The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
GOAT links dietary lipids with the endocrine control of energy balance
Open accessAbstract
Central nervous system nutrient sensing and afferent endocrine signaling have been established as parallel systems communicating metabolic status and energy availability in vertebrates. The only afferent endocrine signal known to require modification with a fatty acid side chain is the orexigenic hormone ghrelin. We find that the ghrelin O-acyl transferase (GOAT), which is essential for ghrelin acylation, is regulated by nutrient availability, depends on specific dietary lipids as acylation substrates and links ingested lipids to energy expenditure and body fat mass. These data implicate the ghrelin-GOAT system as a signaling pathway that alerts the central nervous system to the presence of dietary calories, rather than to their absence as is commonly accepted.
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Cites
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479
Liu, J., Prudom, C. E., Nass, R., Pezzoli, S. S., Oliveri, M. C., Johnson, M. L., Veldhuis, P., Gordon, D. A., Howard, A. D., Witcher, D. R., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2235 · Cited by 248
Cited by
Müller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., Broglio, F., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.03.005 · Cited by 1,034
Self-citationSteinert, R. E., Feinle-Bisset, C., Asarian, L., Horowitz, M., Beglinger, C., & Geary, N. (2017) · Physiological Reviews · doi:10.1152/physrev.00031.2014 · Cited by 578
Role of the Gut in Lipid Homeostasis
Abumrad, N. A., & Davidson, N. O. (2012) · Physiological Reviews · doi:10.1152/physrev.00019.2011 · Cited by 355
Ghrelin regulation of glucose metabolism
Poher, A.-L., Tschöp, M. H., & Müller, T. D. (2018) · Peptides · doi:10.1016/j.peptides.2017.12.015 · Cited by 186
Self-citationThe physiological control of eating: signals, neurons, and networks
Watts, A. G., Kanoski, S. E., Sanchez-Watts, G., & Langhans, W. (2022) · Physiological Reviews · doi:10.1152/physrev.00028.2020 · Cited by 168
Metadata
- Authors
- Kirchner, H., Gutierrez, J. A., Solenberg, P. J., Pfluger, P. T., Czyzyk, T. A., Willency, J. A., Schürmann, A., Joost, H.-G., Jandacek, R. J., Hale, J. E., Heiman, M. L., & Tschöp, M. H.
- Venue
- Nature Medicine
- Published
- 2009-06-05
- Volume
- 15
- Issue
- 7
- Pages
- 741-745
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2039033342
- Cited by
- 401
- References
- 2
- FWCI
- 20.08
- Type
- journal article
- Language
- en
- Open access
- green
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- Kirchner, H., Gutierrez, J. A., Solenberg, P. J., Pfluger, P. T., Czyzyk, T. A., Willency, J. A., Schürmann, A., Joost, H.-G., Jandacek, R. J., Hale, J. E., Heiman, M. L., & Tschöp, M. H. (2009). GOAT links dietary lipids with the endocrine control of energy balance. Nature Medicine. https://doi.org/10.1038/nm.1997
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