · see citing works

Dementia severity and Lewy bodies affect circadian rhythms in Alzheimer disease

Harper, D. G., Stopa, E. G., McKee, A. C., Satlin, A., Fish, D., & Volicer, L. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.04.009 · Cited by 121 · see citing works

Mice with a Partial Deficiency of Manganese Superoxide Dismutase Show Increased Vulnerability to the Mitochondrial Toxins Malonate, 3-Nitropropionic Acid, and MPTP

Andreassen, O. A., Ferrante, R. J., Dedeoglu, A., Albers, D. W., Klivènyi, P., Carlson, E. J., Epstein, C. J., & Beal, M. F. (2001) · Experimental Neurology · doi:10.1006/exnr.2000.7525 · Cited by 114 · see citing works

Genetic modification of prenatal lethality and dilated cardiomyopathy in Mn superoxide dismutase mutant mice

Huang, T., Carlson, E. J., Kozy, H. M., Mantha, S., Goodman, S. I., Ursell, P. C., & Epstein, C. J. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00694-3 · Cited by 114 · see citing works

An antibody against phosphorylated neurofilaments identifies a subset of damaged association axons in Alzheimer's disease.

Masliah, E., Mallory, M. E., Hansen, L. A., Alford, M. F., DeTeresa, R. M., & Terry, R. D. (1993) · PubMed Central · Cited by 107 · see citing works

High β-Secretase Activity Elicits Neurodegeneration in Transgenic Mice Despite Reductions in Amyloid-β Levels

Rockenstein, E. M., Mante, M., Alford, M. F., Adame, A., Crews, L. A., Hashimoto, M., Esposito, L., Mucke, L., & Masliah, E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507016200 · Cited by 93 · see citing works

The Evolution of Aβ Peptide Burden in the APP23 Transgenic Mice: Implications for Aβ Deposition in Alzheimer Disease

Kuo, Y.-M., Beach, T. G., Sue, L. I., Scott, S., Layne, K. J., Kokjohn, T. A., Kalback, W. M., Luehrs, D. C., Vishnivetskaya, T. A., Abramowski, D., et al. (2001) · Molecular Medicine · doi:10.1007/bf03401867 · Cited by 90 · see citing works

Increased Extracellular Amyloid Deposition and Neurodegeneration in Human Amyloid Precursor Protein Transgenic Mice Deficient in Receptor-Associated Protein

Uden, E. V., Mallory, M. E., Veinbergs, I., Alford, M. F., Rockenstein, E. M., & Masliah, E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09298.2002 · Cited by 88 · see citing works

Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APPSWE

Savonenko, A. V., Xu, G. M., Price, D. L., Borchelt, D., & Markowska, A. L. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(02)00012-8 · Cited by 82 · see citing works

Neural consequences of competing stimuli in both visual hemifields: A physiological basis for visual extinction

Fink, G. R., Driver, J., Rorden, C., Baldeweg, T., & Dolan, R. J. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200004)47:4 · Cited by 81 · see citing works

Alzheimer's Disease‐like Cerebrovascular Pathology in Transforming Growth Factor‐β1 Transgenic Mice and Functional Metabolic Correlates

Wyss‐Coray, T., Lin, C., Euw, D. V., Masliah, E., Mucke, L., & Lacombe, P. M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06382.x · Cited by 76 · see citing works

Prepulse inhibition of acoustic startle response in mild cognitive impairment and mild dementia of Alzheimer type

Ueki, A., GOTO, K., Sato, N., Iso, H., & Morita, Y. (2006) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2006.01460.x · Cited by 73 · see citing works

Selective cholinergic denervation, independent from oxidative stress, in a mouse model of Alzheimer’s disease

Aucoin, J.-S., Jiang, P., Aznavour, N., Tong, X.-K., Buttini, M., Descarries, L., & Hamel, E. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.11.047 · Cited by 66 · see citing works

Cerebral amyloid angiopathy: major contributor or decorative response to Alzheimer’s disease pathogenesis

Castellani, R. J., Smith, M. A., Perry, G., & Friedland, R. P. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.12.019 · Cited by 57 · see citing works

Sensorineural hearing loss alters recovery from short-term adaptation in the C57BL/6 mouse

Walton, J. P., Frisina, R. D., & Meierhans, L. R. (1995) · Hearing Research · doi:10.1016/0378-5955(95)00093-j · Cited by 51 · see citing works

Increased auditory startle response and reduced prepulse inhibition of startle in transgenic mice expressing a double mutant form of amyloid precursor protein

McCool, M. F., Varty, G. B., Vecchio, R. A. D., Kazdoba, T. M., Parker, E. M., Hunter, J. C., & Hyde, L. A. (2003) · Brain Research · doi:10.1016/j.brainres.2003.09.025 · Cited by 36 · see citing works

Alteration of neuritic cytoarchitecture in Alzheimer disease.

Onorato, M., Mulvihill, P., Connolly, J., Galloway, P. G., Whitehouse, P. J., & Perry, G. L. (1989) · PubMed · Cited by 36 · see citing works

Induction of vascular amyloidosis-β by oxidative stress depends on APOE genotype

Mazur‐Kolecka, B., Dickson, D. W., & Frackowiak, J. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.04.012 · Cited by 15 · see citing works

Mitochondria in neuroplasticity and neurological disorders

Mattson, M. P., Gleichmann, M., & Cheng, A. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.010 · Cited by 1,081 · see citing works

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

Brand, M. D. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.001 · Cited by 1,063 · see citing works

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

Du, H., Guo, L., Fang, F., Chen, D., Sosunov, A. A., McKhann, G. M., Yan, Y., Wang, C., Zhang, H., Molkentin, J. D., et al. (2008) · Nature Medicine · doi:10.1038/nm.1868 · Cited by 935 · see citing works

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

Kerr, J. S., Adriaanse, B. A., Greig, N. H., Mattson, M. P., Cader, M. Z., Bohr, V. A., & Fang, E. F. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.01.002 · Cited by 870 · see citing works

Oxidative stress mitigation by antioxidants - An overview on their chemistry and influences on health status

Pisoschi, A. M., Pop, A., Iordache, F., Stanca, L., Predoi, G., & Șerban, A. I. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112891 · Cited by 849 · see citing works

Metals in Alzheimer's and Parkinson's Diseases

Barnham, K. J., & Bush, A. I. (2008) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2008.02.019 · Cited by 695 · see citing works

Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer’s disease Neurons

Rajmohan, R., & Reddy, P. H. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160612 · Cited by 695 · see citing works

Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory

Massaad, C. A., & Klann, E. (2011) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2010.3208 · Cited by 635 · see citing works

Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease

Jiang, T., Sun, Q., & Chen, S. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.07.005 · Cited by 594 · see citing works

Microglial cell dysregulation in brain aging and neurodegeneration

von Bernhardi, R., Eugenín-von Bernhardi, L., & Eugenín, J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00124 · Cited by 556 · see citing works

Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

Suberbielle, E., Sanchez, P. E., Kravitz, A. V., Wang, X., Ho, K., Eilertson, K., Devidze, N., Kreitzer, A. C., & Mucke, L. (2013) · Nature Neuroscience · doi:10.1038/nn.3356 · Cited by 487 · see citing works

Oxidative Stress and Neurodegenerative Disorders

Li, J., Wuliji, O., Li, W., Jiang, Z.-G., & Ghanbari, H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141224438 · Cited by 511 · see citing works

Neuroprotective Effect of Antioxidants in the Brain

Lee, K. H., Cha, M., & Lee, B. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197152 · Cited by 527 · see citing works

Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer’s Disease: Understanding the Therapeutics Strategies

Kamat, P. K., Kalani, A., Rai, S., Swarnkar, S., Tota, S., Nath, C., & Tyagi, N. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-9053-6 · Cited by 504 · see citing works

Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD

Wu, J., Basha, R. M., Brock, B., Cox, D. P., Cardozo‐Pelaez, F., McPherson, C. A., Harry, J., Rice, D. C., Maloney, B., Chen, D., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4405-07.2008 · Cited by 473 · see citing works

Update on the oxidative stress theory of aging: Does oxidative stress play a role in aging or healthy aging?

Salmon, A. B., Richardson, A. G., & Pérez, V. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.015 · Cited by 444 · see citing works

Alzheimer disease models and human neuropathology: similarities and differences

Duyckaerts, C. J., Potier, M., & Delatour, B. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0312-8 · Cited by 441 · see citing works

The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease

McManus, M. J., Murphy, M. P., & Franklin, J. L. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0552-11.2011 · Cited by 432 · see citing works

Accelerating Amyloid-β Fibrillization Reduces Oligomer Levels and Functional Deficits in Alzheimer Disease Mouse Models

Cheng, I. H.-J., Scearce-Levie, K. A., Legleiter, J. A., Palop, J. J., Gerstein, H., Bien‐Ly, N., Puolivaöli, J., Lesné, S., Ashe, K. H., Muchowski, P. J., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701078200 · Cited by 403 · see citing works

Neuroprotective strategies involving ROS in Alzheimer disease

Dumont, M., & Beal, M. F. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.11.026 · Cited by 402 · see citing works

SOD2 in mitochondrial dysfunction and neurodegeneration

Flynn, J. M., & Melov, S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.027 · Cited by 390 · see citing works

Oxidative Stress: Signaling Pathways, Biological Functions, and Disease

Liu, S., Liu, J., Wang, Y., Deng, F., & Deng, Z. (2025) · MedComm · doi:10.1002/mco2.70268 · Cited by 439 · see citing works

Antioxidant Therapies for Alzheimer's Disease

Feng, Y., & Wang, X. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/472932 · Cited by 382 · see citing works

Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau

Melov, S., Adlard, P. A., Morten, K., Johnson, F., Golden, T. R., Hinerfeld, D., Schilling, B., Mavros, C., Masters, C. L., Volitakis, I., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000536 · Cited by 363 · see citing works

Manganese in Health and Disease

Ávila, D. S., Puntel, R. L., & Aschner, M. (2013) · Metal ions in life sciences · doi:10.1007/978-94-007-7500-8_7 · Cited by 358 · see citing works

Epigenetics, oxidative stress, and Alzheimer disease

Zawia, N. H., Lahiri, D. K., & Cardozo-Pelaez, F. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.02.006 · Cited by 337 · see citing works

Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein

Park, L., Zhou, P., Pitstick, R., Capone, C., Anrather, J., Norris, E. H., Younkin, L., Younkin, S., Carlson, G., McEwen, B. S., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711568105 · Cited by 332 · see citing works

PINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer’s disease

Du, F., Yu, Q., Yan, S., Hu, G., Lue, L., Walker, D., Wu, L., Yan, S. F., Tieu, K., & Yan, S. S. (2017) · Brain · doi:10.1093/brain/awx258 · Cited by 307 · see citing works

Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure

Wang, Y., Xu, E., Musich, P. R., & Lin, F. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13116 · Cited by 298 · see citing works

Alzheimer disease, the two-hit hypothesis: An update

Zhu, X., Lee, H., Perry, G. L., & Smith, M. A. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.10.014 · Cited by 292 · see citing works

Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection

Shandilya, S., Kumar, S., Jha, N. K., Kesari, K. K., & Ruokolainen, J. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.09.005 · Cited by 300 · see citing works

Antioxidant Therapy in Oxidative Stress-Induced Neurodegenerative Diseases: Role of Nanoparticle-Based Drug Delivery Systems in Clinical Translation

Ashok, A., Andrabi, S. S., Mansoor, S., Kuang, Y., Kwon, B. K., & Labhasetwar, V. D. (2022) · Antioxidants · doi:10.3390/antiox11020408 · Cited by 262 · see citing works

SOD1 (Copper/Zinc Superoxide Dismutase) Deficiency Drives Amyloid β Protein Oligomerization and Memory Loss in Mouse Model of Alzheimer Disease

Murakami, K., Murata, N., Noda, Y., Tahara, S., Kaneko, T., Kinoshita, N., Hatsuta, H., Murayama, S., Barnham, K. J., Irie, K., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.279208 · Cited by 241 · see citing works

Evolving and Expanding the Roles of Mitophagy as a Homeostatic and Pathogenic Process

Gustafsson, Å. B., & Dorn, G. W. (2018) · Physiological Reviews · doi:10.1152/physrev.00005.2018 · Cited by 229 · see citing works

Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease

Massaad, C. A., Washington, T. M., Pautler, R. G., & Klann, E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902714106 · Cited by 223 · see citing works

Cerium oxide nanoparticles protect against Aβ-induced mitochondrial fragmentation and neuronal cell death

Dowding, J. M., Song, W., Bossy, K., Karakoti, A., Kumar, A., Kim, A., Bossy, B., Seal, S., Ellisman, M. H., Perkins, G., et al. (2014) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2014.72 · Cited by 221 · see citing works

Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease

Dumont, M., Wille, E., Stack, C., Calingasan, N. Y., Beal, M. F., & Lin, M. T. (2009) · The FASEB Journal · doi:10.1096/fj.09-132928 · Cited by 221 · see citing works

Neuroprotection Against Oxidative Stress: Phytochemicals Targeting TrkB Signaling and the Nrf2-ARE Antioxidant System

Hannan, M. A., Dash, R., Sohag, A. A. M., Haque, M. N., & Moon, I. S. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00116 · Cited by 212 · see citing works

Role of reactive oxygen species in the progression of Alzheimer’s disease

Bhatt, S., Puli, L., & Patil, C. R. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.12.004 · Cited by 210 · see citing works

Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model

Cen, X., Chen, Y., Xu, X., Wu, R., He, F., Zhao, Q. D., Sun, Q., Yi, C., Wu, J., Najafov, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19547-6 · Cited by 200 · see citing works

Deletion of the 7 Nicotinic Acetylcholine Receptor Gene Improves Cognitive Deficits and Synaptic Pathology in a Mouse Model of Alzheimer's Disease

Dziewczapolski, G., Głogowski, M., Masliah, E., & Heinemann, S. F. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6159-08.2009 · Cited by 197 · see citing works

Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics

Marzetti, E., Csiszár, A., Dutta, D., Balagopal, G., Calvani, R., & Leeuwenburgh, C. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00936.2012 · Cited by 197 · see citing works

Alzheimer's Disease: Redox Dysregulation As a Common Denominator for Diverse Pathogenic Mechanisms

Rommy von Bernhardi, M., & Eugenín, J. L. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4082 · Cited by 189 · see citing works

Current Concepts of Neurodegenerative Mechanisms in Alzheimer’s Disease

Magalingam, K. B., Radhakrishnan, A., Ping, N. S., & Haleagrahara, N. (2018) · BioMed Research International · doi:10.1155/2018/3740461 · Cited by 178 · see citing works

Antioxidant gene therapy against neuronal cell death

Navarro-Yepes, J., Zavala-Flores, L. M., Anandhan, A., Wang, F., Skotak, M., Chandra, N., Li, M., Pappa, A., Martínez‐Fong, D., Razo, L. M. D., et al. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.12.007 · Cited by 177 · see citing works

Mitochondrial Glutathione: Recent Insights and Role in Disease

Marı́, M., de Gregorio, E., de Dios, C., Agujetas, V. R., Cucarull, B., Tutusaus, A., Morales, A., & Colell, A. (2020) · Antioxidants · doi:10.3390/antiox9100909 · Cited by 177 · see citing works

A role for human brain pericytes in neuroinflammation

Jansson, D., Rustenhoven, J., Feng, S. X., Hurley, D., Oldfield, R. L., Bergin, P., Mee, E. W., Faull, R. L. M., & Dragunow, M. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-104 · Cited by 168 · see citing works

Wine Polyphenols: Potential Agents in Neuroprotection

Basli, A., Soulet, S., Chaher, N., Mérillon, J., Chibane, M., Monti, J., & Richard, T. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/805762 · Cited by 159 · see citing works

Increased Oxidative Stress Exacerbates α-Synuclein Aggregation In Vivo

Scudamore, O., & Ciossek, T. (2018) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nly024 · Cited by 158 · see citing works

Mitochondrial biology, targets, and drug delivery

Milane, L. S., Trivedi, M. S., Singh, A., Talekar, M., & Amiji, M. M. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.036 · Cited by 156 · see citing works

Oxidative stress, cellular senescence and ageing

Pole, A., Dimri, M., & Dimri, G. P. (2016) · AIMS molecular science · doi:10.3934/molsci.2016.3.300 · Cited by 158 · see citing works

Mitochondrial abnormalities in spinal and bulbar muscular atrophy

Ranganathan, S., Harmison, G. G., Meyertholen, K., Pennuto, M., Burnett, B. G., & Fischbeck, K. H. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn310 · Cited by 154 · see citing works

Mitochondrial superoxide dismutase SOD2, but not cytosolic SOD1, plays a critical role in protection against glutamate-induced oxidative stress and cell death in HT22 neuronal cells

Fukui, M., & Zhu, B. T. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.024 · Cited by 154 · see citing works

A reciprocal relationship between reactive oxygen species and mitochondrial dynamics in neurodegeneration

Hung, C. H.-L., Cheng, S. S., Cheung, Y.-T., Wuwongse, S., Zhang, N. Q., Ho, J. Y. S., Lee, S. M., & Chang, R. C. (2017) · Redox Biology · doi:10.1016/j.redox.2017.08.010 · Cited by 144 · see citing works

Liberation of Copper from Amyloid Plaques: Making a Risk Factor Useful for Alzheimer’s Disease Treatment

Geng, J., Li, M. C., Wu, L. J., Ren, J., & Qu, X. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm3003813 · Cited by 152 · see citing works

Blocking Early GABA Depolarization with Bumetanide Results in Permanent Alterations in Cortical Circuits and Sensorimotor Gating Deficits

Wang, D. D., & Kriegstein, A. R. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq124 · Cited by 148 · see citing works

A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease

Salek, R. M., Xia, J., Innes, A. E., Sweatman, B. C., Adalbert, R., Randle, S. J., McGowan, E. M., Emson, P. C., & Griffin, J. L. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.04.001 · Cited by 146 · see citing works

Mitochondrial import and degradation of amyloid-β peptide

Pinho, C. M., Teixeira, P. F., & Glaser, E. G. (2014) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2014.02.007 · Cited by 145 · see citing works

Amyloid β-Induced Impairments in Hippocampal Synaptic Plasticity Are Rescued by Decreasing Mitochondrial Superoxide

Ma, T., Hoeffer, C. A., Wong, H., Massaad, C. A., Zhou, P., Iadecola, C., Murphy, M. P., Pautler, R. G., & Klann, E. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6566-10.2011 · Cited by 146 · see citing works

Insights into Manganese Superoxide Dismutase and Human Diseases

Liu, M., Sun, X., Chen, B., Dai, R., Xi, Z., & Xu, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415893 · Cited by 151 · see citing works

Metabolism-Centric Overview of the Pathogenesis of Alzheimer's Disease

Kang, S., Lee, Y., & Lee, J. E. (2017) · Yonsei Medical Journal · doi:10.3349/ymj.2017.58.3.479 · Cited by 143 · see citing works

Vascular amyloidosis impairs the gliovascular unit in a mouse model of Alzheimer’s disease

Kimbrough, I. F., Robel, S., Roberson, E. D., & Sontheimer, H. W. (2015) · Brain · doi:10.1093/brain/awv327 · Cited by 134 · see citing works

A neuronal model of Alzheimer's disease: An insight into the mechanisms of oxidative stress–mediated mitochondrial injury

Sompol, P. M., Ittarat, W., Tangpong, J., Chen, Y., Doubinskaia, I. E., Batinic-Haberle, I., Abdul, H. M., Butterfield, D. A., & Clair, D. K. S. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.044 · Cited by 134 · see citing works

Brain Renin–Angiotensin System at the Intersect of Physical and Cognitive Frailty

Cosarderelioglu, C., Nidadavolu, L. S., George, C. J., Oh, E. S., Bennett, D. A., Walston, J. D., & Abadir, P. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.586314 · Cited by 134 · see citing works

Amyloid β: linking synaptic plasticity failure to memory disruption in Alzheimer’s disease

Ma, T., & Klann, E. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07506.x · Cited by 131 · see citing works

Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice

Han, B. H., Zhou, M.-L., Johnson, A. W., Singh, I., Liao, F., Vellimana, A. K., Nelson, J. W., Milner, E., Cirrito, J. R., Basak, J., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414930112 · Cited by 131 · see citing works

Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase

Hu, D., Cao, P., Thiels, E., Chu, C. T., Wu, G., Oury, T. D., & Klann, E. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.10.003 · Cited by 127 · see citing works

Riding the tiger – physiological and pathological effects of superoxide and hydrogen peroxide generated in the mitochondrial matrix

Brand, M. D. (2020) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2020.1828258 · Cited by 123 · see citing works

The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice

Young, M. L., & Franklin, J. L. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.103409 · Cited by 120 · see citing works

Changes in the mitochondrial antioxidant systems in neurodegenerative diseases and acute brain disorders

Ruszkiewicz, J. A., & Albrecht, J. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2014.12.012 · Cited by 122 · see citing works

Evidence supporting oxidative stress in a moderately affected area of the brain in Alzheimer’s disease

Youssef, P., Chami, B., Lim, J., Middleton, T., Sutherland, G. T., & Witting, P. K. (2018) · Scientific Reports · doi:10.1038/s41598-018-29770-3 · Cited by 118 · see citing works

Abnormal social behaviors in mice lacking Fgf17

Scearce-Levie, K. A., Roberson, E. D., Gerstein, H. C., Cholfin, J. A., Mandiyan, V. S., Shah, N. M., Rubenstein, J. L. R., & Mucke, L. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00357.x · Cited by 113 · see citing works

Triterpenoid CDDO‐methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer’s disease

Dumont, M., Wille, E. J., Calingasan, N. Y., Tampellini, D., Williams, C. R., Gouras, G. K., Liby, K. T., Sporn, M. B., Beal, M. F., & Lin, M. T. S. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05970.x · Cited by 112 · see citing works

Cofilin-mediated neurodegeneration in alzheimer’s disease and other amyloidopathies

Maloney, M. T., & Bamburg, J. R. (2007) · Molecular Neurobiology · doi:10.1007/bf02700622 · Cited by 112 · see citing works

IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease

Sadagurski, M., Cheng, Z., Rozzo, A., Palazzolo, I., Kelley, G. R., Dong, X., Krainc, D., & White, M. F. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46305 · Cited by 107 · see citing works

Therapeutic potential of astaxanthin and superoxide dismutase in Alzheimer's disease

Balendra, V., & Singh, S. K. (2021) · Open Biology · doi:10.1098/rsob.210013 · Cited by 108 · see citing works

Reduced mitochondrial SOD displays mortality characteristics reminiscent of natural aging

Paul, A., Belton, A., Nag, S., Martin, I., Grotewiel, M. S., & Duttaroy, A. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.10.013 · Cited by 105 · see citing works

Neuronal and Vascular Oxidative Stress in Alzheimers Disease

Massaad, C. A. (2011) · Current Neuropharmacology · doi:10.2174/157015911798376244 · Cited by 102 · see citing works

Cerebral Small Vessel Disease: Targeting Oxidative Stress as a Novel Therapeutic Strategy?

Silva, T. M. D., & Miller, A. A. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00061 · Cited by 104 · see citing works

Amyloid-beta aggregation implicates multiple pathways in Alzheimer’s disease: Understanding the mechanisms

Iliyasu, M. O., Musa, S. A., Oladele, S. B., & Iliya, A. I. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1081938 · Cited by 101 · see citing works

Oxidative Stress and Altered Mitochondrial Function in Neurodegenerative Diseases: Lessons From Mouse Models

Fernández-Checa, J. C., Fernandez, A., Morales, A., Marı́, M., García‐Ruiz, C., & Colell, A. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710791556113 · Cited by 98 · see citing works

Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension

Sharma, S., Sud, N., Wiseman, D. A., Carter, A. L., Kumar, S., Hou, Y., Rau, T., Wilham, J. M., Harmon, C., Oishi, P. E., et al. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00247.2007 · Cited by 91 · see citing works

Protective Effects of Positive Lysosomal Modulation in Alzheimer's Disease Transgenic Mouse Models

Butler, D., Hwang, J., Estick, C., Nishiyama, A., Kumar, S., Baveghems, C., Young-Oxendine, H. B., Wisniewski, M. L., Charalambides, A., & Bahr, B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020501 · Cited by 92 · see citing works

Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy

Tapias, V., Jainuddin, S., Ahuja, M., Stack, C., Elipenahli, C., Vignisse, J., Gerges, M., Starkova, N. N., Xu, H., Starkov, A. A., et al. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy201 · Cited by 88 · see citing works

Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice

Matthews, D. G., Caruso, M., Murchison, C. F., Zhu, J. Y., Wright, K. M., Harris, C. J., Gray, N. E., Quinn, J. F., & Soumyanath, A. (2019) · Antioxidants · doi:10.3390/antiox8120630 · Cited by 86 · see citing works

Superoxide dismutases: a physiopharmacological update

Valdivia, A., Perez‐Alvarez, S., Aroca‐Aguilar, J., Ikuta, I., & Jordán, J. (2009) · Journal of Physiology and Biochemistry · doi:10.1007/bf03179070 · Cited by 85 · see citing works

Implications of PI3K/AKT/PTEN Signaling on Superoxide Dismutases Expression and in the Pathogenesis of Alzheimer’s Disease

Matsuda, S., Nakagawa, Y., Tsuji, A., Kitagishi, Y., Nakanishi, A., & Murai, T. (2018) · Diseases · doi:10.3390/diseases6020028 · Cited by 85 · see citing works

Mitochondria and Antioxidant Targeted Therapeutic Strategies for Alzheimer's Disease

Dumont, M., Lin, M. T. S., & Beal, M. F. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100507 · Cited by 84 · see citing works

Oxidative stress in cerebral small vessel disease. Role of reactive species

Grochowski, C., Litak, J., Kamieniak, P., & Maciejewski, R. (2017) · Free Radical Research · doi:10.1080/10715762.2017.1402304 · Cited by 86 · see citing works

Reduction of Cerebral Oxidative Stress Following Environmental Enrichment in Mice with Alzheimer‐Like Pathology

Herring, A., Blome, M., Ambrée, O., Sachser, N., Paulus, W., & Keyvani, K. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00257.x · Cited by 83 · see citing works

Alzheimer's Disease and Amyloid: Culprit or Coincidence?

Skaper, S. D. (2012) · International review of neurobiology · doi:10.1016/b978-0-12-386986-9.00011-9 · Cited by 80 · see citing works

IRS2 integrates insulin/ IGF1 signalling with metabolism, neurodegeneration and longevity

White, M. F. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12347 · Cited by 79 · see citing works

Selective autophagy as a therapeutic target for neurological diseases

Xu, W., Ocak, U., Gao, L., Tu, S., Lenahan, C., Zhang, J., & Shao, A. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03667-9 · Cited by 82 · see citing works

Citrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats

Miler, M., Živanović, J., Ajdžanović, V. Z., Oreščanin-Dušić, Z., Milenković, D., Konić‐Ristić, A., Blagojević, D. P., Milošević, V., & Šošić‐Jurjević, B. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.08.014 · Cited by 79 · see citing works

Study on the neuroprotective effects of Genistein on Alzheimer’s disease

Duan, X., Li, Y., Xu, F., & Ding, H. (2021) · Brain and Behavior · doi:10.1002/brb3.2100 · Cited by 78 · see citing works

Modification of γ‐secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease

Guix, F. X., Wahle, T., Vennekens, K. M., Snellinx, A., Chávez‐Gutiérrez, L., ILL‐Raga, G., Ramos‐Fernández, E., Guardia‐Laguarta, C., Lleó, A., Arimon, M., et al. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200243 · Cited by 79 · see citing works

Synaptic Mitochondria: An Early Target of Amyloid-β and Tau in Alzheimer’s Disease

Torres, A. K., Jara, C., Park-Kang, H. S., Polanco, C. M., Tapia, D., Alarcón, F., de la Peña, A., Llanquinao, J., Vargas-Mardones, G., Álvarez‐Indo, J., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-215139 · Cited by 79 · see citing works

Dissecting the Crosstalk between Endothelial Mitochondrial Damage, Vascular Inflammation, and Neurodegeneration in Cerebral Amyloid Angiopathy and Alzheimer’s Disease

Parodi‐Rullán, R. M., Javadov, S. A., & Fossati, S. (2021) · Cells · doi:10.3390/cells10112903 · Cited by 75 · see citing works

Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition

Dumont, M., Ho, D. J., Calingasan, N. Y., Xu, H., Gibson, G. E., & Beal, M. F. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.07.008 · Cited by 74 · see citing works

Mitochondrial Superoxide Contributes to Blood Flow and Axonal Transport Deficits in the Tg2576 Mouse Model of Alzheimer's Disease

Massaad, C. A., Amin, S. K., Hu, L., Yuan, M., Klann, E., & Pautler, R. G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010561 · Cited by 71 · see citing works

P3–359: Reduction of mitochondrial superoxide dismutase modulates Alzheimer's disease–like pathology in human amyloid precursor protein transgenic mice

Esposito, L., Yan, F., Yu, G.-Q., Wang, X., Puoliväli, J. T., Scearce-Levie, K. A., Masliah, E., & Mucke, L. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.1629

Early Induction of Oxidative Stress in Mouse Model of Alzheimer Disease with Reduced Mitochondrial Superoxide Dismutase Activity

Lee, H. P., Pancholi, N., Esposito, L., Previll, L. A., Wang, X., Zhu, X., Smith, M. A., & Lee, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0028033 · Cited by 60 · see citing works

Early Induction of Oxidative Stress in Mouse Model of Alzheimer Disease with Reduced Mitochondrial Superoxide Dismutase

Lee, H.-P., Pancholi, N., Esposito, L., Previll, L. A., Wang, X., Zhu, X., Smith, M. A., & Lee, H.-G. (2012)

Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease

Massaad, C. A., Washington, T. M., Pautler, R. G., & Klann, E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902714106 · Cited by 223 · see citing works

Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease

Dumont, M., Wille, E., Stack, C., Calingasan, N. Y., Beal, M. F., & Lin, M. T. (2009) · The FASEB Journal · doi:10.1096/fj.09-132928 · Cited by 221 · see citing works